YPR135W / CTF4

Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR135W / CTF4

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.43|P-value:7.08E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:5.82|P-value:1.49E-8 ID:SGTC_93|Compound:0109-0045|FD-Score:4.10|P-value:5.72E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.38|P-value:8.20E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.58|P-value:4.18E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.08|P-value:6.63E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.07|P-value:6.96E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.46|P-value:6.30E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.57|P-value:8.00E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.54|P-value:9.01E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.64|P-value:8.36E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:4.56|P-value:8.32E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:3.88|P-value:1.37E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.26|P-value:3.04E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.42|P-value:7.20E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.49|P-value:5.66E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.71|P-value:7.61E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.94|P-value:2.53E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.90|P-value:1.25E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.67|P-value:7.60E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.56|P-value:4.44E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.64|P-value:5.71E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.82|P-value:1.70E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.37|P-value:8.63E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.64|P-value:3.31E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.49|P-value:5.60E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.40|P-value:7.81E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.35|P-value:9.18E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.66|P-value:3.16E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.61|P-value:3.78E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-3.33|P-value:2.79E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.94|P-value:1.09E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.29|P-value:2.67E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.13|P-value:5.19E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.59|P-value:7.23E-6 ID:SGTC_2105|Compound:5350118|FD-Score:4.65|P-value:5.48E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.78|P-value:2.00E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.24|P-value:6.95E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.16|P-value:4.60E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.55|P-value:8.77E-6 ID:SGTC_2237|Compound:6667747|FD-Score:4.17|P-value:4.47E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.61|P-value:3.78E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.12|P-value:5.40E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.48|P-value:5.88E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-2.97|P-value:9.61E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.53|P-value:9.48E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.20|P-value:4.47E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.94|P-value:1.10E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.74|P-value:5.79E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.06|P-value:6.87E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.77|P-value:2.11E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.54|P-value:1.27E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.47|P-value:6.18E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.03|P-value:9.17E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.74|P-value:2.33E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.89|P-value:1.35E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.13|P-value:5.56E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.51|P-value:5.39E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.33|P-value:2.26E-5 ID:SGTC_47|Compound:0149-0135|FD-Score:3.43|P-value:7.08E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:5.82|P-value:1.49E-8 ID:SGTC_93|Compound:0109-0045|FD-Score:4.10|P-value:5.72E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:3.38|P-value:8.20E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.58|P-value:4.18E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-3.08|P-value:6.63E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.07|P-value:6.96E-4 ID:SGTC_252|Compound:miconazole|FD-Score:3.46|P-value:6.30E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.57|P-value:8.00E-6 ID:SGTC_495|Compound:decylubiquinone|FD-Score:4.54|P-value:9.01E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.64|P-value:8.36E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:4.56|P-value:8.32E-6 ID:SGTC_537|Compound:1334-0398|FD-Score:3.88|P-value:1.37E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.26|P-value:3.04E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:3.42|P-value:7.20E-4 ID:SGTC_732|Compound:3970-1727|FD-Score:3.49|P-value:5.66E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-4.71|P-value:7.61E-7 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.94|P-value:2.53E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.90|P-value:1.25E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.67|P-value:7.60E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.56|P-value:4.44E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.64|P-value:5.71E-6 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.82|P-value:1.70E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.37|P-value:8.63E-4 ID:SGTC_1111|Compound:tnp00062|FD-Score:3.64|P-value:3.31E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.49|P-value:5.60E-4 ID:SGTC_1334|Compound:1486-0610|FD-Score:3.40|P-value:7.81E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.35|P-value:9.18E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.66|P-value:3.16E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.61|P-value:3.78E-4 ID:SGTC_1903|Compound:st060211|FD-Score:-3.33|P-value:2.79E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.94|P-value:1.09E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.29|P-value:2.67E-5 ID:SGTC_2038|Compound:4100038|FD-Score:4.13|P-value:5.19E-5 ID:SGTC_2054|Compound:5233173|FD-Score:4.59|P-value:7.23E-6 ID:SGTC_2105|Compound:5350118|FD-Score:4.65|P-value:5.48E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.78|P-value:2.00E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.24|P-value:6.95E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:4.16|P-value:4.60E-5 ID:SGTC_2136|Compound:5328288|FD-Score:4.55|P-value:8.77E-6 ID:SGTC_2237|Compound:6667747|FD-Score:4.17|P-value:4.47E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.61|P-value:3.78E-4 ID:SGTC_2300|Compound:7976697|FD-Score:4.12|P-value:5.40E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.48|P-value:5.88E-4 ID:SGTC_2335|Compound:9018011|FD-Score:-2.97|P-value:9.61E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.53|P-value:9.48E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-3.20|P-value:4.47E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.94|P-value:1.10E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.74|P-value:5.79E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.06|P-value:6.87E-5 ID:SGTC_2827|Compound:7993847|FD-Score:3.77|P-value:2.11E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-3.54|P-value:1.27E-4 ID:SGTC_2838|Compound:9002687|FD-Score:3.47|P-value:6.18E-4 ID:SGTC_2844|Compound:9010103|FD-Score:5.03|P-value:9.17E-7 ID:SGTC_2894|Compound:9048625|FD-Score:3.74|P-value:2.33E-4 ID:SGTC_2945|Compound:9067681|FD-Score:3.89|P-value:1.35E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.13|P-value:5.56E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.51|P-value:5.39E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.33|P-value:2.26E-5

Top fitness defect scores for YPR135W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_51 1013-0126 5.82 23.4 µM 1.49E-8 15 2.99E-9
2 SGTC_2844 9010103 5.03 26.0 µM 9.17E-7 9 2.42E-7
3 SGTC_2105 5350118 4.65 200.0 µM 5.48E-6 14 1.64E-6
4 SGTC_1017 4239-0030 4.64 168.0 µM 5.71E-6 13 1.71E-6
5 SGTC_2054 5233173 4.59 129.0 µM 7.23E-6 mitochondrial response to ROS 38 2.20E-6
6 SGTC_272 doxorubicin 4.57 8.1 µM 8.00E-6 anthracycline transcription coupled DNA repair 13 2.46E-6
7 SGTC_519 k048-0011 4.56 62.8 µM 8.32E-6 11 2.56E-6
8 SGTC_2136 5328288 4.55 199.3 µM 8.77E-6 12 2.71E-6
9 SGTC_495 decylubiquinone 4.54 155.0 µM 9.01E-6 copper-dependent oxidative stress 11 2.79E-6
10 SGTC_2422 chlorphenesin carbamate 4.53 384.2 µM 9.48E-6 16 2.95E-6
11 SGTC_3131 9127911 4.33 49.5 µM 2.26E-5 19 7.47E-6
12 SGTC_2028 5153890 4.29 36.4 µM 2.67E-5 cell wall signaling 27 8.95E-6
13 SGTC_686 1319-0111 4.26 510.0 µM 3.04E-5 60S ribosome export 25 1.03E-5
14 SGTC_2237 6667747 4.17 47.2 µM 4.47E-5 13 1.56E-5
15 SGTC_2129 girgensonine 4.16 121.0 µM 4.60E-5 heme biosynthesis & mitochondrial translocase 22 1.60E-5
16 SGTC_2038 4100038 4.13 31.0 µM 5.19E-5 plasma membrane duress 46 1.83E-5
17 SGTC_2300 7976697 4.12 71.6 µM 5.40E-5 ERG2 29 1.91E-5
18 SGTC_93 0109-0045 4.10 59.2 µM 5.72E-5 DNA damage response 39 2.03E-5
19 SGTC_2721 ifenprodil 4.06 61.4 µM 6.87E-5 plasma membrane duress 15 2.47E-5
20 SGTC_1967 st070177 3.94 51.4 µM 1.09E-4 13 4.04E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.58E-8 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
0.091 1.40E-7 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.086 6.36E-7 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.082 2.24E-6 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.078 5.81E-6 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.076 1.11E-5 YLR248W RCK2 hom Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication
0.075 1.50E-5 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.51E-5 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.070 5.21E-5 YMR258C ROY1 hom GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p
0.066 1.29E-4 YER087C-B SBH1 hom Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p
0.065 1.55E-4 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.065 1.68E-4 YDR358W GGA1 hom Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
0.065 1.81E-4 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.064 1.95E-4 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.064 2.05E-4 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations