YPR095C / SYT1

Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR095C / SYT1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.61|P-value:2.48E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.24|P-value:5.74E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.10|P-value:2.13E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:4.94|P-value:4.84E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.27|P-value:1.18E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:3.24|P-value:6.83E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.95|P-value:4.62E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.89|P-value:6.23E-7 ID:SGTC_692|Compound:k241-0027|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.33|P-value:5.04E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.21|P-value:7.50E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.23|P-value:7.14E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.33|P-value:7.24E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.60|P-value:1.52E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.18|P-value:8.35E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.11|P-value:2.36E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.59|P-value:1.89E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.36|P-value:7.79E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.22|P-value:7.37E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.18|P-value:1.72E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.88|P-value:2.67E-9 ID:SGTC_1749|Compound:st037932|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.24|P-value:6.76E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.89|P-value:5.93E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.37|P-value:3.72E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.92|P-value:5.26E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.34|P-value:4.05E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.20|P-value:7.87E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.32|P-value:5.16E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.15|P-value:9.32E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.28|P-value:1.10E-5 ID:SGTC_2700|Compound:st077718|FD-Score:-3.23|P-value:6.07E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.34|P-value:6.14E-8 ID:SGTC_2812|Compound:7970281|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.88|P-value:5.09E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.31|P-value:4.60E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.12|P-value:8.91E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.19|P-value:8.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.65|P-value:1.30E-4 ID:SGTC_3314|Compound:9135860|FD-Score:7.62|P-value:1.90E-14 ID:SGTC_3317|Compound:9138495|FD-Score:4.27|P-value:1.20E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.61|P-value:2.48E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.24|P-value:5.74E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.10|P-value:2.13E-7 ID:SGTC_77|Compound:0828-0286|FD-Score:4.94|P-value:4.84E-7 ID:SGTC_164|Compound:4100-3994|FD-Score:3.42|P-value:3.56E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:4.27|P-value:1.18E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:3.24|P-value:6.83E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.95|P-value:4.62E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:4.89|P-value:6.23E-7 ID:SGTC_692|Compound:k241-0027|FD-Score:3.70|P-value:1.25E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:3.33|P-value:5.04E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.21|P-value:7.50E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.23|P-value:7.14E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-4.33|P-value:7.24E-6 ID:SGTC_1039|Compound:k821-0043|FD-Score:-3.60|P-value:1.52E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.18|P-value:8.35E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.11|P-value:2.36E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.59|P-value:1.89E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.36|P-value:7.79E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.75|P-value:1.05E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.22|P-value:7.37E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.18|P-value:1.72E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:5.88|P-value:2.67E-9 ID:SGTC_1749|Compound:st037932|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.26|P-value:6.25E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.76|P-value:1.01E-4 ID:SGTC_2134|Compound:5324836|FD-Score:3.24|P-value:6.76E-4 ID:SGTC_2192|Compound:5915882|FD-Score:3.89|P-value:5.93E-5 ID:SGTC_2320|Compound:7373003|FD-Score:-3.37|P-value:3.72E-4 ID:SGTC_2326|Compound:6164455|FD-Score:3.92|P-value:5.26E-5 ID:SGTC_2424|Compound:5537928|FD-Score:-3.34|P-value:4.05E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.20|P-value:7.87E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.16|P-value:9.03E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:3.32|P-value:5.16E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.15|P-value:9.32E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.28|P-value:1.10E-5 ID:SGTC_2700|Compound:st077718|FD-Score:-3.23|P-value:6.07E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:5.34|P-value:6.14E-8 ID:SGTC_2812|Compound:7970281|FD-Score:3.38|P-value:4.23E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.88|P-value:5.09E-5 ID:SGTC_2877|Compound:9040724|FD-Score:-3.31|P-value:4.60E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-3.12|P-value:8.91E-4 ID:SGTC_3009|Compound:9080819|FD-Score:3.19|P-value:8.19E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.64|P-value:1.57E-4 ID:SGTC_3188|Compound:9110789|FD-Score:-3.65|P-value:1.30E-4 ID:SGTC_3314|Compound:9135860|FD-Score:7.62|P-value:1.90E-14 ID:SGTC_3317|Compound:9138495|FD-Score:4.27|P-value:1.20E-5

Top fitness defect scores for YPR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3314 9135860 7.62 59.4 µM 1.90E-14 1 1.23E-14
2 SGTC_1680 diphenhydramine 5.88 100.0 µM 2.67E-9 NEO1 7 1.99E-9
3 SGTC_2753 fluvastatin 5.34 17.1 µM 6.14E-8 azole & statin 9 4.76E-8
4 SGTC_65 0798-0905 5.10 35.0 µM 2.13E-7 calcium & mitochondrial duress 51 1.68E-7
5 SGTC_77 0828-0286 4.94 12.5 µM 4.84E-7 TSC3-RPN4 11 3.85E-7
6 SGTC_663 1486-0733 4.89 13.9 µM 6.23E-7 cell wall signaling 32 4.98E-7
7 SGTC_58 0957-0393 4.61 9.0 µM 2.48E-6 cell wall 322 2.01E-6
8 SGTC_1495 4469-0029 4.36 237.0 µM 7.79E-6 92 6.44E-6
9 SGTC_2626 ethyl orsellinate 4.28 100.0 µM 1.10E-5 27 9.15E-6
10 SGTC_180 1486-1293 4.27 102.8 µM 1.18E-5 34 9.77E-6
11 SGTC_3317 9138495 4.27 8.8 µM 1.20E-5 30 9.98E-6
12 SGTC_1679 4130-1276 4.18 6.7 µM 1.72E-5 Golgi 56 1.44E-5
13 SGTC_1451 4152-0210 4.11 104.0 µM 2.36E-5 23 1.98E-5
14 SGTC_338 4055-0136 3.95 114.0 µM 4.62E-5 10 3.90E-5
15 SGTC_2326 6164455 3.92 177.6 µM 5.26E-5 mitochondrial processes 23 4.46E-5
16 SGTC_2192 5915882 3.89 198.5 µM 5.93E-5 RNA processing & uracil transport 28 5.03E-5
17 SGTC_2124 5246320 3.76 200.0 µM 1.01E-4 heme biosynthesis & mitochondrial translocase 23 8.61E-5
18 SGTC_1576 erythromycin ethylsuccinate 3.75 23.2 µM 1.05E-4 25 9.00E-5
19 SGTC_692 k241-0027 3.70 77.8 µM 1.25E-4 13 1.08E-4
20 SGTC_1749 st037932 3.70 54.2 µM 1.27E-4 34 1.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 2.38E-23 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.150 2.28E-18 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.149 3.92E-18 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.123 8.76E-13 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.121 1.97E-12 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.120 2.97E-12 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.118 6.39E-12 YCL028W RNQ1 hom [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate
0.116 1.38E-11 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.114 4.17E-11 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.111 1.06E-10 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.111 1.16E-10 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.110 1.45E-10 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.108 2.90E-10 YGR223C HSV2 hom Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
0.108 3.12E-10 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.104 1.42E-9 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs