YPR076W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR076W / YPR076W

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.38|P-value:7.02E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.00|P-value:7.91E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.42|P-value:6.07E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:4.25|P-value:2.90E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.18|P-value:3.95E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.98|P-value:8.41E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:5.29|P-value:2.86E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:4.00|P-value:7.68E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.73|P-value:3.79E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.91|P-value:1.06E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.37|P-value:1.70E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.36|P-value:7.25E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.64|P-value:5.86E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.09|P-value:5.50E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.71|P-value:2.29E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.33|P-value:7.90E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.32|P-value:8.15E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.56|P-value:3.72E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.70|P-value:2.39E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.98|P-value:8.36E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-3.27|P-value:9.78E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.82|P-value:2.59E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_2331|Compound:7980721|FD-Score:5.73|P-value:3.02E-8 ID:SGTC_2368|Compound:9071271|FD-Score:3.69|P-value:2.40E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.45|P-value:1.29E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.30|P-value:8.96E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.36|P-value:7.12E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.40|P-value:6.52E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.62|P-value:3.11E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-7.09|P-value:9.22E-12 ID:SGTC_2783|Compound:7738165|FD-Score:7.12|P-value:8.05E-12 ID:SGTC_2790|Compound:5423970|FD-Score:3.66|P-value:2.74E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.56|P-value:3.73E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.57|P-value:3.59E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.31|P-value:8.75E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.64|P-value:5.82E-6 ID:SGTC_3270|Compound:9137563|FD-Score:3.79|P-value:1.72E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.70|P-value:2.39E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.38|P-value:7.02E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:4.00|P-value:7.91E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.42|P-value:6.07E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:4.25|P-value:2.90E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:4.18|P-value:3.95E-5 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.98|P-value:8.41E-5 ID:SGTC_536|Compound:3852-0578|FD-Score:5.29|P-value:2.86E-7 ID:SGTC_653|Compound:0203-0016|FD-Score:4.00|P-value:7.68E-5 ID:SGTC_772|Compound:k072-0172|FD-Score:4.73|P-value:3.79E-6 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.91|P-value:1.06E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-4.37|P-value:1.70E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.36|P-value:7.25E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:4.64|P-value:5.86E-6 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.09|P-value:5.50E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.71|P-value:2.29E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.33|P-value:7.90E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.32|P-value:8.15E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.56|P-value:3.72E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.70|P-value:2.39E-4 ID:SGTC_1898|Compound:st060199|FD-Score:3.98|P-value:8.36E-5 ID:SGTC_1975|Compound:st070967|FD-Score:-3.27|P-value:9.78E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.82|P-value:2.59E-6 ID:SGTC_2315|Compound:7733312|FD-Score:3.86|P-value:1.31E-4 ID:SGTC_2331|Compound:7980721|FD-Score:5.73|P-value:3.02E-8 ID:SGTC_2368|Compound:9071271|FD-Score:3.69|P-value:2.40E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.45|P-value:1.29E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.30|P-value:8.96E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.36|P-value:7.12E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.40|P-value:6.52E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.62|P-value:3.11E-4 ID:SGTC_2782|Compound:7736369|FD-Score:-7.09|P-value:9.22E-12 ID:SGTC_2783|Compound:7738165|FD-Score:7.12|P-value:8.05E-12 ID:SGTC_2790|Compound:5423970|FD-Score:3.66|P-value:2.74E-4 ID:SGTC_2940|Compound:9060638|FD-Score:-3.56|P-value:3.73E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.57|P-value:3.59E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.31|P-value:8.75E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.64|P-value:5.82E-6 ID:SGTC_3270|Compound:9137563|FD-Score:3.79|P-value:1.72E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.70|P-value:2.39E-4

Top fitness defect scores for YPR076W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2783 7738165 7.12 71.4 µM 8.05E-12 3 5.28E-13
2 SGTC_2331 7980721 5.73 200.0 µM 3.02E-8 3 5.06E-9
3 SGTC_536 3852-0578 5.29 10.6 µM 2.86E-7 5 6.18E-8
4 SGTC_2302 7771753 4.82 200.0 µM 2.59E-6 21 7.17E-7
5 SGTC_772 k072-0172 4.73 35.3 µM 3.79E-6 7 1.10E-6
6 SGTC_3144 9087057 4.64 49.5 µM 5.82E-6 7 1.77E-6
7 SGTC_949 1165-0505 4.64 146.0 µM 5.86E-6 8 1.78E-6
8 SGTC_2385 9074692 4.45 200.0 µM 1.29E-5 32 4.29E-6
9 SGTC_92 0063-0024 4.25 660.9 µM 2.90E-5 6 1.05E-5
10 SGTC_265 mycophenolic acid 4.18 32.9 µM 3.95E-5 RPP1 & pyrimidine depletion 11 1.48E-5
11 SGTC_1129 3453-1384 4.09 223.0 µM 5.50E-5 37 2.15E-5
12 SGTC_653 0203-0016 4.00 55.2 µM 7.68E-5 12 3.11E-5
13 SGTC_41 0478-0632 4.00 82.6 µM 7.91E-5 27 3.22E-5
14 SGTC_1898 st060199 3.98 18.6 µM 8.36E-5 16 3.42E-5
15 SGTC_423 5-fluorouracil 3.98 457.0 µM 8.41E-5 exosome 22 3.44E-5
16 SGTC_2315 7733312 3.86 200.0 µM 1.31E-4 29 5.62E-5
17 SGTC_3270 9137563 3.79 49.5 µM 1.72E-4 RPP1 & pyrimidine depletion 8 7.63E-5
18 SGTC_1173 0443-0020 3.71 122.0 µM 2.29E-4 TSC3-RPN4 43 1.05E-4
19 SGTC_3302 9125395 3.70 16.4 µM 2.39E-4 15 1.10E-4
20 SGTC_1538 2',3',6-trimethoxyflavanone 3.70 63.6 µM 2.39E-4 21 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 1.03E-8 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.096 2.15E-8 YBR076W ECM8 hom Non-essential protein of unknown function
0.094 4.33E-8 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.089 2.56E-7 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.089 2.58E-7 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.084 1.17E-6 YPL023C MET12 hom Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR
0.084 1.18E-6 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.084 1.26E-6 YPR097W YPR097W hom Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.083 1.54E-6 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.082 2.15E-6 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.081 2.34E-6 YDR208W MSS4 het Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
0.080 3.63E-6 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.83E-6 YOL122C SMF1 hom Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
0.079 4.41E-6 YGR284C ERV29 hom Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress
0.079 4.84E-6 YBR066C NRG2 hom Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication