YPR106W / ISR1

Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR106W / ISR1

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-5.49|P-value:2.29E-7 ID:SGTC_38|Compound:0929-0051|FD-Score:3.74|P-value:1.92E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:5.47|P-value:1.22E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:-5.04|P-value:1.82E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.53|P-value:1.63E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.33|P-value:7.48E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.40|P-value:6.03E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.41|P-value:5.84E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-5.24|P-value:7.21E-7 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.52|P-value:4.06E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.56|P-value:3.61E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.86|P-value:1.23E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.81|P-value:1.50E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.29|P-value:8.59E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.27|P-value:9.18E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-4.28|P-value:4.49E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.66|P-value:2.48E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.79|P-value:1.57E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:5.77|P-value:2.56E-8 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.39|P-value:6.20E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.37|P-value:1.75E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:5.33|P-value:2.34E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.99|P-value:7.62E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.64|P-value:2.69E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.26|P-value:9.42E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.82|P-value:2.38E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.73|P-value:3.24E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.18|P-value:3.69E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.45|P-value:5.14E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.54|P-value:3.76E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.80|P-value:2.55E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.26|P-value:2.73E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-4.20|P-value:5.96E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.11|P-value:1.33E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.91|P-value:1.04E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.15|P-value:7.38E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-4.73|P-value:7.22E-6 ID:SGTC_2910|Compound:7948405|FD-Score:3.47|P-value:4.88E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.32|P-value:7.76E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.81|P-value:2.50E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.59|P-value:3.23E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.32|P-value:7.96E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-5.49|P-value:2.29E-7 ID:SGTC_38|Compound:0929-0051|FD-Score:3.74|P-value:1.92E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:5.47|P-value:1.22E-7 ID:SGTC_43|Compound:0570-0105|FD-Score:-5.04|P-value:1.82E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.53|P-value:1.63E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.33|P-value:7.48E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:3.40|P-value:6.03E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.41|P-value:5.84E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-5.24|P-value:7.21E-7 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.52|P-value:4.06E-4 ID:SGTC_458|Compound:nppb|FD-Score:3.56|P-value:3.61E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.86|P-value:1.23E-4 ID:SGTC_671|Compound:0560-0003|FD-Score:3.81|P-value:1.50E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.29|P-value:8.59E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:3.27|P-value:9.18E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:-4.28|P-value:4.49E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.66|P-value:2.48E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.79|P-value:1.57E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:5.77|P-value:2.56E-8 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.39|P-value:6.20E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:4.37|P-value:1.75E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:5.33|P-value:2.34E-7 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.99|P-value:7.62E-5 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.64|P-value:2.69E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.26|P-value:9.42E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.82|P-value:2.38E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.73|P-value:3.24E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.18|P-value:3.69E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.45|P-value:5.14E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.54|P-value:3.76E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.80|P-value:2.55E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.26|P-value:2.73E-5 ID:SGTC_2136|Compound:5328288|FD-Score:-4.20|P-value:5.96E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.11|P-value:1.33E-6 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.91|P-value:1.04E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.15|P-value:7.38E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-4.73|P-value:7.22E-6 ID:SGTC_2910|Compound:7948405|FD-Score:3.47|P-value:4.88E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.32|P-value:7.76E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.81|P-value:2.50E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.59|P-value:3.23E-4 ID:SGTC_3195|Compound:9113082|FD-Score:3.32|P-value:7.96E-4

Top fitness defect scores for YPR106W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_948 3448-0295 5.77 75.3 µM 2.56E-8 6 3.91E-9
2 SGTC_42 0133-0086 5.47 60.6 µM 1.22E-7 5 2.29E-8
3 SGTC_1181 1222-0449 5.33 220.0 µM 2.34E-7 10 4.79E-8
4 SGTC_1167 k781-0610 4.37 148.0 µM 1.75E-5 RNA processing & uracil transport 17 6.26E-6
5 SGTC_2129 girgensonine 4.26 121.0 µM 2.73E-5 heme biosynthesis & mitochondrial translocase 20 1.04E-5
6 SGTC_1712 st032288 4.18 53.4 µM 3.69E-5 calcium & mitochondrial duress 173 1.45E-5
7 SGTC_1184 1269-1718 3.99 139.0 µM 7.62E-5 26 3.28E-5
8 SGTC_2519 cryptotanshinone 3.91 88.0 µM 1.04E-4 heme biosynthesis & mitochondrial translocase 15 4.66E-5
9 SGTC_651 3253-0966 3.86 34.4 µM 1.23E-4 calcium & mitochondrial duress 36 5.65E-5
10 SGTC_671 0560-0003 3.81 407.0 µM 1.50E-4 13 7.06E-5
11 SGTC_910 3454-3003 3.79 490.0 µM 1.57E-4 22 7.41E-5
12 SGTC_38 0929-0051 3.74 58.3 µM 1.92E-4 19 9.27E-5
13 SGTC_902 1120-0002 3.66 2.1 µM 2.48E-4 azole & statin 57 1.24E-4
14 SGTC_1368 1852-0141 3.64 284.0 µM 2.69E-4 ERG2 48 1.35E-4
15 SGTC_3179 9107801 3.59 49.5 µM 3.23E-4 18 1.66E-4
16 SGTC_458 nppb 3.56 133.0 µM 3.61E-4 23 1.89E-4
17 SGTC_1770 st043884 3.54 66.3 µM 3.76E-4 23 1.97E-4
18 SGTC_452 diindolylmethane 3.52 8.0 µM 4.06E-4 RNA processing & uracil transport 17 2.15E-4
19 SGTC_2910 7948405 3.47 26.0 µM 4.88E-4 plasma membrane duress 38 2.65E-4
20 SGTC_1745 st081495 3.45 74.0 µM 5.14E-4 RNA processing & uracil transport 99 2.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.17E-12 YBR031W RPL4A hom Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication
0.108 3.07E-10 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.106 7.92E-10 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.097 1.89E-8 YHL001W RPL14B hom Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.096 2.55E-8 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
0.091 1.46E-7 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.085 9.38E-7 YOR312C RPL20B hom Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
0.079 5.45E-6 YML079W_p YML079W_p hom Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm
0.076 1.07E-5 YDR461W MFA1 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2
0.075 1.23E-5 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.075 1.34E-5 YER014C-A BUD25 hom Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
0.075 1.52E-5 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.073 2.14E-5 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.073 2.24E-5 YDR147W EKI1 hom Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication
0.073 2.53E-5 YML112W CTK3 hom Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress