YPR062W / FCY1

Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR062W / FCY1

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:-3.78|P-value:2.02E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.67|P-value:3.19E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.82|P-value:1.77E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.96|P-value:1.17E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.35|P-value:9.18E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.53|P-value:5.22E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.36|P-value:8.39E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.63|P-value:8.16E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.01|P-value:9.63E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:4.47|P-value:1.58E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.74|P-value:5.13E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:4.72|P-value:5.72E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:-5.55|P-value:1.07E-7 ID:SGTC_784|Compound:4579-0127|FD-Score:3.55|P-value:4.80E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.63|P-value:3.42E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.62|P-value:3.86E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.89|P-value:1.47E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.29|P-value:3.29E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.01|P-value:1.12E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.88|P-value:1.57E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.42|P-value:7.34E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.83|P-value:1.86E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.78|P-value:3.81E-8 ID:SGTC_1256|Compound:0570-0116|FD-Score:5.06|P-value:1.23E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.67|P-value:3.26E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.40|P-value:7.32E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.18|P-value:4.74E-5 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.49|P-value:5.99E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.35|P-value:9.24E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.04|P-value:8.79E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.81|P-value:2.00E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-3.35|P-value:8.55E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.78|P-value:2.07E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.78|P-value:3.73E-8 ID:SGTC_1724|Compound:st037281|FD-Score:4.71|P-value:5.91E-6 ID:SGTC_1732|Compound:st034308|FD-Score:4.47|P-value:1.59E-5 ID:SGTC_1737|Compound:st035557|FD-Score:6.21|P-value:3.70E-9 ID:SGTC_1772|Compound:st048439|FD-Score:6.23|P-value:3.29E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.32|P-value:9.40E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.37|P-value:8.07E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.65|P-value:7.63E-6 ID:SGTC_1895|Compound:st058434|FD-Score:5.84|P-value:2.73E-8 ID:SGTC_2090|Compound:5301565|FD-Score:4.48|P-value:1.55E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.66|P-value:7.43E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.39|P-value:8.27E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.35|P-value:8.59E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.42|P-value:6.96E-4 ID:SGTC_2467|Compound:5474540|FD-Score:5.28|P-value:4.53E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-4.60|P-value:8.40E-6 ID:SGTC_2602|Compound:kawain|FD-Score:-3.31|P-value:9.92E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.27|P-value:3.56E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.62|P-value:3.80E-4 ID:SGTC_2714|Compound:st079313|FD-Score:6.26|P-value:2.84E-9 ID:SGTC_2781|Compound:5567276|FD-Score:3.41|P-value:7.65E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.63|P-value:3.68E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.89|P-value:1.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.66|P-value:3.34E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.99|P-value:1.70E-6 ID:SGTC_3016|Compound:9080866|FD-Score:4.81|P-value:3.90E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.70|P-value:2.93E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.16|P-value:5.43E-5 ID:SGTC_3128|Compound:9127691|FD-Score:5.07|P-value:1.18E-6 ID:SGTC_3149|Compound:9097855|FD-Score:4.79|P-value:4.20E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.82|P-value:1.80E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.66|P-value:3.15E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:-3.78|P-value:2.02E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.67|P-value:3.19E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:-3.82|P-value:1.77E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:3.96|P-value:1.17E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.35|P-value:9.18E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:3.53|P-value:5.22E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.36|P-value:8.39E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:5.63|P-value:8.16E-8 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:4.01|P-value:9.63E-5 ID:SGTC_529|Compound:4076-0302|FD-Score:4.47|P-value:1.58E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.74|P-value:5.13E-6 ID:SGTC_579|Compound:4491-1009|FD-Score:4.72|P-value:5.72E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:-5.55|P-value:1.07E-7 ID:SGTC_784|Compound:4579-0127|FD-Score:3.55|P-value:4.80E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.63|P-value:3.42E-4 ID:SGTC_904|Compound:1141-0088|FD-Score:3.62|P-value:3.86E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.89|P-value:1.47E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:4.29|P-value:3.29E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:6.01|P-value:1.12E-8 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.88|P-value:1.57E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.42|P-value:7.34E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.83|P-value:1.86E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:5.78|P-value:3.81E-8 ID:SGTC_1256|Compound:0570-0116|FD-Score:5.06|P-value:1.23E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.67|P-value:3.26E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.40|P-value:7.32E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.18|P-value:4.74E-5 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.49|P-value:5.99E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.35|P-value:9.24E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:4.04|P-value:8.79E-5 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.81|P-value:2.00E-4 ID:SGTC_1701|Compound:st028638|FD-Score:-3.35|P-value:8.55E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.78|P-value:2.07E-4 ID:SGTC_1723|Compound:st034307|FD-Score:5.78|P-value:3.73E-8 ID:SGTC_1724|Compound:st037281|FD-Score:4.71|P-value:5.91E-6 ID:SGTC_1732|Compound:st034308|FD-Score:4.47|P-value:1.59E-5 ID:SGTC_1737|Compound:st035557|FD-Score:6.21|P-value:3.70E-9 ID:SGTC_1772|Compound:st048439|FD-Score:6.23|P-value:3.29E-9 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.32|P-value:9.40E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-3.37|P-value:8.07E-4 ID:SGTC_1845|Compound:st056753|FD-Score:4.65|P-value:7.63E-6 ID:SGTC_1895|Compound:st058434|FD-Score:5.84|P-value:2.73E-8 ID:SGTC_2090|Compound:5301565|FD-Score:4.48|P-value:1.55E-5 ID:SGTC_2149|Compound:5554786|FD-Score:4.66|P-value:7.43E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.39|P-value:8.27E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.35|P-value:8.59E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.42|P-value:6.96E-4 ID:SGTC_2467|Compound:5474540|FD-Score:5.28|P-value:4.53E-7 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-4.60|P-value:8.40E-6 ID:SGTC_2602|Compound:kawain|FD-Score:-3.31|P-value:9.92E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.27|P-value:3.56E-5 ID:SGTC_2703|Compound:st077852|FD-Score:3.62|P-value:3.80E-4 ID:SGTC_2714|Compound:st079313|FD-Score:6.26|P-value:2.84E-9 ID:SGTC_2781|Compound:5567276|FD-Score:3.41|P-value:7.65E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.63|P-value:3.68E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.89|P-value:1.48E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.66|P-value:3.34E-4 ID:SGTC_2994|Compound:9053520|FD-Score:4.99|P-value:1.70E-6 ID:SGTC_3016|Compound:9080866|FD-Score:4.81|P-value:3.90E-6 ID:SGTC_3089|Compound:9117425|FD-Score:3.70|P-value:2.93E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.16|P-value:5.43E-5 ID:SGTC_3128|Compound:9127691|FD-Score:5.07|P-value:1.18E-6 ID:SGTC_3149|Compound:9097855|FD-Score:4.79|P-value:4.20E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.82|P-value:1.80E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.90|P-value:1.46E-4 ID:SGTC_3214|Compound:9129694|FD-Score:-3.66|P-value:3.15E-4

Top fitness defect scores for YPR062W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2714 st079313 6.26 56.9 µM 2.84E-9 1 1.92E-10
2 SGTC_1772 st048439 6.23 82.2 µM 3.29E-9 8 2.27E-10
3 SGTC_1737 st035557 6.21 69.7 µM 3.70E-9 2 2.60E-10
4 SGTC_1006 4099-6547 6.01 255.0 µM 1.12E-8 6 9.31E-10
5 SGTC_1895 st058434 5.84 18.3 µM 2.73E-8 3 2.58E-9
6 SGTC_1723 st034307 5.78 2.5 µM 3.73E-8 mitochondrial processes 7 3.70E-9
7 SGTC_1109 tnp00067 5.78 928.3 nM 3.81E-8 1 3.78E-9
8 SGTC_436 n,n-dimethylsphingosine 5.63 3.3 µM 8.16E-8 6 9.07E-9
9 SGTC_2467 5474540 5.28 200.0 µM 4.53E-7 3 6.49E-8
10 SGTC_3128 9127691 5.07 49.5 µM 1.18E-6 4 1.95E-7
11 SGTC_1256 0570-0116 5.06 285.0 µM 1.23E-6 2 2.04E-7
12 SGTC_2994 9053520 4.99 71.4 µM 1.70E-6 RPP1 & pyrimidine depletion 9 2.96E-7
13 SGTC_3016 9080866 4.81 49.5 µM 3.90E-6 13 7.66E-7
14 SGTC_3149 9097855 4.79 49.5 µM 4.20E-6 Golgi 8 8.36E-7
15 SGTC_574 1315-0397 4.74 40.0 µM 5.13E-6 17 1.05E-6
16 SGTC_579 4491-1009 4.72 110.0 µM 5.72E-6 60S ribosome export 9 1.19E-6
17 SGTC_1724 st037281 4.71 8.3 µM 5.91E-6 24 1.23E-6
18 SGTC_2149 5554786 4.66 194.8 µM 7.43E-6 cell wall signaling 21 1.61E-6
19 SGTC_1845 st056753 4.65 3.0 µM 7.63E-6 TSC3-RPN4 21 1.65E-6
20 SGTC_2090 5301565 4.48 104.5 µM 1.55E-5 TSC3-RPN4 32 3.72E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.09E-11 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
0.088 3.65E-7 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.080 3.67E-6 YIL079C AIR1 hom Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication
0.079 4.73E-6 YCL025C AGP1 hom Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication
0.076 1.02E-5 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.075 1.37E-5 YGL053W PRM8 hom Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family
0.075 1.39E-5 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.075 1.44E-5 YHL033C RPL8A hom Ribosomal 60S subunit protein L8A; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication
0.074 2.05E-5 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.071 3.72E-5 YOR173W DCS2 hom Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
0.071 4.07E-5 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.070 5.03E-5 YGR140W CBF2 het Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; relative distribution to the spindle pole body decreases upon DNA replication stress
0.069 6.44E-5 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.067 9.26E-5 YJL190C RPS22A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication
0.067 1.04E-4 YJR093C FIP1 het Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p