YPR115W / RGC1

Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR115W / RGC1

Click on Significant Values for Screen Details ID:SGTC_147|Compound:4466-0538|FD-Score:3.39|P-value:4.47E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.61|P-value:1.82E-8 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.51|P-value:2.90E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.83|P-value:1.08E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.27|P-value:6.28E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.76|P-value:8.23E-9 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.59|P-value:1.97E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.56|P-value:3.97E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.47|P-value:5.32E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.57|P-value:2.20E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:5.92|P-value:3.24E-9 ID:SGTC_560|Compound:2332-1943|FD-Score:3.59|P-value:2.20E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.15|P-value:2.33E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.36|P-value:4.95E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.22|P-value:7.99E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.72|P-value:1.88E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.97|P-value:4.99E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.78|P-value:1.06E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.30|P-value:6.24E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.19|P-value:8.23E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.55|P-value:2.55E-4 ID:SGTC_1672|Compound:st016598|FD-Score:6.96|P-value:4.34E-12 ID:SGTC_1682|Compound:st012968|FD-Score:3.55|P-value:2.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.34|P-value:4.95E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.40|P-value:4.02E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.36|P-value:4.65E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-4.06|P-value:3.16E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.29|P-value:6.34E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.54|P-value:2.37E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.00|P-value:4.35E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.14|P-value:2.49E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.29|P-value:1.28E-5 ID:SGTC_2350|Compound:9023895|FD-Score:7.14|P-value:1.20E-12 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.84|P-value:7.73E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.97|P-value:4.90E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.35|P-value:5.25E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.45|P-value:6.49E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.52|P-value:4.67E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-3.41|P-value:3.85E-4 ID:SGTC_2931|Compound:9014674|FD-Score:5.29|P-value:1.07E-7 ID:SGTC_2936|Compound:9038235|FD-Score:4.10|P-value:2.98E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.39|P-value:4.45E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.06|P-value:3.52E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.30|P-value:6.18E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.38|P-value:8.85E-6 ID:SGTC_3157|Compound:9099274|FD-Score:6.01|P-value:1.88E-9 ID:SGTC_3332|Compound:9141069|FD-Score:3.25|P-value:7.41E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.39|P-value:4.47E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:5.61|P-value:1.82E-8 ID:SGTC_488|Compound:nitrendipine|FD-Score:3.51|P-value:2.90E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.83|P-value:1.08E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.27|P-value:6.28E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:5.76|P-value:8.23E-9 ID:SGTC_529|Compound:4076-0302|FD-Score:-3.59|P-value:1.97E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:4.56|P-value:3.97E-6 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.47|P-value:5.32E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:-3.57|P-value:2.20E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:5.92|P-value:3.24E-9 ID:SGTC_560|Compound:2332-1943|FD-Score:3.59|P-value:2.20E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:4.15|P-value:2.33E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:3.36|P-value:4.95E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.22|P-value:7.99E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.72|P-value:1.88E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:3.97|P-value:4.99E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.78|P-value:1.06E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.30|P-value:6.24E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-3.19|P-value:8.23E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.55|P-value:2.55E-4 ID:SGTC_1672|Compound:st016598|FD-Score:6.96|P-value:4.34E-12 ID:SGTC_1682|Compound:st012968|FD-Score:3.55|P-value:2.51E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.34|P-value:4.95E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-3.40|P-value:4.02E-4 ID:SGTC_1881|Compound:5652484|FD-Score:-3.36|P-value:4.65E-4 ID:SGTC_1953|Compound:st076800|FD-Score:-4.06|P-value:3.16E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.29|P-value:6.34E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.54|P-value:2.37E-4 ID:SGTC_2268|Compound:7933382|FD-Score:4.00|P-value:4.35E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.14|P-value:2.49E-5 ID:SGTC_2347|Compound:9049783|FD-Score:4.29|P-value:1.28E-5 ID:SGTC_2350|Compound:9023895|FD-Score:7.14|P-value:1.20E-12 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.84|P-value:7.73E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.97|P-value:4.90E-5 ID:SGTC_2414|Compound:st077232|FD-Score:3.35|P-value:5.25E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:4.45|P-value:6.49E-6 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.52|P-value:4.67E-6 ID:SGTC_2784|Compound:7567673|FD-Score:-3.41|P-value:3.85E-4 ID:SGTC_2931|Compound:9014674|FD-Score:5.29|P-value:1.07E-7 ID:SGTC_2936|Compound:9038235|FD-Score:4.10|P-value:2.98E-5 ID:SGTC_2948|Compound:9070189|FD-Score:3.17|P-value:9.68E-4 ID:SGTC_2969|Compound:9091408|FD-Score:3.39|P-value:4.45E-4 ID:SGTC_3044|Compound:9093193|FD-Score:4.06|P-value:3.52E-5 ID:SGTC_3151|Compound:9099821|FD-Score:3.30|P-value:6.18E-4 ID:SGTC_3154|Compound:9100113|FD-Score:4.38|P-value:8.85E-6 ID:SGTC_3157|Compound:9099274|FD-Score:6.01|P-value:1.88E-9 ID:SGTC_3332|Compound:9141069|FD-Score:3.25|P-value:7.41E-4

Top fitness defect scores for YPR115W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2350 9023895 7.14 38.9 µM 1.20E-12 ergosterol biosynthesis 7 4.57E-13
2 SGTC_1672 st016598 6.96 6.5 µM 4.34E-12 endomembrane recycling 22 1.74E-12
3 SGTC_3157 9099274 6.01 49.5 µM 1.88E-9 2 9.35E-10
4 SGTC_541 4513-1321 5.92 94.0 µM 3.24E-9 5 1.64E-9
5 SGTC_527 4476-4215 5.76 268.0 µM 8.23E-9 PDR1 12 4.32E-9
6 SGTC_362 0310-0100 5.61 9.0 µM 1.82E-8 RPP1 & pyrimidine depletion 4 9.83E-9
7 SGTC_2931 9014674 5.29 55.7 µM 1.07E-7 4 6.17E-8
8 SGTC_491 tetrandrine 4.83 80.3 µM 1.08E-6 3 6.74E-7
9 SGTC_646 4092-0839 4.72 27.3 µM 1.88E-6 plasma membrane duress 12 1.20E-6
10 SGTC_532 1548-0774 4.56 215.0 µM 3.97E-6 7 2.60E-6
11 SGTC_2613 3',4'-dimethoxydalbergione 4.52 24.6 µM 4.67E-6 9 3.08E-6
12 SGTC_2496 diffractaic acid 4.45 79.8 µM 6.49E-6 14 4.34E-6
13 SGTC_3154 9100113 4.38 49.5 µM 8.85E-6 22 5.98E-6
14 SGTC_2347 9049783 4.29 174.8 µM 1.28E-5 17 8.76E-6
15 SGTC_571 k831-0106 4.15 44.2 µM 2.33E-5 10 1.63E-5
16 SGTC_2318 6029776 4.14 164.0 µM 2.49E-5 25 1.75E-5
17 SGTC_2936 9038235 4.10 15.6 µM 2.98E-5 16 2.10E-5
18 SGTC_3044 9093193 4.06 49.5 µM 3.52E-5 21 2.50E-5
19 SGTC_2268 7933382 4.00 153.8 µM 4.35E-5 36 3.11E-5
20 SGTC_2407 paclitaxel 3.97 400.0 µM 4.90E-5 34 3.52E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.59E-21 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.095 3.60E-8 YOR344C TYE7 hom Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
0.087 4.67E-7 YBR114W RAD16 hom Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.083 1.31E-6 YLR003C CMS1 hom Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.083 1.56E-6 YCL055W KAR4 hom Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
0.080 3.51E-6 YCR099C_p YCR099C_p hom Putative protein of unknown function
0.080 3.93E-6 YBR247C ENP1 het Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
0.079 4.38E-6 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.077 7.87E-6 YER042W MXR1 hom Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan
0.077 9.03E-6 YLR196W PWP1 het Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
0.074 1.64E-5 YPR063C_p YPR063C_p hom ER-localized protein of unknown function
0.073 2.22E-5 YHR094C HXT1 hom Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication
0.073 2.34E-5 YBR058C UBP14 hom Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
0.073 2.50E-5 YBL056W PTC3 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication
0.072 2.79E-5 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery