YPR084W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR084W / YPR084W

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.68|P-value:8.61E-7 ID:SGTC_290|Compound:2043-6722|FD-Score:3.13|P-value:6.99E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.71|P-value:7.72E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.62|P-value:9.15E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:-4.68|P-value:6.71E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:4.48|P-value:2.39E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.09|P-value:6.83E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:6.36|P-value:3.84E-11 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.87|P-value:3.16E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.08|P-value:1.51E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.87|P-value:3.89E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.91|P-value:3.30E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.12|P-value:8.00E-8 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.05|P-value:9.31E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.66|P-value:9.18E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.18|P-value:5.00E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:7.54|P-value:5.73E-15 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.95|P-value:2.71E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.51|P-value:1.68E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.68|P-value:8.44E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.24|P-value:7.41E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.22|P-value:5.15E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.33|P-value:4.77E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.32|P-value:5.00E-6 ID:SGTC_1700|Compound:st030840|FD-Score:3.92|P-value:3.18E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.21|P-value:5.24E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.79|P-value:4.41E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.44|P-value:1.89E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.23|P-value:4.19E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.10|P-value:1.42E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.10|P-value:7.90E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.52|P-value:1.62E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.08|P-value:7.07E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.70|P-value:7.81E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.64|P-value:1.01E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.37|P-value:2.97E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.69|P-value:8.32E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.06|P-value:9.02E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.45|P-value:2.67E-6 ID:SGTC_2821|Compound:7996764|FD-Score:5.59|P-value:5.21E-9 ID:SGTC_2957|Compound:9076800|FD-Score:3.04|P-value:9.54E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.01|P-value:2.11E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.35|P-value:3.17E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.54|P-value:1.25E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.68|P-value:8.47E-5 ID:SGTC_3080|Compound:9117754|FD-Score:7.49|P-value:8.47E-15 ID:SGTC_3090|Compound:9117696|FD-Score:-3.49|P-value:1.52E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.68|P-value:8.74E-5 ID:SGTC_3151|Compound:9099821|FD-Score:4.06|P-value:1.65E-5 ID:SGTC_12|Compound:0849-0099|FD-Score:3.06|P-value:9.03E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.68|P-value:8.61E-7 ID:SGTC_290|Compound:2043-6722|FD-Score:3.13|P-value:6.99E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.71|P-value:7.72E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.62|P-value:9.15E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:-4.68|P-value:6.71E-7 ID:SGTC_532|Compound:1548-0774|FD-Score:4.48|P-value:2.39E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:3.63|P-value:1.04E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:-3.09|P-value:6.83E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:6.36|P-value:3.84E-11 ID:SGTC_762|Compound:1165-0429|FD-Score:-3.87|P-value:3.16E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:4.08|P-value:1.51E-5 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.87|P-value:3.89E-5 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.91|P-value:3.30E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:5.12|P-value:8.00E-8 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.05|P-value:9.31E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.66|P-value:9.18E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.54|P-value:1.53E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:-3.18|P-value:5.00E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:7.54|P-value:5.73E-15 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.95|P-value:2.71E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.51|P-value:1.68E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.68|P-value:8.44E-5 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.24|P-value:7.41E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.22|P-value:5.15E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.33|P-value:4.77E-6 ID:SGTC_1698|Compound:5-fluorocytosine|FD-Score:4.32|P-value:5.00E-6 ID:SGTC_1700|Compound:st030840|FD-Score:3.92|P-value:3.18E-5 ID:SGTC_1705|Compound:st027868|FD-Score:3.21|P-value:5.24E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.79|P-value:4.41E-5 ID:SGTC_1878|Compound:temozolomide|FD-Score:-3.44|P-value:1.89E-4 ID:SGTC_1923|Compound:st058458|FD-Score:-3.23|P-value:4.19E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.10|P-value:1.42E-5 ID:SGTC_2333|Compound:9017922|FD-Score:3.10|P-value:7.90E-4 ID:SGTC_2335|Compound:9018011|FD-Score:3.52|P-value:1.62E-4 ID:SGTC_2476|Compound:5806916|FD-Score:-3.08|P-value:7.07E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:3.70|P-value:7.81E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.64|P-value:1.01E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.37|P-value:2.97E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.69|P-value:8.32E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.06|P-value:9.02E-4 ID:SGTC_2815|Compound:7968870|FD-Score:4.45|P-value:2.67E-6 ID:SGTC_2821|Compound:7996764|FD-Score:5.59|P-value:5.21E-9 ID:SGTC_2957|Compound:9076800|FD-Score:3.04|P-value:9.54E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.01|P-value:2.11E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.35|P-value:3.17E-4 ID:SGTC_3039|Compound:9090270|FD-Score:-3.54|P-value:1.25E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.68|P-value:8.47E-5 ID:SGTC_3080|Compound:9117754|FD-Score:7.49|P-value:8.47E-15 ID:SGTC_3090|Compound:9117696|FD-Score:-3.49|P-value:1.52E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.68|P-value:8.74E-5 ID:SGTC_3151|Compound:9099821|FD-Score:4.06|P-value:1.65E-5

Top fitness defect scores for YPR084W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1166 k206-0078 7.54 225.0 µM 5.73E-15 3 2.36E-14
2 SGTC_3080 9117754 7.49 49.5 µM 8.47E-15 1 3.42E-14
3 SGTC_607 4491-0986 6.36 66.8 µM 3.84E-11 heme requiring 5 1.03E-10
4 SGTC_2821 7996764 5.59 71.4 µM 5.21E-9 10 1.11E-8
5 SGTC_1041 0206-0046 5.12 107.0 µM 8.00E-8 13 1.49E-7
6 SGTC_270 tamoxifen 4.68 5.5 µM 8.61E-7 NEO1 15 1.44E-6
7 SGTC_532 1548-0774 4.48 215.0 µM 2.39E-6 10 3.81E-6
8 SGTC_2815 7968870 4.45 71.4 µM 2.67E-6 13 4.23E-6
9 SGTC_1480 1070-0044 4.33 41.2 µM 4.77E-6 13 7.37E-6
10 SGTC_1698 5-fluorocytosine 4.32 1.1 µM 5.00E-6 exosome 6 7.70E-6
11 SGTC_1297 1068-0111 4.24 14.1 µM 7.41E-6 5 1.12E-5
12 SGTC_1936 st074407 4.10 74.3 µM 1.42E-5 DNA damage response 32 2.08E-5
13 SGTC_974 1326-0144 4.08 138.0 µM 1.51E-5 ERG2 39 2.21E-5
14 SGTC_3151 9099821 4.06 49.5 µM 1.65E-5 18 2.41E-5
15 SGTC_2974 9094440 4.01 9.7 µM 2.11E-5 ergosterol biosynthesis 46 3.05E-5
16 SGTC_1174 0739-0097 3.95 51.1 µM 2.71E-5 redox potentiating 34 3.87E-5
17 SGTC_1700 st030840 3.92 7.9 µM 3.18E-5 PDR1 21 4.51E-5
18 SGTC_1034 k072-0165 3.91 12.7 µM 3.30E-5 Golgi 20 4.67E-5
19 SGTC_1014 4130-3005 3.87 69.3 µM 3.89E-5 21 5.47E-5
20 SGTC_403 arphamenine a 3.71 50.0 µM 7.72E-5 60S ribosome export 21 1.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.53E-9 YDR380W ARO10 hom Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
0.083 1.45E-6 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.081 2.54E-6 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.079 5.27E-6 YHL013C OTU2 hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress
0.075 1.50E-5 YCR050C_p YCR050C_p hom Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
0.074 1.73E-5 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.071 3.76E-5 YDR168W CDC37 het Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
0.069 6.22E-5 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.068 7.30E-5 YMR094W CTF13 het Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
0.068 7.59E-5 YNL097C PHO23 hom Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
0.068 8.06E-5 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.068 8.13E-5 YHR079C-A SAE3 hom Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
0.065 1.78E-4 YJL181W_p YJL181W_p hom Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication
0.064 1.98E-4 YPR006C ICL2 hom 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
0.064 2.08E-4 YDR379W RGA2 hom GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p