YPR087W_d / VPS69

Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR087W / VPS69

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:4.71|P-value:8.10E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:6.11|P-value:1.05E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.82|P-value:2.18E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.09|P-value:9.13E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:4.28|P-value:4.45E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:4.47|P-value:2.08E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:4.87|P-value:4.00E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:-3.71|P-value:3.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.65|P-value:1.02E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:4.31|P-value:3.96E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:6.75|P-value:2.98E-10 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:7.46|P-value:3.93E-12 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.36|P-value:4.41E-7 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.60|P-value:4.84E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.73|P-value:3.20E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.84|P-value:2.18E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.65|P-value:4.14E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.89|P-value:3.70E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.46|P-value:7.82E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.43|P-value:8.35E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.62|P-value:4.28E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.92|P-value:1.66E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.37|P-value:9.61E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.44|P-value:2.38E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.59|P-value:4.71E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.91|P-value:3.40E-6 ID:SGTC_2333|Compound:9017922|FD-Score:4.48|P-value:2.02E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.04|P-value:1.08E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.38|P-value:4.12E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.79|P-value:2.41E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.09|P-value:8.29E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.12|P-value:7.41E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.97|P-value:1.39E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.83|P-value:2.07E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.12|P-value:1.34E-6 ID:SGTC_2918|Compound:7977171|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.39|P-value:9.74E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.53|P-value:5.68E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.85|P-value:2.14E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.22|P-value:5.54E-5 ID:SGTC_3043|Compound:9092303|FD-Score:4.39|P-value:2.94E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.39|P-value:2.91E-5 ID:SGTC_3081|Compound:9117243|FD-Score:3.50|P-value:6.86E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.04|P-value:1.91E-6 ID:SGTC_3113|Compound:9123498|FD-Score:5.38|P-value:4.07E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.43|P-value:8.35E-4 ID:SGTC_3205|Compound:9113483|FD-Score:5.85|P-value:4.13E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:4.71|P-value:8.10E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:6.11|P-value:1.05E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:-3.82|P-value:2.18E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:4.09|P-value:9.13E-5 ID:SGTC_329|Compound:k048-0121|FD-Score:4.28|P-value:4.45E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:4.47|P-value:2.08E-5 ID:SGTC_719|Compound:2810-4230|FD-Score:4.87|P-value:4.00E-6 ID:SGTC_725|Compound:1497-0963|FD-Score:-3.71|P-value:3.17E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:4.65|P-value:1.02E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:4.31|P-value:3.96E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:6.75|P-value:2.98E-10 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:7.46|P-value:3.93E-12 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:5.36|P-value:4.41E-7 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.60|P-value:4.84E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.73|P-value:3.20E-4 ID:SGTC_1108|Compound:betulinic acid|FD-Score:3.84|P-value:2.18E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.65|P-value:4.14E-4 ID:SGTC_1231|Compound:0242-0792|FD-Score:4.89|P-value:3.70E-6 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.46|P-value:7.82E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.43|P-value:8.35E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.62|P-value:4.28E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.92|P-value:1.66E-4 ID:SGTC_1860|Compound:st056228|FD-Score:-3.37|P-value:9.61E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:4.44|P-value:2.38E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.59|P-value:4.71E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.91|P-value:3.40E-6 ID:SGTC_2333|Compound:9017922|FD-Score:4.48|P-value:2.02E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.04|P-value:1.08E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.38|P-value:4.12E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.79|P-value:2.41E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.09|P-value:8.29E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.12|P-value:7.41E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.97|P-value:1.39E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-3.83|P-value:2.07E-4 ID:SGTC_2881|Compound:9058953|FD-Score:5.12|P-value:1.34E-6 ID:SGTC_2918|Compound:7977171|FD-Score:3.89|P-value:1.85E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.39|P-value:9.74E-4 ID:SGTC_2955|Compound:9076254|FD-Score:-3.53|P-value:5.68E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.85|P-value:2.14E-4 ID:SGTC_3033|Compound:9090887|FD-Score:4.22|P-value:5.54E-5 ID:SGTC_3043|Compound:9092303|FD-Score:4.39|P-value:2.94E-5 ID:SGTC_3076|Compound:9116187|FD-Score:4.39|P-value:2.91E-5 ID:SGTC_3081|Compound:9117243|FD-Score:3.50|P-value:6.86E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.04|P-value:1.91E-6 ID:SGTC_3113|Compound:9123498|FD-Score:5.38|P-value:4.07E-7 ID:SGTC_3202|Compound:9113761|FD-Score:3.43|P-value:8.35E-4 ID:SGTC_3205|Compound:9113483|FD-Score:5.85|P-value:4.13E-8

Top fitness defect scores for YPR087W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_1069 diphenylcyclopropenone 7.46 8.5 µM 3.93E-12 2 4.32E-14
2 SGTC_1022 4477-0945 6.75 21.3 µM 2.98E-10 4 7.24E-12
3 SGTC_192 3455-0609 6.11 60.9 µM 1.05E-8 3 4.91E-10
4 SGTC_3205 9113483 5.85 49.5 µM 4.13E-8 4 2.47E-9
5 SGTC_3113 9123498 5.38 49.5 µM 4.07E-7 2 3.69E-8
6 SGTC_2752 diclazuril 5.38 33.1 µM 4.12E-7 68 3.74E-8
7 SGTC_1071 trifluoperazine 5.36 6.3 µM 4.41E-7 9 4.05E-8
8 SGTC_2881 9058953 5.12 52.0 µM 1.34E-6 7 1.50E-7
9 SGTC_3098 9119039 5.04 49.5 µM 1.91E-6 Golgi 16 2.29E-7
10 SGTC_2306 7482397 4.91 179.5 µM 3.40E-6 RPP1 & pyrimidine depletion 8 4.53E-7
11 SGTC_1231 0242-0792 4.89 125.0 µM 3.70E-6 9 5.00E-7
12 SGTC_719 2810-4230 4.87 27.3 µM 4.00E-6 3 5.48E-7
13 SGTC_103 0844-0104 4.71 51.8 µM 8.10E-6 ERAD & cell cycle 110 1.26E-6
14 SGTC_800 3448-7362 4.65 155.0 µM 1.02E-5 translation 108 1.65E-6
15 SGTC_2333 9017922 4.48 200.0 µM 2.02E-5 16 3.71E-6
16 SGTC_366 0181-0206 4.47 4.3 µM 2.08E-5 Golgi 25 3.84E-6
17 SGTC_1876 myriocin 4.44 605.0 nM 2.38E-5 25 4.48E-6
18 SGTC_3076 9116187 4.39 49.5 µM 2.91E-5 13 5.69E-6
19 SGTC_3043 9092303 4.39 49.5 µM 2.94E-5 8 5.77E-6
20 SGTC_932 2857-0803 4.31 154.0 µM 3.96E-5 23 8.19E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 3.08E-13 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.111 1.31E-10 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene
0.100 5.62E-9 YBR106W PHO88 hom Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
0.099 9.23E-9 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.086 5.41E-7 YKL181W PRS1 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.084 1.16E-6 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.083 1.58E-6 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.082 1.83E-6 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress
0.081 2.67E-6 YCR048W ARE1 hom Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
0.079 5.28E-6 YOR189W IES4 hom Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
0.078 6.36E-6 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.078 6.40E-6 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.077 7.54E-6 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.077 8.00E-6 YIR021W-A_p YIR021W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.076 9.99E-6 YNL195C_p YNL195C_p hom Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies