YPR093C / ASR1

Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR093C / ASR1

Click on Significant Values for Screen Details ID:SGTC_93|Compound:0109-0045|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.11|P-value:6.82E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.24|P-value:4.22E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.63|P-value:7.81E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.88|P-value:3.08E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.71|P-value:6.50E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.50|P-value:1.32E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.39|P-value:2.42E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.69|P-value:6.98E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:3.25E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.17|P-value:5.40E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.97|P-value:2.10E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.50|P-value:1.72E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.46|P-value:2.06E-6 ID:SGTC_1641|Compound:st009299|FD-Score:-3.35|P-value:2.33E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.19|P-value:5.11E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.82|P-value:3.43E-5 ID:SGTC_1720|Compound:st037298|FD-Score:6.31|P-value:3.42E-11 ID:SGTC_1839|Compound:st053978|FD-Score:3.19|P-value:5.08E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.64|P-value:8.78E-5 ID:SGTC_1946|Compound:st076057|FD-Score:-3.43|P-value:1.75E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.09|P-value:7.23E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.35|P-value:3.54E-6 ID:SGTC_2477|Compound:5967686|FD-Score:5.08|P-value:7.64E-8 ID:SGTC_2479|Compound:5617353|FD-Score:-3.38|P-value:2.12E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.69|P-value:7.06E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.03|P-value:9.12E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.35|P-value:3.53E-6 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-2.96|P-value:9.88E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.27|P-value:3.78E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.64|P-value:8.57E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.67|P-value:7.67E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-7.91|P-value:9.98E-17 ID:SGTC_2939|Compound:9044578|FD-Score:3.14|P-value:6.10E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.18|P-value:5.33E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.23|P-value:4.39E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.98|P-value:1.65E-5 ID:SGTC_3262|Compound:9137218|FD-Score:-3.05|P-value:7.18E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.06|P-value:8.08E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.11|P-value:6.82E-4 ID:SGTC_834|Compound:0312-0008|FD-Score:3.24|P-value:4.22E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.63|P-value:7.81E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:3.88|P-value:3.08E-5 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.71|P-value:6.50E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.50|P-value:1.32E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.39|P-value:2.42E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.69|P-value:6.98E-5 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_1291|Compound:0993-0025|FD-Score:3.31|P-value:3.25E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.17|P-value:5.40E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.97|P-value:2.10E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:4.50|P-value:1.72E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.46|P-value:2.06E-6 ID:SGTC_1641|Compound:st009299|FD-Score:-3.35|P-value:2.33E-4 ID:SGTC_1667|Compound:st014849|FD-Score:3.19|P-value:5.11E-4 ID:SGTC_1717|Compound:st033143|FD-Score:-3.82|P-value:3.43E-5 ID:SGTC_1720|Compound:st037298|FD-Score:6.31|P-value:3.42E-11 ID:SGTC_1839|Compound:st053978|FD-Score:3.19|P-value:5.08E-4 ID:SGTC_1943|Compound:st076331|FD-Score:3.64|P-value:8.78E-5 ID:SGTC_1946|Compound:st076057|FD-Score:-3.43|P-value:1.75E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.09|P-value:7.23E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.35|P-value:3.54E-6 ID:SGTC_2477|Compound:5967686|FD-Score:5.08|P-value:7.64E-8 ID:SGTC_2479|Compound:5617353|FD-Score:-3.38|P-value:2.12E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.69|P-value:7.06E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.03|P-value:9.12E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:4.35|P-value:3.53E-6 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-2.96|P-value:9.88E-4 ID:SGTC_2793|Compound:7325131|FD-Score:3.27|P-value:3.78E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.64|P-value:8.57E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.67|P-value:7.67E-5 ID:SGTC_2834|Compound:9001755|FD-Score:-7.91|P-value:9.98E-17 ID:SGTC_2939|Compound:9044578|FD-Score:3.14|P-value:6.10E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.18|P-value:5.33E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.23|P-value:4.39E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.98|P-value:1.65E-5 ID:SGTC_3262|Compound:9137218|FD-Score:-3.05|P-value:7.18E-4

Top fitness defect scores for YPR093C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1720 st037298 6.31 9.5 µM 3.42E-11 12 1.37E-10
2 SGTC_2477 5967686 5.08 25.2 µM 7.64E-8 14 1.86E-7
3 SGTC_1570 verbenone 4.50 133.0 µM 1.72E-6 8 3.42E-6
4 SGTC_1573 oleylamine 4.46 1.1 µM 2.06E-6 17 4.05E-6
5 SGTC_2758 dehydroepiandrosterone 4.35 69.3 µM 3.53E-6 30 6.73E-6
6 SGTC_2406 ethylparaben 4.35 405.7 µM 3.54E-6 23 6.75E-6
7 SGTC_1568 digitonin 3.97 820.0 nM 2.10E-5 sphingolipid biosynthesis & PDR1 31 3.58E-5
8 SGTC_982 1491-0518 3.88 27.5 µM 3.08E-5 13 5.12E-5
9 SGTC_1062 mesoridazine 3.71 14.2 µM 6.50E-5 22 1.03E-4
10 SGTC_1253 0550-0034 3.69 176.0 µM 6.98E-5 26 1.10E-4
11 SGTC_2703 st077852 3.69 53.4 µM 7.06E-5 31 1.12E-4
12 SGTC_2829 7992743 3.67 58.4 µM 7.67E-5 48 1.21E-4
13 SGTC_2795 7780010 3.64 54.5 µM 8.57E-5 40 1.34E-4
14 SGTC_1943 st076331 3.64 65.2 µM 8.78E-5 22 1.37E-4
15 SGTC_427 1354-0053 3.57 47.3 µM 1.15E-4 33 1.77E-4
16 SGTC_1276 0871-0068 3.56 94.2 µM 1.21E-4 27 1.85E-4
17 SGTC_1243 0416-0003 3.39 5.7 µM 2.42E-4 PDR1 54 3.55E-4
18 SGTC_1291 0993-0025 3.31 5.8 µM 3.25E-4 23 4.68E-4
19 SGTC_2793 7325131 3.27 81.8 µM 3.78E-4 36 5.39E-4
20 SGTC_834 0312-0008 3.24 75.7 µM 4.22E-4 NEO1 68 5.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.221 1.56E-38 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131 2.10E-14 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.125 3.12E-13 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.113 5.35E-11 YPL221W FLC1 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
0.112 9.45E-11 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.109 2.51E-10 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.107 5.10E-10 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.103 2.23E-9 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.099 9.93E-9 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.098 1.18E-8 YNL336W COS1 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.098 1.42E-8 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.095 3.86E-8 YHR073W OSH3 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.095 4.31E-8 YBR055C PRP6 het Splicing factor, component of the U4/U6-U5 snRNP complex
0.094 4.21E-8 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.090 1.61E-7 YPL134C ODC1 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation