YPR085C / ASA1

Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR085C / ASA1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:7.26|P-value:1.07E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:3.80|P-value:4.58E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.87|P-value:3.73E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.78|P-value:4.93E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:5.80|P-value:2.01E-7 ID:SGTC_328|Compound:k915-0120|FD-Score:3.63|P-value:7.79E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:8.58|P-value:3.06E-14 ID:SGTC_533|Compound:1222-0222|FD-Score:4.52|P-value:3.90E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:4.36|P-value:7.12E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.55|P-value:9.75E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:15.80|P-value:1.18E-43 ID:SGTC_660|Compound:4031-1742|FD-Score:4.76|P-value:1.62E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:7.44|P-value:3.90E-11 ID:SGTC_802|Compound:4112-3352|FD-Score:3.74|P-value:5.57E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:8.30|P-value:1.94E-13 ID:SGTC_845|Compound:0330-0138|FD-Score:5.16|P-value:3.33E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:6.04|P-value:6.39E-8 ID:SGTC_885|Compound:0865-0106|FD-Score:5.05|P-value:5.09E-6 ID:SGTC_897|Compound:1000-0139|FD-Score:6.20|P-value:2.92E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:6.70|P-value:2.34E-9 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.79|P-value:4.13E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.54|P-value:6.44E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.02|P-value:2.24E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:11.60|P-value:1.08E-24 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.19|P-value:1.27E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:8.88|P-value:3.83E-15 ID:SGTC_1634|Compound:st006576|FD-Score:3.77|P-value:5.07E-4 ID:SGTC_1643|Compound:st009866|FD-Score:12.90|P-value:8.61E-30 ID:SGTC_1661|Compound:st013063|FD-Score:13.00|P-value:3.35E-30 ID:SGTC_1677|Compound:st019204|FD-Score:4.63|P-value:2.64E-5 ID:SGTC_1682|Compound:st012968|FD-Score:4.03|P-value:2.17E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.24|P-value:1.09E-4 ID:SGTC_1773|Compound:st048542|FD-Score:10.50|P-value:2.27E-20 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.28|P-value:1.99E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:8.17|P-value:4.48E-13 ID:SGTC_2049|Compound:5262831|FD-Score:3.86|P-value:3.85E-4 ID:SGTC_2067|Compound:5224629|FD-Score:8.43|P-value:7.90E-14 ID:SGTC_2110|Compound:5483698|FD-Score:4.94|P-value:8.04E-6 ID:SGTC_2151|Compound:5563267|FD-Score:17.10|P-value:3.50E-51 ID:SGTC_2526|Compound:patulin|FD-Score:6.05|P-value:6.05E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:30.80|P-value:7.81E-161 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:19.90|P-value:3.02E-68 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.75|P-value:2.54E-7 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.30|P-value:8.78E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:4.14E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.40|P-value:1.18E-6 ID:SGTC_2930|Compound:9013230|FD-Score:3.69|P-value:6.42E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.62|P-value:2.69E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-4.80|P-value:1.16E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:7.26|P-value:1.07E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:3.80|P-value:4.58E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.87|P-value:3.73E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:3.78|P-value:4.93E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:5.80|P-value:2.01E-7 ID:SGTC_328|Compound:k915-0120|FD-Score:3.63|P-value:7.79E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:8.58|P-value:3.06E-14 ID:SGTC_533|Compound:1222-0222|FD-Score:4.52|P-value:3.90E-5 ID:SGTC_589|Compound:1227-0070|FD-Score:4.36|P-value:7.12E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:3.55|P-value:9.75E-4 ID:SGTC_639|Compound:0833-0042|FD-Score:15.80|P-value:1.18E-43 ID:SGTC_660|Compound:4031-1742|FD-Score:4.76|P-value:1.62E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:7.44|P-value:3.90E-11 ID:SGTC_802|Compound:4112-3352|FD-Score:3.74|P-value:5.57E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:8.30|P-value:1.94E-13 ID:SGTC_845|Compound:0330-0138|FD-Score:5.16|P-value:3.33E-6 ID:SGTC_860|Compound:0443-0016|FD-Score:6.04|P-value:6.39E-8 ID:SGTC_885|Compound:0865-0106|FD-Score:5.05|P-value:5.09E-6 ID:SGTC_897|Compound:1000-0139|FD-Score:6.20|P-value:2.92E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:6.70|P-value:2.34E-9 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.79|P-value:4.13E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.54|P-value:6.44E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.02|P-value:2.24E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:11.60|P-value:1.08E-24 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.19|P-value:1.27E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:8.88|P-value:3.83E-15 ID:SGTC_1634|Compound:st006576|FD-Score:3.77|P-value:5.07E-4 ID:SGTC_1643|Compound:st009866|FD-Score:12.90|P-value:8.61E-30 ID:SGTC_1661|Compound:st013063|FD-Score:13.00|P-value:3.35E-30 ID:SGTC_1677|Compound:st019204|FD-Score:4.63|P-value:2.64E-5 ID:SGTC_1682|Compound:st012968|FD-Score:4.03|P-value:2.17E-4 ID:SGTC_1723|Compound:st034307|FD-Score:4.24|P-value:1.09E-4 ID:SGTC_1773|Compound:st048542|FD-Score:10.50|P-value:2.27E-20 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.28|P-value:1.99E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:8.17|P-value:4.48E-13 ID:SGTC_2049|Compound:5262831|FD-Score:3.86|P-value:3.85E-4 ID:SGTC_2067|Compound:5224629|FD-Score:8.43|P-value:7.90E-14 ID:SGTC_2110|Compound:5483698|FD-Score:4.94|P-value:8.04E-6 ID:SGTC_2151|Compound:5563267|FD-Score:17.10|P-value:3.50E-51 ID:SGTC_2526|Compound:patulin|FD-Score:6.05|P-value:6.05E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:30.80|P-value:7.81E-161 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:19.90|P-value:3.02E-68 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.75|P-value:2.54E-7 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:4.30|P-value:8.78E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.83|P-value:4.14E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.40|P-value:1.18E-6 ID:SGTC_2930|Compound:9013230|FD-Score:3.69|P-value:6.42E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.62|P-value:2.69E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-4.80|P-value:1.16E-5

Top fitness defect scores for YPR085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2573 2',4'-dihydroxychalcone 30.80 15.0 µM 7.81E-161 1 1.61E-208 20.40
2 SGTC_2574 2',4'-dihydroxychalcone 19.90 14.6 µM 3.02E-68 1 3.40E-88 11.30
3 SGTC_2151 5563267 17.10 85.4 µM 3.50E-51 1 5.08E-66 4.22
4 SGTC_639 0833-0042 15.80 114.0 µM 1.18E-43 1 3.09E-56 5.78
5 SGTC_1661 st013063 13.00 9.7 µM 3.35E-30 3 9.26E-39 3.94
6 SGTC_1643 st009866 12.90 20.2 µM 8.61E-30 3 3.15E-38 0.10
7 SGTC_1273 0849-0096 11.60 14.1 µM 1.08E-24 RPP1 & pyrimidine depletion 1 1.31E-31 5.39
8 SGTC_1773 st048542 10.50 73.6 µM 2.27E-20 2 5.41E-26 2.02
9 SGTC_1585 2',4'-dihydroxychalcone 8.88 10.4 µM 3.83E-15 1 3.30E-19 1.21
10 SGTC_428 3448-4153 8.58 16.5 µM 3.06E-14 TSC3-RPN4 2 4.88E-18 3.45
11 SGTC_2067 5224629 8.43 34.1 µM 7.90E-14 1 1.67E-17 1.79
12 SGTC_820 1582-0060 8.30 59.9 µM 1.94E-13 3 5.38E-17 1.17
13 SGTC_1873 rapamycin 8.17 2.0 nM 4.48E-13 5 1.59E-16 0.60
14 SGTC_720 r052-1644 7.44 49.9 µM 3.90E-11 TSC3-RPN4 4 5.21E-14 2.60
15 SGTC_28 pentachloropyridine N-oxide 7.26 1.6 µM 1.07E-10 TSC3-RPN4 1 1.93E-13 2.40
16 SGTC_926 2268-1401 6.70 59.4 µM 2.34E-9 TSC3-RPN4 2 1.05E-11 1.25
17 SGTC_897 1000-0139 6.20 31.4 µM 2.92E-8 5 2.76E-10 0.51
18 SGTC_2526 patulin 6.05 37.6 µM 6.05E-8 4 7.09E-10 0.66
19 SGTC_860 0443-0016 6.04 25.1 µM 6.39E-8 1 7.61E-10 0.89
20 SGTC_210 3551-0445 5.80 56.8 µM 2.01E-7 7 3.34E-9 0.57

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.413 2.67E-138 YMR185W RTP1 het Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
0.265 4.93E-55 YAL024C LTE1 hom Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures
0.264 1.08E-54 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.217 5.62E-37 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.208 4.44E-34 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.204 8.32E-33 YNL216W RAP1 het Essential DNA-binding transcription regulator that binds at many loci; involved in either transcription activation or repression, chromatin silencing, and telomere length maintenance; conserved protein with an N-terminal BRCT domain, a central region with homology to the Myb DNA binding domain, and a C-terminal Rap1-specific protein-interaction domain (RCT domain)
0.201 8.91E-32 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.194 7.04E-30 YOR262W GPN2 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
0.191 9.84E-29 YHR062C RPP1 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.184 5.50E-27 YOR035C SHE4 hom Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
0.183 9.15E-27 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.169 8.34E-23 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.165 5.87E-22 YER107C GLE2 hom RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1
0.153 3.83E-19 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.151 1.24E-18 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress