YPR089W_p

Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR089W / YPR089W

Click on Significant Values for Screen Details ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.21|P-value:8.80E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:7.00|P-value:4.15E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:3.47|P-value:3.56E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.34|P-value:5.66E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.73|P-value:1.37E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.10|P-value:3.20E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.31|P-value:6.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.98|P-value:5.83E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:4.42|P-value:8.16E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.26|P-value:7.41E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.65|P-value:1.85E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.95|P-value:6.93E-7 ID:SGTC_728|Compound:3030-5151|FD-Score:3.27|P-value:7.11E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:8.20|P-value:6.14E-16 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.32|P-value:5.95E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.81|P-value:1.34E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:4.07|P-value:3.64E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:3.36|P-value:5.27E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.22|P-value:8.25E-4 ID:SGTC_1660|Compound:st012960|FD-Score:4.42|P-value:8.10E-6 ID:SGTC_1661|Compound:st013063|FD-Score:3.55|P-value:2.63E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.36|P-value:5.27E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.23|P-value:8.17E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.07|P-value:3.71E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-4.94|P-value:7.04E-7 ID:SGTC_2056|Compound:5235370|FD-Score:4.08|P-value:3.42E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-3.73|P-value:1.34E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.54|P-value:4.72E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.66|P-value:1.75E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.63|P-value:1.96E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.75|P-value:1.79E-6 ID:SGTC_2361|Compound:9034121|FD-Score:3.21|P-value:8.65E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-4.64|P-value:3.02E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.65|P-value:1.83E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.96|P-value:6.45E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.56|P-value:2.87E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.50|P-value:3.18E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.35|P-value:5.48E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.40|P-value:4.49E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.54|P-value:2.72E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.54|P-value:2.79E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.44|P-value:3.95E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.72|P-value:1.40E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.80|P-value:1.04E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.43|P-value:7.63E-6 ID:SGTC_3349|Compound:9149703|FD-Score:3.68|P-value:1.67E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.44|P-value:3.94E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.21|P-value:8.80E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:7.00|P-value:4.15E-12 ID:SGTC_207|Compound:4185-0010|FD-Score:3.47|P-value:3.56E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.34|P-value:5.66E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.73|P-value:1.37E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:4.10|P-value:3.20E-5 ID:SGTC_518|Compound:1021-0119|FD-Score:3.31|P-value:6.20E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.98|P-value:5.83E-7 ID:SGTC_637|Compound:1181-0519|FD-Score:4.42|P-value:8.16E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:3.26|P-value:7.41E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.65|P-value:1.85E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.95|P-value:6.93E-7 ID:SGTC_728|Compound:3030-5151|FD-Score:3.27|P-value:7.11E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:8.20|P-value:6.14E-16 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.32|P-value:5.95E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:4.81|P-value:1.34E-6 ID:SGTC_925|Compound:2064-1272|FD-Score:4.07|P-value:3.64E-5 ID:SGTC_974|Compound:1326-0144|FD-Score:3.36|P-value:5.27E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.22|P-value:8.25E-4 ID:SGTC_1660|Compound:st012960|FD-Score:4.42|P-value:8.10E-6 ID:SGTC_1661|Compound:st013063|FD-Score:3.55|P-value:2.63E-4 ID:SGTC_1808|Compound:st050063|FD-Score:3.36|P-value:5.27E-4 ID:SGTC_1947|Compound:st076332|FD-Score:3.23|P-value:8.17E-4 ID:SGTC_2049|Compound:5262831|FD-Score:5.07|P-value:3.71E-7 ID:SGTC_2053|Compound:5265679|FD-Score:-4.94|P-value:7.04E-7 ID:SGTC_2056|Compound:5235370|FD-Score:4.08|P-value:3.42E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-3.73|P-value:1.34E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.54|P-value:4.72E-6 ID:SGTC_2325|Compound:6158266|FD-Score:3.66|P-value:1.75E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.63|P-value:1.96E-4 ID:SGTC_2351|Compound:9026858|FD-Score:4.75|P-value:1.79E-6 ID:SGTC_2361|Compound:9034121|FD-Score:3.21|P-value:8.65E-4 ID:SGTC_2453|Compound:5731132|FD-Score:-4.64|P-value:3.02E-6 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:3.65|P-value:1.83E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.96|P-value:6.45E-7 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:5.56|P-value:2.87E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.50|P-value:3.18E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.35|P-value:5.48E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.40|P-value:4.49E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.54|P-value:2.72E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.54|P-value:2.79E-4 ID:SGTC_2910|Compound:7948405|FD-Score:-3.44|P-value:3.95E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.72|P-value:1.40E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.80|P-value:1.04E-4 ID:SGTC_2954|Compound:9074818|FD-Score:4.43|P-value:7.63E-6 ID:SGTC_3349|Compound:9149703|FD-Score:3.68|P-value:1.67E-4 ID:SGTC_3350|Compound:9150499|FD-Score:3.44|P-value:3.94E-4

Top fitness defect scores for YPR089W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_768 0384-0033 8.20 77.3 µM 6.14E-16 fatty acid desaturase (OLE1) 22 1.20E-16
2 SGTC_178 4092-0806 7.00 87.5 µM 4.15E-12 ergosterol depletion effects on membrane 27 1.25E-12
3 SGTC_2502 avocadyne acetate 5.56 18.6 µM 2.87E-8 10 1.34E-8
4 SGTC_2049 5262831 5.07 67.2 µM 3.71E-7 10 1.96E-7
5 SGTC_568 1193-0097 4.98 7.5 µM 5.83E-7 ERAD & cell cycle 87 3.15E-7
6 SGTC_2501 sodium tetradecyl sulfate 4.96 13.4 µM 6.45E-7 19 3.50E-7
7 SGTC_686 1319-0111 4.95 510.0 µM 6.93E-7 60S ribosome export 11 3.77E-7
8 SGTC_842 0271-0008 4.81 11.1 µM 1.34E-6 heme biosynthesis & mitochondrial translocase 12 7.54E-7
9 SGTC_2351 9026858 4.75 72.3 µM 1.79E-6 RNA processing & uracil transport 14 1.02E-6
10 SGTC_2250 alverine citrate 4.54 130.0 µM 4.72E-6 122 2.82E-6
11 SGTC_2954 9074818 4.43 52.7 µM 7.63E-6 26 4.66E-6
12 SGTC_1660 st012960 4.42 28.1 µM 8.10E-6 iron homeostasis 25 4.96E-6
13 SGTC_637 1181-0519 4.42 7.3 µM 8.16E-6 fatty acid desaturase (OLE1) 85 5.00E-6
14 SGTC_350 k064-0020 4.10 19.8 µM 3.20E-5 heme requiring 27 2.09E-5
15 SGTC_2056 5235370 4.08 200.0 µM 3.42E-5 36 2.24E-5
16 SGTC_925 2064-1272 4.07 59.6 µM 3.64E-5 22 2.40E-5
17 SGTC_2950 9072895 3.80 21.5 µM 1.04E-4 44 7.17E-5
18 SGTC_312 4092-0653 3.73 6.8 µM 1.37E-4 ergosterol depletion effects on membrane 97 9.58E-5
19 SGTC_3349 9149703 3.68 23.0 µM 1.67E-4 22 1.18E-4
20 SGTC_2325 6158266 3.66 200.0 µM 1.75E-4 34 1.24E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 1.98E-30 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.181 3.77E-26 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.176 7.95E-25 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.173 5.72E-24 YGR060W ERG25 het C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.167 1.62E-22 YJR060W CBF1 hom Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress
0.159 1.73E-20 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.155 1.49E-19 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.148 8.28E-18 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.144 4.18E-17 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.138 8.28E-16 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.138 8.34E-16 YPL259C APM1 hom Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
0.137 1.60E-15 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.136 3.14E-15 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.133 8.77E-15 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.133 9.95E-15 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport