YPR117W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR117W / YPR117W

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.17|P-value:5.94E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.92|P-value:2.85E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.05|P-value:9.19E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-5.11|P-value:7.88E-8 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.21|P-value:8.53E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.83|P-value:4.46E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.15|P-value:5.99E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.52|P-value:8.01E-9 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.59|P-value:1.12E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.13|P-value:6.44E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.07|P-value:1.58E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.40|P-value:2.57E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.35|P-value:2.91E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.06|P-value:8.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.17|P-value:5.60E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.31|P-value:5.30E-6 ID:SGTC_1697|Compound:st025554|FD-Score:-3.04|P-value:8.83E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.22|P-value:5.05E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.15|P-value:6.50E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.79|P-value:5.48E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.87|P-value:3.79E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.64|P-value:1.03E-6 ID:SGTC_2002|Compound:4023503|FD-Score:3.60|P-value:1.18E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.60|P-value:1.08E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.66|P-value:8.48E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.84|P-value:3.97E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.05|P-value:9.17E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-6.44|P-value:1.86E-11 ID:SGTC_2180|Compound:6301957|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_2182|Compound:6325192|FD-Score:3.04|P-value:9.43E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.68|P-value:7.86E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.26|P-value:4.01E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.53|P-value:1.55E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.10|P-value:7.68E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.10|P-value:7.07E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.77|P-value:4.80E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.18|P-value:5.42E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.82|P-value:4.83E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:3.17|P-value:5.94E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.92|P-value:2.85E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.05|P-value:9.19E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-5.11|P-value:7.88E-8 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.21|P-value:8.53E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.83|P-value:4.46E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:-3.15|P-value:5.99E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:5.52|P-value:8.01E-9 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.59|P-value:1.12E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.13|P-value:6.44E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.07|P-value:1.58E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.40|P-value:2.57E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:-3.35|P-value:2.91E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.47|P-value:2.00E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.06|P-value:8.87E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.17|P-value:5.60E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.31|P-value:5.30E-6 ID:SGTC_1697|Compound:st025554|FD-Score:-3.04|P-value:8.83E-4 ID:SGTC_1699|Compound:st031318|FD-Score:3.22|P-value:5.05E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.15|P-value:6.50E-4 ID:SGTC_1758|Compound:st042942|FD-Score:3.79|P-value:5.48E-5 ID:SGTC_1831|Compound:st055328|FD-Score:3.12|P-value:7.14E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.87|P-value:3.79E-5 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.34|P-value:3.22E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.64|P-value:1.03E-6 ID:SGTC_2002|Compound:4023503|FD-Score:3.60|P-value:1.18E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.60|P-value:1.08E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.66|P-value:8.48E-5 ID:SGTC_2168|Compound:5727979|FD-Score:-3.84|P-value:3.97E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.05|P-value:9.17E-4 ID:SGTC_2172|Compound:5754775|FD-Score:-6.44|P-value:1.86E-11 ID:SGTC_2180|Compound:6301957|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_2182|Compound:6325192|FD-Score:3.04|P-value:9.43E-4 ID:SGTC_2185|Compound:6113692|FD-Score:-3.68|P-value:7.86E-5 ID:SGTC_2236|Compound:dapsone|FD-Score:-3.26|P-value:4.01E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.53|P-value:1.55E-4 ID:SGTC_2381|Compound:9035592|FD-Score:3.10|P-value:7.68E-4 ID:SGTC_2448|Compound:5185112|FD-Score:-3.10|P-value:7.07E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:3.52|P-value:1.59E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-4.77|P-value:4.80E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.18|P-value:5.42E-4 ID:SGTC_2868|Compound:9035608|FD-Score:3.07|P-value:8.45E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.82|P-value:4.83E-5

Top fitness defect scores for YPR117W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1122 capsaicin 5.52 818.6 nM 8.01E-9 4 1.66E-8
2 SGTC_1998 st075797 4.64 76.8 µM 1.03E-6 mitochondrial response to ROS 7 1.72E-6
3 SGTC_1552 6-methylflavone 4.31 10.6 µM 5.30E-6 superoxide 9 8.22E-6
4 SGTC_488 nitrendipine 4.21 139.0 µM 8.53E-6 39 1.30E-5
5 SGTC_2180 6301957 4.08 200.0 µM 1.52E-5 RSC complex & mRNA processing 5 2.25E-5
6 SGTC_1172 0370-0043 4.07 85.0 µM 1.58E-5 19 2.33E-5
7 SGTC_1860 st056228 3.87 74.6 µM 3.79E-5 24 5.39E-5
8 SGTC_658 3253-0951 3.83 102.0 µM 4.46E-5 calcium & mitochondrial duress 64 6.30E-5
9 SGTC_3218 9131285 3.82 49.5 µM 4.83E-5 endomembrane recycling 52 6.80E-5
10 SGTC_1758 st042942 3.79 75.2 µM 5.48E-5 27 7.68E-5
11 SGTC_2002 4023503 3.60 131.0 µM 1.18E-4 mitochondrial processes 47 1.59E-4
12 SGTC_2247 cerulenin 3.53 830.0 nM 1.55E-4 30 2.07E-4
13 SGTC_2538 3',7'-epoxycaryophyllan-6-one 3.52 100.0 µM 1.59E-4 37 2.13E-4
14 SGTC_1262 0737-0114 3.47 49.6 µM 2.00E-4 38 2.65E-4
15 SGTC_1175 0741-0056 3.40 27.6 µM 2.57E-4 44 3.37E-4
16 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 3.34 14.9 µM 3.22E-4 30 4.18E-4
17 SGTC_1699 st031318 3.22 29.1 µM 5.05E-4 41 6.44E-4
18 SGTC_51 1013-0126 3.17 23.4 µM 5.94E-4 47 7.52E-4
19 SGTC_1753 st043925 3.15 64.0 µM 6.50E-4 29 8.19E-4
20 SGTC_1831 st055328 3.12 12.0 µM 7.14E-4 heme biosynthesis & mitochondrial translocase 57 8.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.33E-20 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.140 3.43E-16 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.132 1.35E-14 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.122 1.24E-12 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.115 2.80E-11 YGR045C_d YGR045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.105 1.23E-9 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.104 1.37E-9 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.103 1.94E-9 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.097 1.81E-8 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.097 1.97E-8 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.096 2.77E-8 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.094 4.66E-8 YEL060C PRB1 hom Vacuolar proteinase B (yscB); serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress
0.094 5.92E-8 YDR059C UBC5 hom Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication
0.092 9.12E-8 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.089 2.25E-7 YGL067W NPY1 hom NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member