YPR077C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR077C / YPR077C

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.36|P-value:3.60E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.51|P-value:2.76E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.29|P-value:4.81E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:4.91|P-value:3.87E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:4.14|P-value:1.55E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:4.34|P-value:6.38E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.56|P-value:1.71E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.18|P-value:7.06E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.32|P-value:4.11E-8 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.38|P-value:3.00E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.18|P-value:7.00E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.33|P-value:4.06E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.78|P-value:7.31E-7 ID:SGTC_1068|Compound:loratadine|FD-Score:5.23|P-value:7.00E-8 ID:SGTC_1078|Compound:idebenone|FD-Score:5.76|P-value:3.35E-9 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.32|P-value:6.97E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.39|P-value:4.88E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.90|P-value:3.76E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.84|P-value:5.73E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.08|P-value:9.74E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.35|P-value:3.85E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.25|P-value:5.48E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.73|P-value:8.76E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-3.94|P-value:3.14E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.73|P-value:8.73E-5 ID:SGTC_1649|Compound:st011737|FD-Score:4.45|P-value:3.70E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.44|P-value:4.00E-6 ID:SGTC_1721|Compound:st082152|FD-Score:3.76|P-value:7.82E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.33|P-value:4.04E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.33|P-value:4.12E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.52|P-value:1.76E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.40|P-value:4.87E-6 ID:SGTC_2163|Compound:5671233|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.37|P-value:3.15E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.72|P-value:9.31E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.85|P-value:5.36E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.31|P-value:4.48E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.78|P-value:7.17E-5 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.30|P-value:4.57E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.19|P-value:6.71E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.23|P-value:5.95E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.84|P-value:5.66E-5 ID:SGTC_3022|Compound:9087993|FD-Score:3.42|P-value:2.99E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.18|P-value:6.23E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:8.40E-4 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.36|P-value:3.60E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.51|P-value:2.76E-6 ID:SGTC_253|Compound:dyclonine|FD-Score:3.29|P-value:4.81E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.29|P-value:4.78E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:4.91|P-value:3.87E-7 ID:SGTC_334|Compound:1502-1024|FD-Score:4.14|P-value:1.55E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:4.34|P-value:6.38E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:3.50|P-value:2.14E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:3.56|P-value:1.71E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.18|P-value:7.06E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.32|P-value:4.11E-8 ID:SGTC_910|Compound:3454-3003|FD-Score:-3.38|P-value:3.00E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.18|P-value:7.00E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.33|P-value:4.06E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:4.78|P-value:7.31E-7 ID:SGTC_1068|Compound:loratadine|FD-Score:5.23|P-value:7.00E-8 ID:SGTC_1078|Compound:idebenone|FD-Score:5.76|P-value:3.35E-9 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.32|P-value:6.97E-6 ID:SGTC_1181|Compound:1222-0449|FD-Score:4.39|P-value:4.88E-6 ID:SGTC_1227|Compound:3909-8010|FD-Score:-3.90|P-value:3.76E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.84|P-value:5.73E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.08|P-value:9.74E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.35|P-value:3.85E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.25|P-value:5.48E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.73|P-value:8.76E-5 ID:SGTC_1625|Compound:st003711|FD-Score:-3.94|P-value:3.14E-5 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.73|P-value:8.73E-5 ID:SGTC_1649|Compound:st011737|FD-Score:4.45|P-value:3.70E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.44|P-value:4.00E-6 ID:SGTC_1721|Compound:st082152|FD-Score:3.76|P-value:7.82E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.33|P-value:4.04E-4 ID:SGTC_1825|Compound:st052143|FD-Score:3.33|P-value:4.12E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.52|P-value:1.76E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.40|P-value:4.87E-6 ID:SGTC_2163|Compound:5671233|FD-Score:3.67|P-value:1.11E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.37|P-value:3.15E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.72|P-value:9.31E-5 ID:SGTC_2389|Compound:9091542|FD-Score:3.85|P-value:5.36E-5 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.31|P-value:4.48E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.78|P-value:7.17E-5 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.30|P-value:4.57E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.19|P-value:6.71E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.50|P-value:2.17E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:-3.52|P-value:1.79E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.23|P-value:5.95E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.63|P-value:1.31E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.84|P-value:5.66E-5 ID:SGTC_3022|Compound:9087993|FD-Score:3.42|P-value:2.99E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.18|P-value:6.23E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-3.22|P-value:5.31E-4 ID:SGTC_3192|Compound:9110362|FD-Score:3.13|P-value:8.40E-4

Top fitness defect scores for YPR077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1078 idebenone 5.76 36.1 µM 3.35E-9 Golgi 15 4.31E-9
2 SGTC_887 0885-0007 5.32 9.6 µM 4.11E-8 endomembrane recycling 18 5.05E-8
3 SGTC_1068 loratadine 5.23 26.9 µM 7.00E-8 8 8.54E-8
4 SGTC_333 3486-0131 4.91 40.1 µM 3.87E-7 amide catabolism 2 4.58E-7
5 SGTC_982 1491-0518 4.78 27.5 µM 7.31E-7 3 8.58E-7
6 SGTC_54 0159-0055 4.51 9.0 µM 2.76E-6 ERG2 36 3.17E-6
7 SGTC_1649 st011737 4.45 51.3 µM 3.70E-6 24 4.23E-6
8 SGTC_1680 diphenhydramine 4.44 100.0 µM 4.00E-6 NEO1 20 4.56E-6
9 SGTC_2058 5236698 4.40 133.0 µM 4.87E-6 19 5.54E-6
10 SGTC_1181 1222-0449 4.39 220.0 µM 4.88E-6 20 5.55E-6
11 SGTC_538 2922-0838 4.34 53.3 µM 6.38E-6 Golgi 26 7.22E-6
12 SGTC_1154 4088-0362 4.32 150.0 µM 6.97E-6 13 7.88E-6
13 SGTC_334 1502-1024 4.14 68.5 µM 1.55E-5 9 1.74E-5
14 SGTC_2389 9091542 3.85 195.5 µM 5.36E-5 iron homeostasis 36 5.87E-5
15 SGTC_2971 9092186 3.84 9.9 µM 5.66E-5 ergosterol biosynthesis 35 6.19E-5
16 SGTC_1365 1672-3266 3.84 55.4 µM 5.73E-5 24 6.27E-5
17 SGTC_2563 tomatine 3.78 8.5 µM 7.17E-5 55 7.82E-5
18 SGTC_1721 st082152 3.76 9.3 µM 7.82E-5 60S ribosome export 25 8.51E-5
19 SGTC_1639 Lupinine o-methylbenzoicacid ester hydrochloride 3.73 61.8 µM 8.73E-5 ergosterol biosynthesis 12 9.49E-5
20 SGTC_1579 chlormadinone acetate 3.73 49.4 µM 8.76E-5 12 9.52E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.59E-9 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.101 4.88E-9 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.088 3.81E-7 YHR018C ARG4 hom Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
0.079 4.51E-6 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.079 4.54E-6 YHR044C DOG1 hom 2-deoxyglucose-6-phosphate phosphatase; paralogous to DOG2; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified
0.076 1.14E-5 YKL059C MPE1 het Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
0.076 1.18E-5 YLR090W XDJ1 hom Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.24E-5 YKR021W ALY1 hom Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication
0.073 2.14E-5 YJR050W ISY1 hom Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
0.073 2.46E-5 YOR310C NOP58 het Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
0.072 3.44E-5 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.071 4.04E-5 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.071 4.19E-5 YPR043W RPL43A hom Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication
0.070 5.54E-5 YOR360C PDE2 hom High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
0.069 5.96E-5 YNR064C YNR064C hom Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides