Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YPR086W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.146 | 1.97E-17 | YPR085C | ASA1 | het | Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 |
0.139 | 7.78E-16 | YDR212W | TCP1 | het | Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein |
0.130 | 3.61E-14 | YGR204W | ADE3 | hom | Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine |
0.124 | 6.02E-13 | YMR174C | PAI3 | hom | Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact |
0.111 | 1.30E-10 | YLR400W_d | YLR400W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.107 | 4.52E-10 | YFL042C_p | YFL042C_p | hom | Putative protein of unknown function; YFL042C is not an essential gene |
0.105 | 9.78E-10 | YGR043C | NQM1 | hom | Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift |
0.104 | 1.75E-9 | YPL249C | GYP5 | hom | GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress |
0.103 | 2.66E-9 | YDR302W | GPI11 | het | ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog |
0.098 | 1.29E-8 | YGR049W | SCM4 | hom | Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation |
0.096 | 2.39E-8 | YJL100W | LSB6 | hom | Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization |
0.096 | 2.56E-8 | YJR046W | TAH11 | het | DNA replication licensing factor, required for pre-replication complex assembly |
0.095 | 3.54E-8 | YLR197W | NOP56 | het | Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects |
0.094 | 5.32E-8 | YLR387C | REH1 | hom | Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains |
0.094 | 5.52E-8 | YJL009W_d | YJL009W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex |