HIPHOP chemogenomics database

YPR096C

Protein of unknown function that may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR096C / YPR096C

Click on Significant Values for Screen Details

Top fitness defect scores for YPR096C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2756	carbadox	8.68	75.1 µM	3.02E-21		6	2.05E-18
2	SGTC_1374	2889-5571	6.57	141.0 µM	5.76E-13	RSC complex & mRNA processing	9	2.52E-11
3	SGTC_35	0133-0054	6.50	64.1 µM	1.01E-12		2	4.08E-11
4	SGTC_1130	3454-2858	5.73	15.9 µM	2.77E-10	NEO1	47	5.01E-9
5	SGTC_2713	st079149	5.32	53.4 µM	4.35E-9		8	5.32E-8
6	SGTC_40	0327-0103	5.12	19.8 µM	1.52E-8		10	1.56E-7
7	SGTC_669	0108-0021	5.05	26.2 µM	2.25E-8	fatty acid desaturase (OLE1)	37	2.18E-7
8	SGTC_1042	0350-0096	4.52	82.0 µM	5.06E-7	TSC3-RPN4	11	3.16E-6
9	SGTC_1520	flindersine	4.38	88.0 µM	1.04E-6		21	5.84E-6
10	SGTC_2943	9068529	4.22	45.3 µM	2.50E-6		12	1.25E-5
11	SGTC_3092	9117248	4.18	49.5 µM	3.00E-6	cell wall signaling	3	1.46E-5
12	SGTC_2292	7671323	4.14	168.1 µM	3.77E-6	RNA processing & uracil transport	26	1.77E-5
13	SGTC_2338	7999974	3.71	200.0 µM	2.96E-5		29	1.04E-4
14	SGTC_2759	disulfiram	3.48	3.4 µM	8.19E-5		55	2.51E-4
15	SGTC_37	0566-0070	3.44	1.6 µM	9.54E-5		46	2.86E-4
16	SGTC_36	0335-0881	3.40	14.2 µM	1.17E-4	ubiquinone biosynthesis & proteasome	149	3.41E-4
17	SGTC_1517	deoxycholic acid methyl ester	3.37	49.2 µM	1.33E-4		19	3.81E-4
18	SGTC_1962	st076595	3.28	64.5 µM	1.91E-4	redox potentiating	58	5.20E-4
19	SGTC_2344	7990960	3.27	77.0 µM	2.01E-4		51	5.43E-4
20	SGTC_51	1013-0126	3.24	23.4 µM	2.27E-4		44	6.03E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.130	4.05E-14	YGL210W	YPT32	hom	Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.123	8.60E-13	YOR092W	ECM3	hom	Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.113	6.27E-11	YBL065W_d	YBL065W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.105	9.81E-10	YDR090C_p	YDR090C_p	hom	Putative protein of unknown function
0.100	6.80E-9	YOL137W	BSC6	hom	Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.099	9.53E-9	YGR108W	CLB1	hom	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.096	2.75E-8	YDR261C	EXG2	hom	Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.095	3.44E-8	YFL014W	HSP12	hom	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.095	3.75E-8	YOL102C	TPT1	het	tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.094	5.31E-8	YDR319C_p	YFT2_p	hom	Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens
0.093	6.81E-8	YDL133C-A	RPL41B	hom	Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.093	7.85E-8	YDR440W	DOT1	hom	Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
0.092	1.06E-7	YGR295C	COS6	hom	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.091	1.13E-7	YBR143C	SUP45	het	Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.091	1.40E-7	YDR316W	OMS1	hom	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations