YPR104C / FHL1

Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR104C / FHL1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:3.53|P-value:4.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.10|P-value:2.19E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:6.31|P-value:2.08E-9 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.61|P-value:3.59E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.95|P-value:4.95E-11 ID:SGTC_303|Compound:1348-1668|FD-Score:3.58|P-value:3.98E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.59|P-value:8.98E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:4.17|P-value:4.92E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.74|P-value:2.29E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.51|P-value:4.95E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.49|P-value:1.53E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:8.22|P-value:1.11E-14 ID:SGTC_709|Compound:3807-1509|FD-Score:7.39|P-value:3.20E-12 ID:SGTC_802|Compound:4112-3352|FD-Score:4.08|P-value:6.79E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:7.50|P-value:1.55E-12 ID:SGTC_996|Compound:3970-0799|FD-Score:9.10|P-value:1.39E-17 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.31|P-value:2.78E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.56|P-value:1.12E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:-5.08|P-value:1.71E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.27|P-value:2.58E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.82|P-value:3.44E-6 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.63|P-value:3.37E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:10.30|P-value:6.96E-22 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.55|P-value:4.44E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.42|P-value:9.26E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.40|P-value:1.27E-9 ID:SGTC_1707|Compound:st032323|FD-Score:3.70|P-value:2.68E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.91|P-value:1.25E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.32|P-value:9.27E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.87|P-value:2.79E-6 ID:SGTC_2041|Compound:5107442|FD-Score:10.00|P-value:5.98E-21 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.40|P-value:7.12E-4 ID:SGTC_2109|Compound:5483026|FD-Score:6.07|P-value:7.94E-9 ID:SGTC_2396|Compound:5342950|FD-Score:5.36|P-value:2.92E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.30|P-value:3.90E-7 ID:SGTC_2427|Compound:5545055|FD-Score:4.48|P-value:1.45E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.22|P-value:3.99E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.39|P-value:7.49E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.85|P-value:1.58E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.47|P-value:5.78E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.76|P-value:3.04E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.46|P-value:8.15E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.43|P-value:9.04E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.43|P-value:1.73E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.82|P-value:1.77E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:3.53|P-value:4.68E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:11.10|P-value:2.19E-25 ID:SGTC_138|Compound:0850-0259|FD-Score:6.31|P-value:2.08E-9 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.61|P-value:3.59E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.95|P-value:4.95E-11 ID:SGTC_303|Compound:1348-1668|FD-Score:3.58|P-value:3.98E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:4.59|P-value:8.98E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:4.17|P-value:4.92E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:3.74|P-value:2.29E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.51|P-value:4.95E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:5.49|P-value:1.53E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:8.22|P-value:1.11E-14 ID:SGTC_709|Compound:3807-1509|FD-Score:7.39|P-value:3.20E-12 ID:SGTC_802|Compound:4112-3352|FD-Score:4.08|P-value:6.79E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:7.50|P-value:1.55E-12 ID:SGTC_996|Compound:3970-0799|FD-Score:9.10|P-value:1.39E-17 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.46|P-value:5.93E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.34|P-value:8.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.31|P-value:2.78E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.56|P-value:1.12E-7 ID:SGTC_1155|Compound:4088-0394|FD-Score:-5.08|P-value:1.71E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:6.27|P-value:2.58E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.82|P-value:3.44E-6 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.79|P-value:1.95E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.63|P-value:3.37E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:10.30|P-value:6.96E-22 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.55|P-value:4.44E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:-3.42|P-value:9.26E-4 ID:SGTC_1652|Compound:st011932|FD-Score:6.40|P-value:1.27E-9 ID:SGTC_1707|Compound:st032323|FD-Score:3.70|P-value:2.68E-4 ID:SGTC_1774|Compound:st048371|FD-Score:3.91|P-value:1.25E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.32|P-value:9.27E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.39|P-value:7.41E-4 ID:SGTC_2033|Compound:5192550|FD-Score:4.87|P-value:2.79E-6 ID:SGTC_2041|Compound:5107442|FD-Score:10.00|P-value:5.98E-21 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.40|P-value:7.12E-4 ID:SGTC_2109|Compound:5483026|FD-Score:6.07|P-value:7.94E-9 ID:SGTC_2396|Compound:5342950|FD-Score:5.36|P-value:2.92E-7 ID:SGTC_2419|Compound:paclitaxel|FD-Score:5.30|P-value:3.90E-7 ID:SGTC_2427|Compound:5545055|FD-Score:4.48|P-value:1.45E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.22|P-value:3.99E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.39|P-value:7.49E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.85|P-value:1.58E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.47|P-value:5.78E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.76|P-value:3.04E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.46|P-value:8.15E-4 ID:SGTC_2902|Compound:5787006|FD-Score:-3.43|P-value:9.04E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.43|P-value:1.73E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.82|P-value:1.77E-4

Top fitness defect scores for YPR104C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_58 0957-0393 11.10 9.0 µM 2.19E-25 cell wall 6 3.64E-29 0.44
2 SGTC_1493 4348-0038 10.30 111.0 µM 6.96E-22 RSC complex & mRNA processing 1 4.38E-25 0.75
3 SGTC_2041 5107442 10.00 45.3 µM 5.98E-21 RSC complex & mRNA processing 7 5.36E-24 1.24
4 SGTC_996 3970-0799 9.10 1.8 µM 1.39E-17 4 4.41E-20 0.82
5 SGTC_673 1082-0474 8.22 110.0 µM 1.11E-14 RSC complex & mRNA processing 19 1.05E-16 0.41
6 SGTC_839 0122-0028 7.50 230.0 µM 1.55E-12 RSC complex & mRNA processing 4 3.25E-14 0.71
7 SGTC_709 3807-1509 7.39 243.0 µM 3.20E-12 RSC complex & mRNA processing 7 7.52E-14 0.07
8 SGTC_268 camptothecin 6.95 39.6 µM 4.95E-11 DNA damage response 19 1.81E-12 0.42
9 SGTC_1652 st011932 6.40 78.0 µM 1.27E-9 RSC complex & mRNA processing 22 7.81E-11 0.08
10 SGTC_138 0850-0259 6.31 40.9 µM 2.08E-9 cell wall 30 1.38E-10 0.05
11 SGTC_1229 0139-0193 6.27 12.2 µM 2.58E-9 RSC complex & mRNA processing 5 1.77E-10 0.00
12 SGTC_2109 5483026 6.07 200.0 µM 7.94E-9 RSC complex & mRNA processing 19 6.50E-10 0.01
13 SGTC_1133 3473-0247 5.56 50.0 µM 1.12E-7 RSC complex & mRNA processing 28 1.38E-8 0.15
14 SGTC_586 0957-0265 5.49 8.2 µM 1.53E-7 cell wall 27 2.00E-8 0.22
15 SGTC_2396 5342950 5.36 42.8 µM 2.92E-7 RSC complex & mRNA processing 15 4.20E-8 0.06
16 SGTC_2419 paclitaxel 5.30 166.5 µM 3.90E-7 1 5.88E-8 0.57
17 SGTC_2033 5192550 4.87 145.0 µM 2.79E-6 2 5.71E-7 0.49
18 SGTC_1374 2889-5571 4.82 141.0 µM 3.44E-6 RSC complex & mRNA processing 31 7.26E-7 0.15
19 SGTC_332 4112-0506 4.59 40.9 µM 8.98E-6 17 2.19E-6 0.20
20 SGTC_2427 5545055 4.48 42.8 µM 1.45E-5 4 3.80E-6 0.12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.452 3.92E-168 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.429 2.04E-150 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.404 1.22E-131 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.372 3.56E-110 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.366 4.40E-107 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.348 6.17E-96 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.341 2.82E-92 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.341 6.50E-92 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.333 1.77E-87 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.314 1.42E-77 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.310 9.91E-76 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.300 1.50E-70 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.294 7.25E-68 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.290 6.02E-66 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.288 6.54E-65 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance