HIPHOP chemogenomics database
YPR072W / NOT5 
Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YPR072W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.099 | 8.26E-9 | YPR088C | SRP54 | het | Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain |
| 0.090 | 1.68E-7 | YHR114W | BZZ1 | hom | SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins |
| 0.090 | 2.04E-7 | YLR244C | MAP1 | hom | Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p |
| 0.087 | 5.03E-7 | YJR046W | TAH11 | het | DNA replication licensing factor, required for pre-replication complex assembly |
| 0.087 | 5.33E-7 | YOR222W | ODC2 | hom | Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism |
| 0.083 | 1.69E-6 | YKL080W | VMA5 | hom | Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane |
| 0.081 | 2.53E-6 | YAR007C | RFA1 | het | Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination |
| 0.081 | 2.98E-6 | YIL117C | PRM5 | hom | Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling |
| 0.079 | 4.04E-6 | YGL168W | HUR1 | hom | Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene |
| 0.079 | 4.66E-6 | YIL163C_p | YIL163C_p | hom | Protein of unknown function; mRNA identified as translated by ribosome profiling data |
| 0.078 | 6.32E-6 | YOL121C | RPS19A | hom | Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication |
| 0.077 | 8.83E-6 | YOR078W | BUD21 | hom | Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern |
| 0.072 | 3.23E-5 | YGR271C-A | EFG1 | hom | Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus |
| 0.072 | 3.26E-5 | YLR435W | TSR2 | hom | Protein with a potential role in pre-rRNA processing |
| 0.072 | 3.37E-5 | YNR068C_p | YNR068C_p | hom | Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form |