YPR113W / PIS1

Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR113W / PIS1

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.39|P-value:6.80E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:5.30|P-value:2.75E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.57|P-value:4.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.45|P-value:5.57E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.96|P-value:1.42E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.56|P-value:8.20E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.23|P-value:3.23E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.91|P-value:1.18E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.41|P-value:1.55E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:4.52|P-value:9.65E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:4.50|P-value:1.08E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:4.32|P-value:2.23E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.54|P-value:4.43E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.01|P-value:8.12E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.76|P-value:3.52E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.75|P-value:1.98E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.32|P-value:9.16E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.32|P-value:8.40E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:8.07|P-value:1.35E-14 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.63|P-value:6.16E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.29|P-value:9.41E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.75|P-value:1.98E-4 ID:SGTC_2046|Compound:4110841|FD-Score:7.22|P-value:4.74E-12 ID:SGTC_2070|Compound:5230947|FD-Score:-4.05|P-value:7.04E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.67|P-value:2.67E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.92|P-value:1.15E-8 ID:SGTC_2302|Compound:7771753|FD-Score:-6.84|P-value:6.07E-11 ID:SGTC_2374|Compound:9071832|FD-Score:4.23|P-value:3.22E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.71|P-value:4.37E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.35|P-value:1.98E-5 ID:SGTC_2704|Compound:st078022|FD-Score:4.70|P-value:4.50E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.54|P-value:4.06E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.40|P-value:6.59E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.38|P-value:6.90E-4 ID:SGTC_2993|Compound:9054257|FD-Score:7.26|P-value:3.71E-12 ID:SGTC_3062|Compound:9077494|FD-Score:4.73|P-value:3.97E-6 ID:SGTC_3081|Compound:9117243|FD-Score:3.67|P-value:2.59E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.03|P-value:1.04E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-3.46|P-value:5.66E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-5.64|P-value:5.55E-8 ID:SGTC_3315|Compound:9136395|FD-Score:7.82|P-value:8.13E-14 ID:SGTC_3325|Compound:9138760|FD-Score:-4.13|P-value:5.23E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.39|P-value:6.80E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:5.30|P-value:2.75E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.57|P-value:4.02E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.45|P-value:5.57E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.96|P-value:1.42E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.56|P-value:8.20E-6 ID:SGTC_470|Compound:aa-861|FD-Score:4.23|P-value:3.23E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.91|P-value:1.18E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.38|P-value:7.11E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:4.41|P-value:1.55E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:4.52|P-value:9.65E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:4.50|P-value:1.08E-5 ID:SGTC_980|Compound:1473-0395|FD-Score:4.32|P-value:2.23E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.54|P-value:4.43E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-4.01|P-value:8.12E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.76|P-value:3.52E-6 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.75|P-value:1.98E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.70|P-value:2.36E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:-3.32|P-value:9.16E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.32|P-value:8.40E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:8.07|P-value:1.35E-14 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_1646|Compound:st011709|FD-Score:4.63|P-value:6.16E-6 ID:SGTC_1941|Compound:st076221|FD-Score:3.29|P-value:9.41E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.75|P-value:1.98E-4 ID:SGTC_2046|Compound:4110841|FD-Score:7.22|P-value:4.74E-12 ID:SGTC_2070|Compound:5230947|FD-Score:-4.05|P-value:7.04E-5 ID:SGTC_2158|Compound:5657123|FD-Score:3.67|P-value:2.67E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.92|P-value:1.15E-8 ID:SGTC_2302|Compound:7771753|FD-Score:-6.84|P-value:6.07E-11 ID:SGTC_2374|Compound:9071832|FD-Score:4.23|P-value:3.22E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.93|P-value:1.01E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:4.71|P-value:4.37E-6 ID:SGTC_2639|Compound:lactacystin|FD-Score:4.35|P-value:1.98E-5 ID:SGTC_2704|Compound:st078022|FD-Score:4.70|P-value:4.50E-6 ID:SGTC_2781|Compound:5567276|FD-Score:3.54|P-value:4.06E-4 ID:SGTC_2963|Compound:9082507|FD-Score:3.40|P-value:6.59E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.38|P-value:6.90E-4 ID:SGTC_2993|Compound:9054257|FD-Score:7.26|P-value:3.71E-12 ID:SGTC_3062|Compound:9077494|FD-Score:4.73|P-value:3.97E-6 ID:SGTC_3081|Compound:9117243|FD-Score:3.67|P-value:2.59E-4 ID:SGTC_3126|Compound:9127922|FD-Score:5.03|P-value:1.04E-6 ID:SGTC_3274|Compound:9138298|FD-Score:-3.46|P-value:5.66E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-5.64|P-value:5.55E-8 ID:SGTC_3315|Compound:9136395|FD-Score:7.82|P-value:8.13E-14 ID:SGTC_3325|Compound:9138760|FD-Score:-4.13|P-value:5.23E-5

Top fitness defect scores for YPR113W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1503 4585-0012 8.07 61.3 µM 1.35E-14 1 3.57E-16 1.64
2 SGTC_3315 9136395 7.82 68.5 µM 8.13E-14 1 2.68E-15 1.58
3 SGTC_2993 9054257 7.26 71.4 µM 3.71E-12 fatty acid desaturase (OLE1) 4 1.95E-13 0.09
4 SGTC_2046 4110841 7.22 106.0 µM 4.74E-12 iron homeostasis 3 2.57E-13 1.39
5 SGTC_2301 7769476 5.92 200.0 µM 1.15E-8 4 1.61E-9 0.82
6 SGTC_133 0724-0033 5.30 378.9 µM 2.75E-7 4 5.64E-8 0.48
7 SGTC_3126 9127922 5.03 49.5 µM 1.04E-6 fatty acid desaturase (OLE1) 16 2.51E-7 0.18
8 SGTC_407 eburnamonine 4.96 100.0 µM 1.42E-6 1 3.55E-7 0.56
9 SGTC_1131 3454-3128 4.76 32.3 µM 3.52E-6 6 9.78E-7 0.02
10 SGTC_3062 9077494 4.73 49.5 µM 3.97E-6 mitochondrial response to ROS 3 1.12E-6 0.55
11 SGTC_2630 antimycin a 4.71 100.0 µM 4.37E-6 mitochondrial processes 5 1.25E-6 0.15
12 SGTC_2704 st078022 4.70 71.1 µM 4.50E-6 2 1.29E-6 0.60
13 SGTC_1646 st011709 4.63 75.6 µM 6.16E-6 5 1.83E-6 0.79
14 SGTC_416 estradiol valerate 4.56 100.0 µM 8.20E-6 1 2.52E-6 0.42
15 SGTC_948 3448-0295 4.52 75.3 µM 9.65E-6 7 3.03E-6 0.04
16 SGTC_950 1165-0508 4.50 94.1 µM 1.08E-5 2 3.43E-6 0.42
17 SGTC_628 1636-0253 4.41 16.0 µM 1.55E-5 sphingolipid biosynthesis & PDR1 5 5.13E-6 0.04
18 SGTC_2639 lactacystin 4.35 53.0 µM 1.98E-5 7 6.76E-6 0.34
19 SGTC_980 1473-0395 4.32 201.0 µM 2.23E-5 2 7.72E-6 0.17
20 SGTC_2374 9071832 4.23 200.0 µM 3.22E-5 endomembrane recycling 4 1.17E-5 0.42

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.34E-9 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.102 3.30E-9 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.097 1.57E-8 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.094 4.71E-8 YOL111C MDY2 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
0.094 5.67E-8 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.092 9.79E-8 YLR190W MMR1 hom Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
0.086 5.27E-7 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.084 1.23E-6 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.083 1.59E-6 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.083 1.69E-6 YDR326C YSP2 hom Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification; YSP2 has a paralog, YHR080C, that arose from the whole genome duplication
0.083 1.70E-6 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.082 2.15E-6 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.079 4.63E-6 YBL030C PET9 het Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication
0.077 7.30E-6 YDR028C REG1 hom Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
0.077 7.64E-6 YGL171W ROK1 het RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation