YPR068C / HOS1

Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR068C / HOS1

Click on Significant Values for Screen Details ID:SGTC_49|Compound:0717-0965|FD-Score:3.35|P-value:1.04E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-2.97|P-value:5.50E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.03|P-value:4.13E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:5.93|P-value:2.94E-11 ID:SGTC_336|Compound:4111-0029|FD-Score:3.03|P-value:3.93E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.91|P-value:6.43E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.25|P-value:1.61E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.12|P-value:3.06E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.58|P-value:3.81E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.03|P-value:4.05E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.93|P-value:7.08E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:-2.95|P-value:5.95E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:6.49|P-value:3.81E-13 ID:SGTC_533|Compound:1222-0222|FD-Score:3.32|P-value:1.19E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.25|P-value:1.74E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.68|P-value:2.31E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.42|P-value:7.80E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.83|P-value:8.55E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.01|P-value:4.40E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.39|P-value:8.87E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.20|P-value:1.99E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.24|P-value:1.68E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.57|P-value:3.89E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.90|P-value:6.60E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.10|P-value:3.01E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.48|P-value:5.93E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.60|P-value:3.47E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.25|P-value:1.59E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.18|P-value:2.16E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.20|P-value:2.03E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.01|P-value:4.34E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.49|P-value:5.69E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.97|P-value:5.66E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.01|P-value:4.69E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-2.82|P-value:9.61E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.55|P-value:4.75E-5 ID:SGTC_2043|Compound:5101342|FD-Score:4.02|P-value:4.47E-6 ID:SGTC_2254|Compound:7938975|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-3.09|P-value:3.39E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.71|P-value:2.21E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.67|P-value:2.45E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.50|P-value:5.40E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.82|P-value:1.18E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-4.07|P-value:3.81E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.29|P-value:1.50E-4 ID:SGTC_2845|Compound:9003024|FD-Score:2.83|P-value:8.54E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.34|P-value:1.12E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.52|P-value:5.00E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.04|P-value:4.19E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.45|P-value:4.35E-7 ID:SGTC_2983|Compound:9022671|FD-Score:3.06|P-value:3.52E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.52|P-value:5.50E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.16|P-value:2.38E-6 ID:SGTC_3130|Compound:9127414|FD-Score:4.22|P-value:1.58E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.12|P-value:2.83E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.97|P-value:5.64E-6 ID:SGTC_3255|Compound:9139072|FD-Score:-3.01|P-value:4.64E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-2.92|P-value:6.63E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.12|P-value:3.04E-4 ID:SGTC_49|Compound:0717-0965|FD-Score:3.35|P-value:1.04E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-2.97|P-value:5.50E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.03|P-value:4.13E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:5.93|P-value:2.94E-11 ID:SGTC_336|Compound:4111-0029|FD-Score:3.03|P-value:3.93E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:2.91|P-value:6.43E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.25|P-value:1.61E-4 ID:SGTC_398|Compound:bronopol|FD-Score:-3.12|P-value:3.06E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:3.58|P-value:3.81E-5 ID:SGTC_502|Compound:l-744,832|FD-Score:3.03|P-value:4.05E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.93|P-value:7.08E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:-2.95|P-value:5.95E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:6.49|P-value:3.81E-13 ID:SGTC_533|Compound:1222-0222|FD-Score:3.32|P-value:1.19E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.25|P-value:1.74E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:3.68|P-value:2.31E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.42|P-value:7.80E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.83|P-value:8.55E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.01|P-value:4.40E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.39|P-value:8.87E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.20|P-value:1.99E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.24|P-value:1.68E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.57|P-value:3.89E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.33|P-value:1.17E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:2.90|P-value:6.60E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.10|P-value:3.01E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.48|P-value:5.93E-5 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.60|P-value:3.47E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.25|P-value:1.59E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.18|P-value:2.16E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.20|P-value:2.03E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.01|P-value:4.34E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.49|P-value:5.69E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.97|P-value:5.66E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.01|P-value:4.69E-6 ID:SGTC_1886|Compound:st057356|FD-Score:3.34|P-value:1.08E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-2.82|P-value:9.61E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.55|P-value:4.75E-5 ID:SGTC_2043|Compound:5101342|FD-Score:4.02|P-value:4.47E-6 ID:SGTC_2254|Compound:7938975|FD-Score:2.99|P-value:4.65E-4 ID:SGTC_2370|Compound:9071495|FD-Score:-3.09|P-value:3.39E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.71|P-value:2.21E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.67|P-value:2.45E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.50|P-value:5.40E-5 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.82|P-value:1.18E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.34|P-value:1.10E-4 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-4.07|P-value:3.81E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:-3.29|P-value:1.50E-4 ID:SGTC_2845|Compound:9003024|FD-Score:2.83|P-value:8.54E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.34|P-value:1.12E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.52|P-value:5.00E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-3.04|P-value:4.19E-4 ID:SGTC_2949|Compound:9072542|FD-Score:4.45|P-value:4.35E-7 ID:SGTC_2983|Compound:9022671|FD-Score:3.06|P-value:3.52E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.52|P-value:5.50E-5 ID:SGTC_3108|Compound:9121785|FD-Score:-4.16|P-value:2.38E-6 ID:SGTC_3130|Compound:9127414|FD-Score:4.22|P-value:1.58E-6 ID:SGTC_3181|Compound:9108277|FD-Score:3.12|P-value:2.83E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.97|P-value:5.64E-6 ID:SGTC_3255|Compound:9139072|FD-Score:-3.01|P-value:4.64E-4 ID:SGTC_3275|Compound:9138069|FD-Score:-2.92|P-value:6.63E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.12|P-value:3.04E-4

