YPR123C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR123C / YPR123C

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:5.50|P-value:1.02E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.43|P-value:7.29E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:7.45|P-value:2.01E-7 ID:SGTC_106|Compound:0092-0003|FD-Score:13.10|P-value:1.17E-19 ID:SGTC_113|Compound:0099-0221|FD-Score:5.61|P-value:7.53E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:13.40|P-value:1.80E-20 ID:SGTC_134|Compound:0269-0018|FD-Score:10.10|P-value:2.20E-12 ID:SGTC_141|Compound:0443-0274|FD-Score:4.84|P-value:5.69E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.01|P-value:3.71E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.45|P-value:1.18E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:5.33|P-value:1.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.88|P-value:6.82E-10 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.64|P-value:4.33E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.97|P-value:2.69E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.77|P-value:6.78E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.73|P-value:7.34E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.91|P-value:3.18E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.88|P-value:2.34E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.48|P-value:5.53E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:4.84|P-value:5.74E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.30|P-value:9.92E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:13.40|P-value:1.72E-20 ID:SGTC_626|Compound:0214-0009|FD-Score:6.87|P-value:1.52E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:6.34|P-value:8.67E-6 ID:SGTC_672|Compound:1441-0018|FD-Score:4.86|P-value:5.43E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.77|P-value:4.72E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:5.78|P-value:4.60E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:9.96|P-value:4.74E-12 ID:SGTC_768|Compound:0384-0033|FD-Score:5.56|P-value:8.70E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:4.73|P-value:7.49E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.44|P-value:1.19E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.83|P-value:5.82E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:5.87|P-value:3.54E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.60|P-value:9.95E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.55|P-value:5.36E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:5.06|P-value:3.25E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:8.21|P-value:1.09E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:11.70|P-value:4.69E-16 ID:SGTC_1075|Compound:aripiprazole|FD-Score:5.74|P-value:5.20E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.73|P-value:5.44E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.10|P-value:1.33E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:8.02|P-value:2.29E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:6.20|P-value:1.35E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.09|P-value:3.00E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.45|P-value:6.94E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:5.15|P-value:2.62E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.84|P-value:5.73E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.83|P-value:1.75E-6 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.72|P-value:7.51E-4 ID:SGTC_1629|Compound:st005085|FD-Score:5.57|P-value:8.49E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.85|P-value:3.83E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.13|P-value:2.75E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.46|P-value:6.72E-4 ID:SGTC_1830|Compound:st055982|FD-Score:10.30|P-value:8.99E-13 ID:SGTC_1844|Compound:rapamycin|FD-Score:-14.90|P-value:6.72E-26 ID:SGTC_1865|Compound:st057639|FD-Score:4.62|P-value:9.52E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.88|P-value:5.20E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.30|P-value:9.95E-6 ID:SGTC_2029|Compound:5175081|FD-Score:-4.34|P-value:8.92E-4 ID:SGTC_2066|Compound:5222451|FD-Score:8.24|P-value:9.64E-9 ID:SGTC_2068|Compound:5226020|FD-Score:9.17|P-value:1.93E-10 ID:SGTC_2080|Compound:5212524|FD-Score:14.40|P-value:1.61E-23 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.52|P-value:5.79E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:8.53|P-value:2.99E-9 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.19|P-value:5.28E-6 ID:SGTC_2171|Compound:5739187|FD-Score:10.70|P-value:1.15E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.02|P-value:1.64E-4 ID:SGTC_2259|Compound:7964009|FD-Score:5.05|P-value:3.40E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.69|P-value:8.17E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-4.83|P-value:2.71E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.48|P-value:6.47E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.83|P-value:5.74E-4 ID:SGTC_2481|Compound:5478948|FD-Score:11.20|P-value:6.71E-15 ID:SGTC_2507|Compound:purpurin|FD-Score:16.20|P-value:3.20E-29 ID:SGTC_2516|Compound:gossypol|FD-Score:8.24|P-value:9.92E-9 ID:SGTC_2526|Compound:patulin|FD-Score:6.13|P-value:1.66E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.81|P-value:1.91E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.53|P-value:3.97E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.02|P-value:3.62E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.99|P-value:3.89E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:11.70|P-value:4.14E-16 ID:SGTC_2630|Compound:antimycin a|FD-Score:-6.59|P-value:1.39E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:8.82|P-value:8.72E-10 ID:SGTC_2671|Compound:danthron|FD-Score:7.96|P-value:2.89E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.95|P-value:4.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.82|P-value:1.54E-8 ID:SGTC_2681|Compound:menadione|FD-Score:6.21|P-value:1.31E-5 ID:SGTC_2696|Compound:st077691|FD-Score:6.27|P-value:1.09E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.15|P-value:2.58E-4 ID:SGTC_2781|Compound:5567276|FD-Score:6.55|P-value:4.49E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-4.66|P-value:4.15E-4 ID:SGTC_2931|Compound:9014674|FD-Score:5.73|P-value:5.39E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.98|P-value:4.04E-4 ID:SGTC_2981|Compound:9013952|FD-Score:7.13|P-value:6.34E-7 ID:SGTC_2999|Compound:9069765|FD-Score:6.48|P-value:5.55E-6 ID:SGTC_3062|Compound:9077494|FD-Score:5.45|P-value:1.17E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.90|P-value:4.86E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-4.67|P-value:4.03E-4 ID:SGTC_3158|Compound:9100007|FD-Score:5.61|P-value:7.45E-5 ID:SGTC_3181|Compound:9108277|FD-Score:5.10|P-value:2.99E-4 ID:SGTC_3219|Compound:9131112|FD-Score:7.45|P-value:2.02E-7 ID:SGTC_3224|Compound:9130643|FD-Score:4.83|P-value:5.86E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.97|P-value:4.09E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.57|P-value:3.47E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:5.50|P-value:1.02E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-4.43|P-value:7.29E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:7.45|P-value:2.01E-7 ID:SGTC_106|Compound:0092-0003|FD-Score:13.10|P-value:1.17E-19 ID:SGTC_113|Compound:0099-0221|FD-Score:5.61|P-value:7.53E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:13.40|P-value:1.80E-20 ID:SGTC_134|Compound:0269-0018|FD-Score:10.10|P-value:2.20E-12 ID:SGTC_141|Compound:0443-0274|FD-Score:4.84|P-value:5.69E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:5.01|P-value:3.71E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:5.45|P-value:1.18E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:5.33|P-value:1.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.88|P-value:6.82E-10 ID:SGTC_245|Compound:methotrexate|FD-Score:-4.64|P-value:4.33E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:5.97|P-value:2.69E-5 ID:SGTC_384|Compound:k007-0144|FD-Score:4.77|P-value:6.78E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.73|P-value:7.34E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:5.91|P-value:3.18E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-4.88|P-value:2.34E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:6.48|P-value:5.53E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:4.84|P-value:5.74E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.30|P-value:9.92E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:13.40|P-value:1.72E-20 ID:SGTC_626|Compound:0214-0009|FD-Score:6.87|P-value:1.52E-6 ID:SGTC_670|Compound:4204-0025|FD-Score:6.34|P-value:8.67E-6 ID:SGTC_672|Compound:1441-0018|FD-Score:4.86|P-value:5.43E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:5.77|P-value:4.72E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:5.78|P-value:4.60E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:9.96|P-value:4.74E-12 ID:SGTC_768|Compound:0384-0033|FD-Score:5.56|P-value:8.70E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:4.73|P-value:7.49E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:5.44|P-value:1.19E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.83|P-value:5.82E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:5.87|P-value:3.54E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.60|P-value:9.95E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-4.55|P-value:5.36E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:5.06|P-value:3.25E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:8.21|P-value:1.09E-8 ID:SGTC_1001|Compound:4048-4355|FD-Score:11.70|P-value:4.69E-16 ID:SGTC_1075|Compound:aripiprazole|FD-Score:5.74|P-value:5.20E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.73|P-value:5.44E-5 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-5.10|P-value:1.33E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:8.02|P-value:2.29E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:6.20|P-value:1.35E-5 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.09|P-value:3.00E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-4.45|P-value:6.94E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:5.15|P-value:2.62E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:4.84|P-value:5.73E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.83|P-value:1.75E-6 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.72|P-value:7.51E-4 ID:SGTC_1629|Compound:st005085|FD-Score:5.57|P-value:8.49E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.85|P-value:3.83E-5 ID:SGTC_1746|Compound:st038117|FD-Score:5.13|P-value:2.75E-4 ID:SGTC_1829|Compound:berberine|FD-Score:-4.46|P-value:6.72E-4 ID:SGTC_1830|Compound:st055982|FD-Score:10.30|P-value:8.99E-13 ID:SGTC_1844|Compound:rapamycin|FD-Score:-14.90|P-value:6.72E-26 ID:SGTC_1865|Compound:st057639|FD-Score:4.62|P-value:9.52E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:4.88|P-value:5.20E-4 ID:SGTC_2004|Compound:4023728|FD-Score:6.30|P-value:9.95E-6 ID:SGTC_2029|Compound:5175081|FD-Score:-4.34|P-value:8.92E-4 ID:SGTC_2066|Compound:5222451|FD-Score:8.24|P-value:9.64E-9 ID:SGTC_2068|Compound:5226020|FD-Score:9.17|P-value:1.93E-10 ID:SGTC_2080|Compound:5212524|FD-Score:14.40|P-value:1.61E-23 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.52|P-value:5.79E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:8.53|P-value:2.99E-9 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.19|P-value:5.28E-6 ID:SGTC_2171|Compound:5739187|FD-Score:10.70|P-value:1.15E-13 ID:SGTC_2233|Compound:sulbentine|FD-Score:-5.02|P-value:1.64E-4 ID:SGTC_2259|Compound:7964009|FD-Score:5.05|P-value:3.40E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.69|P-value:8.17E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-4.83|P-value:2.71E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.48|P-value:6.47E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:4.83|P-value:5.74E-4 ID:SGTC_2481|Compound:5478948|FD-Score:11.20|P-value:6.71E-15 ID:SGTC_2507|Compound:purpurin|FD-Score:16.20|P-value:3.20E-29 ID:SGTC_2516|Compound:gossypol|FD-Score:8.24|P-value:9.92E-9 ID:SGTC_2526|Compound:patulin|FD-Score:6.13|P-value:1.66E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.81|P-value:1.91E-6 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-5.53|P-value:3.97E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.02|P-value:3.62E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.99|P-value:3.89E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:11.70|P-value:4.14E-16 ID:SGTC_2630|Compound:antimycin a|FD-Score:-6.59|P-value:1.39E-6 ID:SGTC_2640|Compound:pentamidine|FD-Score:8.82|P-value:8.72E-10 ID:SGTC_2671|Compound:danthron|FD-Score:7.96|P-value:2.89E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:4.95|P-value:4.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-7.82|P-value:1.54E-8 ID:SGTC_2681|Compound:menadione|FD-Score:6.21|P-value:1.31E-5 ID:SGTC_2696|Compound:st077691|FD-Score:6.27|P-value:1.09E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:5.15|P-value:2.58E-4 ID:SGTC_2781|Compound:5567276|FD-Score:6.55|P-value:4.49E-6 ID:SGTC_2806|Compound:7952793|FD-Score:-4.66|P-value:4.15E-4 ID:SGTC_2931|Compound:9014674|FD-Score:5.73|P-value:5.39E-5 ID:SGTC_2969|Compound:9091408|FD-Score:4.98|P-value:4.04E-4 ID:SGTC_2981|Compound:9013952|FD-Score:7.13|P-value:6.34E-7 ID:SGTC_2999|Compound:9069765|FD-Score:6.48|P-value:5.55E-6 ID:SGTC_3062|Compound:9077494|FD-Score:5.45|P-value:1.17E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.90|P-value:4.86E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-4.67|P-value:4.03E-4 ID:SGTC_3158|Compound:9100007|FD-Score:5.61|P-value:7.45E-5 ID:SGTC_3181|Compound:9108277|FD-Score:5.10|P-value:2.99E-4 ID:SGTC_3219|Compound:9131112|FD-Score:7.45|P-value:2.02E-7 ID:SGTC_3224|Compound:9130643|FD-Score:4.83|P-value:5.86E-4 ID:SGTC_3225|Compound:9130819|FD-Score:4.97|P-value:4.09E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.57|P-value:3.47E-5

Top fitness defect scores for YPR123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2507 purpurin 16.20 79.7 µM 3.20E-29 copper-dependent oxidative stress 2 1.84E-59
2 SGTC_2080 5212524 14.40 12.4 µM 1.61E-23 copper-dependent oxidative stress 1 1.40E-47
3 SGTC_612 0302-0167 13.40 22.4 µM 1.72E-20 copper-dependent oxidative stress 4 2.87E-41
4 SGTC_116 0155-0182 13.40 31.8 µM 1.80E-20 mitochondrial response to ROS 3 3.15E-41
5 SGTC_106 0092-0003 13.10 11.6 µM 1.17E-19 copper-dependent oxidative stress 1 1.55E-39
6 SGTC_2617 dihydrotanshinone i 11.70 20.8 µM 4.14E-16 copper-dependent oxidative stress 3 3.84E-32
7 SGTC_1001 4048-4355 11.70 44.4 µM 4.69E-16 copper-dependent oxidative stress 2 5.00E-32
8 SGTC_2481 5478948 11.20 45.2 µM 6.71E-15 PDR1 1 1.28E-29
9 SGTC_2171 5739187 10.70 198.1 µM 1.15E-13 copper-dependent oxidative stress 2 4.77E-27
10 SGTC_1830 st055982 10.30 50.3 µM 8.99E-13 1 3.45E-25
11 SGTC_134 0269-0018 10.10 6.9 µM 2.20E-12 39 2.22E-24
12 SGTC_754 3474-0146 9.96 171.0 µM 4.74E-12 copper-dependent oxidative stress 1 1.10E-23
13 SGTC_2068 5226020 9.17 147.0 µM 1.93E-10 2 2.46E-20
14 SGTC_236 1509-0011 8.88 5.3 µM 6.82E-10 223 3.42E-19
15 SGTC_2640 pentamidine 8.82 10.4 µM 8.72E-10 mitochondrial processes 3 5.70E-19
16 SGTC_2130 NSC 7 8.53 2.5 µM 2.99E-9 copper-dependent oxidative stress 3 7.40E-18
17 SGTC_2066 5222451 8.24 176.0 µM 9.64E-9 heme biosynthesis & mitochondrial translocase 2 8.45E-17
18 SGTC_2516 gossypol 8.24 71.5 µM 9.92E-9 2 8.96E-17
19 SGTC_1000 4048-0884 8.21 8.7 µM 1.09E-8 copper-dependent oxidative stress 3 1.08E-16
20 SGTC_1126 isoteolin 8.02 1.0 µM 2.29E-8 1 5.11E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.416 1.22E-140 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.405 2.28E-132 YPR124W CTR1 hom High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress
0.339 1.21E-90 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.327 6.71E-84 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.274 7.10E-59 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.193 1.93E-29 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.169 8.15E-23 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.165 6.43E-22 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.163 1.83E-21 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.155 2.03E-19 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.151 1.27E-18 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.148 6.45E-18 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.145 2.59E-17 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.143 8.48E-17 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.142 1.49E-16 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex