YPR121W / THI22

Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR121W / THI22

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.09|P-value:7.07E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.25|P-value:3.99E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.72|P-value:6.66E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.27|P-value:1.41E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.59|P-value:1.10E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.64|P-value:1.92E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.96|P-value:2.44E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.25|P-value:4.05E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.03|P-value:8.64E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.09|P-value:7.00E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.38|P-value:2.52E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.44|P-value:4.03E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.10|P-value:6.86E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.63|P-value:9.54E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.09|P-value:1.39E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.25|P-value:4.05E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.95|P-value:2.52E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.93|P-value:2.81E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.49|P-value:1.67E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.02|P-value:1.49E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.91|P-value:2.99E-5 ID:SGTC_2625|Compound:euphol|FD-Score:5.52|P-value:9.35E-9 ID:SGTC_2819|Compound:7996655|FD-Score:-3.85|P-value:8.46E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.47|P-value:1.79E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.22|P-value:7.84E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-4.00|P-value:4.48E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.82|P-value:4.46E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.00|P-value:9.55E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.50|P-value:3.28E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.36|P-value:5.33E-4 ID:SGTC_3326|Compound:9140064|FD-Score:6.98|P-value:6.76E-13 ID:SGTC_35|Compound:0133-0054|FD-Score:3.09|P-value:7.07E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.55|P-value:1.30E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.25|P-value:3.99E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:3.72|P-value:6.66E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.27|P-value:1.41E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:3.59|P-value:1.10E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:-3.64|P-value:1.92E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.96|P-value:2.44E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:3.25|P-value:4.05E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.03|P-value:8.64E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.09|P-value:7.00E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.36|P-value:2.72E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.38|P-value:2.52E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.44|P-value:4.03E-4 ID:SGTC_1645|Compound:Cervolide|FD-Score:3.10|P-value:6.86E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.63|P-value:9.54E-5 ID:SGTC_1691|Compound:st019933|FD-Score:4.09|P-value:1.39E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.25|P-value:4.05E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.95|P-value:2.52E-5 ID:SGTC_2066|Compound:5222451|FD-Score:3.93|P-value:2.81E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.49|P-value:1.67E-4 ID:SGTC_2413|Compound:inermin|FD-Score:5.02|P-value:1.49E-7 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:3.91|P-value:2.99E-5 ID:SGTC_2625|Compound:euphol|FD-Score:5.52|P-value:9.35E-9 ID:SGTC_2819|Compound:7996655|FD-Score:-3.85|P-value:8.46E-5 ID:SGTC_3016|Compound:9080866|FD-Score:3.47|P-value:1.79E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.22|P-value:7.84E-6 ID:SGTC_3136|Compound:9095672|FD-Score:-4.00|P-value:4.48E-5 ID:SGTC_3189|Compound:9110682|FD-Score:3.82|P-value:4.46E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.00|P-value:9.55E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.50|P-value:3.28E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.36|P-value:5.33E-4 ID:SGTC_3326|Compound:9140064|FD-Score:6.98|P-value:6.76E-13

Top fitness defect scores for YPR121W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3326 9140064 6.98 16.4 µM 6.76E-13 3 1.48E-12
2 SGTC_2625 euphol 5.52 100.0 µM 9.35E-9 8 1.72E-8
3 SGTC_2413 inermin 5.02 26.1 µM 1.49E-7 28 2.59E-7
4 SGTC_3108 9121785 4.22 49.5 µM 7.84E-6 7 1.24E-5
5 SGTC_1691 st019933 4.09 84.6 µM 1.39E-5 11 2.17E-5
6 SGTC_240 5hr heat shock (37°C) + Streptovitacin 3.96 300.0 µM 2.44E-5 heat shock/prefoldin 41 3.77E-5
7 SGTC_1900 st060200 3.95 72.8 µM 2.52E-5 22 3.89E-5
8 SGTC_2066 5222451 3.93 176.0 µM 2.81E-5 heme biosynthesis & mitochondrial translocase 31 4.33E-5
9 SGTC_2565 isoliquiritigenin 3.91 100.0 µM 2.99E-5 36 4.59E-5
10 SGTC_3189 9110682 3.82 49.5 µM 4.46E-5 41 6.79E-5
11 SGTC_69 0096-0274 3.72 206.7 µM 6.66E-5 mitochondrial processes 51 1.00E-4
12 SGTC_1657 st012939 3.63 43.4 µM 9.54E-5 17 1.42E-4
13 SGTC_122 0236-0016 3.59 402.4 µM 1.10E-4 RNA processing & uracil transport 48 1.63E-4
14 SGTC_55 0767-0285 3.55 6.6 µM 1.30E-4 53 1.92E-4
15 SGTC_2253 7938677 3.49 135.8 µM 1.67E-4 21 2.46E-4
16 SGTC_3016 9080866 3.47 49.5 µM 1.79E-4 40 2.63E-4
17 SGTC_885 0865-0106 3.38 16.8 µM 2.52E-4 TSC3-RPN4 45 3.67E-4
18 SGTC_853 0419-0306 3.36 21.0 µM 2.72E-4 34 3.94E-4
19 SGTC_60 0986-0278 3.25 202.0 µM 3.99E-4 29 5.73E-4
20 SGTC_372 0155-0182 3.25 15.9 µM 4.05E-4 mitochondrial response to ROS 56 5.81E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 7.68E-31 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.130 5.14E-14 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.116 1.56E-11 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.115 2.10E-11 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.111 1.08E-10 YFR035C_p YFR035C_p hom Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein
0.102 3.62E-9 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.101 3.92E-9 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.096 2.62E-8 YPL111W CAR1 hom Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
0.096 2.71E-8 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.093 7.82E-8 YOL146W PSF3 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.088 2.82E-7 YNL318C HXT14 hom Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.31E-7 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.088 3.69E-7 YDR250C_d YDR250C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.084 1.02E-6 YER113C TMN3 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
0.083 1.69E-6 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data