YPR134W / MSS18

Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR134W / MSS18

Click on Significant Values for Screen Details ID:SGTC_89|Compound:0302-0250|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.25|P-value:5.87E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.12|P-value:2.24E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:3.50|P-value:2.66E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.13|P-value:9.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.83|P-value:7.54E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:4.57|P-value:2.94E-6 ID:SGTC_338|Compound:4055-0136|FD-Score:4.34|P-value:8.49E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.24|P-value:6.72E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.94|P-value:4.93E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:3.19|P-value:7.90E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.56|P-value:2.08E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.72|P-value:1.13E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.21|P-value:1.50E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:4.41|P-value:6.18E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.36|P-value:4.34E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:9.15|P-value:5.17E-20 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.26|P-value:6.35E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.13|P-value:8.65E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.16|P-value:8.78E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.30|P-value:1.01E-5 ID:SGTC_1531|Compound:st059297|FD-Score:3.82|P-value:7.86E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.19|P-value:7.94E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.50|P-value:2.67E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.09|P-value:9.90E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.32|P-value:4.99E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.60|P-value:2.60E-6 ID:SGTC_1825|Compound:st052143|FD-Score:3.19|P-value:7.84E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.79|P-value:8.59E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.28|P-value:5.80E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.59|P-value:1.46E-8 ID:SGTC_2009|Compound:4012297|FD-Score:3.87|P-value:6.35E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.30|P-value:5.49E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.35|P-value:8.10E-6 ID:SGTC_2277|Compound:7947813|FD-Score:6.21|P-value:3.52E-10 ID:SGTC_2278|Compound:7948257|FD-Score:-4.42|P-value:5.17E-6 ID:SGTC_2365|Compound:9042475|FD-Score:3.89|P-value:5.92E-5 ID:SGTC_2451|Compound:5856223|FD-Score:4.56|P-value:3.08E-6 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.38|P-value:7.01E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.55|P-value:1.90E-8 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.20|P-value:1.36E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.82|P-value:7.65E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.29|P-value:5.61E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.27|P-value:5.98E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.49|P-value:4.20E-6 ID:SGTC_2931|Compound:9014674|FD-Score:4.39|P-value:6.66E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.13|P-value:9.91E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.93|P-value:4.97E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-4.13|P-value:1.86E-5 ID:SGTC_3196|Compound:9111891|FD-Score:5.34|P-value:5.93E-8 ID:SGTC_3197|Compound:9113331|FD-Score:-3.75|P-value:9.07E-5 ID:SGTC_3316|Compound:9136639|FD-Score:5.16|P-value:1.55E-7 ID:SGTC_3343|Compound:9148379|FD-Score:4.00|P-value:3.64E-5 ID:SGTC_3344|Compound:9148862|FD-Score:5.21|P-value:1.21E-7 ID:SGTC_3353|Compound:9151644|FD-Score:4.12|P-value:2.21E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.64|P-value:1.54E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.25|P-value:5.87E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.58|P-value:1.93E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.12|P-value:2.24E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:3.50|P-value:2.66E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:3.13|P-value:9.61E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.83|P-value:7.54E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:4.57|P-value:2.94E-6 ID:SGTC_338|Compound:4055-0136|FD-Score:4.34|P-value:8.49E-6 ID:SGTC_527|Compound:4476-4215|FD-Score:3.24|P-value:6.72E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.94|P-value:4.93E-7 ID:SGTC_548|Compound:1436-0017|FD-Score:3.19|P-value:7.90E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.56|P-value:2.08E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.72|P-value:1.13E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_918|Compound:glabranin|FD-Score:4.21|P-value:1.50E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:4.41|P-value:6.18E-6 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.36|P-value:4.34E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:9.15|P-value:5.17E-20 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.26|P-value:6.35E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.13|P-value:8.65E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.16|P-value:8.78E-4 ID:SGTC_1514|Compound:1189-1591|FD-Score:4.30|P-value:1.01E-5 ID:SGTC_1531|Compound:st059297|FD-Score:3.82|P-value:7.86E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:3.22|P-value:7.09E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.63|P-value:1.62E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_1731|Compound:st035964|FD-Score:3.19|P-value:7.94E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.50|P-value:2.67E-4 ID:SGTC_1758|Compound:st042942|FD-Score:-3.09|P-value:9.90E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.32|P-value:4.99E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.60|P-value:2.60E-6 ID:SGTC_1825|Compound:st052143|FD-Score:3.19|P-value:7.84E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:3.79|P-value:8.59E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.28|P-value:5.80E-4 ID:SGTC_1937|Compound:st074714|FD-Score:4.29|P-value:1.08E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.41|P-value:3.63E-4 ID:SGTC_2003|Compound:4023581|FD-Score:5.59|P-value:1.46E-8 ID:SGTC_2009|Compound:4012297|FD-Score:3.87|P-value:6.35E-5 ID:SGTC_2154|Compound:5570129|FD-Score:3.30|P-value:5.49E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.51|P-value:2.55E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.35|P-value:8.10E-6 ID:SGTC_2277|Compound:7947813|FD-Score:6.21|P-value:3.52E-10 ID:SGTC_2278|Compound:7948257|FD-Score:-4.42|P-value:5.17E-6 ID:SGTC_2365|Compound:9042475|FD-Score:3.89|P-value:5.92E-5 ID:SGTC_2451|Compound:5856223|FD-Score:4.56|P-value:3.08E-6 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.38|P-value:7.01E-6 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:5.55|P-value:1.90E-8 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.20|P-value:1.36E-5 ID:SGTC_2835|Compound:9006588|FD-Score:3.82|P-value:7.65E-5 ID:SGTC_2864|Compound:9034755|FD-Score:3.29|P-value:5.61E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.22|P-value:7.13E-4 ID:SGTC_2922|Compound:7999257|FD-Score:3.27|P-value:5.98E-4 ID:SGTC_2923|Compound:7992654|FD-Score:4.49|P-value:4.20E-6 ID:SGTC_2931|Compound:9014674|FD-Score:4.39|P-value:6.66E-6 ID:SGTC_2936|Compound:9038235|FD-Score:3.59|P-value:1.90E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.13|P-value:9.91E-4 ID:SGTC_3159|Compound:9100096|FD-Score:3.93|P-value:4.97E-5 ID:SGTC_3190|Compound:9110366|FD-Score:-4.13|P-value:1.86E-5 ID:SGTC_3196|Compound:9111891|FD-Score:5.34|P-value:5.93E-8 ID:SGTC_3197|Compound:9113331|FD-Score:-3.75|P-value:9.07E-5 ID:SGTC_3316|Compound:9136639|FD-Score:5.16|P-value:1.55E-7 ID:SGTC_3343|Compound:9148379|FD-Score:4.00|P-value:3.64E-5 ID:SGTC_3344|Compound:9148862|FD-Score:5.21|P-value:1.21E-7 ID:SGTC_3353|Compound:9151644|FD-Score:4.12|P-value:2.21E-5

Top fitness defect scores for YPR134W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1205 4161-2785 9.15 76.0 µM 5.17E-20 3 2.85E-20
2 SGTC_2277 7947813 6.21 106.9 µM 3.52E-10 RSC complex & mRNA processing 6 2.58E-10
3 SGTC_2003 4023581 5.59 200.0 µM 1.46E-8 cell wall signaling 16 1.12E-8
4 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 5.55 100.0 µM 1.90E-8 6 1.47E-8
5 SGTC_3196 9111891 5.34 49.5 µM 5.93E-8 mitochondrial processes 4 4.65E-8
6 SGTC_3344 9148862 5.21 3.9 µM 1.21E-7 2 9.60E-8
7 SGTC_3316 9136639 5.16 10.6 µM 1.55E-7 5 1.23E-7
8 SGTC_543 3844-1095 4.94 191.0 µM 4.93E-7 ERG2 29 3.98E-7
9 SGTC_1820 st053765 4.60 18.6 µM 2.60E-6 RPP1 & pyrimidine depletion 6 2.15E-6
10 SGTC_274 sirtinol 4.57 40.1 µM 2.94E-6 12 2.43E-6
11 SGTC_2451 5856223 4.56 45.7 µM 3.08E-6 14 2.54E-6
12 SGTC_2923 7992654 4.49 58.1 µM 4.20E-6 Golgi 15 3.49E-6
13 SGTC_1068 loratadine 4.41 26.9 µM 6.18E-6 14 5.16E-6
14 SGTC_2931 9014674 4.39 55.7 µM 6.66E-6 12 5.56E-6
15 SGTC_2500 5-alpha-androstan-3,17-dione 4.38 61.4 µM 7.01E-6 32 5.86E-6
16 SGTC_2274 7947094 4.35 46.1 µM 8.10E-6 21 6.79E-6
17 SGTC_338 4055-0136 4.34 114.0 µM 8.49E-6 3 7.12E-6
18 SGTC_1514 1189-1591 4.30 158.0 µM 1.01E-5 28 8.47E-6
19 SGTC_1937 st074714 4.29 47.2 µM 1.08E-5 34 9.07E-6
20 SGTC_918 glabranin 4.21 770.7 nM 1.50E-5 26 1.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.52E-13 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.122 1.38E-12 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.121 2.10E-12 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.120 2.80E-12 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.117 1.01E-11 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.117 1.20E-11 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.116 1.58E-11 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.114 3.92E-11 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.112 9.13E-11 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.111 1.21E-10 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.110 1.49E-10 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.109 2.11E-10 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.107 4.37E-10 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.107 4.94E-10 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.107 5.93E-10 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER