YPR128C / ANT1

Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR128C / ANT1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:3.94|P-value:8.01E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.40|P-value:1.30E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.32|P-value:7.38E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.51|P-value:4.58E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.02|P-value:5.92E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:4.06|P-value:5.20E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:-4.69|P-value:4.56E-6 ID:SGTC_776|Compound:4476-4378|FD-Score:4.85|P-value:1.78E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.31|P-value:1.90E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.86|P-value:1.09E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:5.67|P-value:3.04E-8 ID:SGTC_801|Compound:0866-0028|FD-Score:5.04|P-value:7.25E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.02|P-value:7.11E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.25|P-value:9.19E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.94|P-value:9.79E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.54|P-value:4.05E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.48|P-value:4.99E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.28|P-value:8.37E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.69|P-value:2.04E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.91|P-value:9.05E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.51|P-value:3.82E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.61|P-value:2.70E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.31|P-value:7.69E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.39|P-value:1.34E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.25|P-value:2.37E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.41|P-value:5.40E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.56|P-value:3.24E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.63|P-value:2.54E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.90|P-value:1.42E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.55|P-value:3.35E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.43|P-value:5.92E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.97|P-value:5.94E-9 ID:SGTC_1714|Compound:st033236|FD-Score:3.52|P-value:3.75E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.25|P-value:2.58E-7 ID:SGTC_1725|Compound:st036284|FD-Score:4.99|P-value:9.18E-7 ID:SGTC_1731|Compound:st035964|FD-Score:3.93|P-value:8.32E-5 ID:SGTC_1736|Compound:st036774|FD-Score:7.04|P-value:8.88E-12 ID:SGTC_1740|Compound:st038286|FD-Score:5.50|P-value:7.24E-8 ID:SGTC_1952|Compound:st077036|FD-Score:3.57|P-value:3.18E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-4.29|P-value:2.40E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-3.65|P-value:2.78E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.30|P-value:9.14E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:5.81|P-value:1.42E-8 ID:SGTC_2345|Compound:9052315|FD-Score:6.90|P-value:2.22E-11 ID:SGTC_2390|Compound:9097792|FD-Score:3.83|P-value:1.24E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.47|P-value:5.15E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.45|P-value:4.73E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.62|P-value:2.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.25|P-value:9.11E-4 ID:SGTC_2961|Compound:9083290|FD-Score:4.40|P-value:1.26E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.39|P-value:5.82E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.54|P-value:4.02E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.33|P-value:7.22E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.99|P-value:6.79E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.29|P-value:8.23E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.49|P-value:4.19E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.25|P-value:9.38E-4 ID:SGTC_3306|Compound:9127676|FD-Score:4.01|P-value:6.18E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:3.94|P-value:8.01E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:4.40|P-value:1.30E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:3.32|P-value:7.38E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.51|P-value:4.58E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.02|P-value:5.92E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:4.06|P-value:5.20E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:-4.69|P-value:4.56E-6 ID:SGTC_776|Compound:4476-4378|FD-Score:4.85|P-value:1.78E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:4.31|P-value:1.90E-5 ID:SGTC_786|Compound:4544-0069|FD-Score:3.86|P-value:1.09E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:5.67|P-value:3.04E-8 ID:SGTC_801|Compound:0866-0028|FD-Score:5.04|P-value:7.25E-7 ID:SGTC_823|Compound:0417-1665|FD-Score:-4.02|P-value:7.11E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:3.25|P-value:9.19E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.94|P-value:9.79E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.54|P-value:4.05E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.48|P-value:4.99E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.28|P-value:8.37E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.69|P-value:2.04E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.91|P-value:9.05E-5 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.51|P-value:3.82E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.61|P-value:2.70E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:3.31|P-value:7.69E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.39|P-value:1.34E-5 ID:SGTC_1195|Compound:1502-0147|FD-Score:4.25|P-value:2.37E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.41|P-value:5.40E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:3.56|P-value:3.24E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.63|P-value:2.54E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:4.90|P-value:1.42E-6 ID:SGTC_1446|Compound:4239-0190|FD-Score:3.55|P-value:3.35E-4 ID:SGTC_1591|Compound:genipin|FD-Score:-3.43|P-value:5.92E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.97|P-value:5.94E-9 ID:SGTC_1714|Compound:st033236|FD-Score:3.52|P-value:3.75E-4 ID:SGTC_1720|Compound:st037298|FD-Score:5.25|P-value:2.58E-7 ID:SGTC_1725|Compound:st036284|FD-Score:4.99|P-value:9.18E-7 ID:SGTC_1731|Compound:st035964|FD-Score:3.93|P-value:8.32E-5 ID:SGTC_1736|Compound:st036774|FD-Score:7.04|P-value:8.88E-12 ID:SGTC_1740|Compound:st038286|FD-Score:5.50|P-value:7.24E-8 ID:SGTC_1952|Compound:st077036|FD-Score:3.57|P-value:3.18E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-4.29|P-value:2.40E-5 ID:SGTC_2088|Compound:5278280|FD-Score:-3.65|P-value:2.78E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.30|P-value:9.14E-4 ID:SGTC_2236|Compound:dapsone|FD-Score:5.81|P-value:1.42E-8 ID:SGTC_2345|Compound:9052315|FD-Score:6.90|P-value:2.22E-11 ID:SGTC_2390|Compound:9097792|FD-Score:3.83|P-value:1.24E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.47|P-value:5.15E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.45|P-value:4.73E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_2744|Compound:captopril|FD-Score:3.62|P-value:2.68E-4 ID:SGTC_2936|Compound:9038235|FD-Score:3.25|P-value:9.11E-4 ID:SGTC_2961|Compound:9083290|FD-Score:4.40|P-value:1.26E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.39|P-value:5.82E-4 ID:SGTC_3139|Compound:9095020|FD-Score:-3.54|P-value:4.02E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.33|P-value:7.22E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.99|P-value:6.79E-5 ID:SGTC_3249|Compound:9135183|FD-Score:3.29|P-value:8.23E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.49|P-value:4.19E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.25|P-value:9.38E-4 ID:SGTC_3306|Compound:9127676|FD-Score:4.01|P-value:6.18E-5

Top fitness defect scores for YPR128C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1736 st036774 7.04 51.0 µM 8.88E-12 3 9.38E-13
2 SGTC_2345 9052315 6.90 157.4 µM 2.22E-11 3 2.57E-12
3 SGTC_1713 st033146 5.97 12.8 µM 5.94E-9 4 1.19E-9
4 SGTC_2236 dapsone 5.81 200.0 µM 1.42E-8 1 3.09E-9
5 SGTC_790 1575-0012 5.67 79.1 µM 3.04E-8 TSC3-RPN4 6 7.13E-9
6 SGTC_1740 st038286 5.50 13.2 µM 7.24E-8 5 1.85E-8
7 SGTC_1720 st037298 5.25 9.5 µM 2.58E-7 18 7.46E-8
8 SGTC_801 0866-0028 5.04 10.1 µM 7.25E-7 10 2.31E-7
9 SGTC_1725 st036284 4.99 20.6 µM 9.18E-7 13 3.00E-7
10 SGTC_1389 3405-0187 4.90 19.0 µM 1.42E-6 7 4.84E-7
11 SGTC_776 4476-4378 4.85 112.0 µM 1.78E-6 ERG2 12 6.20E-7
12 SGTC_2961 9083290 4.40 32.5 µM 1.26E-5 12 5.29E-6
13 SGTC_402 epigallocatechin gallate 4.40 10.0 µM 1.30E-5 15 5.47E-6
14 SGTC_1165 k072-0275 4.39 30.3 µM 1.34E-5 30 5.65E-6
15 SGTC_778 3456-2434 4.31 196.0 µM 1.90E-5 mitochondrial response to ROS 64 8.28E-6
16 SGTC_1195 1502-0147 4.25 41.1 µM 2.37E-5 16 1.05E-5
17 SGTC_524 r073-0010 4.06 27.8 µM 5.20E-5 47 2.49E-5
18 SGTC_523 1934-0222 4.02 13.7 µM 5.92E-5 30 2.87E-5
19 SGTC_3306 9127676 4.01 59.8 µM 6.18E-5 20 3.01E-5
20 SGTC_3246 9135460 3.99 33.0 µM 6.79E-5 5 3.34E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.103 2.60E-9 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.094 5.00E-8 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.091 1.23E-7 YOR379C_d YOR379C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W
0.091 1.40E-7 YMR172C-A_d YMR172C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.085 8.52E-7 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.084 1.08E-6 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.082 2.01E-6 YOR180C DCI1 hom Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed
0.078 6.09E-6 YPL071C_p YPL071C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.078 6.64E-6 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.075 1.31E-5 YPL070W MUK1 hom Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
0.073 2.51E-5 YPR028W YOP1 hom Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; forms ER foci upon DNA replication stress
0.070 4.61E-5 YJL044C GYP6 hom GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport
0.070 4.83E-5 YOR263C_d YOR263C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
0.069 5.67E-5 YNL154C YCK2 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
0.068 8.70E-5 YGR059W SPR3 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI