YPR127W

Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR127W / YPR127W

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.41|P-value:2.58E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.34|P-value:4.19E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.88|P-value:3.45E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.54|P-value:1.39E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:6.80|P-value:1.61E-12 ID:SGTC_355|Compound:1311-2252|FD-Score:-5.17|P-value:6.87E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:4.10|P-value:1.29E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.05|P-value:8.71E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:-5.06|P-value:1.26E-7 ID:SGTC_647|Compound:0140-0236|FD-Score:3.80|P-value:4.81E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.40|P-value:2.41E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.13|P-value:6.45E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.99|P-value:2.13E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.08|P-value:7.76E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.79|P-value:4.95E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:6.80|P-value:1.57E-12 ID:SGTC_854|Compound:0422-0053|FD-Score:3.23|P-value:4.43E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.76|P-value:5.62E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.53|P-value:1.45E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.16|P-value:5.74E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.53|P-value:1.66E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.28|P-value:4.19E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.26|P-value:4.10E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.50|P-value:1.59E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:6.38|P-value:3.10E-11 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.78|P-value:5.20E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.25|P-value:6.39E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.02|P-value:9.63E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.45|P-value:2.50E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.42|P-value:2.23E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.27|P-value:3.84E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.16|P-value:9.70E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.64|P-value:9.14E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.11|P-value:6.97E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.20|P-value:5.00E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-4.25|P-value:7.55E-6 ID:SGTC_1771|Compound:st048882|FD-Score:-3.67|P-value:9.30E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.51|P-value:1.79E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.24|P-value:4.97E-4 ID:SGTC_1947|Compound:st076332|FD-Score:6.90|P-value:7.77E-13 ID:SGTC_2051|Compound:5263410|FD-Score:-3.10|P-value:8.05E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.84|P-value:3.39E-7 ID:SGTC_2111|Compound:5486399|FD-Score:3.18|P-value:5.42E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.77|P-value:5.41E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.26|P-value:4.01E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.15|P-value:6.84E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.19|P-value:8.36E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.36|P-value:3.75E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.02|P-value:9.52E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.27|P-value:3.16E-8 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.45|P-value:1.96E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.30|P-value:3.43E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-6.33|P-value:5.29E-11 ID:SGTC_2841|Compound:9004761|FD-Score:3.14|P-value:6.27E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.77|P-value:4.91E-7 ID:SGTC_3058|Compound:9093861|FD-Score:3.09|P-value:7.49E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.69|P-value:7.56E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.19|P-value:5.28E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.21|P-value:4.84E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.41|P-value:2.58E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:4.34|P-value:4.19E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.88|P-value:3.45E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.54|P-value:1.39E-4 ID:SGTC_285|Compound:1486-1325|FD-Score:6.80|P-value:1.61E-12 ID:SGTC_355|Compound:1311-2252|FD-Score:-5.17|P-value:6.87E-8 ID:SGTC_361|Compound:000s-0510|FD-Score:4.10|P-value:1.29E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:4.14|P-value:1.06E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:3.05|P-value:8.49E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.37|P-value:2.69E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.05|P-value:8.71E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:-5.06|P-value:1.26E-7 ID:SGTC_647|Compound:0140-0236|FD-Score:3.80|P-value:4.81E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.40|P-value:2.41E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:3.54|P-value:1.40E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.13|P-value:6.45E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.99|P-value:2.13E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:3.08|P-value:7.76E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.79|P-value:4.95E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:6.80|P-value:1.57E-12 ID:SGTC_854|Compound:0422-0053|FD-Score:3.23|P-value:4.43E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.59|P-value:1.13E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:3.76|P-value:5.62E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.48|P-value:1.75E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:3.26|P-value:4.00E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.53|P-value:1.45E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.16|P-value:5.74E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:4.53|P-value:1.66E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:3.57|P-value:1.20E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-3.28|P-value:4.19E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.26|P-value:4.10E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.53|P-value:1.42E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.50|P-value:1.59E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:6.38|P-value:3.10E-11 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.78|P-value:5.20E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.25|P-value:6.39E-6 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.02|P-value:9.63E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.45|P-value:2.50E-6 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.42|P-value:2.23E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:3.27|P-value:3.84E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.16|P-value:9.70E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.64|P-value:9.14E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.11|P-value:6.97E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.20|P-value:5.00E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-4.25|P-value:7.55E-6 ID:SGTC_1771|Compound:st048882|FD-Score:-3.67|P-value:9.30E-5 ID:SGTC_1812|Compound:st052057|FD-Score:-3.51|P-value:1.79E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.24|P-value:4.97E-4 ID:SGTC_1947|Compound:st076332|FD-Score:6.90|P-value:7.77E-13 ID:SGTC_2051|Compound:5263410|FD-Score:-3.10|P-value:8.05E-4 ID:SGTC_2052|Compound:5265182|FD-Score:4.84|P-value:3.39E-7 ID:SGTC_2111|Compound:5486399|FD-Score:3.18|P-value:5.42E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.77|P-value:5.41E-5 ID:SGTC_2147|Compound:5545932|FD-Score:3.26|P-value:4.01E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.15|P-value:6.84E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.19|P-value:8.36E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.60|P-value:1.09E-4 ID:SGTC_2498|Compound:4'-Methoxychalcone|FD-Score:4.36|P-value:3.75E-6 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.02|P-value:9.52E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.27|P-value:3.16E-8 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.45|P-value:1.96E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.30|P-value:3.43E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-6.33|P-value:5.29E-11 ID:SGTC_2841|Compound:9004761|FD-Score:3.14|P-value:6.27E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.77|P-value:4.91E-7 ID:SGTC_3058|Compound:9093861|FD-Score:3.09|P-value:7.49E-4 ID:SGTC_3185|Compound:9108267|FD-Score:3.69|P-value:7.56E-5 ID:SGTC_3187|Compound:9109394|FD-Score:3.19|P-value:5.28E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.21|P-value:4.84E-4

