YPR092W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR092W / YPR092W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.78|P-value:2.56E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:5.94|P-value:7.05E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:3.91|P-value:9.61E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.25|P-value:9.68E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.95|P-value:6.74E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:3.68|P-value:2.18E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.68|P-value:2.21E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.24|P-value:9.98E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.82|P-value:1.31E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.81|P-value:1.35E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.35|P-value:6.83E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.73|P-value:1.88E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:5.16|P-value:4.26E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.29|P-value:8.42E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.49|P-value:8.14E-8 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.44|P-value:5.05E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.50|P-value:4.21E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.85|P-value:1.17E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.72|P-value:1.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.90|P-value:9.81E-5 ID:SGTC_1723|Compound:st034307|FD-Score:3.27|P-value:8.93E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.04|P-value:5.76E-5 ID:SGTC_1760|Compound:st045453|FD-Score:12.40|P-value:9.05E-33 ID:SGTC_1800|Compound:st050079|FD-Score:7.50|P-value:3.99E-13 ID:SGTC_1801|Compound:st050089|FD-Score:5.64|P-value:3.67E-8 ID:SGTC_1803|Compound:st050068|FD-Score:18.20|P-value:5.23E-68 ID:SGTC_1818|Compound:st052136|FD-Score:4.26|P-value:2.34E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.37|P-value:6.40E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.85|P-value:1.86E-6 ID:SGTC_2021|Compound:4019055|FD-Score:7.80|P-value:5.00E-14 ID:SGTC_2424|Compound:5537928|FD-Score:4.50|P-value:8.69E-6 ID:SGTC_2429|Compound:5902844|FD-Score:4.05|P-value:5.61E-5 ID:SGTC_2484|Compound:5809818|FD-Score:4.77|P-value:2.58E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.63|P-value:2.63E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.19|P-value:3.25E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.28|P-value:2.22E-5 ID:SGTC_2939|Compound:9044578|FD-Score:8.36|P-value:7.17E-16 ID:SGTC_3300|Compound:9124615|FD-Score:4.15|P-value:3.75E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.72|P-value:1.96E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.73|P-value:1.84E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:4.78|P-value:2.56E-6 ID:SGTC_197|Compound:4544-0043|FD-Score:5.94|P-value:7.05E-9 ID:SGTC_362|Compound:0310-0100|FD-Score:3.91|P-value:9.61E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.25|P-value:9.68E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.95|P-value:6.74E-9 ID:SGTC_663|Compound:1486-0733|FD-Score:3.68|P-value:2.18E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.68|P-value:2.21E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.24|P-value:9.98E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.82|P-value:1.31E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.81|P-value:1.35E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.35|P-value:6.83E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:-3.73|P-value:1.88E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:5.16|P-value:4.26E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.29|P-value:8.42E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:5.49|P-value:8.14E-8 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.44|P-value:5.05E-4 ID:SGTC_1441|Compound:4106-0040|FD-Score:3.84|P-value:1.21E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.50|P-value:4.21E-4 ID:SGTC_1624|Compound:st003710|FD-Score:3.85|P-value:1.17E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.72|P-value:1.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.90|P-value:9.81E-5 ID:SGTC_1723|Compound:st034307|FD-Score:3.27|P-value:8.93E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.04|P-value:5.76E-5 ID:SGTC_1760|Compound:st045453|FD-Score:12.40|P-value:9.05E-33 ID:SGTC_1800|Compound:st050079|FD-Score:7.50|P-value:3.99E-13 ID:SGTC_1801|Compound:st050089|FD-Score:5.64|P-value:3.67E-8 ID:SGTC_1803|Compound:st050068|FD-Score:18.20|P-value:5.23E-68 ID:SGTC_1818|Compound:st052136|FD-Score:4.26|P-value:2.34E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.37|P-value:6.40E-4 ID:SGTC_2020|Compound:4017018|FD-Score:4.85|P-value:1.86E-6 ID:SGTC_2021|Compound:4019055|FD-Score:7.80|P-value:5.00E-14 ID:SGTC_2424|Compound:5537928|FD-Score:4.50|P-value:8.69E-6 ID:SGTC_2429|Compound:5902844|FD-Score:4.05|P-value:5.61E-5 ID:SGTC_2484|Compound:5809818|FD-Score:4.77|P-value:2.58E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.63|P-value:2.63E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.19|P-value:3.25E-5 ID:SGTC_2911|Compound:7942208|FD-Score:3.88|P-value:1.05E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.28|P-value:2.22E-5 ID:SGTC_2939|Compound:9044578|FD-Score:8.36|P-value:7.17E-16 ID:SGTC_3300|Compound:9124615|FD-Score:4.15|P-value:3.75E-5 ID:SGTC_3323|Compound:9138564|FD-Score:-3.72|P-value:1.96E-4

Top fitness defect scores for YPR092W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1803 st050068 18.20 52.4 µM 5.23E-68 NEO1-PIK1 2 1.69E-74
2 SGTC_1760 st045453 12.40 10.4 µM 9.05E-33 NEO1-PIK1 21 8.53E-36
3 SGTC_2939 9044578 8.36 71.4 µM 7.17E-16 10 3.02E-17
4 SGTC_2021 4019055 7.80 173.0 µM 5.00E-14 endomembrane recycling 24 3.18E-15
5 SGTC_1800 st050079 7.50 29.1 µM 3.99E-13 NEO1-PIK1 18 3.11E-14
6 SGTC_445 e6 berbamine 5.95 66.0 µM 6.74E-9 NEO1-PIK1 33 1.34E-9
7 SGTC_197 4544-0043 5.94 41.6 µM 7.05E-9 endomembrane recycling 16 1.40E-9
8 SGTC_1801 st050089 5.64 28.4 µM 3.67E-8 NEO1-PIK1 53 8.57E-9
9 SGTC_1204 4049-0315 5.49 18.3 µM 8.14E-8 4 2.05E-8
10 SGTC_1006 4099-6547 5.16 255.0 µM 4.26E-7 10 1.26E-7
11 SGTC_2020 4017018 4.85 200.0 µM 1.86E-6 5 6.28E-7
12 SGTC_146 3448-8650 4.78 53.1 µM 2.56E-6 NEO1-PIK1 94 8.93E-7
13 SGTC_2484 5809818 4.77 12.0 µM 2.58E-6 9 9.01E-7
14 SGTC_2424 5537928 4.50 59.2 µM 8.69E-6 24 3.40E-6
15 SGTC_2938 9059746 4.28 27.3 µM 2.22E-5 fatty acid desaturase (OLE1) 34 9.48E-6
16 SGTC_1818 st052136 4.26 56.3 µM 2.34E-5 NEO1-PIK1 38 1.00E-5
17 SGTC_3300 9124615 4.15 50.5 µM 3.75E-5 16 1.68E-5
18 SGTC_2429 5902844 4.05 64.4 µM 5.61E-5 23 2.62E-5
19 SGTC_1754 st042065 4.04 16.1 µM 5.76E-5 NEO1-PIK1 171 2.69E-5
20 SGTC_362 0310-0100 3.91 9.0 µM 9.61E-5 RPP1 & pyrimidine depletion 34 4.71E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.461 4.85E-176 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.417 5.78E-141 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.395 1.79E-125 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.387 4.65E-120 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.370 3.24E-109 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.360 5.29E-103 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.350 5.31E-97 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.342 1.20E-92 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.336 6.04E-89 YAR042W SWH1 hom Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.327 1.77E-84 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.324 8.27E-83 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.317 2.78E-79 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.308 1.26E-74 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.299 3.14E-70 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.286 4.68E-64 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription