YPR096C

Protein of unknown function that may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR096C / YPR096C

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:6.50|P-value:1.01E-12 ID:SGTC_36|Compound:0335-0881|FD-Score:3.40|P-value:1.17E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.44|P-value:9.54E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:5.12|P-value:1.52E-8 ID:SGTC_51|Compound:1013-0126|FD-Score:3.24|P-value:2.27E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.14|P-value:3.38E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:2.92|P-value:7.72E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.95|P-value:7.07E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.05|P-value:2.25E-8 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.54|P-value:6.69E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:2.95|P-value:6.93E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.78|P-value:2.26E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.52|P-value:5.06E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.73|P-value:2.77E-10 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.57|P-value:5.76E-13 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.37|P-value:1.33E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.38|P-value:1.04E-6 ID:SGTC_1922|Compound:5578187|FD-Score:-3.26|P-value:2.11E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.42|P-value:1.09E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.28|P-value:1.91E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.14|P-value:3.77E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.17|P-value:3.03E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.21|P-value:2.59E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.71|P-value:2.96E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.27|P-value:2.01E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.77|P-value:2.32E-5 ID:SGTC_2713|Compound:st079149|FD-Score:5.32|P-value:4.35E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:8.68|P-value:3.02E-21 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.48|P-value:8.19E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-4.92|P-value:5.26E-8 ID:SGTC_2875|Compound:9039966|FD-Score:3.15|P-value:3.26E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-4.93|P-value:5.03E-8 ID:SGTC_2943|Compound:9068529|FD-Score:4.22|P-value:2.50E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-2.93|P-value:7.83E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.53|P-value:6.82E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.09|P-value:4.19E-4 ID:SGTC_3092|Compound:9117248|FD-Score:4.18|P-value:3.00E-6 ID:SGTC_3131|Compound:9127911|FD-Score:-5.05|P-value:2.39E-8 ID:SGTC_3137|Compound:9097352|FD-Score:-3.32|P-value:1.65E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.65|P-value:2.50E-7 ID:SGTC_3280|Compound:9140961|FD-Score:-5.08|P-value:1.96E-8 ID:SGTC_35|Compound:0133-0054|FD-Score:6.50|P-value:1.01E-12 ID:SGTC_36|Compound:0335-0881|FD-Score:3.40|P-value:1.17E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.44|P-value:9.54E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:5.12|P-value:1.52E-8 ID:SGTC_51|Compound:1013-0126|FD-Score:3.24|P-value:2.27E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:3.14|P-value:3.38E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:2.92|P-value:7.72E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.95|P-value:7.07E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:5.05|P-value:2.25E-8 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.54|P-value:6.69E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:2.95|P-value:6.93E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.78|P-value:2.26E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.52|P-value:5.06E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.73|P-value:2.77E-10 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.57|P-value:5.76E-13 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:3.37|P-value:1.33E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.38|P-value:1.04E-6 ID:SGTC_1922|Compound:5578187|FD-Score:-3.26|P-value:2.11E-4 ID:SGTC_1933|Compound:st074711|FD-Score:-3.42|P-value:1.09E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.28|P-value:1.91E-4 ID:SGTC_2292|Compound:7671323|FD-Score:4.14|P-value:3.77E-6 ID:SGTC_2310|Compound:7668677|FD-Score:3.17|P-value:3.03E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-3.21|P-value:2.59E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.71|P-value:2.96E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.27|P-value:2.01E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.77|P-value:2.32E-5 ID:SGTC_2713|Compound:st079149|FD-Score:5.32|P-value:4.35E-9 ID:SGTC_2756|Compound:carbadox|FD-Score:8.68|P-value:3.02E-21 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.48|P-value:8.19E-5 ID:SGTC_2874|Compound:9043904|FD-Score:-4.92|P-value:5.26E-8 ID:SGTC_2875|Compound:9039966|FD-Score:3.15|P-value:3.26E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-4.93|P-value:5.03E-8 ID:SGTC_2943|Compound:9068529|FD-Score:4.22|P-value:2.50E-6 ID:SGTC_2955|Compound:9076254|FD-Score:-2.93|P-value:7.83E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.53|P-value:6.82E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.09|P-value:4.19E-4 ID:SGTC_3092|Compound:9117248|FD-Score:4.18|P-value:3.00E-6 ID:SGTC_3131|Compound:9127911|FD-Score:-5.05|P-value:2.39E-8 ID:SGTC_3137|Compound:9097352|FD-Score:-3.32|P-value:1.65E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-4.65|P-value:2.50E-7 ID:SGTC_3280|Compound:9140961|FD-Score:-5.08|P-value:1.96E-8

Top fitness defect scores for YPR096C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2756 carbadox 8.68 75.1 µM 3.02E-21 6 2.05E-18
2 SGTC_1374 2889-5571 6.57 141.0 µM 5.76E-13 RSC complex & mRNA processing 9 2.52E-11
3 SGTC_35 0133-0054 6.50 64.1 µM 1.01E-12 2 4.08E-11
4 SGTC_1130 3454-2858 5.73 15.9 µM 2.77E-10 NEO1 47 5.01E-9
5 SGTC_2713 st079149 5.32 53.4 µM 4.35E-9 8 5.32E-8
6 SGTC_40 0327-0103 5.12 19.8 µM 1.52E-8 10 1.56E-7
7 SGTC_669 0108-0021 5.05 26.2 µM 2.25E-8 fatty acid desaturase (OLE1) 37 2.18E-7
8 SGTC_1042 0350-0096 4.52 82.0 µM 5.06E-7 TSC3-RPN4 11 3.16E-6
9 SGTC_1520 flindersine 4.38 88.0 µM 1.04E-6 21 5.84E-6
10 SGTC_2943 9068529 4.22 45.3 µM 2.50E-6 12 1.25E-5
11 SGTC_3092 9117248 4.18 49.5 µM 3.00E-6 cell wall signaling 3 1.46E-5
12 SGTC_2292 7671323 4.14 168.1 µM 3.77E-6 RNA processing & uracil transport 26 1.77E-5
13 SGTC_2338 7999974 3.71 200.0 µM 2.96E-5 29 1.04E-4
14 SGTC_2759 disulfiram 3.48 3.4 µM 8.19E-5 55 2.51E-4
15 SGTC_37 0566-0070 3.44 1.6 µM 9.54E-5 46 2.86E-4
16 SGTC_36 0335-0881 3.40 14.2 µM 1.17E-4 ubiquinone biosynthesis & proteasome 149 3.41E-4
17 SGTC_1517 deoxycholic acid methyl ester 3.37 49.2 µM 1.33E-4 19 3.81E-4
18 SGTC_1962 st076595 3.28 64.5 µM 1.91E-4 redox potentiating 58 5.20E-4
19 SGTC_2344 7990960 3.27 77.0 µM 2.01E-4 51 5.43E-4
20 SGTC_51 1013-0126 3.24 23.4 µM 2.27E-4 44 6.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.130 4.05E-14 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.123 8.60E-13 YOR092W ECM3 hom Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication
0.113 6.27E-11 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.105 9.81E-10 YDR090C_p YDR090C_p hom Putative protein of unknown function
0.100 6.80E-9 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.099 9.53E-9 YGR108W CLB1 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
0.096 2.75E-8 YDR261C EXG2 hom Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.095 3.44E-8 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.095 3.75E-8 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.094 5.31E-8 YDR319C_p YFT2_p hom Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens
0.093 6.81E-8 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.093 7.85E-8 YDR440W DOT1 hom Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
0.092 1.06E-7 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.091 1.13E-7 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.091 1.40E-7 YDR316W OMS1 hom Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations