YPR109W_p

Predicted membrane protein; dipoid deletion strain has high budding index

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR109W / YPR109W

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.61|P-value:3.36E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.10|P-value:4.34E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:5.57|P-value:7.05E-8 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.70|P-value:1.93E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.64|P-value:2.37E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.31|P-value:9.02E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.46|P-value:4.47E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.51|P-value:4.71E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.51|P-value:1.00E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.43|P-value:4.92E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.50|P-value:4.82E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.29|P-value:8.07E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.63|P-value:6.00E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.82|P-value:2.62E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.47|P-value:9.19E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:3.52|P-value:4.45E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.67|P-value:5.00E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.41|P-value:6.46E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.33|P-value:6.97E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.38|P-value:7.21E-4 ID:SGTC_1590|Compound:st077108|FD-Score:-3.38|P-value:5.93E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.52|P-value:4.58E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.96|P-value:9.26E-5 ID:SGTC_1969|Compound:st069479|FD-Score:-3.62|P-value:2.62E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.10|P-value:5.39E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.49|P-value:4.97E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.40|P-value:1.63E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.39|P-value:5.67E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.24|P-value:9.31E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.25|P-value:9.08E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.84|P-value:1.46E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.38|P-value:1.75E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.38|P-value:5.93E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.52|P-value:3.73E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.99|P-value:8.34E-5 ID:SGTC_2803|Compound:7707263|FD-Score:5.35|P-value:2.11E-7 ID:SGTC_2972|Compound:9093619|FD-Score:3.30|P-value:9.49E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.66|P-value:2.82E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.35|P-value:2.09E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:3.61|P-value:3.36E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:-4.10|P-value:4.34E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:5.57|P-value:7.05E-8 ID:SGTC_183|Compound:3914-0051|FD-Score:-3.70|P-value:1.93E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.64|P-value:2.37E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.31|P-value:9.02E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:-3.46|P-value:4.47E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:3.51|P-value:4.71E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:4.51|P-value:1.00E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:-3.43|P-value:4.92E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.50|P-value:4.82E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:-3.29|P-value:8.07E-4 ID:SGTC_636|Compound:0kpi-0074|FD-Score:4.63|P-value:6.00E-6 ID:SGTC_895|Compound:0964-0006|FD-Score:4.82|P-value:2.62E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:-4.47|P-value:9.19E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:3.52|P-value:4.45E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:4.67|P-value:5.00E-6 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.41|P-value:6.46E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:-3.33|P-value:6.97E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.38|P-value:7.21E-4 ID:SGTC_1590|Compound:st077108|FD-Score:-3.38|P-value:5.93E-4 ID:SGTC_1709|Compound:st033179|FD-Score:3.52|P-value:4.58E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.96|P-value:9.26E-5 ID:SGTC_1969|Compound:st069479|FD-Score:-3.62|P-value:2.62E-4 ID:SGTC_2001|Compound:4023502|FD-Score:4.10|P-value:5.39E-5 ID:SGTC_2095|Compound:5432005|FD-Score:3.49|P-value:4.97E-4 ID:SGTC_2098|Compound:5376439|FD-Score:4.40|P-value:1.63E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.53|P-value:4.31E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.39|P-value:5.67E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-3.24|P-value:9.31E-4 ID:SGTC_2313|Compound:7726885|FD-Score:3.92|P-value:1.10E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-3.25|P-value:9.08E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.84|P-value:1.46E-4 ID:SGTC_2601|Compound:securinine|FD-Score:4.38|P-value:1.75E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:-3.38|P-value:5.93E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.52|P-value:3.73E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.99|P-value:8.34E-5 ID:SGTC_2803|Compound:7707263|FD-Score:5.35|P-value:2.11E-7 ID:SGTC_2972|Compound:9093619|FD-Score:3.30|P-value:9.49E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.66|P-value:2.82E-4 ID:SGTC_3333|Compound:9141820|FD-Score:5.35|P-value:2.09E-7

Top fitness defect scores for YPR109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_181 1447-1644 5.57 8.1 µM 7.05E-8 endomembrane recycling 17 1.31E-8
2 SGTC_3333 9141820 5.35 12.1 µM 2.09E-7 7 4.37E-8
3 SGTC_2803 7707263 5.35 71.4 µM 2.11E-7 13 4.40E-8
4 SGTC_895 0964-0006 4.82 13.7 µM 2.62E-6 3 7.18E-7
5 SGTC_1205 4161-2785 4.67 76.0 µM 5.00E-6 15 1.47E-6
6 SGTC_636 0kpi-0074 4.63 126.0 µM 6.00E-6 12 1.80E-6
7 SGTC_346 4513-0042 4.51 7.2 µM 1.00E-5 azole & statin 27 3.18E-6
8 SGTC_2098 5376439 4.40 882.5 nM 1.63E-5 8 5.43E-6
9 SGTC_2601 securinine 4.38 100.0 µM 1.75E-5 19 5.89E-6
10 SGTC_2001 4023502 4.10 57.7 µM 5.39E-5 mitochondrial processes 14 2.05E-5
11 SGTC_2798 7813637 3.99 45.5 µM 8.34E-5 30 3.32E-5
12 SGTC_1879 gemcitabine 3.96 100.0 µM 9.26E-5 14 3.73E-5
13 SGTC_2313 7726885 3.92 200.0 µM 1.10E-4 RPP1 & pyrimidine depletion 35 4.51E-5
14 SGTC_2571 chrysanthemic acid 3.84 100.0 µM 1.46E-4 21 6.18E-5
15 SGTC_3328 9140624 3.66 29.0 µM 2.82E-4 27 1.28E-4
16 SGTC_68 0986-0284 3.61 82.8 µM 3.36E-4 87 1.55E-4
17 SGTC_2170 morpholine 3.53 200.0 µM 4.31E-4 21 2.05E-4
18 SGTC_970 1315-0089 3.52 19.5 µM 4.45E-4 RSC & ERG11 40 2.12E-4
19 SGTC_1709 st033179 3.52 39.1 µM 4.58E-4 25 2.19E-4
20 SGTC_344 k064-0035 3.51 6.4 µM 4.71E-4 60S ribosome export 36 2.26E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.110 1.45E-10 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.092 8.79E-8 YOR113W AZF1 hom Zinc-finger transcription factor; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity
0.091 1.48E-7 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.089 2.36E-7 YMR084W_p YMR084W_p hom Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.086 6.13E-7 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.085 7.96E-7 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.081 2.89E-6 YER116C SLX8 hom Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress
0.076 1.12E-5 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.072 3.01E-5 YER046W-A_d YER046W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.071 4.26E-5 YBR203W COS111 hom Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.070 5.16E-5 YGR137W_d YGR137W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 6.11E-5 YKR015C_p YKR015C_p hom Putative protein of unknown function
0.069 6.84E-5 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.067 9.40E-5 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.067 9.93E-5 YPR073C LTP1 hom Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine