YPR101W / SNT309

Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR101W / SNT309

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:3.88|P-value:1.67E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.77|P-value:2.50E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.55|P-value:5.16E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.51|P-value:1.47E-5 ID:SGTC_228|Compound:caffeine|FD-Score:-3.52|P-value:5.83E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.84|P-value:1.87E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.16|P-value:6.38E-9 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.87|P-value:1.74E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.97|P-value:1.22E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.20|P-value:5.15E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.59|P-value:4.56E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.30|P-value:3.44E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.79|P-value:2.29E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.35|P-value:9.50E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.34|P-value:2.99E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:4.90|P-value:2.84E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.65|P-value:3.76E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.51|P-value:5.74E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:5.69|P-value:7.03E-8 ID:SGTC_891|Compound:0929-0073|FD-Score:3.88|P-value:1.67E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.15|P-value:6.36E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.48|P-value:1.97E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.53|P-value:5.38E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.45|P-value:1.91E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.38|P-value:8.71E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.02|P-value:1.00E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.79|P-value:2.26E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.74|P-value:2.76E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.37|P-value:8.95E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.51|P-value:5.78E-4 ID:SGTC_2134|Compound:5324836|FD-Score:6.54|P-value:7.21E-10 ID:SGTC_2138|Compound:5575593|FD-Score:4.22|P-value:4.79E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.49|P-value:6.18E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.43|P-value:2.05E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.35|P-value:9.57E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.96|P-value:2.23E-6 ID:SGTC_2241|Compound:6772625|FD-Score:5.98|P-value:1.55E-8 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-7.72|P-value:4.81E-13 ID:SGTC_2255|Compound:7941087|FD-Score:3.99|P-value:1.12E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.43|P-value:7.80E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.87|P-value:1.69E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.41|P-value:7.91E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.75|P-value:2.64E-4 ID:SGTC_2361|Compound:9034121|FD-Score:5.70|P-value:6.78E-8 ID:SGTC_2367|Compound:9070478|FD-Score:-3.74|P-value:2.77E-4 ID:SGTC_2443|Compound:5493264|FD-Score:4.03|P-value:9.70E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.89|P-value:3.05E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.34|P-value:9.88E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.95|P-value:1.27E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.79|P-value:2.25E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.95|P-value:1.29E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.40|P-value:8.24E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.36|P-value:9.66E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.80|P-value:2.28E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.36|P-value:9.25E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.40|P-value:8.18E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.13|P-value:6.65E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.83|P-value:1.97E-4 ID:SGTC_3114|Compound:9122766|FD-Score:5.23|P-value:6.53E-7 ID:SGTC_3145|Compound:9085516|FD-Score:-4.06|P-value:8.89E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.55|P-value:5.16E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.56|P-value:4.88E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.88|P-value:1.67E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.77|P-value:2.50E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:-3.55|P-value:5.16E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.97|P-value:1.20E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:4.51|P-value:1.47E-5 ID:SGTC_228|Compound:caffeine|FD-Score:-3.52|P-value:5.83E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.84|P-value:1.87E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.16|P-value:6.38E-9 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.87|P-value:1.74E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:3.97|P-value:1.22E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:4.20|P-value:5.15E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.59|P-value:4.56E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.30|P-value:3.44E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:3.79|P-value:2.29E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.35|P-value:9.50E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.34|P-value:2.99E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:4.90|P-value:2.84E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-3.65|P-value:3.76E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.51|P-value:5.74E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:5.69|P-value:7.03E-8 ID:SGTC_891|Compound:0929-0073|FD-Score:3.88|P-value:1.67E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-4.15|P-value:6.36E-5 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:5.48|P-value:1.97E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:3.53|P-value:5.38E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:4.45|P-value:1.91E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.38|P-value:8.71E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.02|P-value:1.00E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.79|P-value:2.26E-4 ID:SGTC_2049|Compound:5262831|FD-Score:-3.74|P-value:2.76E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.37|P-value:8.95E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.51|P-value:5.78E-4 ID:SGTC_2134|Compound:5324836|FD-Score:6.54|P-value:7.21E-10 ID:SGTC_2138|Compound:5575593|FD-Score:4.22|P-value:4.79E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.49|P-value:6.18E-4 ID:SGTC_2161|Compound:5662504|FD-Score:4.43|P-value:2.05E-5 ID:SGTC_2174|Compound:5790901|FD-Score:3.35|P-value:9.57E-4 ID:SGTC_2209|Compound:5-(5-methyl-2-thenylidene)-Barbituric acid|FD-Score:4.96|P-value:2.23E-6 ID:SGTC_2241|Compound:6772625|FD-Score:5.98|P-value:1.55E-8 ID:SGTC_2251|Compound:lansoprazole|FD-Score:-7.72|P-value:4.81E-13 ID:SGTC_2255|Compound:7941087|FD-Score:3.99|P-value:1.12E-4 ID:SGTC_2256|Compound:7954252|FD-Score:-3.43|P-value:7.80E-4 ID:SGTC_2298|Compound:7976326|FD-Score:3.87|P-value:1.69E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.41|P-value:7.91E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.75|P-value:2.64E-4 ID:SGTC_2361|Compound:9034121|FD-Score:5.70|P-value:6.78E-8 ID:SGTC_2367|Compound:9070478|FD-Score:-3.74|P-value:2.77E-4 ID:SGTC_2443|Compound:5493264|FD-Score:4.03|P-value:9.70E-5 ID:SGTC_2591|Compound:skatole|FD-Score:4.89|P-value:3.05E-6 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.34|P-value:9.88E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.95|P-value:1.27E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.79|P-value:2.25E-4 ID:SGTC_2789|Compound:5281112|FD-Score:3.95|P-value:1.29E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.40|P-value:8.24E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.36|P-value:9.66E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.80|P-value:2.28E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.36|P-value:9.25E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.40|P-value:8.18E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.13|P-value:6.65E-5 ID:SGTC_3106|Compound:9121286|FD-Score:3.83|P-value:1.97E-4 ID:SGTC_3114|Compound:9122766|FD-Score:5.23|P-value:6.53E-7 ID:SGTC_3145|Compound:9085516|FD-Score:-4.06|P-value:8.89E-5 ID:SGTC_3188|Compound:9110789|FD-Score:-3.55|P-value:5.16E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.56|P-value:4.88E-4

Top fitness defect scores for YPR101W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2134 5324836 6.54 1.5 µM 7.21E-10 3 3.05E-11
2 SGTC_2241 6772625 5.98 37.8 µM 1.55E-8 6 1.09E-9
3 SGTC_2361 9034121 5.70 116.0 µM 6.78E-8 RSC complex & mRNA processing 2 6.07E-9
4 SGTC_889 0919-1524 5.69 82.7 µM 7.03E-8 1 6.33E-9
5 SGTC_1077 5-fluorocytosine 5.48 377.0 nM 1.97E-7 exosome 3 2.10E-8
6 SGTC_3114 9122766 5.23 49.5 µM 6.53E-7 6 8.48E-8
7 SGTC_2209 5-(5-methyl-2-thenylidene)-Barbituric acid 4.96 122.8 µM 2.23E-6 1 3.53E-7
8 SGTC_735 3076-0345 4.90 636.0 µM 2.84E-6 13 4.69E-7
9 SGTC_2591 skatole 4.89 100.0 µM 3.05E-6 11 5.08E-7
10 SGTC_212 3807-4682 4.51 38.8 µM 1.47E-5 tubulin folding & SWR complex 46 3.17E-6
11 SGTC_1314 1222-0010 4.45 41.1 µM 1.91E-5 7 4.29E-6
12 SGTC_2161 5662504 4.43 8.5 µM 2.05E-5 tubulin folding & SWR complex 15 4.64E-6
13 SGTC_674 0498-0004 4.34 451.0 µM 2.99E-5 heme requiring 17 7.20E-6
14 SGTC_602 3130-1533 4.30 38.1 µM 3.44E-5 12 8.50E-6
15 SGTC_2138 5575593 4.22 77.7 µM 4.79E-5 6 1.25E-5
16 SGTC_565 1418-0001 4.20 44.5 µM 5.15E-5 13 1.36E-5
17 SGTC_3054 9094397 4.13 49.5 µM 6.65E-5 fatty acid desaturase (OLE1) 28 1.82E-5
18 SGTC_2443 5493264 4.03 126.7 µM 9.70E-5 18 2.83E-5
19 SGTC_1873 rapamycin 4.02 2.0 nM 1.00E-4 67 2.93E-5
20 SGTC_2255 7941087 3.99 197.4 µM 1.12E-4 29 3.32E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 5.66E-9 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.097 1.60E-8 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.094 4.28E-8 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.088 3.02E-7 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.085 8.43E-7 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.085 8.94E-7 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.081 2.55E-6 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.078 5.88E-6 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.078 6.29E-6 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.077 8.57E-6 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.076 1.14E-5 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.074 1.65E-5 YDL111C RRP42 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.074 1.72E-5 YNR071C_p YNR071C_p hom Putative aldose 1-epimerase
0.074 1.86E-5 YNL067W-B_p YNL067W-B_p hom Putative protein of unknown function
0.074 1.88E-5 YLL031C GPI13 het ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein