| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.101 |
5.53E-9 |
YDR380W |
ARO10 |
hom |
Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway |
| 0.083 |
1.45E-6 |
YGL155W |
CDC43 |
het |
Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis |
| 0.081 |
2.54E-6 |
YHR190W |
ERG9 |
het |
Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway |
| 0.079 |
5.27E-6 |
YHL013C |
OTU2 |
hom |
Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress |
| 0.075 |
1.50E-5 |
YCR050C_p |
YCR050C_p |
hom |
Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein |
| 0.074 |
1.73E-5 |
YDL007W |
RPT2 |
het |
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle |
| 0.071 |
3.76E-5 |
YDR168W |
CDC37 |
het |
Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding |
| 0.069 |
6.22E-5 |
YLL006W-A_p |
YLL006W-A_p |
hom |
Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.068 |
7.30E-5 |
YMR094W |
CTF13 |
het |
Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis |
| 0.068 |
7.59E-5 |
YNL097C |
PHO23 |
hom |
Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3 |
| 0.068 |
8.06E-5 |
YBR085W |
AAC3 |
hom |
Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication |
| 0.068 |
8.13E-5 |
YHR079C-A |
SAE3 |
hom |
Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p |
| 0.065 |
1.78E-4 |
YJL181W_p |
YJL181W_p |
hom |
Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; YJL181W has a paralog, YJR030C, that arose from the whole genome duplication |
| 0.064 |
1.98E-4 |
YPR006C |
ICL2 |
hom |
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol |
| 0.064 |
2.08E-4 |
YDR379W |
RGA2 |
hom |
GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p |
