YPR063C_p

ER-localized protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR063C / YPR063C

Click on Significant Values for Screen Details ID:SGTC_110|Compound:0850-0284|FD-Score:3.95|P-value:9.62E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.84|P-value:1.97E-8 ID:SGTC_192|Compound:3455-0609|FD-Score:3.27|P-value:9.76E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.68|P-value:2.52E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.50|P-value:1.04E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.39|P-value:6.66E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.28|P-value:9.51E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.34|P-value:2.31E-7 ID:SGTC_792|Compound:4534-1957|FD-Score:6.14|P-value:3.43E-9 ID:SGTC_866|Compound:0495-0101|FD-Score:3.74|P-value:2.00E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.89|P-value:1.93E-6 ID:SGTC_1759|Compound:st043059|FD-Score:4.22|P-value:3.38E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.38|P-value:1.72E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.71|P-value:2.27E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.88|P-value:1.34E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.69|P-value:2.46E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.89|P-value:1.29E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.89|P-value:1.16E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.01|P-value:8.19E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.06|P-value:8.65E-7 ID:SGTC_2160|Compound:5660466|FD-Score:-3.61|P-value:3.54E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.32|P-value:2.22E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.69|P-value:2.42E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.32|P-value:8.39E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.59|P-value:3.42E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.34|P-value:2.07E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.29|P-value:9.40E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.62|P-value:3.13E-4 ID:SGTC_3146|Compound:9095609|FD-Score:5.34|P-value:2.28E-7 ID:SGTC_3155|Compound:9099265|FD-Score:5.10|P-value:7.13E-7 ID:SGTC_3161|Compound:9100388|FD-Score:5.06|P-value:8.66E-7 ID:SGTC_3164|Compound:9100705|FD-Score:3.52|P-value:4.34E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.48|P-value:1.27E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.53|P-value:4.22E-4 ID:SGTC_3177|Compound:9107506|FD-Score:6.11|P-value:4.12E-9 ID:SGTC_3185|Compound:9108267|FD-Score:-6.24|P-value:2.27E-9 ID:SGTC_3194|Compound:9111903|FD-Score:-3.90|P-value:1.24E-4 ID:SGTC_3229|Compound:9132204|FD-Score:-3.42|P-value:6.66E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.85|P-value:1.49E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.69|P-value:2.43E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.40|P-value:6.47E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.95|P-value:9.62E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:-5.84|P-value:1.97E-8 ID:SGTC_192|Compound:3455-0609|FD-Score:3.27|P-value:9.76E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.68|P-value:2.52E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:4.50|P-value:1.04E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.39|P-value:6.66E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.28|P-value:9.51E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.34|P-value:2.31E-7 ID:SGTC_792|Compound:4534-1957|FD-Score:6.14|P-value:3.43E-9 ID:SGTC_866|Compound:0495-0101|FD-Score:3.74|P-value:2.00E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.89|P-value:1.93E-6 ID:SGTC_1759|Compound:st043059|FD-Score:4.22|P-value:3.38E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.38|P-value:1.72E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.71|P-value:2.27E-4 ID:SGTC_2018|Compound:5133068|FD-Score:-3.88|P-value:1.34E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.69|P-value:2.46E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-3.89|P-value:1.29E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.89|P-value:1.16E-4 ID:SGTC_2114|Compound:5491910|FD-Score:-4.01|P-value:8.19E-5 ID:SGTC_2122|Compound:5258151|FD-Score:5.06|P-value:8.65E-7 ID:SGTC_2160|Compound:5660466|FD-Score:-3.61|P-value:3.54E-4 ID:SGTC_2283|Compound:7944793|FD-Score:4.32|P-value:2.22E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.69|P-value:2.42E-4 ID:SGTC_2428|Compound:5615643|FD-Score:3.32|P-value:8.39E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.59|P-value:3.42E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:4.34|P-value:2.07E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.29|P-value:9.40E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.62|P-value:3.13E-4 ID:SGTC_3146|Compound:9095609|FD-Score:5.34|P-value:2.28E-7 ID:SGTC_3155|Compound:9099265|FD-Score:5.10|P-value:7.13E-7 ID:SGTC_3161|Compound:9100388|FD-Score:5.06|P-value:8.66E-7 ID:SGTC_3164|Compound:9100705|FD-Score:3.52|P-value:4.34E-4 ID:SGTC_3165|Compound:9101544|FD-Score:-4.48|P-value:1.27E-5 ID:SGTC_3170|Compound:9103054|FD-Score:3.53|P-value:4.22E-4 ID:SGTC_3177|Compound:9107506|FD-Score:6.11|P-value:4.12E-9 ID:SGTC_3185|Compound:9108267|FD-Score:-6.24|P-value:2.27E-9 ID:SGTC_3194|Compound:9111903|FD-Score:-3.90|P-value:1.24E-4 ID:SGTC_3229|Compound:9132204|FD-Score:-3.42|P-value:6.66E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.85|P-value:1.49E-4 ID:SGTC_3265|Compound:9137266|FD-Score:3.69|P-value:2.43E-4 ID:SGTC_3300|Compound:9124615|FD-Score:3.40|P-value:6.47E-4

Top fitness defect scores for YPR063C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_792 4534-1957 6.14 155.0 µM 3.43E-9 10 4.19E-10
2 SGTC_3177 9107506 6.11 49.5 µM 4.12E-9 ERG2 3 5.14E-10
3 SGTC_3146 9095609 5.34 49.5 µM 2.28E-7 4 4.61E-8
4 SGTC_787 4152-0075 5.34 138.0 µM 2.31E-7 4 4.68E-8
5 SGTC_3155 9099265 5.10 49.5 µM 7.13E-7 8 1.66E-7
6 SGTC_2122 5258151 5.06 111.7 µM 8.65E-7 13 2.05E-7
7 SGTC_3161 9100388 5.06 49.5 µM 8.66E-7 iron homeostasis 2 2.06E-7
8 SGTC_1096 rimcazole 4.89 32.2 µM 1.93E-6 1 5.05E-7
9 SGTC_541 4513-1321 4.50 94.0 µM 1.04E-5 13 3.34E-6
10 SGTC_1789 tunicamycin 4.38 25.0 nM 1.72E-5 unfolded protein response 35 5.82E-6
11 SGTC_2767 sibutramine 4.34 71.5 µM 2.07E-5 14 7.18E-6
12 SGTC_2283 7944793 4.32 200.0 µM 2.22E-5 30 7.74E-6
13 SGTC_1759 st043059 4.22 70.0 µM 3.38E-5 amide catabolism 16 1.24E-5
14 SGTC_110 0850-0284 3.95 111.6 µM 9.62E-5 16 3.99E-5
15 SGTC_2111 5486399 3.89 200.0 µM 1.16E-4 48 4.93E-5
16 SGTC_866 0495-0101 3.74 262.0 µM 2.00E-4 60S ribosome export 23 9.04E-5
17 SGTC_1862 st057513 3.71 3.8 µM 2.27E-4 16 1.04E-4
18 SGTC_2425 5628681 3.69 7.8 µM 2.42E-4 35 1.12E-4
19 SGTC_3265 9137266 3.69 49.5 µM 2.43E-4 13 1.12E-4
20 SGTC_2021 4019055 3.69 173.0 µM 2.46E-4 endomembrane recycling 138 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.22E-7 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.090 1.56E-7 YGL176C_p YGL176C_p hom Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype
0.078 5.96E-6 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.074 1.64E-5 YPR115W RGC1 hom Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication
0.074 1.96E-5 YHR109W CTM1 hom Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth
0.069 5.62E-5 YOL124C TRM11 hom Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
0.067 1.00E-4 YPL149W ATG5 hom Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation
0.067 1.06E-4 YDL213C NOP6 hom rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
0.065 1.47E-4 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.065 1.59E-4 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.065 1.79E-4 YKL010C UFD4 hom Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.064 2.06E-4 YGR283C YGR283C hom Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus
0.063 2.68E-4 YLR080W EMP46 hom Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
0.063 2.72E-4 YDR135C YCF1 hom Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR
0.061 3.74E-4 YIL014W MNT3 hom Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation