YPR129W / SCD6

Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR129W / SCD6

Click on Significant Values for Screen Details ID:SGTC_27|Compound:0485-0001|FD-Score:-4.11|P-value:9.22E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.03|P-value:1.34E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.66|P-value:4.78E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.92|P-value:3.92E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.71|P-value:4.09E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.87|P-value:2.38E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.60|P-value:5.27E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.60|P-value:5.76E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.85|P-value:2.49E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.61|P-value:5.57E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.67|P-value:4.25E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-6.71|P-value:5.63E-10 ID:SGTC_1348|Compound:1493-0373|FD-Score:5.16|P-value:1.57E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.72|P-value:3.95E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.44|P-value:9.42E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:6.04|P-value:2.35E-8 ID:SGTC_1489|Compound:4065-0444|FD-Score:-3.44|P-value:8.69E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.52|P-value:6.87E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-4.15|P-value:8.05E-5 ID:SGTC_1658|Compound:st012944|FD-Score:4.12|P-value:9.83E-5 ID:SGTC_1669|Compound:st015249|FD-Score:3.72|P-value:3.89E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.72|P-value:3.55E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.46|P-value:8.14E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.66|P-value:1.12E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.05|P-value:1.27E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.57|P-value:6.31E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.52|P-value:2.22E-5 ID:SGTC_2193|Compound:5925765|FD-Score:5.78|P-value:8.45E-8 ID:SGTC_2349|Compound:9023730|FD-Score:3.50|P-value:7.99E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.62|P-value:5.40E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.43|P-value:9.78E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.18|P-value:1.41E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.26|P-value:7.62E-9 ID:SGTC_2693|Compound:st077581|FD-Score:-3.47|P-value:7.88E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.37|P-value:3.93E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.13|P-value:9.62E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.92|P-value:2.02E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.96|P-value:1.74E-4 ID:SGTC_2882|Compound:9058044|FD-Score:8.24|P-value:4.56E-14 ID:SGTC_2885|Compound:9057732|FD-Score:6.31|P-value:5.84E-9 ID:SGTC_2926|Compound:9010726|FD-Score:5.63|P-value:1.77E-7 ID:SGTC_3123|Compound:9126162|FD-Score:3.64|P-value:5.10E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.29|P-value:8.78E-7 ID:SGTC_3308|Compound:9128332|FD-Score:3.65|P-value:4.88E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-4.11|P-value:9.22E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:4.03|P-value:1.34E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.66|P-value:4.78E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.92|P-value:3.92E-6 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.71|P-value:4.09E-4 ID:SGTC_444|Compound:curcumin|FD-Score:3.87|P-value:2.38E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.60|P-value:5.27E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.60|P-value:5.76E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:3.85|P-value:2.49E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:3.61|P-value:5.57E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:-3.67|P-value:4.25E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:-6.71|P-value:5.63E-10 ID:SGTC_1348|Compound:1493-0373|FD-Score:5.16|P-value:1.57E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.72|P-value:3.95E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.44|P-value:9.42E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:6.04|P-value:2.35E-8 ID:SGTC_1489|Compound:4065-0444|FD-Score:-3.44|P-value:8.69E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.52|P-value:6.87E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-4.15|P-value:8.05E-5 ID:SGTC_1658|Compound:st012944|FD-Score:4.12|P-value:9.83E-5 ID:SGTC_1669|Compound:st015249|FD-Score:3.72|P-value:3.89E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.72|P-value:3.55E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.46|P-value:8.14E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.66|P-value:1.12E-5 ID:SGTC_1959|Compound:st077091|FD-Score:4.05|P-value:1.27E-4 ID:SGTC_2001|Compound:4023502|FD-Score:3.57|P-value:6.31E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.52|P-value:2.22E-5 ID:SGTC_2193|Compound:5925765|FD-Score:5.78|P-value:8.45E-8 ID:SGTC_2349|Compound:9023730|FD-Score:3.50|P-value:7.99E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.62|P-value:5.40E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.43|P-value:9.78E-4 ID:SGTC_2428|Compound:5615643|FD-Score:5.18|P-value:1.41E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.26|P-value:7.62E-9 ID:SGTC_2693|Compound:st077581|FD-Score:-3.47|P-value:7.88E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.37|P-value:3.93E-5 ID:SGTC_2831|Compound:7999036|FD-Score:4.13|P-value:9.62E-5 ID:SGTC_2856|Compound:9022925|FD-Score:3.92|P-value:2.02E-4 ID:SGTC_2881|Compound:9058953|FD-Score:3.96|P-value:1.74E-4 ID:SGTC_2882|Compound:9058044|FD-Score:8.24|P-value:4.56E-14 ID:SGTC_2885|Compound:9057732|FD-Score:6.31|P-value:5.84E-9 ID:SGTC_2926|Compound:9010726|FD-Score:5.63|P-value:1.77E-7 ID:SGTC_3123|Compound:9126162|FD-Score:3.64|P-value:5.10E-4 ID:SGTC_3188|Compound:9110789|FD-Score:5.29|P-value:8.78E-7 ID:SGTC_3308|Compound:9128332|FD-Score:3.65|P-value:4.88E-4

Top fitness defect scores for YPR129W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2882 9058044 8.24 58.4 µM 4.56E-14 1 8.94E-17
2 SGTC_2885 9057732 6.31 52.0 µM 5.84E-9 2 1.43E-10
3 SGTC_2583 asiatic acid 6.26 100.0 µM 7.62E-9 11 1.98E-10
4 SGTC_1467 k284-1082 6.04 293.0 µM 2.35E-8 2 7.74E-10
5 SGTC_2193 5925765 5.78 200.0 µM 8.45E-8 1 3.66E-9
6 SGTC_2926 9010726 5.63 65.2 µM 1.77E-7 8 8.96E-9
7 SGTC_3188 9110789 5.29 49.5 µM 8.78E-7 iron homeostasis 7 6.25E-8
8 SGTC_2428 5615643 5.18 7.8 µM 1.41E-6 16 1.11E-7
9 SGTC_1348 1493-0373 5.16 93.8 µM 1.57E-6 6 1.26E-7
10 SGTC_2010 4012422 4.52 159.0 µM 2.22E-5 11 3.13E-6
11 SGTC_2829 7992743 4.37 58.4 µM 3.93E-5 28 6.23E-6
12 SGTC_2831 7999036 4.13 19.5 µM 9.62E-5 38 1.84E-5
13 SGTC_1658 st012944 4.12 20.0 µM 9.83E-5 iron homeostasis 72 1.89E-5
14 SGTC_1959 st077091 4.05 55.8 µM 1.27E-4 RPP1 & pyrimidine depletion 45 2.57E-5
15 SGTC_166 k072-0058 4.03 166.4 µM 1.34E-4 DNA intercalators 32 2.75E-5
16 SGTC_2881 9058953 3.96 52.0 µM 1.74E-4 18 3.76E-5
17 SGTC_2856 9022925 3.92 19.5 µM 2.02E-4 19 4.51E-5
18 SGTC_444 curcumin 3.87 90.4 µM 2.38E-4 iron homeostasis 29 5.51E-5
19 SGTC_780 0109-0199 3.85 192.0 µM 2.49E-4 15 5.82E-5
20 SGTC_1669 st015249 3.72 58.4 µM 3.89E-4 Golgi 8 9.94E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.85E-8 YCL059C KRR1 het Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
0.082 2.20E-6 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.080 3.32E-6 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.078 5.44E-6 YAR035C-A_p YAR035C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis
0.078 5.75E-6 YMR172W HOT1 hom Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p
0.076 1.16E-5 YDR161W_p YDR161W_p hom Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
0.075 1.21E-5 YDR128W MTC5 hom Subunit of the SEA (Seh1-associated) complex; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1; relative distribution to vacuolar membrane punctae decreases upon DNA replication stress
0.075 1.41E-5 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.075 1.47E-5 YOR181W LAS17 het Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
0.074 1.98E-5 YKL101W HSL1 hom Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
0.073 2.07E-5 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.072 2.69E-5 YJR135C MCM22 hom Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4
0.072 3.37E-5 YOL149W DCP1 het Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
0.070 4.64E-5 YJR090C GRR1 hom F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification
0.070 5.29E-5 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene