YPR126C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR126C / YPR126C

Click on Significant Values for Screen Details ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.54|P-value:2.21E-4 ID:SGTC_482|Compound:fipronil|FD-Score:-3.28|P-value:5.60E-4 ID:SGTC_490|Compound:phenamil|FD-Score:3.93|P-value:4.75E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.25|P-value:6.26E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.16|P-value:1.80E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:7.28|P-value:2.57E-13 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.78|P-value:8.65E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.33|P-value:4.75E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.22|P-value:6.87E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.96|P-value:4.30E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.16|P-value:4.93E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.47|P-value:2.79E-8 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.30|P-value:5.33E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.69|P-value:1.25E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.94|P-value:4.54E-5 ID:SGTC_2487|Compound:5918373|FD-Score:4.22|P-value:1.43E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.61|P-value:1.31E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.22|P-value:1.43E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.47|P-value:4.59E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.24|P-value:6.48E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.41|P-value:3.57E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.15|P-value:8.79E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.15|P-value:8.75E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.62|P-value:1.62E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.20|P-value:7.37E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.56|P-value:2.06E-4 ID:SGTC_3224|Compound:9130643|FD-Score:11.50|P-value:1.32E-30 ID:SGTC_3307|Compound:9126885|FD-Score:-3.23|P-value:6.79E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-5.92|P-value:2.15E-9 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:3.54|P-value:2.21E-4 ID:SGTC_482|Compound:fipronil|FD-Score:-3.28|P-value:5.60E-4 ID:SGTC_490|Compound:phenamil|FD-Score:3.93|P-value:4.75E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:3.25|P-value:6.26E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:4.16|P-value:1.80E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:7.28|P-value:2.57E-13 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.78|P-value:8.65E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.33|P-value:4.75E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:-3.22|P-value:6.87E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.96|P-value:4.30E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.16|P-value:4.93E-10 ID:SGTC_1463|Compound:k081-0032|FD-Score:-5.47|P-value:2.79E-8 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.30|P-value:5.33E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.69|P-value:1.25E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.94|P-value:4.54E-5 ID:SGTC_2487|Compound:5918373|FD-Score:4.22|P-value:1.43E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-5.61|P-value:1.31E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-4.22|P-value:1.43E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.47|P-value:4.59E-6 ID:SGTC_2646|Compound:retinol|FD-Score:3.24|P-value:6.48E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.41|P-value:3.57E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.15|P-value:8.79E-4 ID:SGTC_2840|Compound:9008771|FD-Score:3.15|P-value:8.75E-4 ID:SGTC_3044|Compound:9093193|FD-Score:-3.29|P-value:5.41E-4 ID:SGTC_3067|Compound:9117431|FD-Score:3.62|P-value:1.62E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.20|P-value:7.37E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-3.56|P-value:2.06E-4 ID:SGTC_3224|Compound:9130643|FD-Score:11.50|P-value:1.32E-30 ID:SGTC_3307|Compound:9126885|FD-Score:-3.23|P-value:6.79E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-5.92|P-value:2.15E-9

Top fitness defect scores for YPR126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3224 9130643 11.50 49.5 µM 1.32E-30 RPP1 & pyrimidine depletion 1 4.72E-31
2 SGTC_669 0108-0021 7.28 26.2 µM 2.57E-13 fatty acid desaturase (OLE1) 18 1.70E-13
3 SGTC_2487 5918373 4.22 44.0 µM 1.43E-5 10 1.24E-5
4 SGTC_650 1328-0195 4.16 38.0 µM 1.80E-5 14 1.56E-5
5 SGTC_1160 4092-0570 3.96 10.5 µM 4.30E-5 plasma membrane duress 39 3.78E-5
6 SGTC_490 phenamil 3.93 164.0 µM 4.75E-5 heme requiring 11 4.19E-5
7 SGTC_2006 4011487 3.69 200.0 µM 1.25E-4 endomembrane recycling 90 1.11E-4
8 SGTC_3067 9117431 3.62 49.5 µM 1.62E-4 21 1.45E-4
9 SGTC_475 α-linolenic acid 3.54 10.0 µM 2.21E-4 excess fatty acid 30 1.99E-4
10 SGTC_2711 st079103 3.41 59.1 µM 3.57E-4 15 3.24E-4
11 SGTC_875 0709-0210 3.33 25.7 µM 4.75E-4 fatty acid desaturase (OLE1) 54 4.33E-4
12 SGTC_1546 5-methoxyflavanone 3.30 78.7 µM 5.33E-4 26 4.87E-4
13 SGTC_511 blebbistatin 3.25 171.0 µM 6.26E-4 DNA intercalators 36 5.73E-4
14 SGTC_2646 retinol 3.24 96.8 µM 6.48E-4 34 5.94E-4
15 SGTC_3213 9129884 3.20 49.5 µM 7.37E-4 42 6.77E-4
16 SGTC_2840 9008771 3.15 71.4 µM 8.75E-4 26 8.05E-4
17 SGTC_1043 0916-0009 3.11 19.3 µM 0.00102 60 9.45E-4
18 SGTC_295 k015-0027 3.05 31.0 µM 0.00122 PDR1 37 0.00113
19 SGTC_2678 equilin 3.01 100.0 µM 0.00142 58 0.00131
20 SGTC_874 0599-0792 2.98 117.0 µM 0.00155 81 0.00143

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 6.13E-39 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.220 6.45E-38 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.219 2.12E-37 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.218 6.62E-37 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.208 4.59E-34 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.203 2.16E-32 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.192 4.50E-29 YDR459C PFA5 hom Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain
0.191 9.61E-29 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.188 6.94E-28 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.185 4.62E-27 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.184 5.79E-27 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.176 1.60E-24 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.171 3.28E-23 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.170 4.04E-23 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.170 4.85E-23 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension