YPR097W

Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR097W / YPR097W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.43|P-value:4.51E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:5.06|P-value:7.20E-7 ID:SGTC_54|Compound:0159-0055|FD-Score:5.84|P-value:1.24E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:11.40|P-value:6.23E-28 ID:SGTC_60|Compound:0986-0278|FD-Score:-5.81|P-value:1.03E-8 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.95|P-value:6.82E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.42|P-value:4.63E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.20|P-value:9.68E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.36|P-value:6.99E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.30|P-value:2.12E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.02|P-value:3.17E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.25|P-value:8.13E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.34|P-value:6.17E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.65|P-value:2.61E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.60|P-value:2.44E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.91|P-value:8.61E-9 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.81|P-value:1.44E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:4.08|P-value:5.14E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.34|P-value:6.06E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.91|P-value:1.00E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-4.52|P-value:6.24E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.03|P-value:4.82E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.49|P-value:4.57E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.25|P-value:8.27E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.72|P-value:2.04E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:-4.36|P-value:1.28E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.31|P-value:8.35E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.74|P-value:1.88E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.57|P-value:6.81E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.85|P-value:1.23E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.35|P-value:7.37E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.94|P-value:8.84E-5 ID:SGTC_1902|Compound:st060212|FD-Score:4.28|P-value:2.28E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.33|P-value:1.91E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.30|P-value:8.73E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.71|P-value:2.09E-4 ID:SGTC_2187|Compound:6125751|FD-Score:5.16|P-value:4.25E-7 ID:SGTC_2270|Compound:7924575|FD-Score:3.93|P-value:9.29E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.11|P-value:4.67E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-3.25|P-value:8.14E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-6.78|P-value:3.14E-11 ID:SGTC_2365|Compound:9042475|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.62|P-value:2.32E-4 ID:SGTC_2368|Compound:9071271|FD-Score:7.37|P-value:9.81E-13 ID:SGTC_2470|Compound:5664817|FD-Score:3.80|P-value:1.48E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.49|P-value:4.59E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.51|P-value:4.30E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.67|P-value:2.38E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.68|P-value:2.30E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.94|P-value:8.91E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_3322|Compound:9139058|FD-Score:4.32|P-value:1.97E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.43|P-value:4.51E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:5.06|P-value:7.20E-7 ID:SGTC_54|Compound:0159-0055|FD-Score:5.84|P-value:1.24E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:11.40|P-value:6.23E-28 ID:SGTC_60|Compound:0986-0278|FD-Score:-5.81|P-value:1.03E-8 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.95|P-value:6.82E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:-3.42|P-value:4.63E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:-3.20|P-value:9.68E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.36|P-value:6.99E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:5.30|P-value:2.12E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.02|P-value:3.17E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.25|P-value:8.13E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:-3.34|P-value:6.17E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.65|P-value:2.61E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.60|P-value:2.44E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.91|P-value:8.61E-9 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.81|P-value:1.44E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:4.08|P-value:5.14E-5 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.34|P-value:6.06E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.91|P-value:1.00E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-4.52|P-value:6.24E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.03|P-value:4.82E-5 ID:SGTC_874|Compound:0599-0792|FD-Score:3.49|P-value:4.57E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.25|P-value:8.27E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.72|P-value:2.04E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:-4.36|P-value:1.28E-5 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.31|P-value:8.35E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.74|P-value:1.88E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:4.57|P-value:6.81E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:3.85|P-value:1.23E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.35|P-value:7.37E-4 ID:SGTC_1864|Compound:st057645|FD-Score:3.94|P-value:8.84E-5 ID:SGTC_1902|Compound:st060212|FD-Score:4.28|P-value:2.28E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.33|P-value:1.91E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.30|P-value:8.73E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.71|P-value:2.09E-4 ID:SGTC_2187|Compound:6125751|FD-Score:5.16|P-value:4.25E-7 ID:SGTC_2270|Compound:7924575|FD-Score:3.93|P-value:9.29E-5 ID:SGTC_2285|Compound:7945142|FD-Score:4.11|P-value:4.67E-5 ID:SGTC_2361|Compound:9034121|FD-Score:-3.25|P-value:8.14E-4 ID:SGTC_2362|Compound:9071156|FD-Score:-6.78|P-value:3.14E-11 ID:SGTC_2365|Compound:9042475|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_2366|Compound:9070441|FD-Score:-3.62|P-value:2.32E-4 ID:SGTC_2368|Compound:9071271|FD-Score:7.37|P-value:9.81E-13 ID:SGTC_2470|Compound:5664817|FD-Score:3.80|P-value:1.48E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.49|P-value:4.59E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.51|P-value:4.30E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.67|P-value:2.38E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:3.68|P-value:2.30E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.94|P-value:8.91E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_3322|Compound:9139058|FD-Score:4.32|P-value:1.97E-5

Top fitness defect scores for YPR097W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 11.40 9.0 µM 6.23E-28 cell wall 57 2.38E-30
2 SGTC_2368 9071271 7.37 200.0 µM 9.81E-13 1 8.64E-14
3 SGTC_272 doxorubicin 5.91 8.1 µM 8.61E-9 anthracycline transcription coupled DNA repair 5 1.72E-9
4 SGTC_54 0159-0055 5.84 9.0 µM 1.24E-8 ERG2 22 2.55E-9
5 SGTC_146 3448-8650 5.30 53.1 µM 2.12E-7 NEO1-PIK1 68 5.64E-8
6 SGTC_2187 6125751 5.16 200.0 µM 4.25E-7 RSC complex & mRNA processing 4 1.20E-7
7 SGTC_51 1013-0126 5.06 23.4 µM 7.20E-7 19 2.14E-7
8 SGTC_1443 4112-3303 4.57 14.0 µM 6.81E-6 3 2.48E-6
9 SGTC_1916 st067606 4.33 49.2 µM 1.91E-5 26 7.62E-6
10 SGTC_3322 9139058 4.32 2.1 µM 1.97E-5 cell wall 21 7.91E-6
11 SGTC_1902 st060212 4.28 70.5 µM 2.28E-5 8 9.24E-6
12 SGTC_2285 7945142 4.11 200.0 µM 4.67E-5 20 2.02E-5
13 SGTC_305 1682-2595 4.08 20.8 µM 5.14E-5 RNA processing & uracil transport 20 2.24E-5
14 SGTC_1864 st057645 3.94 30.4 µM 8.84E-5 amide catabolism 4 4.05E-5
15 SGTC_2873 9040596 3.94 71.4 µM 8.91E-5 48 4.09E-5
16 SGTC_2270 7924575 3.93 90.9 µM 9.29E-5 RPP1 & pyrimidine depletion 15 4.28E-5
17 SGTC_674 0498-0004 3.91 451.0 µM 1.00E-4 heme requiring 25 4.65E-5
18 SGTC_1457 k015-0032 3.85 57.3 µM 1.23E-4 40 5.80E-5
19 SGTC_3109 9122853 3.84 49.5 µM 1.28E-4 7 6.08E-5
20 SGTC_2788 5282734 3.83 71.4 µM 1.32E-4 54 6.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.07E-38 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.216 1.41E-36 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.215 2.23E-36 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.207 1.00E-33 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.194 7.15E-30 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.191 5.52E-29 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.189 2.02E-28 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.188 4.52E-28 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.186 1.76E-27 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.178 2.29E-25 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.177 3.67E-25 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.173 6.58E-24 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.173 6.94E-24 YML057W CMP2 hom Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.170 4.19E-23 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.166 4.25E-22 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated