YPR073C / LTP1

Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR073C / LTP1

Click on Significant Values for Screen Details ID:SGTC_472|Compound:calcifediol|FD-Score:-4.46|P-value:1.66E-6 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.21|P-value:3.50E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.45|P-value:1.36E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.93|P-value:1.03E-7 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.44|P-value:1.45E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.06|P-value:7.32E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.01|P-value:7.45E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.23|P-value:3.91E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.23|P-value:3.89E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.29|P-value:1.28E-8 ID:SGTC_1733|Compound:st037357|FD-Score:2.98|P-value:8.28E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.09|P-value:6.46E-4 ID:SGTC_2018|Compound:5133068|FD-Score:6.98|P-value:1.06E-13 ID:SGTC_2026|Compound:5148700|FD-Score:3.01|P-value:7.42E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.09|P-value:6.41E-4 ID:SGTC_2100|Compound:5377183|FD-Score:5.55|P-value:2.55E-9 ID:SGTC_2117|Compound:5521686|FD-Score:3.04|P-value:6.57E-4 ID:SGTC_2182|Compound:6325192|FD-Score:4.22|P-value:4.40E-6 ID:SGTC_2300|Compound:7976697|FD-Score:3.26|P-value:2.88E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.16|P-value:2.81E-8 ID:SGTC_2437|Compound:5741531|FD-Score:4.31|P-value:2.76E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.05|P-value:6.49E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.40|P-value:1.68E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.06|P-value:6.26E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.89|P-value:2.08E-5 ID:SGTC_3095|Compound:9117207|FD-Score:-3.04|P-value:7.89E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.39|P-value:1.86E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.36|P-value:2.31E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.09|P-value:6.41E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.77|P-value:3.58E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-2.97|P-value:9.80E-4 ID:SGTC_3354|Compound:9151612|FD-Score:2.96|P-value:8.89E-4 ID:SGTC_472|Compound:calcifediol|FD-Score:-4.46|P-value:1.66E-6 ID:SGTC_477|Compound:mead ethanolamide|FD-Score:3.21|P-value:3.50E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.45|P-value:1.36E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.93|P-value:1.03E-7 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.49|P-value:1.19E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.44|P-value:1.45E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.06|P-value:7.32E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.01|P-value:7.45E-4 ID:SGTC_1607|Compound:st000305|FD-Score:-3.23|P-value:3.91E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.23|P-value:3.89E-4 ID:SGTC_1622|Compound:st003707|FD-Score:5.29|P-value:1.28E-8 ID:SGTC_1733|Compound:st037357|FD-Score:2.98|P-value:8.28E-4 ID:SGTC_1778|Compound:st046819|FD-Score:-3.09|P-value:6.46E-4 ID:SGTC_2018|Compound:5133068|FD-Score:6.98|P-value:1.06E-13 ID:SGTC_2026|Compound:5148700|FD-Score:3.01|P-value:7.42E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.09|P-value:6.41E-4 ID:SGTC_2100|Compound:5377183|FD-Score:5.55|P-value:2.55E-9 ID:SGTC_2117|Compound:5521686|FD-Score:3.04|P-value:6.57E-4 ID:SGTC_2182|Compound:6325192|FD-Score:4.22|P-value:4.40E-6 ID:SGTC_2300|Compound:7976697|FD-Score:3.26|P-value:2.88E-4 ID:SGTC_2306|Compound:7482397|FD-Score:5.16|P-value:2.81E-8 ID:SGTC_2437|Compound:5741531|FD-Score:4.31|P-value:2.76E-6 ID:SGTC_2442|Compound:5158906|FD-Score:3.05|P-value:6.49E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.40|P-value:1.68E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.06|P-value:6.26E-4 ID:SGTC_3046|Compound:9092212|FD-Score:3.89|P-value:2.08E-5 ID:SGTC_3095|Compound:9117207|FD-Score:-3.04|P-value:7.89E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.39|P-value:1.86E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-3.36|P-value:2.31E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.09|P-value:6.41E-4 ID:SGTC_3333|Compound:9141820|FD-Score:3.77|P-value:3.58E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.34|P-value:2.11E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-2.97|P-value:9.80E-4 ID:SGTC_3354|Compound:9151612|FD-Score:2.96|P-value:8.89E-4

Top fitness defect scores for YPR073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2018 5133068 6.98 143.0 µM 1.06E-13 2 1.46E-12
2 SGTC_2100 5377183 5.55 190.0 µM 2.55E-9 60S ribosome export 3 1.39E-8
3 SGTC_1622 st003707 5.29 19.4 µM 1.28E-8 calcium & mitochondrial duress 14 6.05E-8
4 SGTC_2306 7482397 5.16 179.5 µM 2.81E-8 RPP1 & pyrimidine depletion 7 1.24E-7
5 SGTC_620 0109-0052 4.93 432.0 µM 1.03E-7 7 4.02E-7
6 SGTC_3099 9120367 4.39 49.5 µM 1.86E-6 12 5.61E-6
7 SGTC_2437 5741531 4.31 144.2 µM 2.76E-6 27 8.02E-6
8 SGTC_2182 6325192 4.22 200.0 µM 4.40E-6 Golgi 10 1.23E-5
9 SGTC_3046 9092212 3.89 49.5 µM 2.08E-5 5 5.03E-5
10 SGTC_3333 9141820 3.77 12.1 µM 3.58E-5 17 8.25E-5
11 SGTC_1150 3909-7983 3.49 10.9 µM 1.19E-4 44 2.45E-4
12 SGTC_557 1315-0110 3.45 16.2 µM 1.36E-4 Golgi 34 2.79E-4
13 SGTC_1195 1502-0147 3.44 41.1 µM 1.45E-4 46 2.94E-4
14 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 3.40 100.0 µM 1.68E-4 50 3.38E-4
15 SGTC_3340 9146634 3.34 11.1 µM 2.11E-4 29 4.15E-4
16 SGTC_2300 7976697 3.26 71.6 µM 2.88E-4 ERG2 61 5.51E-4
17 SGTC_477 mead ethanolamide 3.21 10.0 µM 3.50E-4 9 6.57E-4
18 SGTC_2802 7925815 3.06 54.5 µM 6.26E-4 80 0.00112
19 SGTC_2442 5158906 3.05 48.5 µM 6.49E-4 54 0.00115
20 SGTC_2117 5521686 3.04 200.0 µM 6.57E-4 57 0.00117

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.52E-16 YLR457C NBP1 het Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication
0.123 7.24E-13 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.112 7.43E-11 YDL123W SNA4 hom Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated
0.104 1.80E-9 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.097 1.97E-8 YGR018C_p YGR018C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W
0.096 2.83E-8 YGR249W MGA1 hom Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
0.089 2.74E-7 YLR136C TIS11 hom mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.086 6.02E-7 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.085 9.06E-7 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.085 9.14E-7 YKR071C DRE2 het Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress
0.082 1.84E-6 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.082 2.14E-6 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.082 2.31E-6 YDR119W_p VBA4_p hom Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene
0.080 3.41E-6 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.080 3.51E-6 YLR126C YLR126C hom Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress