YPR110C / RPC40

RNA polymerase subunit AC40, common to RNA polymerase I and III

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR110C / RPC40

Click on Significant Values for Screen Details ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.97|P-value:1.83E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.11|P-value:2.34E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.66|P-value:5.16E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-6.00|P-value:3.67E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:4.12|P-value:1.10E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:5.83|P-value:8.56E-8 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.34|P-value:5.05E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.70|P-value:4.50E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.66|P-value:5.26E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.10|P-value:1.19E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:6.58|P-value:1.80E-9 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.86|P-value:2.63E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.62|P-value:5.90E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:6.25|P-value:1.03E-8 ID:SGTC_1903|Compound:st060211|FD-Score:-3.90|P-value:2.30E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.67|P-value:4.87E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.67|P-value:4.88E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-4.32|P-value:5.27E-5 ID:SGTC_2484|Compound:5809818|FD-Score:4.65|P-value:1.54E-5 ID:SGTC_2789|Compound:5281112|FD-Score:4.26|P-value:6.82E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.68|P-value:4.93E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.36|P-value:4.66E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-5.81|P-value:9.28E-8 ID:SGTC_2927|Compound:9011802|FD-Score:3.48|P-value:9.08E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.83|P-value:2.96E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.70|P-value:4.52E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.51|P-value:8.04E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.54|P-value:7.51E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-5.42|P-value:5.69E-7 ID:SGTC_3342|Compound:9147791|FD-Score:-3.97|P-value:1.84E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.97|P-value:1.83E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:5.11|P-value:2.34E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.66|P-value:5.16E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-6.00|P-value:3.67E-8 ID:SGTC_926|Compound:2268-1401|FD-Score:4.12|P-value:1.10E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:5.83|P-value:8.56E-8 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.34|P-value:5.05E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.70|P-value:4.50E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:3.66|P-value:5.26E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.10|P-value:1.19E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:6.58|P-value:1.80E-9 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:-3.86|P-value:2.63E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.62|P-value:5.90E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:6.25|P-value:1.03E-8 ID:SGTC_1903|Compound:st060211|FD-Score:-3.90|P-value:2.30E-4 ID:SGTC_2025|Compound:5147754|FD-Score:-3.67|P-value:4.87E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.67|P-value:4.88E-4 ID:SGTC_2421|Compound:5690543|FD-Score:-4.32|P-value:5.27E-5 ID:SGTC_2484|Compound:5809818|FD-Score:4.65|P-value:1.54E-5 ID:SGTC_2789|Compound:5281112|FD-Score:4.26|P-value:6.82E-5 ID:SGTC_2796|Compound:7949634|FD-Score:3.68|P-value:4.93E-4 ID:SGTC_2810|Compound:7959871|FD-Score:4.36|P-value:4.66E-5 ID:SGTC_2919|Compound:7978188|FD-Score:-5.81|P-value:9.28E-8 ID:SGTC_2927|Compound:9011802|FD-Score:3.48|P-value:9.08E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.83|P-value:2.96E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.70|P-value:4.52E-4 ID:SGTC_3215|Compound:9129942|FD-Score:-3.51|P-value:8.04E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.54|P-value:7.51E-4 ID:SGTC_3314|Compound:9135860|FD-Score:-5.42|P-value:5.69E-7 ID:SGTC_3342|Compound:9147791|FD-Score:-3.97|P-value:1.84E-4

Top fitness defect scores for YPR110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1575 cyproterone acetate 6.58 48.0 µM 1.80E-9 1 2.30E-11 1.23
2 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 6.25 14.9 µM 1.03E-8 1 2.01E-10 1.15
3 SGTC_970 1315-0089 5.83 19.5 µM 8.56E-8 RSC & ERG11 3 2.74E-9 0.13
4 SGTC_792 4534-1957 5.11 155.0 µM 2.34E-6 1 1.62E-7 0.83
5 SGTC_2484 5809818 4.65 12.0 µM 1.54E-5 1 1.66E-6 0.43
6 SGTC_2810 7959871 4.36 45.5 µM 4.66E-5 copper-dependent oxidative stress 14 6.51E-6 0.15
7 SGTC_1042 0350-0096 4.34 82.0 µM 5.05E-5 TSC3-RPN4 6 7.18E-6 0.07
8 SGTC_2789 5281112 4.26 71.4 µM 6.82E-5 6 1.04E-5 0.05
9 SGTC_926 2268-1401 4.12 59.4 µM 1.10E-4 TSC3-RPN4 7 1.88E-5 0.10
10 SGTC_1564 D-Arginine 4.10 115.0 µM 1.19E-4 7 2.07E-5 0.04
11 SGTC_2981 9013952 3.83 39.0 µM 2.96E-4 11 6.31E-5 0.10
12 SGTC_3158 9100007 3.70 49.5 µM 4.52E-4 7 1.06E-4 0.12
13 SGTC_2796 7949634 3.68 45.5 µM 4.93E-4 12 1.18E-4 0.23
14 SGTC_854 0422-0053 3.66 192.0 µM 5.16E-4 PDR1 8 1.25E-4 0.12
15 SGTC_1299 1079-1439 3.66 3.7 µM 5.26E-4 TSC3-RPN4 5 1.28E-4 0.03
16 SGTC_1887 st057648 3.62 70.8 µM 5.90E-4 8 1.47E-4 0.20
17 SGTC_3245 9134821 3.54 49.5 µM 7.51E-4 6 1.98E-4 0.01
18 SGTC_2927 9011802 3.48 47.9 µM 9.08E-4 12 2.50E-4 0.20
19 SGTC_980 1473-0395 3.42 201.0 µM 0.00110 10 3.16E-4 0.01
20 SGTC_1187 1391-0724 3.38 117.0 µM 0.00124 amide catabolism 8 3.68E-4 0.16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 5.47E-9 YOR151C RPB2 het RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
0.097 2.10E-8 YDR143C SAN1 hom Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition
0.094 4.53E-8 YGL125W MET13 hom Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
0.090 2.02E-7 YGR010W NMA2 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication
0.087 4.21E-7 YKL033W TTI1 het Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies
0.086 5.36E-7 YAR030C_d YAR030C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9
0.082 1.89E-6 YLR146C SPE4 hom Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
0.081 2.47E-6 YIL071C PCI8 hom Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
0.079 4.55E-6 YNL093W YPT53 hom Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
0.077 7.87E-6 YGR191W HIP1 het High-affinity histidine permease, also involved in the transport of manganese ions
0.076 1.00E-5 YHR148W IMP3 het Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.076 1.09E-5 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.076 1.20E-5 YPL272C_p YPL272C_p hom Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
0.076 1.19E-5 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.074 1.90E-5 YPL031C PHO85 hom Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle