YPR082C / DIB1

17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR082C / DIB1

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.29|P-value:5.86E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.32|P-value:5.18E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.35|P-value:5.91E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.28|P-value:1.24E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.29|P-value:5.86E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.06|P-value:4.11E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.31|P-value:1.46E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.35|P-value:5.93E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.42|P-value:4.60E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.29|P-value:5.86E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.87|P-value:6.67E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.19|P-value:8.05E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.43|P-value:3.60E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.05|P-value:4.29E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.37|P-value:5.48E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.99|P-value:5.43E-5 ID:SGTC_1828|Compound:st055811|FD-Score:-3.40|P-value:3.95E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-3.39|P-value:4.14E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.21|P-value:7.64E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.59|P-value:2.54E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.24|P-value:1.74E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.79|P-value:9.34E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.80|P-value:1.14E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.25|P-value:8.16E-4 ID:SGTC_3079|Compound:9117512|FD-Score:3.36|P-value:5.70E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.48|P-value:2.97E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.43|P-value:4.51E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-4.99|P-value:4.50E-7 ID:SGTC_3314|Compound:9135860|FD-Score:-4.41|P-value:6.96E-6 ID:SGTC_3342|Compound:9147791|FD-Score:-3.13|P-value:9.95E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.36|P-value:4.53E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.29|P-value:5.86E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.32|P-value:5.18E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.35|P-value:5.91E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.58|P-value:2.57E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.28|P-value:1.24E-5 ID:SGTC_959|Compound:1222-0044|FD-Score:-3.29|P-value:5.86E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.06|P-value:4.11E-5 ID:SGTC_1025|Compound:k007-0731|FD-Score:4.31|P-value:1.46E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.35|P-value:5.93E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.42|P-value:4.60E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.29|P-value:5.86E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.87|P-value:6.67E-5 ID:SGTC_1499|Compound:4480-0877|FD-Score:-3.19|P-value:8.05E-4 ID:SGTC_1630|Compound:st005209|FD-Score:-3.43|P-value:3.60E-4 ID:SGTC_1777|Compound:st045864|FD-Score:4.05|P-value:4.29E-5 ID:SGTC_1782|Compound:st039423|FD-Score:3.37|P-value:5.48E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.99|P-value:5.43E-5 ID:SGTC_1828|Compound:st055811|FD-Score:-3.40|P-value:3.95E-4 ID:SGTC_1832|Compound:st054113|FD-Score:-3.39|P-value:4.14E-4 ID:SGTC_1913|Compound:st060213|FD-Score:-3.21|P-value:7.64E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.59|P-value:2.54E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.24|P-value:1.74E-7 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.79|P-value:9.34E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.80|P-value:1.14E-4 ID:SGTC_2990|Compound:9074105|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.25|P-value:8.16E-4 ID:SGTC_3079|Compound:9117512|FD-Score:3.36|P-value:5.70E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.48|P-value:2.97E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.43|P-value:4.51E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-4.99|P-value:4.50E-7 ID:SGTC_3314|Compound:9135860|FD-Score:-4.41|P-value:6.96E-6 ID:SGTC_3342|Compound:9147791|FD-Score:-3.13|P-value:9.95E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.36|P-value:4.53E-4

Top fitness defect scores for YPR082C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2607 solasodine 5.24 47.4 µM 1.74E-7 5 7.94E-8 0.15
2 SGTC_1025 k007-0731 4.31 70.0 µM 1.46E-5 3 8.35E-6 0.71
3 SGTC_1016 4226-1401 4.06 38.0 µM 4.11E-5 RNA pol III & RNase P/MRP 17 2.47E-5 0.23
4 SGTC_1777 st045864 4.05 34.8 µM 4.29E-5 1 2.58E-5 0.36
5 SGTC_1816 st051957 3.99 91.6 µM 5.43E-5 2 3.31E-5 0.37
6 SGTC_2969 9091408 3.80 28.7 µM 1.14E-4 8 7.20E-5 0.16
7 SGTC_2018 5133068 3.59 143.0 µM 2.54E-4 11 1.67E-4 0.05
8 SGTC_521 r062-0005 3.58 13.8 µM 2.57E-4 5 1.70E-4 0.07
9 SGTC_2990 9074105 3.48 71.4 µM 3.73E-4 7 2.50E-4 0.20
10 SGTC_3302 9125395 3.43 16.4 µM 4.51E-4 7 3.06E-4 0.05
11 SGTC_1171 0368-0077 3.42 21.4 µM 4.60E-4 17 3.12E-4 0.01
12 SGTC_1782 st039423 3.37 80.6 µM 5.48E-4 7 3.76E-4 0.14
13 SGTC_3079 9117512 3.36 49.5 µM 5.70E-4 3 3.91E-4 0.29
14 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.35 44.4 nM 5.91E-4 DNA damage response 12 4.06E-4 0.03
15 SGTC_1168 k815-0004 3.35 80.5 µM 5.93E-4 DNA damage response 24 4.08E-4 0.02
16 SGTC_3057 9095946 3.25 49.5 µM 8.16E-4 Golgi 8 5.71E-4 0.08
17 SGTC_122 0236-0016 3.11 402.4 µM 0.00133 RNA processing & uracil transport 27 9.51E-4 0.02
18 SGTC_1486 3970-0793 3.08 4.5 µM 0.00144 10 0.00103 0.00
19 SGTC_906 1165-0455 3.05 526.0 µM 0.00160 12 0.00116 0.20
20 SGTC_1711 st032263 3.04 62.8 µM 0.00161 6 0.00117 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.186 1.84E-27 YDR465C RMT2 hom Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress
0.147 9.11E-18 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.137 1.89E-15 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.131 2.42E-14 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.130 5.09E-14 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.122 1.23E-12 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.118 6.39E-12 YDL123W SNA4 hom Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated
0.115 2.03E-11 YPL186C UIP4 hom Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
0.112 9.51E-11 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.111 1.11E-10 YDR215C_d YDR215C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
0.106 8.03E-10 YDR244W PEX5 hom Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.105 9.10E-10 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.103 2.38E-9 YOR176W HEM15 het Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
0.103 2.42E-9 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.103 2.44E-9 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein