YPR118W / MRI1

5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR118W / MRI1

Click on Significant Values for Screen Details ID:SGTC_403|Compound:arphamenine a|FD-Score:3.37|P-value:6.65E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.87|P-value:1.09E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.25|P-value:9.58E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.29|P-value:8.42E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.67|P-value:2.26E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.37|P-value:6.32E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.70|P-value:2.72E-8 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.30|P-value:8.06E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.30|P-value:8.17E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:-3.46|P-value:4.75E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.62|P-value:2.66E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:6.42|P-value:4.44E-10 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.59|P-value:3.00E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.83|P-value:1.31E-8 ID:SGTC_1207|Compound:2099-0101|FD-Score:-3.60|P-value:2.89E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.86|P-value:1.77E-6 ID:SGTC_1870|Compound:st057514|FD-Score:4.25|P-value:2.52E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.63|P-value:2.65E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.50|P-value:8.90E-6 ID:SGTC_2007|Compound:4011539|FD-Score:6.06|P-value:3.65E-9 ID:SGTC_2063|Compound:5246145|FD-Score:-4.57|P-value:6.20E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-3.38|P-value:6.16E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.12|P-value:4.33E-5 ID:SGTC_2388|Compound:9080168|FD-Score:3.37|P-value:6.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.28|P-value:8.82E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-5.72|P-value:2.35E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.71|P-value:2.04E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.63|P-value:2.66E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.59|P-value:3.02E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.28|P-value:8.83E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.37|P-value:6.65E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:-3.87|P-value:1.09E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:-3.25|P-value:9.58E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.64|P-value:2.55E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.29|P-value:8.42E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:-3.67|P-value:2.26E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:-3.37|P-value:6.32E-4 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.70|P-value:2.72E-8 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.30|P-value:8.06E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.30|P-value:8.17E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:-3.46|P-value:4.75E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:-3.62|P-value:2.66E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:6.42|P-value:4.44E-10 ID:SGTC_1194|Compound:1488-0194|FD-Score:-3.59|P-value:3.00E-4 ID:SGTC_1195|Compound:1502-0147|FD-Score:5.83|P-value:1.31E-8 ID:SGTC_1207|Compound:2099-0101|FD-Score:-3.60|P-value:2.89E-4 ID:SGTC_1649|Compound:st011737|FD-Score:4.86|P-value:1.77E-6 ID:SGTC_1870|Compound:st057514|FD-Score:4.25|P-value:2.52E-5 ID:SGTC_1881|Compound:5652484|FD-Score:3.63|P-value:2.65E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.50|P-value:8.90E-6 ID:SGTC_2007|Compound:4011539|FD-Score:6.06|P-value:3.65E-9 ID:SGTC_2063|Compound:5246145|FD-Score:-4.57|P-value:6.20E-6 ID:SGTC_2071|Compound:5230951|FD-Score:-3.38|P-value:6.16E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.12|P-value:4.33E-5 ID:SGTC_2388|Compound:9080168|FD-Score:3.37|P-value:6.56E-4 ID:SGTC_2403|Compound:6032726|FD-Score:3.28|P-value:8.82E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-5.72|P-value:2.35E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.71|P-value:2.04E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.63|P-value:2.66E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.59|P-value:3.02E-4 ID:SGTC_3029|Compound:9088683|FD-Score:3.28|P-value:8.83E-4

Top fitness defect scores for YPR118W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1190 1486-1332 6.42 13.0 µM 4.44E-10 2 6.69E-11
2 SGTC_2007 4011539 6.06 71.8 µM 3.65E-9 cell wall signaling 24 6.73E-10
3 SGTC_1195 1502-0147 5.83 41.1 µM 1.31E-8 4 2.72E-9
4 SGTC_1029 k015-0030 5.70 64.7 µM 2.72E-8 7 6.05E-9
5 SGTC_1649 st011737 4.86 51.3 µM 1.77E-6 17 5.84E-7
6 SGTC_2005 4024620 4.50 188.0 µM 8.90E-6 13 3.43E-6
7 SGTC_1870 st057514 4.25 26.5 µM 2.52E-5 RSC & ERG11 19 1.07E-5
8 SGTC_2343 7990716 4.12 14.8 µM 4.33E-5 15 1.93E-5
9 SGTC_2612 dictamnine 3.71 15.5 µM 2.04E-4 RNA pol III & RNase P/MRP 49 1.05E-4
10 SGTC_792 4534-1957 3.64 155.0 µM 2.55E-4 49 1.34E-4
11 SGTC_1881 5652484 3.63 16.0 µM 2.65E-4 TRP & mitochondrial translation 39 1.40E-4
12 SGTC_2855 9016525 3.63 58.4 µM 2.66E-4 25 1.40E-4
13 SGTC_2388 9080168 3.37 200.0 µM 6.56E-4 14 3.76E-4
14 SGTC_403 arphamenine a 3.37 50.0 µM 6.65E-4 60S ribosome export 31 3.82E-4
15 SGTC_1082 camptothecin 3.30 424.9 nM 8.17E-4 DNA damage response 69 4.78E-4
16 SGTC_851 0394-0702 3.29 453.0 µM 8.42E-4 mitochondrial processes 24 4.94E-4
17 SGTC_2403 6032726 3.28 181.2 µM 8.82E-4 63 5.19E-4
18 SGTC_3029 9088683 3.28 49.5 µM 8.83E-4 38 5.21E-4
19 SGTC_2425 5628681 3.23 7.8 µM 0.00102 61 6.12E-4
20 SGTC_2993 9054257 3.19 71.4 µM 0.00118 fatty acid desaturase (OLE1) 84 7.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.090 2.02E-7 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.089 2.83E-7 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.088 3.39E-7 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.085 8.79E-7 YBR284W_p YBR284W_p hom Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication
0.081 2.28E-6 YNL144C_p YNL144C_p hom Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study
0.079 4.44E-6 YPL020C ULP1 het Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
0.078 6.88E-6 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.076 1.11E-5 YPL192C PRM3 hom Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body
0.076 1.13E-5 YBR158W AMN1 hom Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
0.073 2.17E-5 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.073 2.40E-5 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.073 2.61E-5 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.072 3.02E-5 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.072 3.08E-5 YLL041C SDH2 hom Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
0.071 3.81E-5 YLR130C ZRT2 hom Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor