YPR108W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR108W-A / YPR108W-A

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.31|P-value:7.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.76|P-value:1.55E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.08|P-value:4.46E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.68|P-value:2.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.20|P-value:2.98E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.36|P-value:6.26E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.93|P-value:1.06E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.33|P-value:7.05E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.58|P-value:2.87E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.93|P-value:7.93E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.58|P-value:2.95E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:5.04|P-value:6.69E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.29|P-value:8.02E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.33|P-value:6.92E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.62|P-value:2.63E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.42|P-value:5.30E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.94|P-value:7.87E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.95|P-value:1.05E-6 ID:SGTC_1115|Compound:galangin|FD-Score:4.01|P-value:6.06E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.45|P-value:4.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.26|P-value:2.17E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.60|P-value:2.82E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:5.65|P-value:2.91E-8 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.55|P-value:3.30E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.92|P-value:8.60E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.31|P-value:7.52E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.34|P-value:6.73E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.58|P-value:3.02E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.37|P-value:5.99E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.72|P-value:2.88E-6 ID:SGTC_2132|Compound:5317594|FD-Score:3.63|P-value:2.54E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.28|P-value:7.94E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.21|P-value:2.70E-5 ID:SGTC_2450|Compound:5739737|FD-Score:4.21|P-value:2.68E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.64|P-value:2.30E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.79|P-value:1.39E-8 ID:SGTC_2931|Compound:9014674|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_3079|Compound:9117512|FD-Score:-4.83|P-value:1.76E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.57|P-value:2.98E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.89|P-value:7.91E-9 ID:SGTC_3206|Compound:9114350|FD-Score:-3.27|P-value:8.26E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.44|P-value:4.89E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.31|P-value:7.46E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.76|P-value:1.55E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-4.08|P-value:4.46E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.68|P-value:2.09E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:5.20|P-value:2.98E-7 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:-3.36|P-value:6.26E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.93|P-value:1.06E-6 ID:SGTC_557|Compound:1315-0110|FD-Score:3.33|P-value:7.05E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.58|P-value:2.87E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.93|P-value:7.93E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:3.58|P-value:2.95E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:5.04|P-value:6.69E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.29|P-value:8.02E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.33|P-value:6.92E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.62|P-value:2.63E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.42|P-value:5.30E-4 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.94|P-value:7.87E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.95|P-value:1.05E-6 ID:SGTC_1115|Compound:galangin|FD-Score:4.01|P-value:6.06E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.45|P-value:4.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.26|P-value:2.17E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.60|P-value:2.82E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.79|P-value:1.41E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:5.65|P-value:2.91E-8 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.55|P-value:3.30E-4 ID:SGTC_1530|Compound:rhein|FD-Score:3.92|P-value:8.60E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.31|P-value:7.52E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:3.34|P-value:6.73E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.58|P-value:3.02E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.37|P-value:5.99E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-4.72|P-value:2.88E-6 ID:SGTC_2132|Compound:5317594|FD-Score:3.63|P-value:2.54E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.28|P-value:7.94E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.21|P-value:2.70E-5 ID:SGTC_2450|Compound:5739737|FD-Score:4.21|P-value:2.68E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.64|P-value:2.30E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.79|P-value:1.39E-8 ID:SGTC_2931|Compound:9014674|FD-Score:-3.47|P-value:4.22E-4 ID:SGTC_3079|Compound:9117512|FD-Score:-4.83|P-value:1.76E-6 ID:SGTC_3154|Compound:9100113|FD-Score:-3.57|P-value:2.98E-4 ID:SGTC_3201|Compound:9113999|FD-Score:5.89|P-value:7.91E-9 ID:SGTC_3206|Compound:9114350|FD-Score:-3.27|P-value:8.26E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.44|P-value:4.89E-4

Top fitness defect scores for YPR108W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3201 9113999 5.89 49.5 µM 7.91E-9 5 1.90E-9
2 SGTC_2695 st077686 5.79 52.0 µM 1.39E-8 7 3.52E-9
3 SGTC_1452 4194-0072 5.65 190.0 µM 2.91E-8 1 7.80E-9
4 SGTC_236 1509-0011 5.20 5.3 µM 2.98E-7 317 9.72E-8
5 SGTC_653 0203-0016 5.04 55.2 µM 6.69E-7 5 2.33E-7
6 SGTC_1026 k007-1105 4.95 30.6 µM 1.05E-6 ERAD & cell cycle 62 3.78E-7
7 SGTC_1248 0469-0687 4.26 58.6 µM 2.17E-5 19 1.01E-5
8 SGTC_2450 5739737 4.21 12.9 µM 2.68E-5 20 1.26E-5
9 SGTC_2413 inermin 4.21 26.1 µM 2.70E-5 44 1.27E-5
10 SGTC_1115 galangin 4.01 695.7 nM 6.06E-5 RPP1 & pyrimidine depletion 12 3.06E-5
11 SGTC_1021 4476-0760 3.94 85.3 µM 7.87E-5 26 4.06E-5
12 SGTC_1530 rhein 3.92 70.4 µM 8.60E-5 19 4.47E-5
13 SGTC_1448 4255-0083 3.79 152.0 µM 1.41E-4 ERG2 20 7.62E-5
14 SGTC_69 0096-0274 3.76 206.7 µM 1.55E-4 mitochondrial processes 48 8.45E-5
15 SGTC_146 3448-8650 3.68 53.1 µM 2.09E-4 NEO1-PIK1 159 1.17E-4
16 SGTC_2132 5317594 3.63 122.7 µM 2.54E-4 SWF1 & branched chain AA biosynthesis 30 1.44E-4
17 SGTC_900 1112-0045 3.62 141.0 µM 2.63E-4 NEO1 33 1.49E-4
18 SGTC_1251 0490-5699 3.60 265.0 µM 2.82E-4 44 1.61E-4
19 SGTC_633 0437-0093 3.58 97.7 µM 2.95E-4 DNA intercalators 20 1.69E-4
20 SGTC_1603 st002045 3.58 67.8 µM 3.02E-4 TSC3-RPN4 22 1.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.02E-24 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.142 1.27E-16 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.138 1.07E-15 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.137 1.84E-15 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.134 7.82E-15 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.132 1.90E-14 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.130 3.82E-14 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.129 5.73E-14 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.128 1.23E-13 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.123 1.02E-12 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.121 2.42E-12 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.117 1.15E-11 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.116 1.84E-11 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.114 3.41E-11 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.114 4.14E-11 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase