YPR105C / COG4

Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR105C / COG4

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.71|P-value:2.39E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.40|P-value:6.93E-7 ID:SGTC_81|Compound:0411-0046|FD-Score:5.83|P-value:9.73E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:3.64|P-value:3.53E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-2.83|P-value:9.33E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.58|P-value:2.94E-7 ID:SGTC_271|Compound:rotenone|FD-Score:-2.97|P-value:5.55E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:-4.21|P-value:1.96E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-2.93|P-value:6.47E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.01|P-value:4.78E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.10|P-value:3.69E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.81|P-value:6.88E-8 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.97|P-value:5.50E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.74|P-value:2.07E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.32|P-value:1.47E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.36|P-value:1.13E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.19|P-value:2.31E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.01|P-value:4.85E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.68|P-value:2.69E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.51|P-value:5.93E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.95|P-value:6.45E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.88|P-value:8.56E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:8.89|P-value:1.37E-22 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.68|P-value:2.91E-10 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.61|P-value:4.22E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.12|P-value:3.05E-4 ID:SGTC_1558|Compound:st069300|FD-Score:2.88|P-value:8.65E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.67|P-value:3.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.71|P-value:2.36E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.52|P-value:6.34E-5 ID:SGTC_1696|Compound:st025591|FD-Score:2.86|P-value:9.15E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.38|P-value:1.13E-4 ID:SGTC_1754|Compound:st042065|FD-Score:2.96|P-value:6.21E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.02|P-value:4.69E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.69|P-value:1.58E-7 ID:SGTC_1932|Compound:st074806|FD-Score:-5.93|P-value:4.27E-11 ID:SGTC_1936|Compound:st074407|FD-Score:-4.12|P-value:3.07E-6 ID:SGTC_2050|Compound:5263056|FD-Score:4.11|P-value:3.65E-6 ID:SGTC_2245|Compound:6637752|FD-Score:4.04|P-value:5.21E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.31|P-value:1.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.54|P-value:3.57E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.28|P-value:1.74E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.68|P-value:1.50E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.88|P-value:1.08E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.18|P-value:2.42E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.68|P-value:3.05E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.85|P-value:9.68E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.95|P-value:8.14E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.34|P-value:1.22E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:-3.84|P-value:1.25E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.49|P-value:7.21E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.01|P-value:4.85E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.28|P-value:1.73E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.13|P-value:3.32E-6 ID:SGTC_3031|Compound:9088762|FD-Score:2.89|P-value:8.25E-4 ID:SGTC_3036|Compound:9090181|FD-Score:2.94|P-value:6.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-2.96|P-value:5.76E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.45|P-value:8.42E-5 ID:SGTC_3110|Compound:9122132|FD-Score:3.02|P-value:4.93E-4 ID:SGTC_3154|Compound:9100113|FD-Score:2.86|P-value:9.25E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.57|P-value:4.44E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-4.63|P-value:1.94E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-4.02|P-value:5.27E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.22|P-value:2.22E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.71|P-value:2.39E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.40|P-value:6.93E-7 ID:SGTC_81|Compound:0411-0046|FD-Score:5.83|P-value:9.73E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:3.64|P-value:3.53E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:-2.83|P-value:9.33E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:4.58|P-value:2.94E-7 ID:SGTC_271|Compound:rotenone|FD-Score:-2.97|P-value:5.55E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:-4.21|P-value:1.96E-6 ID:SGTC_333|Compound:3486-0131|FD-Score:-2.93|P-value:6.47E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.01|P-value:4.78E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.10|P-value:3.69E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:-4.81|P-value:6.88E-8 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.97|P-value:5.50E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-3.74|P-value:2.07E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.32|P-value:1.47E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.36|P-value:1.13E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.19|P-value:2.31E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.01|P-value:4.85E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.68|P-value:2.69E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:-3.51|P-value:5.93E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.95|P-value:6.45E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:2.88|P-value:8.56E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:8.89|P-value:1.37E-22 ID:SGTC_1250|Compound:0485-0349|FD-Score:5.68|P-value:2.91E-10 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.61|P-value:4.22E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.12|P-value:3.05E-4 ID:SGTC_1558|Compound:st069300|FD-Score:2.88|P-value:8.65E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.67|P-value:3.18E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-3.71|P-value:2.36E-5 ID:SGTC_1690|Compound:st023502|FD-Score:3.52|P-value:6.34E-5 ID:SGTC_1696|Compound:st025591|FD-Score:2.86|P-value:9.15E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.38|P-value:1.13E-4 ID:SGTC_1754|Compound:st042065|FD-Score:2.96|P-value:6.21E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-3.02|P-value:4.69E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.69|P-value:1.58E-7 ID:SGTC_1932|Compound:st074806|FD-Score:-5.93|P-value:4.27E-11 ID:SGTC_1936|Compound:st074407|FD-Score:-4.12|P-value:3.07E-6 ID:SGTC_2050|Compound:5263056|FD-Score:4.11|P-value:3.65E-6 ID:SGTC_2245|Compound:6637752|FD-Score:4.04|P-value:5.21E-6 ID:SGTC_2329|Compound:6138490|FD-Score:3.31|P-value:1.57E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.54|P-value:3.57E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.28|P-value:1.74E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.68|P-value:1.50E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.88|P-value:1.08E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.18|P-value:2.42E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.68|P-value:3.05E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:2.85|P-value:9.68E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.95|P-value:8.14E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.34|P-value:1.22E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:-3.84|P-value:1.25E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:3.49|P-value:7.21E-5 ID:SGTC_2796|Compound:7949634|FD-Score:-3.01|P-value:4.85E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.28|P-value:1.73E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.13|P-value:3.32E-6 ID:SGTC_3031|Compound:9088762|FD-Score:2.89|P-value:8.25E-4 ID:SGTC_3036|Compound:9090181|FD-Score:2.94|P-value:6.87E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-2.96|P-value:5.76E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.45|P-value:8.42E-5 ID:SGTC_3110|Compound:9122132|FD-Score:3.02|P-value:4.93E-4 ID:SGTC_3154|Compound:9100113|FD-Score:2.86|P-value:9.25E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-3.57|P-value:4.44E-5 ID:SGTC_3196|Compound:9111891|FD-Score:-4.63|P-value:1.94E-7 ID:SGTC_3200|Compound:9114385|FD-Score:-4.02|P-value:5.27E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.22|P-value:2.22E-4

Top fitness defect scores for YPR105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1245 0418-0076 8.89 17.2 µM 1.37E-22 ERG2 1 3.05E-19 2.22
2 SGTC_81 0411-0046 5.83 10.0 µM 9.73E-11 20 2.74E-9 0.03
3 SGTC_1250 0485-0349 5.68 40.2 µM 2.91E-10 2 6.91E-9 0.49
4 SGTC_1912 st060209 4.69 90.8 µM 1.58E-7 6 1.39E-6 0.48
5 SGTC_171 k064-0041 4.58 9.7 µM 2.94E-7 heme requiring 11 2.34E-6 0.02
6 SGTC_2409 alverine citrate 4.54 64.0 µM 3.57E-7 10 2.76E-6 0.47
7 SGTC_2975 9084847 4.13 53.7 µM 3.32E-6 10 1.82E-5 0.13
8 SGTC_2050 5263056 4.11 171.0 µM 3.65E-6 fatty acid desaturase (OLE1) 24 1.97E-5 0.03
9 SGTC_2245 6637752 4.04 200.0 µM 5.21E-6 6 2.65E-5 0.59
10 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.95 100.0 µM 8.14E-6 7 3.87E-5 0.17
11 SGTC_2612 dictamnine 3.68 15.5 µM 3.05E-5 RNA pol III & RNase P/MRP 33 1.18E-4 0.08
12 SGTC_1626 st003712 3.67 1.8 µM 3.18E-5 12 1.22E-4 0.03
13 SGTC_140 0062-0056 3.64 502.5 µM 3.53E-5 6 1.34E-4 0.23
14 SGTC_1381 2324-0066 3.61 62.1 µM 4.22E-5 11 1.56E-4 0.04
15 SGTC_1690 st023502 3.52 41.2 µM 6.34E-5 calcium & mitochondrial duress 4 2.20E-4 0.10
16 SGTC_2739 tacrine 3.49 100.9 µM 7.21E-5 heme requiring 9 2.45E-4 0.03
17 SGTC_3103 9120822 3.45 49.5 µM 8.42E-5 11 2.80E-4 0.01
18 SGTC_1752 st044819 3.38 83.0 µM 1.13E-4 18 3.58E-4 0.04
19 SGTC_551 k048-0028 3.32 34.9 µM 1.47E-4 18 4.47E-4 0.21
20 SGTC_2329 6138490 3.31 200.0 µM 1.57E-4 21 4.75E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.30E-15 YMR260C TIF11 het Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
0.110 1.79E-10 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.108 3.04E-10 YOR059C YOR059C hom Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress
0.104 1.79E-9 YGL202W ARO8 hom Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
0.093 7.70E-8 YKR068C BET3 het Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex
0.088 2.85E-7 YDR272W GLO2 hom Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.087 4.80E-7 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.087 4.84E-7 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.086 6.36E-7 YDR109C_p YDR109C_p hom Putative kinase
0.082 1.83E-6 YMR255W GFD1 hom Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress
0.081 2.37E-6 YNR061C YNR061C hom Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.079 4.24E-6 YPR031W NTO1 hom Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3
0.078 5.90E-6 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.077 8.84E-6 YBR063C_p YBR063C_p hom Putative protein of unknown function; YBR063C is not an essential gene
0.076 1.08E-5 YPR160W GPH1 hom Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway