| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.091 |
1.22E-7 |
YNL149C |
PGA2 |
het |
Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect |
| 0.090 |
1.56E-7 |
YGL176C_p |
YGL176C_p |
hom |
Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype |
| 0.078 |
5.96E-6 |
YGR267C |
FOL2 |
het |
GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway |
| 0.074 |
1.64E-5 |
YPR115W |
RGC1 |
hom |
Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication |
| 0.074 |
1.96E-5 |
YHR109W |
CTM1 |
hom |
Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth |
| 0.069 |
5.62E-5 |
YOL124C |
TRM11 |
hom |
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain |
| 0.067 |
1.00E-4 |
YPL149W |
ATG5 |
hom |
Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation |
| 0.067 |
1.06E-4 |
YDL213C |
NOP6 |
hom |
rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes |
| 0.065 |
1.47E-4 |
YBR243C |
ALG7 |
het |
UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin |
| 0.065 |
1.59E-4 |
YAR030C_d |
YAR030C_d |
hom |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 |
| 0.065 |
1.79E-4 |
YKL010C |
UFD4 |
hom |
Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress |
| 0.064 |
2.06E-4 |
YGR283C |
YGR283C |
hom |
Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus |
| 0.063 |
2.68E-4 |
YLR080W |
EMP46 |
hom |
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport |
| 0.063 |
2.72E-4 |
YDR135C |
YCF1 |
hom |
Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR |
| 0.061 |
3.74E-4 |
YIL014W |
MNT3 |
hom |
Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation |
