YPR069C / SPE3

Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR069C / SPE3

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-3.56|P-value:3.27E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.94|P-value:1.38E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.80|P-value:2.23E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.39|P-value:8.97E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.88|P-value:1.69E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.46|P-value:7.12E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.49|P-value:1.64E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.94|P-value:1.39E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.72|P-value:3.00E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.29|P-value:3.61E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.40|P-value:1.37E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.60|P-value:4.47E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.60|P-value:4.54E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.90|P-value:2.79E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:6.71|P-value:2.25E-10 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.86|P-value:3.29E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.13|P-value:9.80E-7 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.08|P-value:8.24E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.50|P-value:6.36E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.44|P-value:7.66E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:-3.33|P-value:7.22E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.02|P-value:1.02E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.08|P-value:8.10E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.66|P-value:3.69E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.85|P-value:1.89E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.89|P-value:1.66E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.96|P-value:1.29E-4 ID:SGTC_2146|Compound:5545642|FD-Score:7.73|P-value:3.15E-13 ID:SGTC_2271|Compound:7849410|FD-Score:-3.37|P-value:6.24E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.55|P-value:3.41E-4 ID:SGTC_2318|Compound:6029776|FD-Score:6.45|P-value:9.91E-10 ID:SGTC_2413|Compound:inermin|FD-Score:-4.12|P-value:4.27E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.40|P-value:8.80E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.35|P-value:2.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.28|P-value:2.57E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.98|P-value:1.17E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.47|P-value:1.74E-5 ID:SGTC_3131|Compound:9127911|FD-Score:4.06|P-value:8.97E-5 ID:SGTC_3139|Compound:9095020|FD-Score:3.63|P-value:4.13E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.48|P-value:1.67E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.39|P-value:9.10E-4 ID:SGTC_3234|Compound:9132280|FD-Score:5.11|P-value:1.10E-6 ID:SGTC_3264|Compound:9137442|FD-Score:7.92|P-value:8.04E-14 ID:SGTC_3269|Compound:9137823|FD-Score:5.39|P-value:2.84E-7 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.56|P-value:3.27E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:3.94|P-value:1.38E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.80|P-value:2.23E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:3.39|P-value:8.97E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.88|P-value:1.69E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.46|P-value:7.12E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:4.49|P-value:1.64E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.94|P-value:1.39E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.72|P-value:3.00E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.29|P-value:3.61E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.40|P-value:1.37E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.60|P-value:4.47E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.60|P-value:4.54E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:4.90|P-value:2.79E-6 ID:SGTC_1187|Compound:1391-0724|FD-Score:6.71|P-value:2.25E-10 ID:SGTC_1193|Compound:1488-0126|FD-Score:4.86|P-value:3.29E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.13|P-value:9.80E-7 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.08|P-value:8.24E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.50|P-value:6.36E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.44|P-value:7.66E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:-3.33|P-value:7.22E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.02|P-value:1.02E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.08|P-value:8.10E-5 ID:SGTC_1742|Compound:st038235|FD-Score:3.66|P-value:3.69E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.85|P-value:1.89E-4 ID:SGTC_2110|Compound:5483698|FD-Score:3.89|P-value:1.66E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.96|P-value:1.29E-4 ID:SGTC_2146|Compound:5545642|FD-Score:7.73|P-value:3.15E-13 ID:SGTC_2271|Compound:7849410|FD-Score:-3.37|P-value:6.24E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.55|P-value:3.41E-4 ID:SGTC_2318|Compound:6029776|FD-Score:6.45|P-value:9.91E-10 ID:SGTC_2413|Compound:inermin|FD-Score:-4.12|P-value:4.27E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.40|P-value:8.80E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.35|P-value:2.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.28|P-value:2.57E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.98|P-value:1.17E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.47|P-value:1.74E-5 ID:SGTC_3131|Compound:9127911|FD-Score:4.06|P-value:8.97E-5 ID:SGTC_3139|Compound:9095020|FD-Score:3.63|P-value:4.13E-4 ID:SGTC_3192|Compound:9110362|FD-Score:4.48|P-value:1.67E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.39|P-value:9.10E-4 ID:SGTC_3234|Compound:9132280|FD-Score:5.11|P-value:1.10E-6 ID:SGTC_3264|Compound:9137442|FD-Score:7.92|P-value:8.04E-14 ID:SGTC_3269|Compound:9137823|FD-Score:5.39|P-value:2.84E-7

Top fitness defect scores for YPR069C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3264 9137442 7.92 49.5 µM 8.04E-14 1 1.17E-15
2 SGTC_2146 5545642 7.73 200.0 µM 3.15E-13 1 5.56E-15
3 SGTC_1187 1391-0724 6.71 117.0 µM 2.25E-10 amide catabolism 2 1.00E-11
4 SGTC_2318 6029776 6.45 164.0 µM 9.91E-10 3 5.45E-11
5 SGTC_3269 9137823 5.39 49.5 µM 2.84E-7 60S ribosome export 3 3.49E-8
6 SGTC_1195 1502-0147 5.13 41.1 µM 9.80E-7 8 1.44E-7
7 SGTC_3234 9132280 5.11 49.5 µM 1.10E-6 4 1.64E-7
8 SGTC_1151 3909-8316 4.90 15.3 µM 2.79E-6 4 4.74E-7
9 SGTC_1193 1488-0126 4.86 41.5 µM 3.29E-6 12 5.73E-7
10 SGTC_696 1560-0013 4.49 611.0 µM 1.64E-5 14 3.59E-6
11 SGTC_3192 9110362 4.48 49.5 µM 1.67E-5 mitochondrial processes 3 3.67E-6
12 SGTC_2617 dihydrotanshinone i 4.47 20.8 µM 1.74E-5 copper-dependent oxidative stress 20 3.85E-6
13 SGTC_2580 diallyl disulphide 4.35 81.4 µM 2.84E-5 14 6.72E-6
14 SGTC_1081 sertraline 4.29 6.0 µM 3.61E-5 60S ribosome export 25 8.84E-6
15 SGTC_1719 st032227 4.08 49.2 µM 8.10E-5 20 2.23E-5
16 SGTC_1202 1988-0068 4.08 29.6 µM 8.24E-5 RNA processing & uracil transport 23 2.27E-5
17 SGTC_3131 9127911 4.06 49.5 µM 8.97E-5 27 2.51E-5
18 SGTC_1454 4239-0054 4.02 42.6 µM 1.02E-4 34 2.89E-5
19 SGTC_2593 nobiletin 3.98 86.2 µM 1.17E-4 25 3.40E-5
20 SGTC_2119 5528445 3.96 120.6 µM 1.29E-4 19 3.80E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.31E-8 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.085 7.80E-7 YPL264C_p YPL264C_p hom Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene
0.080 3.89E-6 YJR055W HIT1 hom Protein of unknown function, required for growth at high temperature
0.079 4.94E-6 YOL136C PFK27 hom 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
0.077 8.38E-6 YHL007C STE20 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p
0.074 1.93E-5 YGR269W_d YGR269W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
0.073 2.14E-5 YHR202W_p YHR202W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
0.073 2.46E-5 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.073 2.56E-5 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.072 3.08E-5 YLR278C_p YLR278C_p hom Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene
0.071 3.53E-5 YKL120W OAC1 hom Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family
0.071 3.66E-5 YDR079C-A TFB5 hom Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair
0.070 4.68E-5 YEL059W_d HHY1_d hom Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking
0.070 5.17E-5 YMR310C_p YMR310C_p hom Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene
0.070 5.45E-5 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress