YPR061C / JID1

Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR061C / JID1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.44|P-value:4.11E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.24|P-value:5.66E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.75|P-value:9.87E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:9.97|P-value:1.03E-23 ID:SGTC_73|Compound:0327-0325|FD-Score:4.70|P-value:1.18E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:3.41|P-value:3.06E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.73|P-value:1.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.24|P-value:2.08E-13 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.31|P-value:5.27E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.45|P-value:2.30E-8 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.15|P-value:8.94E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.37|P-value:5.76E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:4.54|P-value:2.62E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.46|P-value:2.98E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.19|P-value:6.76E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.50|P-value:2.21E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.42|P-value:2.91E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.97|P-value:3.42E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.39|P-value:3.25E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:15.60|P-value:3.28E-55 ID:SGTC_691|Compound:1548-0686|FD-Score:3.68|P-value:1.09E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.76|P-value:8.10E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.11|P-value:8.86E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.32|P-value:4.26E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.57|P-value:1.99E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.18|P-value:8.14E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.34|P-value:4.65E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.27|P-value:5.03E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.51|P-value:3.03E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.28|P-value:5.72E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.72|P-value:4.89E-9 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.04|P-value:2.47E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.70|P-value:1.01E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.26|P-value:5.16E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.31|P-value:4.45E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.00|P-value:2.90E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.15|P-value:7.76E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.80|P-value:7.33E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:4.59|P-value:2.02E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.09|P-value:9.48E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.55|P-value:1.35E-8 ID:SGTC_1652|Compound:st011932|FD-Score:4.01|P-value:2.89E-5 ID:SGTC_1661|Compound:st013063|FD-Score:4.46|P-value:3.91E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.13|P-value:8.23E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.54|P-value:2.60E-6 ID:SGTC_1910|Compound:st062352|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.88|P-value:4.86E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.25|P-value:5.39E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.26|P-value:5.32E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.30|P-value:4.54E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.23|P-value:5.87E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.34|P-value:3.99E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.88|P-value:4.92E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.23|P-value:5.86E-4 ID:SGTC_2215|Compound:7188065|FD-Score:4.03|P-value:2.55E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.20|P-value:6.41E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.53|P-value:1.94E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.86|P-value:2.16E-9 ID:SGTC_2336|Compound:9001819|FD-Score:4.66|P-value:1.44E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.30|P-value:4.48E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.06|P-value:2.33E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:9.16|P-value:2.54E-20 ID:SGTC_2756|Compound:carbadox|FD-Score:5.77|P-value:3.70E-9 ID:SGTC_2777|Compound:climbazole|FD-Score:4.65|P-value:1.53E-6 ID:SGTC_2848|Compound:9016370|FD-Score:5.34|P-value:4.43E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.89|P-value:5.78E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.17|P-value:8.37E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.18|P-value:6.86E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.49|P-value:2.24E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.52|P-value:2.03E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.25|P-value:5.43E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.74|P-value:9.76E-7 ID:SGTC_3247|Compound:9135149|FD-Score:3.07|P-value:9.92E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.44|P-value:4.11E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:3.21|P-value:6.33E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.24|P-value:5.66E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:-3.75|P-value:9.87E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:9.97|P-value:1.03E-23 ID:SGTC_73|Compound:0327-0325|FD-Score:4.70|P-value:1.18E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:3.41|P-value:3.06E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-3.73|P-value:1.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.24|P-value:2.08E-13 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.31|P-value:5.27E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:5.45|P-value:2.30E-8 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.15|P-value:8.94E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:4.37|P-value:5.76E-6 ID:SGTC_203|Compound:k066-0004|FD-Score:4.54|P-value:2.62E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.46|P-value:2.98E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.19|P-value:6.76E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.50|P-value:2.21E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.42|P-value:2.91E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.97|P-value:3.42E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.39|P-value:3.25E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:15.60|P-value:3.28E-55 ID:SGTC_691|Compound:1548-0686|FD-Score:3.68|P-value:1.09E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.76|P-value:8.10E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.23|P-value:5.81E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.11|P-value:8.86E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.32|P-value:4.26E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:-3.57|P-value:1.99E-4 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.18|P-value:8.14E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:-3.34|P-value:4.65E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.45|P-value:2.59E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:3.27|P-value:5.03E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.51|P-value:3.03E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:-3.28|P-value:5.72E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:5.72|P-value:4.89E-9 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.04|P-value:2.47E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.70|P-value:1.01E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.26|P-value:5.16E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.31|P-value:4.45E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.00|P-value:2.90E-5 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.15|P-value:7.76E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.80|P-value:7.33E-7 ID:SGTC_1520|Compound:flindersine|FD-Score:4.59|P-value:2.02E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.09|P-value:9.48E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:5.55|P-value:1.35E-8 ID:SGTC_1652|Compound:st011932|FD-Score:4.01|P-value:2.89E-5 ID:SGTC_1661|Compound:st013063|FD-Score:4.46|P-value:3.91E-6 ID:SGTC_1707|Compound:st032323|FD-Score:3.13|P-value:8.23E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.54|P-value:2.60E-6 ID:SGTC_1910|Compound:st062352|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.29|P-value:4.77E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.88|P-value:4.86E-5 ID:SGTC_1917|Compound:st066507|FD-Score:3.25|P-value:5.39E-4 ID:SGTC_2007|Compound:4011539|FD-Score:3.26|P-value:5.32E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.30|P-value:4.54E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.23|P-value:5.87E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.34|P-value:3.99E-4 ID:SGTC_2140|Compound:5586273|FD-Score:3.88|P-value:4.92E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.23|P-value:5.86E-4 ID:SGTC_2215|Compound:7188065|FD-Score:4.03|P-value:2.55E-5 ID:SGTC_2219|Compound:9098279|FD-Score:3.20|P-value:6.41E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.53|P-value:1.94E-4 ID:SGTC_2289|Compound:7946404|FD-Score:5.86|P-value:2.16E-9 ID:SGTC_2336|Compound:9001819|FD-Score:4.66|P-value:1.44E-6 ID:SGTC_2412|Compound:st077135|FD-Score:3.30|P-value:4.48E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.06|P-value:2.33E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.21|P-value:6.25E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:9.16|P-value:2.54E-20 ID:SGTC_2756|Compound:carbadox|FD-Score:5.77|P-value:3.70E-9 ID:SGTC_2777|Compound:climbazole|FD-Score:4.65|P-value:1.53E-6 ID:SGTC_2848|Compound:9016370|FD-Score:5.34|P-value:4.43E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-3.89|P-value:5.78E-5 ID:SGTC_2907|Compound:7721985|FD-Score:-3.17|P-value:8.37E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.18|P-value:6.86E-4 ID:SGTC_3001|Compound:9076041|FD-Score:3.49|P-value:2.24E-4 ID:SGTC_3011|Compound:9081274|FD-Score:3.52|P-value:2.03E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.25|P-value:5.43E-4 ID:SGTC_3234|Compound:9132280|FD-Score:4.74|P-value:9.76E-7 ID:SGTC_3247|Compound:9135149|FD-Score:3.07|P-value:9.92E-4

Top fitness defect scores for YPR061C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 15.60 2.6 nM 3.28E-55 cell wall 5 2.90E-55
2 SGTC_58 0957-0393 9.97 9.0 µM 1.03E-23 cell wall 77 1.07E-23
3 SGTC_2619 obliquin 9.16 87.9 µM 2.54E-20 cell wall 29 2.67E-20
4 SGTC_138 0850-0259 7.24 40.9 µM 2.08E-13 cell wall 72 2.22E-13
5 SGTC_2289 7946404 5.86 165.1 µM 2.16E-9 39 2.33E-9
6 SGTC_2756 carbadox 5.77 75.1 µM 3.70E-9 20 3.98E-9
7 SGTC_1044 1222-0021 5.72 1.8 µM 4.89E-9 heme biosynthesis & mitochondrial translocase 16 5.26E-9
8 SGTC_1580 hydrocortisone 21-hemisuccinate 5.55 43.2 µM 1.35E-8 4 1.45E-8
9 SGTC_184 1494-0393 5.45 24.7 µM 2.30E-8 20 2.47E-8
10 SGTC_453 enantio-paf c16 5.39 10.0 µM 3.25E-8 72 3.50E-8
11 SGTC_2848 9016370 5.34 26.0 µM 4.43E-8 7 4.77E-8
12 SGTC_1424 4048-1941 4.80 275.0 µM 7.33E-7 10 7.87E-7
13 SGTC_3234 9132280 4.74 49.5 µM 9.76E-7 8 1.05E-6
14 SGTC_73 0327-0325 4.70 16.2 µM 1.18E-6 DNA damage response 29 1.27E-6
15 SGTC_2336 9001819 4.66 198.7 µM 1.44E-6 heme biosynthesis & mitochondrial translocase 30 1.55E-6
16 SGTC_2777 climbazole 4.65 1.5 µM 1.53E-6 iron homeostasis 25 1.64E-6
17 SGTC_1520 flindersine 4.59 88.0 µM 2.02E-6 17 2.17E-6
18 SGTC_1723 st034307 4.54 2.5 µM 2.60E-6 mitochondrial processes 18 2.79E-6
19 SGTC_203 k066-0004 4.54 30.9 µM 2.62E-6 RSC & ERG11 11 2.81E-6
20 SGTC_994 3910-0338 4.51 138.0 µM 3.03E-6 calcium & mitochondrial duress 31 3.25E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.415 3.09E-140 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.406 1.80E-133 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.399 1.51E-128 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.380 1.51E-115 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.378 4.14E-114 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.352 1.75E-98 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.321 7.23E-81 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.318 1.40E-79 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.306 7.74E-74 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.300 1.02E-70 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.289 1.13E-65 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.271 1.21E-57 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.269 1.24E-56 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.265 8.11E-55 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.262 1.32E-53 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member