Top fitness defect scores for YPR068C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_530 4358-1714 6.49 28.0 µM 3.81E-13 6 4.31E-11
2 SGTC_135 0933-0004 5.93 26.4 µM 2.94E-11 60S ribosome export 2 1.55E-9
3 SGTC_2949 9072542 4.45 2.2 µM 4.35E-7 TSC3-RPN4 25 4.29E-6
4 SGTC_3130 9127414 4.22 49.5 µM 1.58E-6 15 1.25E-5
5 SGTC_99 0109-0120 4.03 622.8 µM 4.13E-6 13 2.76E-5
6 SGTC_2043 5101342 4.02 149.0 µM 4.47E-6 SWF1 & branched chain AA biosynthesis 19 2.95E-5
7 SGTC_1479 0549-0158 4.01 134.0 µM 4.69E-6 24 3.06E-5
8 SGTC_3233 9132340 3.97 49.5 µM 5.64E-6 16 3.57E-5
9 SGTC_1451 4152-0210 3.97 104.0 µM 5.66E-6 27 3.58E-5
10 SGTC_525 k781-2675 3.93 26.7 µM 7.08E-6 redox potentiating 56 4.31E-5
11 SGTC_2616 abietic acid 3.82 100.0 µM 1.18E-5 34 6.56E-5
12 SGTC_545 4218-0007 3.68 221.0 µM 2.31E-5 34 1.15E-4
13 SGTC_2563 tomatine 3.67 8.5 µM 2.45E-5 62 1.20E-4
14 SGTC_1294 1000-1494 3.60 117.0 µM 3.47E-5 31 1.61E-4
15 SGTC_424 splitomicin 3.58 100.0 mM 3.81E-5 29 1.74E-4
16 SGTC_1116 jasmonic acid 3.57 1.6 µM 3.89E-5 29 1.77E-4
17 SGTC_2910 7948405 3.52 26.0 µM 5.00E-5 plasma membrane duress 37 2.18E-4
18 SGTC_2604 4'-hydroxychalcone 3.50 11.3 µM 5.40E-5 58 2.32E-4
19 SGTC_1447 4239-0816 3.49 81.9 µM 5.69E-5 48 2.42E-4
20 SGTC_1214 0358-0031 3.48 63.7 µM 5.93E-5 29 2.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.88E-13 YOL113W SKM1 hom Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth
0.125 3.89E-13 YOR021C SFM1 hom SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
0.117 9.05E-12 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.094 5.02E-8 YKR068C BET3 het Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
0.086 5.96E-7 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.084 9.69E-7 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.081 2.46E-6 YDL214C PRR2 hom Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance
0.080 3.88E-6 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.079 4.40E-6 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.078 7.11E-6 YDR473C PRP3 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.076 1.13E-5 YGR132C PHB1 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.075 1.22E-5 YLR351C NIT3 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.075 1.33E-5 YHR161C YAP1801 hom Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication
0.072 2.81E-5 YER114C BOI2 hom Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication
0.072 3.08E-5 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing