YPR098C

Protein of unknown function, localized to the mitochondrial outer membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR098C / YPR098C

Click on Significant Values for Screen Details ID:SGTC_94|Compound:0334-0113|FD-Score:3.38|P-value:9.13E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.70|P-value:3.21E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.79|P-value:2.39E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.55|P-value:5.02E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.91|P-value:1.42E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.51|P-value:1.47E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.88|P-value:1.74E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.64|P-value:9.57E-6 ID:SGTC_1591|Compound:genipin|FD-Score:-4.47|P-value:1.69E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.49|P-value:6.54E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.60|P-value:4.19E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.39|P-value:8.28E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.40|P-value:2.54E-5 ID:SGTC_2163|Compound:5671233|FD-Score:-3.40|P-value:8.12E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.49|P-value:6.50E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-4.99|P-value:1.83E-6 ID:SGTC_2259|Compound:7964009|FD-Score:3.98|P-value:1.24E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.20|P-value:5.43E-5 ID:SGTC_2275|Compound:7947463|FD-Score:-3.50|P-value:5.89E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.41|P-value:3.01E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.39|P-value:2.64E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.40|P-value:8.61E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.25|P-value:4.46E-5 ID:SGTC_2910|Compound:7948405|FD-Score:5.23|P-value:7.04E-7 ID:SGTC_3001|Compound:9076041|FD-Score:3.48|P-value:6.66E-4 ID:SGTC_3025|Compound:9087895|FD-Score:5.44|P-value:2.55E-7 ID:SGTC_3206|Compound:9114350|FD-Score:5.06|P-value:1.51E-6 ID:SGTC_3245|Compound:9134821|FD-Score:4.28|P-value:3.94E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.97|P-value:1.15E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.53|P-value:5.67E-4 ID:SGTC_3279|Compound:9140807|FD-Score:4.35|P-value:3.04E-5 ID:SGTC_3284|Compound:9108171|FD-Score:5.29|P-value:5.41E-7 ID:SGTC_3286|Compound:9117135|FD-Score:3.43|P-value:7.84E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-3.58|P-value:4.45E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.38|P-value:9.13E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.70|P-value:3.21E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.79|P-value:2.39E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.55|P-value:5.02E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.91|P-value:1.42E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-4.51|P-value:1.47E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.88|P-value:1.74E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.64|P-value:9.57E-6 ID:SGTC_1591|Compound:genipin|FD-Score:-4.47|P-value:1.69E-5 ID:SGTC_1913|Compound:st060213|FD-Score:3.49|P-value:6.54E-4 ID:SGTC_2009|Compound:4012297|FD-Score:-3.60|P-value:4.19E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.39|P-value:8.28E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.40|P-value:2.54E-5 ID:SGTC_2163|Compound:5671233|FD-Score:-3.40|P-value:8.12E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.49|P-value:6.50E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-4.99|P-value:1.83E-6 ID:SGTC_2259|Compound:7964009|FD-Score:3.98|P-value:1.24E-4 ID:SGTC_2263|Compound:7948595|FD-Score:4.20|P-value:5.43E-5 ID:SGTC_2275|Compound:7947463|FD-Score:-3.50|P-value:5.89E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:5.41|P-value:3.01E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.39|P-value:2.64E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.40|P-value:8.61E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.25|P-value:4.46E-5 ID:SGTC_2910|Compound:7948405|FD-Score:5.23|P-value:7.04E-7 ID:SGTC_3001|Compound:9076041|FD-Score:3.48|P-value:6.66E-4 ID:SGTC_3025|Compound:9087895|FD-Score:5.44|P-value:2.55E-7 ID:SGTC_3206|Compound:9114350|FD-Score:5.06|P-value:1.51E-6 ID:SGTC_3245|Compound:9134821|FD-Score:4.28|P-value:3.94E-5 ID:SGTC_3252|Compound:9135871|FD-Score:-3.97|P-value:1.15E-4 ID:SGTC_3258|Compound:9138477|FD-Score:3.53|P-value:5.67E-4 ID:SGTC_3279|Compound:9140807|FD-Score:4.35|P-value:3.04E-5 ID:SGTC_3284|Compound:9108171|FD-Score:5.29|P-value:5.41E-7 ID:SGTC_3286|Compound:9117135|FD-Score:3.43|P-value:7.84E-4 ID:SGTC_3288|Compound:9119690|FD-Score:-3.58|P-value:4.45E-4

Top fitness defect scores for YPR098C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3025 9087895 5.44 49.5 µM 2.55E-7 PDR1 21 2.60E-8
2 SGTC_2420 aureobasidin a 5.41 50.0 nM 3.01E-7 16 3.15E-8
3 SGTC_3284 9108171 5.29 64.9 µM 5.41E-7 8 6.25E-8
4 SGTC_2910 7948405 5.23 26.0 µM 7.04E-7 plasma membrane duress 10 8.49E-8
5 SGTC_3206 9114350 5.06 49.5 µM 1.51E-6 4 2.07E-7
6 SGTC_1580 hydrocortisone 21-hemisuccinate 4.64 43.2 µM 9.57E-6 7 1.78E-6
7 SGTC_2066 5222451 4.40 176.0 µM 2.54E-5 heme biosynthesis & mitochondrial translocase 23 5.54E-6
8 SGTC_2429 5902844 4.39 64.4 µM 2.64E-5 11 5.79E-6
9 SGTC_3279 9140807 4.35 49.5 µM 3.04E-5 11 6.85E-6
10 SGTC_3245 9134821 4.28 49.5 µM 3.94E-5 10 9.24E-6
11 SGTC_2800 7887935 4.25 81.8 µM 4.46E-5 RPP1 & pyrimidine depletion 24 1.07E-5
12 SGTC_2263 7948595 4.20 193.3 µM 5.43E-5 1 1.34E-5
13 SGTC_2259 7964009 3.98 200.0 µM 1.24E-4 superoxide 29 3.50E-5
14 SGTC_1451 4152-0210 3.88 104.0 µM 1.74E-4 29 5.20E-5
15 SGTC_524 r073-0010 3.79 27.8 µM 2.39E-4 56 7.53E-5
16 SGTC_215 1287-0124 3.70 461.5 µM 3.21E-4 3 1.06E-4
17 SGTC_3258 9138477 3.53 49.5 µM 5.67E-4 11 2.06E-4
18 SGTC_2167 5876490 3.49 200.0 µM 6.50E-4 49 2.41E-4
19 SGTC_1913 st060213 3.49 96.1 µM 6.54E-4 49 2.42E-4
20 SGTC_3001 9076041 3.48 71.4 µM 6.66E-4 23 2.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 6.13E-12 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.081 2.63E-6 YDL101C DUN1 hom Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair
0.076 1.08E-5 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes
0.072 3.00E-5 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.068 8.17E-5 YLR344W RPL26A hom Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication
0.066 1.23E-4 YGR259C_d YGR259C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
0.066 1.32E-4 YDR248C_p YDR248C_p hom Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1
0.066 1.35E-4 YBR289W SNF5 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions
0.064 2.27E-4 YOR099W KTR1 hom Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.064 2.31E-4 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.062 3.00E-4 YDR216W ADR1 hom Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
0.062 3.27E-4 YDR488C PAC11 hom Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
0.061 3.95E-4 YNL158W PGA1 het Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
0.060 5.16E-4 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.060 5.27E-4 YOR380W RDR1 hom Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins