YPR119W / CLB2

B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR119W / CLB2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:1.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:10.40|P-value:2.01E-22 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.50|P-value:5.51E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.91|P-value:1.33E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.62|P-value:8.22E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:6.07|P-value:7.80E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:4.31|P-value:2.92E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.99|P-value:9.98E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.46|P-value:6.38E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.15|P-value:5.45E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.38|P-value:2.21E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-3.47|P-value:5.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.68|P-value:6.52E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:3.33|P-value:9.73E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:5.37|P-value:2.80E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.38|P-value:2.28E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.96|P-value:1.12E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.74|P-value:4.91E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:5.35|P-value:3.14E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:3.48|P-value:5.92E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:7.05|P-value:2.53E-11 ID:SGTC_829|Compound:1635-0120|FD-Score:3.45|P-value:6.48E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.45|P-value:6.47E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.28|P-value:3.31E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.72|P-value:2.59E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.92|P-value:2.23E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.60|P-value:3.83E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.42|P-value:1.93E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.92|P-value:1.32E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.48|P-value:5.82E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.80|P-value:3.77E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.70|P-value:2.79E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.42|P-value:1.87E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.58|P-value:4.23E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.58|P-value:4.28E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.28|P-value:3.28E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.32|P-value:2.83E-5 ID:SGTC_1771|Compound:st048882|FD-Score:4.87|P-value:2.86E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.76|P-value:2.30E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.96|P-value:1.86E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.39|P-value:2.19E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.55|P-value:4.64E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.38|P-value:2.20E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.93|P-value:2.16E-6 ID:SGTC_1966|Compound:st070145|FD-Score:3.47|P-value:6.12E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.58|P-value:4.26E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-4.31|P-value:2.91E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.05|P-value:8.01E-5 ID:SGTC_2080|Compound:5212524|FD-Score:-3.35|P-value:8.73E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.54|P-value:4.83E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.36|P-value:8.67E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.76|P-value:4.60E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.07|P-value:7.37E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.34|P-value:9.23E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.35|P-value:3.10E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.35|P-value:3.06E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:5.57|P-value:1.04E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.55|P-value:4.75E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.64|P-value:3.38E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.59|P-value:4.07E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.87|P-value:1.49E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.31|P-value:2.03E-9 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.66|P-value:6.94E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.92|P-value:1.28E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.41|P-value:7.37E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.87|P-value:2.84E-6 ID:SGTC_2923|Compound:7992654|FD-Score:3.33|P-value:9.61E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.37|P-value:8.52E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.68|P-value:3.01E-4 ID:SGTC_3085|Compound:9117376|FD-Score:4.04|P-value:8.36E-5 ID:SGTC_3099|Compound:9120367|FD-Score:6.37|P-value:1.43E-9 ID:SGTC_3210|Compound:9128157|FD-Score:4.93|P-value:2.16E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.43|P-value:2.07E-7 ID:SGTC_3321|Compound:9137793|FD-Score:4.88|P-value:2.68E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.84|P-value:1.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:10.40|P-value:2.01E-22 ID:SGTC_237|Compound:nikkomycin|FD-Score:3.50|P-value:5.51E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.91|P-value:1.33E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.62|P-value:8.22E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:6.07|P-value:7.80E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:4.31|P-value:2.92E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.99|P-value:9.98E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.46|P-value:6.38E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.15|P-value:5.45E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.38|P-value:2.21E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-3.47|P-value:5.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.68|P-value:6.52E-6 ID:SGTC_521|Compound:r062-0005|FD-Score:3.33|P-value:9.73E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:5.37|P-value:2.80E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.38|P-value:2.28E-5 ID:SGTC_707|Compound:0865-0008|FD-Score:3.96|P-value:1.12E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.74|P-value:4.91E-6 ID:SGTC_723|Compound:4182-0001|FD-Score:5.35|P-value:3.14E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:3.48|P-value:5.92E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:7.05|P-value:2.53E-11 ID:SGTC_829|Compound:1635-0120|FD-Score:3.45|P-value:6.48E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:3.45|P-value:6.47E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.28|P-value:3.31E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.37|P-value:2.35E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:3.72|P-value:2.59E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.92|P-value:2.23E-6 ID:SGTC_953|Compound:1188-0045|FD-Score:-3.60|P-value:3.83E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.42|P-value:1.93E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.92|P-value:1.32E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-3.48|P-value:5.82E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.80|P-value:3.77E-6 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.70|P-value:2.79E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.42|P-value:1.87E-5 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.58|P-value:4.23E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:3.58|P-value:4.28E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.28|P-value:3.28E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.32|P-value:2.83E-5 ID:SGTC_1771|Compound:st048882|FD-Score:4.87|P-value:2.86E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.76|P-value:2.30E-4 ID:SGTC_1783|Compound:st039459|FD-Score:4.96|P-value:1.86E-6 ID:SGTC_1797|Compound:st048695|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_1815|Compound:st051655|FD-Score:4.39|P-value:2.19E-5 ID:SGTC_1870|Compound:st057514|FD-Score:3.55|P-value:4.64E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.38|P-value:2.20E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.93|P-value:2.16E-6 ID:SGTC_1966|Compound:st070145|FD-Score:3.47|P-value:6.12E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.58|P-value:4.26E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-4.31|P-value:2.91E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.05|P-value:8.01E-5 ID:SGTC_2080|Compound:5212524|FD-Score:-3.35|P-value:8.73E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.54|P-value:4.83E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.36|P-value:8.67E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.76|P-value:4.60E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.07|P-value:7.37E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.34|P-value:9.23E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:5.35|P-value:3.10E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:5.35|P-value:3.06E-7 ID:SGTC_2584|Compound:androsterone|FD-Score:5.57|P-value:1.04E-7 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.55|P-value:4.75E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.64|P-value:3.38E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:-3.59|P-value:4.07E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.87|P-value:1.49E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:6.31|P-value:2.03E-9 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.66|P-value:6.94E-6 ID:SGTC_2800|Compound:7887935|FD-Score:-3.92|P-value:1.28E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.41|P-value:7.37E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.87|P-value:2.84E-6 ID:SGTC_2923|Compound:7992654|FD-Score:3.33|P-value:9.61E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.37|P-value:8.52E-4 ID:SGTC_3083|Compound:9117465|FD-Score:3.68|P-value:3.01E-4 ID:SGTC_3085|Compound:9117376|FD-Score:4.04|P-value:8.36E-5 ID:SGTC_3099|Compound:9120367|FD-Score:6.37|P-value:1.43E-9 ID:SGTC_3210|Compound:9128157|FD-Score:4.93|P-value:2.16E-6 ID:SGTC_3311|Compound:9131146|FD-Score:5.43|P-value:2.07E-7 ID:SGTC_3321|Compound:9137793|FD-Score:4.88|P-value:2.68E-6

Top fitness defect scores for YPR119W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 10.40 40.9 µM 2.01E-22 cell wall 41 1.66E-25
2 SGTC_777 1315-0167 7.05 517.0 µM 2.53E-11 Golgi 1 9.15E-13
3 SGTC_3099 9120367 6.37 49.5 µM 1.43E-9 1 9.38E-11
4 SGTC_2619 obliquin 6.31 87.9 µM 2.03E-9 cell wall 68 1.40E-10
5 SGTC_364 0083-0097 6.07 67.7 µM 7.80E-9 5 6.54E-10
6 SGTC_2584 androsterone 5.57 48.7 µM 1.04E-7 cell wall 66 1.28E-8
7 SGTC_3311 9131146 5.43 2.9 µM 2.07E-7 cell wall 75 2.80E-8
8 SGTC_531 3788-1495 5.37 174.0 µM 2.80E-7 unfolded protein response 10 3.95E-8
9 SGTC_2565 isoliquiritigenin 5.35 100.0 µM 3.06E-7 15 4.38E-8
10 SGTC_2528 xanthyletin 5.35 44.8 µM 3.10E-7 9 4.45E-8
11 SGTC_723 4182-0001 5.35 115.0 µM 3.14E-7 13 4.51E-8
12 SGTC_1783 st039459 4.96 87.5 µM 1.86E-6 Golgi 12 3.46E-7
13 SGTC_1934 st074720 4.93 32.6 µM 2.16E-6 31 4.09E-7
14 SGTC_3210 9128157 4.93 49.5 µM 2.16E-6 25 4.10E-7
15 SGTC_928 2764-0428 4.92 58.7 µM 2.23E-6 cell wall 31 4.25E-7
16 SGTC_3321 9137793 4.88 26.8 µM 2.68E-6 cell wall 46 5.26E-7
17 SGTC_2912 7964298 4.87 10.9 µM 2.84E-6 cell wall 70 5.60E-7
18 SGTC_1771 st048882 4.87 4.2 µM 2.86E-6 RPP1 & pyrimidine depletion 8 5.65E-7
19 SGTC_1039 k821-0043 4.80 94.0 µM 3.77E-6 Golgi 10 7.76E-7
20 SGTC_2367 9070478 4.76 135.4 µM 4.60E-6 cell wall 21 9.75E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.315 4.66E-78 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.311 2.09E-76 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.301 2.76E-71 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.300 1.12E-70 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.265 5.64E-55 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.261 3.33E-53 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.248 2.20E-48 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.248 2.35E-48 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.248 4.40E-48 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.246 2.05E-47 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.246 2.63E-47 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.228 8.32E-41 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.225 6.99E-40 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.225 1.12E-39 YNL283C WSC2 hom Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
0.224 1.53E-39 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria