YPR130C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR130C / YPR130C

Click on Significant Values for Screen Details ID:SGTC_154|Compound:3389-1638|FD-Score:3.21|P-value:8.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.71|P-value:1.43E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.92|P-value:6.26E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.34|P-value:8.53E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:6.23|P-value:5.40E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:3.48|P-value:3.29E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.44|P-value:3.72E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.90|P-value:6.65E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:5.29|P-value:1.08E-7 ID:SGTC_417|Compound:st075190|FD-Score:4.17|P-value:2.18E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:-3.78|P-value:1.10E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-4.17|P-value:2.25E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.65|P-value:2.63E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.84|P-value:8.30E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.76|P-value:1.59E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:4.39|P-value:8.47E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:-4.13|P-value:2.61E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.44|P-value:3.76E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.67|P-value:1.63E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.43|P-value:3.92E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.48|P-value:3.30E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.30|P-value:1.28E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.32|P-value:5.64E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.40|P-value:4.41E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:7.42|P-value:1.81E-13 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.16|P-value:9.67E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.63|P-value:1.86E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.22|P-value:7.98E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.22|P-value:1.81E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.44|P-value:3.78E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.14|P-value:2.55E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.41|P-value:4.26E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.18|P-value:9.30E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.43|P-value:3.96E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.79|P-value:1.06E-4 ID:SGTC_2165|Compound:5727197|FD-Score:5.95|P-value:2.76E-9 ID:SGTC_2290|Compound:7904846|FD-Score:3.55|P-value:2.55E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-4.05|P-value:3.69E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.17|P-value:9.54E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.90|P-value:6.84E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-3.28|P-value:6.56E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.11|P-value:2.83E-7 ID:SGTC_2715|Compound:st079500|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.90|P-value:6.87E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.74|P-value:1.23E-4 ID:SGTC_2855|Compound:9016525|FD-Score:4.30|P-value:1.29E-5 ID:SGTC_3044|Compound:9093193|FD-Score:5.71|P-value:1.15E-8 ID:SGTC_3109|Compound:9122853|FD-Score:3.36|P-value:4.92E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.21|P-value:8.37E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.71|P-value:1.43E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.92|P-value:6.26E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:5.34|P-value:8.53E-8 ID:SGTC_308|Compound:4092-1169|FD-Score:6.23|P-value:5.40E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:3.48|P-value:3.29E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.44|P-value:3.72E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.90|P-value:6.65E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:5.29|P-value:1.08E-7 ID:SGTC_417|Compound:st075190|FD-Score:4.17|P-value:2.18E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:-3.78|P-value:1.10E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-4.17|P-value:2.25E-5 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.65|P-value:2.63E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.84|P-value:8.30E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:4.76|P-value:1.59E-6 ID:SGTC_809|Compound:3998-0021|FD-Score:4.39|P-value:8.47E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:-4.13|P-value:2.61E-5 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.44|P-value:3.76E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.67|P-value:1.63E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:-3.43|P-value:3.92E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:-3.48|P-value:3.30E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.30|P-value:1.28E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.32|P-value:5.64E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.40|P-value:4.41E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:7.42|P-value:1.81E-13 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.16|P-value:9.67E-4 ID:SGTC_1406|Compound:3909-7906|FD-Score:3.63|P-value:1.86E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.53|P-value:2.68E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.22|P-value:7.98E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.22|P-value:1.81E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.44|P-value:3.78E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.14|P-value:2.55E-5 ID:SGTC_1848|Compound:st056003|FD-Score:-3.41|P-value:4.26E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.18|P-value:9.30E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.43|P-value:3.96E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.79|P-value:1.06E-4 ID:SGTC_2165|Compound:5727197|FD-Score:5.95|P-value:2.76E-9 ID:SGTC_2290|Compound:7904846|FD-Score:3.55|P-value:2.55E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-4.05|P-value:3.69E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.17|P-value:9.54E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.90|P-value:6.84E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-3.28|P-value:6.56E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.11|P-value:2.83E-7 ID:SGTC_2715|Compound:st079500|FD-Score:3.79|P-value:1.04E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.90|P-value:6.87E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.74|P-value:1.23E-4 ID:SGTC_2855|Compound:9016525|FD-Score:4.30|P-value:1.29E-5 ID:SGTC_3044|Compound:9093193|FD-Score:5.71|P-value:1.15E-8 ID:SGTC_3109|Compound:9122853|FD-Score:3.36|P-value:4.92E-4

Top fitness defect scores for YPR130C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1379 2144-0755 7.42 36.5 µM 1.81E-13 3 5.73E-14
2 SGTC_308 4092-1169 6.23 104.0 µM 5.40E-10 plasma membrane duress 16 2.39E-10
3 SGTC_2165 5727197 5.95 32.1 µM 2.76E-9 14 1.31E-9
4 SGTC_3044 9093193 5.71 49.5 µM 1.15E-8 4 5.78E-9
5 SGTC_266 formosanin C 5.34 406.0 nM 8.53E-8 sphingolipid biosynthesis & PDR1 41 4.67E-8
6 SGTC_407 eburnamonine 5.29 100.0 µM 1.08E-7 4 5.99E-8
7 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 5.11 70.0 µM 2.83E-7 redox potentiating 39 1.63E-7
8 SGTC_807 1315-0151 4.76 48.0 µM 1.59E-6 13 9.80E-7
9 SGTC_809 3998-0021 4.39 90.0 µM 8.47E-6 RNA processing & uracil transport 7 5.61E-6
10 SGTC_1311 1190-0148 4.30 100.0 µM 1.28E-5 azole & statin 22 8.62E-6
11 SGTC_2855 9016525 4.30 58.4 µM 1.29E-5 13 8.70E-6
12 SGTC_1779 st039427 4.22 55.0 µM 1.81E-5 20 1.24E-5
13 SGTC_417 st075190 4.17 100.0 µM 2.18E-5 6 1.50E-5
14 SGTC_1829 berberine 4.14 14.4 µM 2.55E-5 60S ribosome export 15 1.77E-5
15 SGTC_262 fenpropimorph 3.92 62.5 µM 6.26E-5 ergosterol depletion effects on membrane 27 4.50E-5
16 SGTC_374 0880-0231 3.90 82.3 µM 6.65E-5 iron homeostasis 22 4.79E-5
17 SGTC_779 1360-0071 3.84 233.0 µM 8.30E-5 fatty acid desaturase (OLE1) 28 6.03E-5
18 SGTC_2715 st079500 3.79 56.4 µM 1.04E-4 13 7.65E-5
19 SGTC_2836 9010338 3.74 19.5 µM 1.23E-4 RPP1 & pyrimidine depletion 33 9.06E-5
20 SGTC_1228 0124-0032 3.67 52.5 µM 1.63E-4 27 1.22E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.133 9.43E-15 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.120 2.73E-12 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.105 9.84E-10 YKR021W ALY1 hom Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication
0.099 8.08E-9 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.095 3.83E-8 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.082 1.96E-6 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.082 2.27E-6 YML026C RPS18B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.081 2.35E-6 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.080 3.50E-6 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.079 5.30E-6 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.078 6.65E-6 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.077 8.01E-6 YLR393W ATP10 hom Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
0.076 9.62E-6 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.074 1.57E-5 YLR349W_d YLR349W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
0.074 1.60E-5 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins