YPR074C / TKL1

Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR074C / TKL1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:8.18|P-value:4.43E-13 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:11.30|P-value:3.03E-23 ID:SGTC_29|Compound:0299-0004|FD-Score:6.16|P-value:3.85E-8 ID:SGTC_40|Compound:0327-0103|FD-Score:4.09|P-value:1.93E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.80|P-value:1.51E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:9.08|P-value:1.02E-15 ID:SGTC_162|Compound:k030-0015|FD-Score:4.83|P-value:1.35E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:5.11|P-value:4.35E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:4.73|P-value:1.94E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.97|P-value:4.72E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.52|P-value:8.12E-4 ID:SGTC_394|Compound:menadione|FD-Score:9.83|P-value:4.01E-18 ID:SGTC_470|Compound:aa-861|FD-Score:9.41|P-value:9.04E-17 ID:SGTC_513|Compound:4245-1575|FD-Score:5.70|P-value:3.47E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:4.67|P-value:2.52E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:4.03|P-value:2.37E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:9.03|P-value:1.38E-15 ID:SGTC_594|Compound:1487-1584|FD-Score:3.60|P-value:9.30E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.90|P-value:3.62E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.34|P-value:7.49E-11 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.78|P-value:1.61E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:13.90|P-value:2.35E-34 ID:SGTC_750|Compound:4073-0104|FD-Score:5.18|P-value:3.23E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:23.30|P-value:1.08E-93 ID:SGTC_810|Compound:3825-7150|FD-Score:3.92|P-value:3.40E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.87|P-value:6.98E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:7.49|P-value:2.97E-11 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.32|P-value:1.80E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.74|P-value:5.94E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:23.90|P-value:2.38E-98 ID:SGTC_1300|Compound:1094-0077|FD-Score:7.49|P-value:3.12E-11 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.46|P-value:5.29E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:8.25|P-value:2.75E-13 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.71|P-value:6.55E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.26|P-value:1.10E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:14.10|P-value:2.62E-35 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:10.20|P-value:3.17E-19 ID:SGTC_1591|Compound:genipin|FD-Score:4.70|P-value:2.17E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.53|P-value:7.24E-7 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.72|P-value:6.29E-4 ID:SGTC_1608|Compound:st001473|FD-Score:8.18|P-value:4.25E-13 ID:SGTC_1643|Compound:st009866|FD-Score:5.66|P-value:4.11E-7 ID:SGTC_1673|Compound:st016611|FD-Score:3.63|P-value:8.26E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.82|P-value:3.19E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.70|P-value:6.82E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.72|P-value:6.35E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:6.26|P-value:2.42E-8 ID:SGTC_1796|Compound:st049173|FD-Score:3.77|P-value:5.41E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.24|P-value:1.16E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.23|P-value:1.23E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.54|P-value:2.59E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-4.20|P-value:8.66E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-4.28|P-value:6.57E-5 ID:SGTC_1953|Compound:st076800|FD-Score:5.06|P-value:5.29E-6 ID:SGTC_2036|Compound:5160441|FD-Score:4.30|P-value:9.61E-5 ID:SGTC_2040|Compound:5100729|FD-Score:4.87|P-value:1.13E-5 ID:SGTC_2051|Compound:5263410|FD-Score:4.01|P-value:2.51E-4 ID:SGTC_2054|Compound:5233173|FD-Score:5.13|P-value:4.11E-6 ID:SGTC_2068|Compound:5226020|FD-Score:5.81|P-value:2.07E-7 ID:SGTC_2085|Compound:5307070|FD-Score:4.07|P-value:2.10E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.87|P-value:4.03E-4 ID:SGTC_2139|Compound:5578692|FD-Score:13.30|P-value:1.50E-31 ID:SGTC_2198|Compound:6589944|FD-Score:4.49|P-value:4.84E-5 ID:SGTC_2214|Compound:7179297|FD-Score:5.70|P-value:3.42E-7 ID:SGTC_2223|Compound:6903751|FD-Score:9.67|P-value:1.33E-17 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.61|P-value:3.96E-9 ID:SGTC_2259|Compound:7964009|FD-Score:10.40|P-value:4.63E-20 ID:SGTC_2266|Compound:7929956|FD-Score:8.11|P-value:6.87E-13 ID:SGTC_2308|Compound:7584454|FD-Score:-4.91|P-value:5.93E-6 ID:SGTC_2356|Compound:9061756|FD-Score:5.50|P-value:8.34E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.13|P-value:1.72E-4 ID:SGTC_2421|Compound:5690543|FD-Score:6.46|P-value:8.66E-9 ID:SGTC_2429|Compound:5902844|FD-Score:6.97|P-value:5.74E-10 ID:SGTC_2430|Compound:5571206|FD-Score:9.55|P-value:3.23E-17 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.37|P-value:1.44E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.33|P-value:8.56E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.59|P-value:2.98E-14 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.65|P-value:7.90E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.03|P-value:2.37E-4 ID:SGTC_2681|Compound:menadione|FD-Score:21.60|P-value:7.24E-81 ID:SGTC_2735|Compound:sertaconazole|FD-Score:4.30|P-value:9.34E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:5.13|P-value:4.07E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.24|P-value:2.56E-6 ID:SGTC_2781|Compound:5567276|FD-Score:7.23|P-value:1.35E-10 ID:SGTC_2799|Compound:7812892|FD-Score:16.70|P-value:6.98E-49 ID:SGTC_2810|Compound:7959871|FD-Score:-3.48|P-value:9.20E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.66|P-value:5.26E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.59|P-value:6.46E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.42|P-value:6.13E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.84|P-value:4.42E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.11|P-value:1.80E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.60|P-value:9.11E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.72|P-value:4.34E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:8.18|P-value:4.43E-13 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:11.30|P-value:3.03E-23 ID:SGTC_29|Compound:0299-0004|FD-Score:6.16|P-value:3.85E-8 ID:SGTC_40|Compound:0327-0103|FD-Score:4.09|P-value:1.93E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.80|P-value:1.51E-5 ID:SGTC_106|Compound:0092-0003|FD-Score:9.08|P-value:1.02E-15 ID:SGTC_162|Compound:k030-0015|FD-Score:4.83|P-value:1.35E-5 ID:SGTC_169|Compound:k015-0017|FD-Score:5.11|P-value:4.35E-6 ID:SGTC_177|Compound:1327-0068|FD-Score:4.73|P-value:1.94E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.97|P-value:4.72E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.52|P-value:8.12E-4 ID:SGTC_394|Compound:menadione|FD-Score:9.83|P-value:4.01E-18 ID:SGTC_470|Compound:aa-861|FD-Score:9.41|P-value:9.04E-17 ID:SGTC_513|Compound:4245-1575|FD-Score:5.70|P-value:3.47E-7 ID:SGTC_523|Compound:1934-0222|FD-Score:4.67|P-value:2.52E-5 ID:SGTC_526|Compound:4469-0568|FD-Score:4.03|P-value:2.37E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:9.03|P-value:1.38E-15 ID:SGTC_594|Compound:1487-1584|FD-Score:3.60|P-value:9.30E-4 ID:SGTC_615|Compound:k087-0205|FD-Score:3.90|P-value:3.62E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.34|P-value:7.49E-11 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.78|P-value:1.61E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:13.90|P-value:2.35E-34 ID:SGTC_750|Compound:4073-0104|FD-Score:5.18|P-value:3.23E-6 ID:SGTC_799|Compound:1310-0557|FD-Score:23.30|P-value:1.08E-93 ID:SGTC_810|Compound:3825-7150|FD-Score:3.92|P-value:3.40E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.87|P-value:6.98E-6 ID:SGTC_823|Compound:0417-1665|FD-Score:7.49|P-value:2.97E-11 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.32|P-value:1.80E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:3.74|P-value:5.94E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:23.90|P-value:2.38E-98 ID:SGTC_1300|Compound:1094-0077|FD-Score:7.49|P-value:3.12E-11 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.46|P-value:5.29E-5 ID:SGTC_1355|Compound:1499-0035|FD-Score:8.25|P-value:2.75E-13 ID:SGTC_1439|Compound:4092-1168|FD-Score:3.71|P-value:6.55E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.26|P-value:1.10E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:14.10|P-value:2.62E-35 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:10.20|P-value:3.17E-19 ID:SGTC_1591|Compound:genipin|FD-Score:4.70|P-value:2.17E-5 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.53|P-value:7.24E-7 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.72|P-value:6.29E-4 ID:SGTC_1608|Compound:st001473|FD-Score:8.18|P-value:4.25E-13 ID:SGTC_1643|Compound:st009866|FD-Score:5.66|P-value:4.11E-7 ID:SGTC_1673|Compound:st016611|FD-Score:3.63|P-value:8.26E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.82|P-value:3.19E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.70|P-value:6.82E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.72|P-value:6.35E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:6.26|P-value:2.42E-8 ID:SGTC_1796|Compound:st049173|FD-Score:3.77|P-value:5.41E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.24|P-value:1.16E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.23|P-value:1.23E-4 ID:SGTC_1940|Compound:st075990|FD-Score:-4.54|P-value:2.59E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-4.20|P-value:8.66E-5 ID:SGTC_1952|Compound:st077036|FD-Score:-4.28|P-value:6.57E-5 ID:SGTC_1953|Compound:st076800|FD-Score:5.06|P-value:5.29E-6 ID:SGTC_2036|Compound:5160441|FD-Score:4.30|P-value:9.61E-5 ID:SGTC_2040|Compound:5100729|FD-Score:4.87|P-value:1.13E-5 ID:SGTC_2051|Compound:5263410|FD-Score:4.01|P-value:2.51E-4 ID:SGTC_2054|Compound:5233173|FD-Score:5.13|P-value:4.11E-6 ID:SGTC_2068|Compound:5226020|FD-Score:5.81|P-value:2.07E-7 ID:SGTC_2085|Compound:5307070|FD-Score:4.07|P-value:2.10E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.87|P-value:4.03E-4 ID:SGTC_2139|Compound:5578692|FD-Score:13.30|P-value:1.50E-31 ID:SGTC_2198|Compound:6589944|FD-Score:4.49|P-value:4.84E-5 ID:SGTC_2214|Compound:7179297|FD-Score:5.70|P-value:3.42E-7 ID:SGTC_2223|Compound:6903751|FD-Score:9.67|P-value:1.33E-17 ID:SGTC_2233|Compound:sulbentine|FD-Score:6.61|P-value:3.96E-9 ID:SGTC_2259|Compound:7964009|FD-Score:10.40|P-value:4.63E-20 ID:SGTC_2266|Compound:7929956|FD-Score:8.11|P-value:6.87E-13 ID:SGTC_2308|Compound:7584454|FD-Score:-4.91|P-value:5.93E-6 ID:SGTC_2356|Compound:9061756|FD-Score:5.50|P-value:8.34E-7 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.13|P-value:1.72E-4 ID:SGTC_2421|Compound:5690543|FD-Score:6.46|P-value:8.66E-9 ID:SGTC_2429|Compound:5902844|FD-Score:6.97|P-value:5.74E-10 ID:SGTC_2430|Compound:5571206|FD-Score:9.55|P-value:3.23E-17 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:5.37|P-value:1.44E-6 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:4.33|P-value:8.56E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:8.59|P-value:2.98E-14 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.65|P-value:7.90E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.03|P-value:2.37E-4 ID:SGTC_2681|Compound:menadione|FD-Score:21.60|P-value:7.24E-81 ID:SGTC_2735|Compound:sertaconazole|FD-Score:4.30|P-value:9.34E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:5.13|P-value:4.07E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.24|P-value:2.56E-6 ID:SGTC_2781|Compound:5567276|FD-Score:7.23|P-value:1.35E-10 ID:SGTC_2799|Compound:7812892|FD-Score:16.70|P-value:6.98E-49 ID:SGTC_2810|Compound:7959871|FD-Score:-3.48|P-value:9.20E-4 ID:SGTC_2866|Compound:9034245|FD-Score:-3.66|P-value:5.26E-4 ID:SGTC_2870|Compound:9038528|FD-Score:-3.59|P-value:6.46E-4 ID:SGTC_2939|Compound:9044578|FD-Score:4.42|P-value:6.13E-5 ID:SGTC_2956|Compound:9076196|FD-Score:3.84|P-value:4.42E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.11|P-value:1.80E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.60|P-value:9.11E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.72|P-value:4.34E-4

Top fitness defect scores for YPR074C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1239 0337-0584 23.90 35.4 µM 2.38E-98 unfolded protein response 3 8.10E-127
2 SGTC_799 1310-0557 23.30 151.0 µM 1.08E-93 superoxide 1 8.47E-121
3 SGTC_2681 menadione 21.60 3.2 µM 7.24E-81 superoxide 1 3.19E-104
4 SGTC_2799 7812892 16.70 81.8 µM 6.98E-49 superoxide 1 7.09E-63
5 SGTC_1556 plumbagin 14.10 1.5 µM 2.62E-35 superoxide 4 2.53E-45
6 SGTC_690 glyoxal 13.90 20.3 µM 2.35E-34 6 4.32E-44
7 SGTC_2139 5578692 13.30 56.5 µM 1.50E-31 superoxide 1 1.84E-40
8 SGTC_28 pentachloropyridine N-oxide 11.30 1.6 µM 3.03E-23 TSC3-RPN4 4 1.02E-29
9 SGTC_2259 7964009 10.40 200.0 µM 4.63E-20 superoxide 6 1.34E-25
10 SGTC_1589 2',5'-dimethoxyflavone 10.20 47.2 µM 3.17E-19 1 1.62E-24
11 SGTC_394 menadione 9.83 8.3 µM 4.01E-18 superoxide 3 4.31E-23
12 SGTC_2223 6903751 9.67 107.6 µM 1.33E-17 superoxide 2 2.03E-22
13 SGTC_2430 5571206 9.55 200.0 µM 3.23E-17 8 6.41E-22
14 SGTC_470 aa-861 9.41 153.0 µM 9.04E-17 sphingolipid biosynthesis & PDR1 12 2.43E-21
15 SGTC_106 0092-0003 9.08 11.6 µM 1.02E-15 copper-dependent oxidative stress 3 5.61E-20
16 SGTC_548 1436-0017 9.03 110.0 µM 1.38E-15 TSC3-RPN4 3 8.27E-20
17 SGTC_2575 plumbagin 8.59 510.0 nM 2.98E-14 superoxide 7 4.40E-18
18 SGTC_1355 1499-0035 8.25 1.7 µM 2.75E-13 1 7.78E-17
19 SGTC_1608 st001473 8.18 40.5 µM 4.25E-13 6 1.37E-16
20 SGTC_9 0092-0002 8.18 10.4 µM 4.43E-13 2 1.45E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.459 2.33E-174 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.448 1.03E-165 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.285 8.85E-64 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.269 8.16E-57 YHR206W SKN7 hom Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; SKN7 has a paralog, HMS2, that arose from the whole genome duplication
0.255 4.82E-51 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.246 1.57E-47 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.234 3.74E-43 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.212 1.56E-35 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.208 4.76E-34 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.200 1.70E-31 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.181 4.39E-26 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.161 7.95E-21 YMR161W HLJ1 hom Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ
0.157 6.83E-20 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.151 1.29E-18 YLR292C SEC72 hom Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.150 2.78E-18 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport