YPR064W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR064W / YPR064W

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:6.98|P-value:6.01E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:7.91|P-value:8.18E-15 ID:SGTC_67|Compound:0335-0847|FD-Score:7.69|P-value:4.16E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:9.54|P-value:1.14E-20 ID:SGTC_137|Compound:0438-0332|FD-Score:10.20|P-value:1.76E-23 ID:SGTC_138|Compound:0850-0259|FD-Score:6.67|P-value:4.56E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:14.90|P-value:1.24E-47 ID:SGTC_158|Compound:k038-0087|FD-Score:20.20|P-value:4.98E-85 ID:SGTC_165|Compound:k038-0023|FD-Score:4.10|P-value:3.28E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:5.38|P-value:8.17E-8 ID:SGTC_213|Compound:1246-0773|FD-Score:3.25|P-value:7.41E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:5.18|P-value:2.31E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.51|P-value:7.78E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.32|P-value:7.61E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.20|P-value:8.74E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.17|P-value:9.80E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.97|P-value:5.34E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:3.49|P-value:3.33E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.61|P-value:2.82E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.71|P-value:1.96E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-6.96|P-value:1.14E-11 ID:SGTC_661|Compound:1304-0007|FD-Score:4.73|P-value:2.10E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.22|P-value:8.37E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.70|P-value:2.33E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:4.32|P-value:1.28E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.87|P-value:1.11E-14 ID:SGTC_837|Compound:0091-0265|FD-Score:3.62|P-value:2.03E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.32|P-value:7.64E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:7.62|P-value:6.81E-14 ID:SGTC_852|Compound:0418-0143|FD-Score:5.81|P-value:8.14E-9 ID:SGTC_929|Compound:2805-0021|FD-Score:-4.08|P-value:4.71E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.50|P-value:3.16E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.33|P-value:1.09E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.55|P-value:3.44E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.63|P-value:4.65E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.39|P-value:5.95E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.32|P-value:1.28E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.73|P-value:1.80E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.62|P-value:2.75E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.86|P-value:8.28E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.62|P-value:2.04E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.10|P-value:3.23E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-4.41|P-value:1.21E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.56|P-value:2.57E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.37|P-value:4.96E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.75|P-value:1.90E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.74|P-value:1.74E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.53|P-value:2.82E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.29|P-value:8.39E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.87|P-value:1.07E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.77|P-value:1.19E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.41|P-value:4.34E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.53|P-value:2.87E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.91|P-value:8.63E-7 ID:SGTC_2709|Compound:st078560|FD-Score:3.45|P-value:3.84E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.87|P-value:8.12E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.63|P-value:4.65E-6 ID:SGTC_2858|Compound:9025781|FD-Score:4.41|P-value:8.84E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.32|P-value:7.69E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.36|P-value:5.23E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.21|P-value:8.57E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.69|P-value:2.12E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:6.98|P-value:6.01E-12 ID:SGTC_64|Compound:000l-0018|FD-Score:7.91|P-value:8.18E-15 ID:SGTC_67|Compound:0335-0847|FD-Score:7.69|P-value:4.16E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:9.54|P-value:1.14E-20 ID:SGTC_137|Compound:0438-0332|FD-Score:10.20|P-value:1.76E-23 ID:SGTC_138|Compound:0850-0259|FD-Score:6.67|P-value:4.56E-11 ID:SGTC_142|Compound:0335-0849|FD-Score:14.90|P-value:1.24E-47 ID:SGTC_158|Compound:k038-0087|FD-Score:20.20|P-value:4.98E-85 ID:SGTC_165|Compound:k038-0023|FD-Score:4.10|P-value:3.28E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:5.38|P-value:8.17E-8 ID:SGTC_213|Compound:1246-0773|FD-Score:3.25|P-value:7.41E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:5.18|P-value:2.31E-7 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.51|P-value:7.78E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:-3.32|P-value:7.61E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.20|P-value:8.74E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:3.17|P-value:9.80E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.97|P-value:5.34E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:3.49|P-value:3.33E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.61|P-value:2.82E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.71|P-value:1.96E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-6.96|P-value:1.14E-11 ID:SGTC_661|Compound:1304-0007|FD-Score:4.73|P-value:2.10E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.22|P-value:8.37E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.70|P-value:2.33E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:4.32|P-value:1.28E-5 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.53|P-value:3.69E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:7.87|P-value:1.11E-14 ID:SGTC_837|Compound:0091-0265|FD-Score:3.62|P-value:2.03E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:-3.32|P-value:7.64E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:7.62|P-value:6.81E-14 ID:SGTC_852|Compound:0418-0143|FD-Score:5.81|P-value:8.14E-9 ID:SGTC_929|Compound:2805-0021|FD-Score:-4.08|P-value:4.71E-5 ID:SGTC_1033|Compound:k072-0102|FD-Score:3.50|P-value:3.16E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:5.33|P-value:1.09E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.55|P-value:3.44E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.63|P-value:4.65E-6 ID:SGTC_1243|Compound:0416-0003|FD-Score:-3.39|P-value:5.95E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.32|P-value:1.28E-5 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.73|P-value:1.80E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:-3.62|P-value:2.75E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.78|P-value:1.51E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.86|P-value:8.28E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.62|P-value:2.04E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.10|P-value:3.23E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-4.41|P-value:1.21E-5 ID:SGTC_1658|Compound:st012944|FD-Score:3.56|P-value:2.57E-4 ID:SGTC_1693|Compound:xanthone|FD-Score:3.37|P-value:4.96E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.75|P-value:1.90E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.74|P-value:1.74E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:3.53|P-value:2.82E-4 ID:SGTC_1884|Compound:5633444|FD-Score:-3.29|P-value:8.39E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.87|P-value:1.07E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.77|P-value:1.19E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.41|P-value:4.34E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.53|P-value:2.87E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:4.91|P-value:8.63E-7 ID:SGTC_2709|Compound:st078560|FD-Score:3.45|P-value:3.84E-4 ID:SGTC_2786|Compound:7743617|FD-Score:3.87|P-value:8.12E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-4.63|P-value:4.65E-6 ID:SGTC_2858|Compound:9025781|FD-Score:4.41|P-value:8.84E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.32|P-value:7.69E-4 ID:SGTC_2906|Compound:7926292|FD-Score:3.36|P-value:5.23E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.21|P-value:8.57E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.69|P-value:2.12E-4

Top fitness defect scores for YPR064W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_158 k038-0087 20.20 26.4 µM 4.98E-85 ubiquinone biosynthesis & proteasome 6 1.13E-90
2 SGTC_142 0335-0849 14.90 62.7 µM 1.24E-47 ubiquinone biosynthesis & proteasome 15 1.13E-50
3 SGTC_137 0438-0332 10.20 85.4 µM 1.76E-23 ubiquinone biosynthesis & proteasome 22 7.24E-25
4 SGTC_86 0417-1630 9.54 471.9 µM 1.14E-20 ubiquinone biosynthesis & proteasome 43 7.27E-22
5 SGTC_64 000l-0018 7.91 272.1 µM 8.18E-15 ubiquinone biosynthesis & proteasome 49 1.28E-15
6 SGTC_794 k038-0031 7.87 316.0 µM 1.11E-14 ubiquinone biosynthesis & proteasome 33 1.77E-15
7 SGTC_67 0335-0847 7.69 266.0 µM 4.16E-14 ubiquinone biosynthesis & proteasome 43 7.26E-15
8 SGTC_846 0335-0850 7.62 148.0 µM 6.81E-14 ubiquinone biosynthesis & proteasome 10 1.23E-14
9 SGTC_36 0335-0881 6.98 14.2 µM 6.01E-12 ubiquinone biosynthesis & proteasome 46 1.45E-12
10 SGTC_138 0850-0259 6.67 40.9 µM 4.56E-11 cell wall 84 1.26E-11
11 SGTC_852 0418-0143 5.81 439.0 µM 8.14E-9 calcium & mitochondrial duress 30 3.13E-9
12 SGTC_200 k038-0079 5.38 37.5 µM 8.17E-8 ubiquinone biosynthesis & proteasome 35 3.63E-8
13 SGTC_1050 3232-1156 5.33 69.3 µM 1.09E-7 RSC complex & mRNA processing 5 4.94E-8
14 SGTC_216 k038-0035 5.18 28.4 µM 2.31E-7 ubiquinone biosynthesis & proteasome 33 1.09E-7
15 SGTC_2651 1327-0036 4.91 5.0 µM 8.63E-7 111 4.44E-7
16 SGTC_1715 st032160 4.75 10.2 µM 1.90E-6 27 1.03E-6
17 SGTC_661 1304-0007 4.73 33.6 µM 2.10E-6 9 1.14E-6
18 SGTC_690 glyoxal 4.70 20.3 µM 2.33E-6 61 1.28E-6
19 SGTC_2858 9025781 4.41 9.0 µM 8.84E-6 sphingolipid biosynthesis & PDR1 79 5.25E-6
20 SGTC_1244 0416-0015 4.32 52.5 µM 1.28E-5 ERG2 23 7.79E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.601 0 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.572 6.89E-291 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.567 5.22E-285 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.550 1.95E-264 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.536 1.56E-249 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.515 8.86E-227 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.508 1.25E-219 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.505 2.49E-216 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.481 4.11E-194 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.471 3.24E-185 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.471 3.74E-185 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.469 4.81E-183 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.462 1.06E-176 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.460 1.64E-175 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.457 1.04E-172 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation