YPR083W / MDM36

Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR083W / MDM36

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.39|P-value:3.83E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.55|P-value:2.91E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.25|P-value:8.30E-8 ID:SGTC_162|Compound:k030-0015|FD-Score:3.31|P-value:5.01E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.81|P-value:7.53E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:7.11|P-value:6.30E-13 ID:SGTC_426|Compound:0988-0037|FD-Score:-8.61|P-value:2.62E-18 ID:SGTC_428|Compound:3448-4153|FD-Score:5.81|P-value:3.50E-9 ID:SGTC_429|Compound:1112-0049|FD-Score:8.13|P-value:2.32E-16 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.93|P-value:3.39E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:4.06|P-value:2.65E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.72|P-value:1.08E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.59|P-value:1.47E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.36|P-value:4.20E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-5.51|P-value:1.45E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.75|P-value:8.43E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:4.49|P-value:3.93E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:3.44|P-value:3.12E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.17|P-value:1.67E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.17|P-value:6.94E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.24|P-value:5.28E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.17|P-value:8.25E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.13|P-value:1.99E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.85|P-value:6.69E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:3.77|P-value:8.78E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.33|P-value:3.85E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.22|P-value:6.88E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.78|P-value:8.53E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.22|P-value:6.86E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.33|P-value:4.64E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.16|P-value:8.43E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.64|P-value:1.93E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.95|P-value:4.19E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.47|P-value:2.27E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.19|P-value:6.27E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.88|P-value:4.47E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.62|P-value:1.58E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.93|P-value:3.78E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.54|P-value:2.13E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.29|P-value:4.41E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.14|P-value:9.21E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.59|P-value:1.46E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.16|P-value:8.48E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.16|P-value:8.33E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.34|P-value:3.67E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.35|P-value:4.41E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.11|P-value:1.79E-7 ID:SGTC_2683|Compound:piperine|FD-Score:-3.53|P-value:1.85E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.16|P-value:7.15E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.90|P-value:5.27E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.16|P-value:8.41E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_3220|Compound:9131269|FD-Score:4.23|P-value:1.25E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.26|P-value:5.97E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:3.39|P-value:3.83E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.55|P-value:2.91E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.36|P-value:3.43E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.25|P-value:8.30E-8 ID:SGTC_162|Compound:k030-0015|FD-Score:3.31|P-value:5.01E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:3.81|P-value:7.53E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:7.11|P-value:6.30E-13 ID:SGTC_426|Compound:0988-0037|FD-Score:-8.61|P-value:2.62E-18 ID:SGTC_428|Compound:3448-4153|FD-Score:5.81|P-value:3.50E-9 ID:SGTC_429|Compound:1112-0049|FD-Score:8.13|P-value:2.32E-16 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.93|P-value:3.39E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:4.06|P-value:2.65E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:3.72|P-value:1.08E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:-3.59|P-value:1.47E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.36|P-value:4.20E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:-5.51|P-value:1.45E-8 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.75|P-value:8.43E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:4.49|P-value:3.93E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:3.44|P-value:3.12E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.17|P-value:1.67E-5 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.17|P-value:6.94E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:4.27|P-value:1.06E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:-3.24|P-value:5.28E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:3.17|P-value:8.25E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.13|P-value:1.99E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.85|P-value:6.69E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:3.77|P-value:8.78E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:-3.33|P-value:3.85E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.22|P-value:6.88E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.78|P-value:8.53E-5 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.22|P-value:6.86E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.33|P-value:4.64E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.16|P-value:8.43E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.64|P-value:1.93E-6 ID:SGTC_1834|Compound:st055981|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.95|P-value:4.19E-5 ID:SGTC_1854|Compound:st056233|FD-Score:-3.47|P-value:2.27E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.19|P-value:6.27E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-3.88|P-value:4.47E-5 ID:SGTC_2001|Compound:4023502|FD-Score:3.62|P-value:1.58E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.93|P-value:3.78E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.54|P-value:2.13E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.29|P-value:4.41E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.14|P-value:9.21E-4 ID:SGTC_2318|Compound:6029776|FD-Score:-3.59|P-value:1.46E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.16|P-value:8.48E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.16|P-value:8.33E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.34|P-value:3.67E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.35|P-value:4.41E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.11|P-value:1.79E-7 ID:SGTC_2683|Compound:piperine|FD-Score:-3.53|P-value:1.85E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.12|P-value:9.59E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.16|P-value:7.15E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.90|P-value:5.27E-5 ID:SGTC_3048|Compound:9093155|FD-Score:3.16|P-value:8.41E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_3220|Compound:9131269|FD-Score:4.23|P-value:1.25E-5 ID:SGTC_3263|Compound:9137018|FD-Score:3.26|P-value:5.97E-4

Top fitness defect scores for YPR083W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_429 1112-0049 8.13 25.5 µM 2.32E-16 DNA damage response 6 2.10E-16
2 SGTC_422 cantharidin 7.11 155.0 µM 6.30E-13 cell wall signaling 14 5.70E-13
3 SGTC_428 3448-4153 5.81 16.5 µM 3.50E-9 TSC3-RPN4 11 3.18E-9
4 SGTC_137 0438-0332 5.25 85.4 µM 8.30E-8 ubiquinone biosynthesis & proteasome 72 7.57E-8
5 SGTC_2616 abietic acid 5.11 100.0 µM 1.79E-7 16 1.63E-7
6 SGTC_1041 0206-0046 4.85 107.0 µM 6.69E-7 20 6.12E-7
7 SGTC_1514 1189-1591 4.64 158.0 µM 1.93E-6 26 1.77E-6
8 SGTC_115 0527-0192 4.55 112.0 µM 2.91E-6 50 2.67E-6
9 SGTC_661 1304-0007 4.49 33.6 µM 3.93E-6 13 3.60E-6
10 SGTC_922 1866-0035 4.27 480.0 µM 1.06E-5 excess fatty acid 41 9.74E-6
11 SGTC_3220 9131269 4.23 49.5 µM 1.25E-5 7 1.15E-5
12 SGTC_769 0302-0231 4.17 76.0 µM 1.67E-5 31 1.54E-5
13 SGTC_1028 k015-0029 4.13 4.8 µM 1.99E-5 18 1.84E-5
14 SGTC_438 sphingosine 4.06 6.7 µM 2.65E-5 19 2.44E-5
15 SGTC_1846 st056244 3.95 14.8 µM 4.19E-5 27 3.87E-5
16 SGTC_2766 oltipraz 3.90 83.9 µM 5.27E-5 heme requiring 25 4.87E-5
17 SGTC_348 k064-0012 3.81 10.7 µM 7.53E-5 60S ribosome export 17 6.96E-5
18 SGTC_1295 1013-0063 3.78 9.8 µM 8.53E-5 17 7.88E-5
19 SGTC_1123 mangostin 3.77 811.3 nM 8.78E-5 mitochondrial response to ROS 46 8.12E-5
20 SGTC_519 k048-0011 3.72 62.8 µM 1.08E-4 28 9.95E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.18E-11 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.111 1.15E-10 YLR168C UPS2 hom Mitochondrial protein involved in phospholipid metabolism; localizes to the intermembrane space; has a role in regulation of phospholipid metabolism by inhibiting conversion of phosphatidylethanolamine to phosphatidylcholine; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI
0.108 3.97E-10 YJL217W REE1 hom Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle
0.104 1.69E-9 YKL015W PUT3 hom Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain
0.103 1.85E-9 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.099 1.05E-8 YLL001W DNM1 hom Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance
0.097 2.06E-8 YPL190C NAB3 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
0.095 3.71E-8 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.091 1.41E-7 YER131W RPS26B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication
0.090 1.70E-7 YDL130W RPP1B hom Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component
0.089 2.67E-7 YJL041W NSP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
0.084 1.09E-6 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.082 1.91E-6 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.082 2.13E-6 YNL248C RPA49 hom RNA polymerase I subunit A49
0.081 2.67E-6 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress