YPR122W / AXL1

Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR122W / AXL1

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:3.19|P-value:4.15E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.26|P-value:4.15E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:2.96|P-value:9.85E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.03|P-value:8.33E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.34|P-value:2.58E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.73|P-value:3.76E-7 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.00|P-value:9.23E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.16|P-value:6.74E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:7.03|P-value:1.03E-13 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.83|P-value:3.48E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.15|P-value:7.33E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:7.01|P-value:1.24E-13 ID:SGTC_983|Compound:1491-0821|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.06|P-value:6.87E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.17|P-value:4.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.37|P-value:2.11E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.62|P-value:6.98E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.25|P-value:3.34E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.61|P-value:7.83E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.37|P-value:2.13E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.63|P-value:7.20E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.10|P-value:8.89E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.95|P-value:1.83E-5 ID:SGTC_1558|Compound:st069300|FD-Score:-3.10|P-value:6.35E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.12|P-value:5.52E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.98|P-value:1.56E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-3.61|P-value:8.79E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.48|P-value:1.37E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.21|P-value:3.99E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.30|P-value:2.78E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-3.07|P-value:7.22E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.34|P-value:2.34E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.75|P-value:4.86E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.19|P-value:4.22E-4 ID:SGTC_2385|Compound:9074692|FD-Score:6.64|P-value:2.02E-12 ID:SGTC_2388|Compound:9080168|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.28|P-value:3.05E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.01|P-value:8.98E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.68|P-value:5.93E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.08|P-value:6.41E-4 ID:SGTC_2867|Compound:9039098|FD-Score:2.97|P-value:9.41E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.04|P-value:7.88E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.30|P-value:2.76E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.22|P-value:3.71E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.11|P-value:8.75E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.24|P-value:3.46E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.10|P-value:5.91E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.08|P-value:6.99E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.48|P-value:1.35E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.08|P-value:6.24E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.53|P-value:1.09E-6 ID:SGTC_1|Compound:0258-0098|FD-Score:3.19|P-value:4.15E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.26|P-value:4.15E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:2.96|P-value:9.85E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.03|P-value:8.33E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.34|P-value:2.58E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.73|P-value:3.76E-7 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.00|P-value:9.23E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.00|P-value:8.54E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:4.16|P-value:6.74E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:7.03|P-value:1.03E-13 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.83|P-value:3.48E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.15|P-value:7.33E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:7.01|P-value:1.24E-13 ID:SGTC_983|Compound:1491-0821|FD-Score:3.12|P-value:5.57E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.06|P-value:6.87E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.17|P-value:4.98E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.37|P-value:2.11E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.62|P-value:6.98E-7 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.25|P-value:3.34E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.61|P-value:7.83E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:3.37|P-value:2.13E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:3.63|P-value:7.20E-5 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.10|P-value:8.89E-6 ID:SGTC_1547|Compound:harmine|FD-Score:3.95|P-value:1.83E-5 ID:SGTC_1558|Compound:st069300|FD-Score:-3.10|P-value:6.35E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.12|P-value:5.52E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.98|P-value:1.56E-5 ID:SGTC_1607|Compound:st000305|FD-Score:-3.61|P-value:8.79E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-3.56|P-value:1.08E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.48|P-value:1.37E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.21|P-value:3.99E-4 ID:SGTC_1857|Compound:st056007|FD-Score:3.30|P-value:2.78E-4 ID:SGTC_1906|Compound:st060206|FD-Score:-3.07|P-value:7.22E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.34|P-value:2.34E-4 ID:SGTC_2381|Compound:9035592|FD-Score:-3.75|P-value:4.86E-5 ID:SGTC_2384|Compound:9036245|FD-Score:3.19|P-value:4.22E-4 ID:SGTC_2385|Compound:9074692|FD-Score:6.64|P-value:2.02E-12 ID:SGTC_2388|Compound:9080168|FD-Score:3.45|P-value:1.55E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.28|P-value:3.05E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.01|P-value:8.98E-4 ID:SGTC_2681|Compound:menadione|FD-Score:3.68|P-value:5.93E-5 ID:SGTC_2825|Compound:7998094|FD-Score:3.08|P-value:6.41E-4 ID:SGTC_2867|Compound:9039098|FD-Score:2.97|P-value:9.41E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.04|P-value:7.88E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.30|P-value:2.76E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.22|P-value:3.71E-4 ID:SGTC_3004|Compound:9076122|FD-Score:4.11|P-value:8.75E-6 ID:SGTC_3033|Compound:9090887|FD-Score:3.24|P-value:3.46E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.10|P-value:5.91E-4 ID:SGTC_3101|Compound:9120531|FD-Score:-3.08|P-value:6.99E-4 ID:SGTC_3132|Compound:9126706|FD-Score:3.48|P-value:1.35E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.08|P-value:6.24E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.53|P-value:1.09E-6

Top fitness defect scores for YPR122W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_871 0574-0004 7.03 149.0 µM 1.03E-13 10 1.01E-12
2 SGTC_883 0850-0245 7.01 24.6 µM 1.24E-13 cell wall 7 1.20E-12
3 SGTC_2385 9074692 6.64 200.0 µM 2.02E-12 7 1.55E-11
4 SGTC_577 r071-0003 4.73 38.6 µM 3.76E-7 fatty acid desaturase (OLE1) 30 1.10E-6
5 SGTC_1225 1216-0074 4.62 20.6 µM 6.98E-7 16 1.95E-6
6 SGTC_3280 9140961 4.53 49.5 µM 1.09E-6 60S ribosome export 8 2.93E-6
7 SGTC_151 3013-0144 4.26 2.3 µM 4.15E-6 iron homeostasis 21 1.01E-5
8 SGTC_801 0866-0028 4.16 10.1 µM 6.74E-6 21 1.57E-5
9 SGTC_881 0833-0569 4.15 170.0 µM 7.33E-6 21 1.70E-5
10 SGTC_3004 9076122 4.11 71.4 µM 8.75E-6 16 2.00E-5
11 SGTC_1538 2',3',6-trimethoxyflavanone 4.10 63.6 µM 8.89E-6 13 2.03E-5
12 SGTC_1605 st000082 3.98 49.1 µM 1.56E-5 60S ribosome export 13 3.41E-5
13 SGTC_1547 harmine 3.95 94.2 µM 1.83E-5 ergosterol biosynthesis 40 3.94E-5
14 SGTC_2681 menadione 3.68 3.2 µM 5.93E-5 superoxide 31 1.16E-4
15 SGTC_1524 corynanthine 3.63 62.1 µM 7.20E-5 27 1.39E-4
16 SGTC_1447 4239-0816 3.61 81.9 µM 7.83E-5 41 1.50E-4
17 SGTC_3132 9126706 3.48 49.5 µM 1.35E-4 41 2.48E-4
18 SGTC_1789 tunicamycin 3.48 25.0 nM 1.37E-4 unfolded protein response 68 2.52E-4
19 SGTC_2388 9080168 3.45 200.0 µM 1.55E-4 10 2.82E-4
20 SGTC_1126 isoteolin 3.37 1.0 µM 2.11E-4 52 3.75E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 6.05E-13 YNR026C SEC12 het Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER
0.103 2.55E-9 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.089 2.33E-7 YER169W RPH1 hom JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
0.087 4.07E-7 YHR022C-A_p YHR022C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.084 1.02E-6 YLR309C IMH1 hom Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
0.080 3.50E-6 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.078 6.68E-6 YGL092W NUP145 het Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98
0.077 7.11E-6 YLR193C UPS1 hom Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI
0.076 9.29E-6 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.076 1.01E-5 YEL017W GTT3 hom Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
0.073 2.17E-5 YLR437C DIF1 hom Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein
0.070 4.73E-5 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
0.068 8.01E-5 YMR319C FET4 hom Low-affinity Fe(II) transporter of the plasma membrane
0.066 1.38E-4 YMR205C PFK2 hom Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
0.065 1.57E-4 YOR216C RUD3 hom Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1