YPR072W / NOT5

Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR072W / NOT5

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:3.93|P-value:3.51E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.24|P-value:5.26E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.41|P-value:4.05E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.57|P-value:1.53E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.17|P-value:6.67E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.25|P-value:7.09E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.37|P-value:2.82E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-4.14|P-value:1.17E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.05|P-value:1.56E-7 ID:SGTC_462|Compound:ag-879|FD-Score:-4.41|P-value:3.33E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.48|P-value:2.14E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.23|P-value:9.41E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.96|P-value:3.11E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:4.69|P-value:1.03E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.40|P-value:2.95E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.60|P-value:5.71E-9 ID:SGTC_999|Compound:4022-0066|FD-Score:3.07|P-value:9.40E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.88|P-value:4.31E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.43|P-value:2.33E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:5.27|P-value:4.59E-8 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.70|P-value:7.73E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.55|P-value:1.43E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-5.27|P-value:3.80E-8 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.73|P-value:7.93E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.53|P-value:1.75E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.39|P-value:3.02E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.33|P-value:3.80E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.16|P-value:6.14E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.09|P-value:8.93E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.36|P-value:3.38E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.20|P-value:5.96E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.53|P-value:1.58E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.15|P-value:6.44E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.26|P-value:4.35E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.46|P-value:2.33E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.09|P-value:8.90E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.85|P-value:4.87E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.13|P-value:7.70E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.77|P-value:6.69E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.12|P-value:8.09E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-4.31|P-value:5.57E-6 ID:SGTC_2285|Compound:7945142|FD-Score:-3.08|P-value:8.10E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.13|P-value:1.43E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.69|P-value:9.27E-5 ID:SGTC_2450|Compound:5739737|FD-Score:4.51|P-value:2.48E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.15|P-value:1.31E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:5.62|P-value:5.97E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.30|P-value:3.76E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.09|P-value:9.07E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.95|P-value:2.77E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.03|P-value:9.87E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.21|P-value:8.50E-6 ID:SGTC_3197|Compound:9113331|FD-Score:-3.22|P-value:5.02E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-3.48|P-value:1.88E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.50|P-value:1.76E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.93|P-value:3.51E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.24|P-value:5.26E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:4.41|P-value:4.05E-6 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.57|P-value:1.53E-4 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.24|P-value:5.19E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:3.17|P-value:6.67E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-4.25|P-value:7.09E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.37|P-value:2.82E-4 ID:SGTC_443|Compound:clozapine|FD-Score:-4.14|P-value:1.17E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:5.05|P-value:1.56E-7 ID:SGTC_462|Compound:ag-879|FD-Score:-4.41|P-value:3.33E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.48|P-value:2.14E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.69|P-value:9.42E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:4.23|P-value:9.41E-6 ID:SGTC_676|Compound:falcarinol|FD-Score:3.96|P-value:3.11E-5 ID:SGTC_763|Compound:3453-1109|FD-Score:4.69|P-value:1.03E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:3.40|P-value:2.95E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.60|P-value:5.71E-9 ID:SGTC_999|Compound:4022-0066|FD-Score:3.07|P-value:9.40E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.88|P-value:4.31E-5 ID:SGTC_1002|Compound:4049-0206|FD-Score:-3.43|P-value:2.33E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:5.27|P-value:4.59E-8 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.70|P-value:7.73E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:-3.55|P-value:1.43E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:-5.27|P-value:3.80E-8 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.73|P-value:7.93E-5 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.53|P-value:1.75E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.39|P-value:3.02E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:3.33|P-value:3.80E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.16|P-value:6.14E-4 ID:SGTC_1722|Compound:st034304|FD-Score:3.09|P-value:8.93E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.36|P-value:3.38E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.20|P-value:5.96E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.53|P-value:1.58E-4 ID:SGTC_1946|Compound:st076057|FD-Score:-3.15|P-value:6.44E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-3.26|P-value:4.35E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.46|P-value:2.33E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.09|P-value:8.90E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.85|P-value:4.87E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.13|P-value:7.70E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.77|P-value:6.69E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.12|P-value:8.09E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-4.31|P-value:5.57E-6 ID:SGTC_2285|Compound:7945142|FD-Score:-3.08|P-value:8.10E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.13|P-value:1.43E-5 ID:SGTC_2380|Compound:9035439|FD-Score:3.69|P-value:9.27E-5 ID:SGTC_2450|Compound:5739737|FD-Score:4.51|P-value:2.48E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.15|P-value:1.31E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:5.62|P-value:5.97E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.63|P-value:1.19E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.30|P-value:3.76E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.09|P-value:9.07E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.95|P-value:2.77E-5 ID:SGTC_2941|Compound:9056145|FD-Score:-3.03|P-value:9.87E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-4.21|P-value:8.50E-6 ID:SGTC_3197|Compound:9113331|FD-Score:-3.22|P-value:5.02E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-3.48|P-value:1.88E-4 ID:SGTC_3308|Compound:9128332|FD-Score:-3.50|P-value:1.76E-4

Top fitness defect scores for YPR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2595 hexamethylquercetagetin 5.62 100.0 µM 5.97E-9 7 9.30E-9
2 SGTC_1269 0831-0796 5.27 3.0 µM 4.59E-8 60S ribosome export 4 6.75E-8
3 SGTC_450 aminopyrene 5.05 156.0 nM 1.56E-7 16 2.21E-7
4 SGTC_763 3453-1109 4.69 128.0 µM 1.03E-6 8 1.39E-6
5 SGTC_2450 5739737 4.51 12.9 µM 2.48E-6 11 3.26E-6
6 SGTC_99 0109-0120 4.41 622.8 µM 4.05E-6 9 5.24E-6
7 SGTC_646 4092-0839 4.23 27.3 µM 9.41E-6 plasma membrane duress 22 1.19E-5
8 SGTC_2594 a-mangostin 4.15 100.0 µM 1.31E-5 27 1.65E-5
9 SGTC_2334 9017922 4.13 200.0 µM 1.43E-5 20 1.79E-5
10 SGTC_676 falcarinol 3.96 140.0 µM 3.11E-5 54 3.82E-5
11 SGTC_24 0417-1663 3.93 219.0 µM 3.51E-5 16 4.28E-5
12 SGTC_1001 4048-4355 3.88 44.4 µM 4.31E-5 copper-dependent oxidative stress 37 5.24E-5
13 SGTC_2248 tofa 3.85 1.1 µM 4.87E-5 sphingolipid biosynthesis & PDR1 41 5.90E-5
14 SGTC_2263 7948595 3.77 193.3 µM 6.69E-5 9 8.03E-5
15 SGTC_1358 1509-0022 3.73 2.5 µM 7.93E-5 12 9.48E-5
16 SGTC_2380 9035439 3.69 200.0 µM 9.27E-5 endomembrane recycling 34 1.10E-4
17 SGTC_625 k213-0058 3.69 121.0 µM 9.42E-5 translation 127 1.12E-4
18 SGTC_1278 0874-0585 3.64 172.0 µM 1.13E-4 18 1.34E-4
19 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.63 70.0 µM 1.19E-4 redox potentiating 87 1.41E-4
20 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.57 4.6 µM 1.53E-4 heat shock/prefoldin 49 1.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 8.26E-9 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.090 1.68E-7 YHR114W BZZ1 hom SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
0.090 2.04E-7 YLR244C MAP1 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.087 5.03E-7 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.087 5.33E-7 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.083 1.69E-6 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.081 2.53E-6 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.081 2.98E-6 YIL117C PRM5 hom Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
0.079 4.04E-6 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.079 4.66E-6 YIL163C_p YIL163C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.078 6.32E-6 YOL121C RPS19A hom Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication
0.077 8.83E-6 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.072 3.23E-5 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.072 3.26E-5 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing
0.072 3.37E-5 YNR068C_p YNR068C_p hom Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form