Top fitness defect scores for YPR127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1947 st076332 6.90 61.6 µM 7.77E-13 1 2.63E-12
2 SGTC_843 0310-0051 6.80 143.0 µM 1.57E-12 2 5.14E-12
3 SGTC_285 1486-1325 6.80 46.0 µM 1.61E-12 7 5.27E-12
4 SGTC_1272 0839-0021 6.38 27.0 µM 3.10E-11 4 8.91E-11
5 SGTC_2507 purpurin 5.27 79.7 µM 3.16E-8 copper-dependent oxidative stress 17 6.67E-8
6 SGTC_2052 5265182 4.84 7.1 µM 3.39E-7 12 6.43E-7
7 SGTC_2931 9014674 4.77 55.7 µM 4.91E-7 8 9.15E-7
8 SGTC_1016 4226-1401 4.53 38.0 µM 1.66E-6 RNA pol III & RNase P/MRP 10 2.92E-6
9 SGTC_1408 3909-7976 4.45 48.8 µM 2.50E-6 Golgi 13 4.34E-6
10 SGTC_2498 4'-Methoxychalcone 4.36 54.6 µM 3.75E-6 RPP1 & pyrimidine depletion 25 6.38E-6
11 SGTC_150 3970-0969 4.34 77.2 µM 4.19E-6 48 7.09E-6
12 SGTC_1390 3413-2614 4.25 145.0 µM 6.39E-6 fatty acid desaturase (OLE1) 19 1.06E-5
13 SGTC_2339 9000433 4.19 200.0 µM 8.36E-6 31 1.37E-5
14 SGTC_1439 4092-1168 4.16 46.0 µM 9.70E-6 7 1.58E-5
15 SGTC_410 α-linolenic acid 4.14 100.0 µM 1.06E-5 excess fatty acid 32 1.72E-5
16 SGTC_361 000s-0510 4.10 1.4 µM 1.29E-5 29 2.08E-5
17 SGTC_778 3456-2434 3.99 196.0 µM 2.13E-5 mitochondrial response to ROS 72 3.36E-5
18 SGTC_230 MPP+ 3.88 141.7 µM 3.45E-5 16 5.31E-5
19 SGTC_647 0140-0236 3.80 81.0 µM 4.81E-5 9 7.30E-5
20 SGTC_810 3825-7150 3.79 143.0 µM 4.95E-5 60S ribosome export 13 7.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.25E-8 YGL056C SDS23 hom One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; SDS23 has a paralog, SDS24, that arose from the whole genome duplication
0.078 6.17E-6 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.073 2.23E-5 YLR363C NMD4 hom Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.073 2.60E-5 YMR295C YMR295C hom Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress
0.072 2.80E-5 YBR257W POP4 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P
0.071 3.77E-5 YIL047C SYG1 hom Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
0.071 4.12E-5 YIR027C DAL1 hom Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
0.071 4.16E-5 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.066 1.38E-4 YNL334C SNO2 hom Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin
0.065 1.54E-4 YOR354C MSC6 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.064 1.89E-4 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.064 2.10E-4 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.063 2.57E-4 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.063 2.71E-4 YHR031C RRM3 hom DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
0.063 2.81E-4 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects