YPR124W / CTR1

High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR124W / CTR1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:-4.38|P-value:5.14E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:9.82|P-value:1.35E-12 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.60|P-value:6.50E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:4.85|P-value:3.44E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.23|P-value:1.19E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:8.52|P-value:6.92E-10 ID:SGTC_177|Compound:1327-0068|FD-Score:8.78|P-value:2.13E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.76|P-value:1.89E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.75|P-value:2.53E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:-5.40|P-value:2.94E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:5.74|P-value:2.66E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.16|P-value:1.46E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:-4.57|P-value:3.14E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:9.55|P-value:5.12E-12 ID:SGTC_394|Compound:menadione|FD-Score:6.44|P-value:2.73E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:7.46|P-value:6.17E-8 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.78|P-value:4.10E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-9.39|P-value:2.51E-12 ID:SGTC_513|Compound:4245-1575|FD-Score:5.38|P-value:7.84E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:5.38|P-value:7.85E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:-5.14|P-value:6.41E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:7.48|P-value:5.70E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:4.55|P-value:7.34E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.38|P-value:7.76E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:5.46|P-value:6.25E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.72|P-value:2.09E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:5.01|P-value:2.24E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.90|P-value:5.18E-7 ID:SGTC_670|Compound:4204-0025|FD-Score:7.07|P-value:2.80E-7 ID:SGTC_688|Compound:0527-0193|FD-Score:4.75|P-value:4.40E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:6.06|P-value:9.63E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:7.13|P-value:2.26E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:7.30|P-value:1.18E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:5.96|P-value:1.31E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:5.01|P-value:2.20E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.68|P-value:5.28E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.18|P-value:1.39E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:10.00|P-value:5.14E-13 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.61|P-value:6.30E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.00|P-value:3.60E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.28|P-value:1.03E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.41|P-value:7.24E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:-5.67|P-value:1.24E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:4.71|P-value:4.94E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.53|P-value:5.70E-12 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.11|P-value:1.70E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.94|P-value:2.69E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.26|P-value:1.11E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:7.51|P-value:5.15E-8 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.88|P-value:3.14E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:6.47|P-value:2.46E-6 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.53|P-value:3.46E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:12.30|P-value:5.45E-19 ID:SGTC_1246|Compound:0422-0085|FD-Score:-7.34|P-value:2.88E-8 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.51|P-value:8.08E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-6.27|P-value:1.68E-6 ID:SGTC_1421|Compound:4029-0249|FD-Score:6.70|P-value:1.10E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:5.51|P-value:5.24E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.65|P-value:5.76E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:13.70|P-value:5.93E-23 ID:SGTC_1521|Compound:st012942|FD-Score:-4.33|P-value:5.82E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:5.48|P-value:5.78E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:6.11|P-value:8.18E-6 ID:SGTC_1635|Compound:st007035|FD-Score:6.45|P-value:2.62E-6 ID:SGTC_1762|Compound:st045503|FD-Score:-6.44|P-value:8.94E-7 ID:SGTC_1763|Compound:st044482|FD-Score:8.94|P-value:1.03E-10 ID:SGTC_1771|Compound:st048882|FD-Score:4.95|P-value:2.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.09|P-value:8.01E-8 ID:SGTC_1933|Compound:st074711|FD-Score:4.69|P-value:5.10E-4 ID:SGTC_1950|Compound:st077106|FD-Score:7.82|P-value:1.46E-8 ID:SGTC_2066|Compound:5222451|FD-Score:6.59|P-value:1.62E-6 ID:SGTC_2080|Compound:5212524|FD-Score:5.62|P-value:3.78E-5 ID:SGTC_2090|Compound:5301565|FD-Score:5.54|P-value:4.80E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.67|P-value:2.42E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.83|P-value:3.62E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.07|P-value:1.88E-4 ID:SGTC_2153|Compound:5569715|FD-Score:5.39|P-value:7.68E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.43|P-value:9.45E-7 ID:SGTC_2171|Compound:5739187|FD-Score:11.10|P-value:1.34E-15 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.50|P-value:3.76E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.75|P-value:2.60E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.88|P-value:1.35E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.51|P-value:8.11E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.73|P-value:1.04E-5 ID:SGTC_2462|Compound:5162487|FD-Score:-5.66|P-value:1.28E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:6.93|P-value:4.72E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:10.20|P-value:1.67E-13 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.19|P-value:1.33E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.51|P-value:2.14E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.00|P-value:2.26E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:10.30|P-value:1.20E-13 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.85|P-value:1.45E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.79|P-value:4.01E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.31|P-value:4.24E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-5.14|P-value:6.33E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:10.30|P-value:1.07E-13 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.55|P-value:4.72E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-12.60|P-value:1.56E-20 ID:SGTC_2781|Compound:5567276|FD-Score:13.60|P-value:1.38E-22 ID:SGTC_2916|Compound:7875993|FD-Score:4.61|P-value:6.31E-4 ID:SGTC_2924|Compound:9010168|FD-Score:6.34|P-value:3.78E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-5.10|P-value:7.10E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-6.02|P-value:3.93E-6 ID:SGTC_3175|Compound:9106517|FD-Score:4.54|P-value:7.48E-4 ID:SGTC_3233|Compound:9132340|FD-Score:6.43|P-value:2.82E-6 ID:SGTC_3308|Compound:9128332|FD-Score:4.55|P-value:7.33E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:-4.38|P-value:5.14E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:9.82|P-value:1.35E-12 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.60|P-value:6.50E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:4.85|P-value:3.44E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.23|P-value:1.19E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:8.52|P-value:6.92E-10 ID:SGTC_177|Compound:1327-0068|FD-Score:8.78|P-value:2.13E-10 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.76|P-value:1.89E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.75|P-value:2.53E-5 ID:SGTC_222|Compound:nsc-310342|FD-Score:-5.40|P-value:2.94E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:5.74|P-value:2.66E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:5.16|P-value:1.46E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:-4.57|P-value:3.14E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:9.55|P-value:5.12E-12 ID:SGTC_394|Compound:menadione|FD-Score:6.44|P-value:2.73E-6 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:7.46|P-value:6.17E-8 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.78|P-value:4.10E-4 ID:SGTC_493|Compound:zm226600|FD-Score:-9.39|P-value:2.51E-12 ID:SGTC_513|Compound:4245-1575|FD-Score:5.38|P-value:7.84E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:5.38|P-value:7.85E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:-5.14|P-value:6.41E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:7.48|P-value:5.70E-8 ID:SGTC_577|Compound:r071-0003|FD-Score:4.55|P-value:7.34E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:5.38|P-value:7.76E-5 ID:SGTC_612|Compound:0302-0167|FD-Score:5.46|P-value:6.25E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.72|P-value:2.09E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:5.01|P-value:2.24E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:6.90|P-value:5.18E-7 ID:SGTC_670|Compound:4204-0025|FD-Score:7.07|P-value:2.80E-7 ID:SGTC_688|Compound:0527-0193|FD-Score:4.75|P-value:4.40E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:6.06|P-value:9.63E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:7.13|P-value:2.26E-7 ID:SGTC_778|Compound:3456-2434|FD-Score:7.30|P-value:1.18E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:5.96|P-value:1.31E-5 ID:SGTC_948|Compound:3448-0295|FD-Score:5.01|P-value:2.20E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:4.68|P-value:5.28E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:5.18|P-value:1.39E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:10.00|P-value:5.14E-13 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.61|P-value:6.30E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:7.00|P-value:3.60E-7 ID:SGTC_1036|Compound:k216-0215|FD-Score:5.28|P-value:1.03E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:5.41|P-value:7.24E-5 ID:SGTC_1063|Compound:disulfiram|FD-Score:-5.67|P-value:1.24E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:4.71|P-value:4.94E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:9.53|P-value:5.70E-12 ID:SGTC_1105|Compound:epirubicin|FD-Score:5.11|P-value:1.70E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.94|P-value:2.69E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.26|P-value:1.11E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:7.51|P-value:5.15E-8 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.88|P-value:3.14E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:6.47|P-value:2.46E-6 ID:SGTC_1214|Compound:0358-0031|FD-Score:-4.53|P-value:3.46E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:12.30|P-value:5.45E-19 ID:SGTC_1246|Compound:0422-0085|FD-Score:-7.34|P-value:2.88E-8 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.51|P-value:8.08E-4 ID:SGTC_1298|Compound:1079-1278|FD-Score:-6.27|P-value:1.68E-6 ID:SGTC_1421|Compound:4029-0249|FD-Score:6.70|P-value:1.10E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:5.51|P-value:5.24E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.65|P-value:5.76E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:13.70|P-value:5.93E-23 ID:SGTC_1521|Compound:st012942|FD-Score:-4.33|P-value:5.82E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:5.48|P-value:5.78E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:6.11|P-value:8.18E-6 ID:SGTC_1635|Compound:st007035|FD-Score:6.45|P-value:2.62E-6 ID:SGTC_1762|Compound:st045503|FD-Score:-6.44|P-value:8.94E-7 ID:SGTC_1763|Compound:st044482|FD-Score:8.94|P-value:1.03E-10 ID:SGTC_1771|Compound:st048882|FD-Score:4.95|P-value:2.61E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-7.09|P-value:8.01E-8 ID:SGTC_1933|Compound:st074711|FD-Score:4.69|P-value:5.10E-4 ID:SGTC_1950|Compound:st077106|FD-Score:7.82|P-value:1.46E-8 ID:SGTC_2066|Compound:5222451|FD-Score:6.59|P-value:1.62E-6 ID:SGTC_2080|Compound:5212524|FD-Score:5.62|P-value:3.78E-5 ID:SGTC_2090|Compound:5301565|FD-Score:5.54|P-value:4.80E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.67|P-value:2.42E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.83|P-value:3.62E-4 ID:SGTC_2149|Compound:5554786|FD-Score:5.07|P-value:1.88E-4 ID:SGTC_2153|Compound:5569715|FD-Score:5.39|P-value:7.68E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-6.43|P-value:9.45E-7 ID:SGTC_2171|Compound:5739187|FD-Score:11.10|P-value:1.34E-15 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.50|P-value:3.76E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.75|P-value:2.60E-5 ID:SGTC_2271|Compound:7849410|FD-Score:-4.88|P-value:1.35E-4 ID:SGTC_2275|Compound:7947463|FD-Score:4.51|P-value:8.11E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.73|P-value:1.04E-5 ID:SGTC_2462|Compound:5162487|FD-Score:-5.66|P-value:1.28E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:6.93|P-value:4.72E-7 ID:SGTC_2575|Compound:plumbagin|FD-Score:10.20|P-value:1.67E-13 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.19|P-value:1.33E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.51|P-value:2.14E-6 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.00|P-value:2.26E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:10.30|P-value:1.20E-13 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.85|P-value:1.45E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.79|P-value:4.01E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.31|P-value:4.24E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-5.14|P-value:6.33E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:10.30|P-value:1.07E-13 ID:SGTC_2757|Compound:clomiphene|FD-Score:5.55|P-value:4.72E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:-12.60|P-value:1.56E-20 ID:SGTC_2781|Compound:5567276|FD-Score:13.60|P-value:1.38E-22 ID:SGTC_2916|Compound:7875993|FD-Score:4.61|P-value:6.31E-4 ID:SGTC_2924|Compound:9010168|FD-Score:6.34|P-value:3.78E-6 ID:SGTC_2928|Compound:9011484|FD-Score:-5.10|P-value:7.10E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-6.02|P-value:3.93E-6 ID:SGTC_3175|Compound:9106517|FD-Score:4.54|P-value:7.48E-4 ID:SGTC_3233|Compound:9132340|FD-Score:6.43|P-value:2.82E-6 ID:SGTC_3308|Compound:9128332|FD-Score:4.55|P-value:7.33E-4

Top fitness defect scores for YPR124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1450 4112-4260 13.70 37.6 µM 5.93E-23 calcium & mitochondrial duress 3 5.91E-43
2 SGTC_2781 5567276 13.60 71.4 µM 1.38E-22 2 3.01E-42
3 SGTC_1239 0337-0584 12.30 35.4 µM 5.45E-19 unfolded protein response 7 2.45E-35
4 SGTC_2171 5739187 11.10 198.1 µM 1.34E-15 copper-dependent oxidative stress 1 8.10E-29
5 SGTC_2756 carbadox 10.30 75.1 µM 1.07E-13 5 3.62E-25
6 SGTC_2617 dihydrotanshinone i 10.30 20.8 µM 1.20E-13 copper-dependent oxidative stress 4 4.58E-25
7 SGTC_2575 plumbagin 10.20 510.0 nM 1.67E-13 superoxide 5 8.59E-25
8 SGTC_1001 4048-4355 10.00 44.4 µM 5.14E-13 copper-dependent oxidative stress 3 7.44E-24
9 SGTC_100 0086-0128 9.82 49.6 µM 1.35E-12 copper-dependent oxidative stress 8 4.75E-23
10 SGTC_362 0310-0100 9.55 9.0 µM 5.12E-12 RPP1 & pyrimidine depletion 1 6.18E-22
11 SGTC_1083 didemethylchlorpromazine sulfoxide 9.53 707.4 nM 5.70E-12 redox potentiating 7 7.59E-22
12 SGTC_1763 st044482 8.94 94.5 µM 1.03E-10 copper-dependent oxidative stress 2 1.96E-19
13 SGTC_177 1327-0068 8.78 8.4 µM 2.13E-10 12 8.00E-19
14 SGTC_156 3474-0145 8.52 5.6 µM 6.92E-10 endomembrane recycling 9 7.66E-18
15 SGTC_1950 st077106 7.82 7.2 µM 1.46E-8 RNA processing & uracil transport 4 2.69E-15
16 SGTC_1170 0310-0127 7.51 64.8 µM 5.15E-8 1 3.01E-14
17 SGTC_575 k072-0246 7.48 11.9 µM 5.70E-8 5 3.66E-14
18 SGTC_402 epigallocatechin gallate 7.46 10.0 µM 6.17E-8 1 4.26E-14
19 SGTC_778 3456-2434 7.30 196.0 µM 1.18E-7 mitochondrial response to ROS 13 1.48E-13
20 SGTC_740 k014-0057 7.13 261.0 µM 2.26E-7 2 5.13E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.422 5.70E-145 YMR021C MAC1 hom Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
0.405 2.28E-132 YPR123C_d YPR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
0.313 6.20E-77 YMR038C CCS1 hom Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress
0.298 5.24E-70 YGL167C PMR1 hom High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
0.266 1.59E-55 YJR104C SOD1 hom Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
0.220 7.33E-38 YMR073C IRC21 hom Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study
0.180 7.22E-26 YHR008C SOD2 hom Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
0.173 5.03E-24 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.136 3.24E-15 YOR209C NPT1 hom Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus
0.131 2.54E-14 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.120 3.10E-12 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.117 1.01E-11 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.115 2.49E-11 YNL241C ZWF1 hom Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress
0.108 3.07E-10 YJL120W_d YJL120W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
0.107 5.19E-10 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome