YPR136C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR136C / YPR136C

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-4.01|P-value:4.87E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.20|P-value:9.48E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.89|P-value:7.89E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.23|P-value:8.78E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.49|P-value:3.48E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:6.15|P-value:1.18E-9 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:6.68|P-value:4.65E-11 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.32|P-value:1.37E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.58|P-value:2.59E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.96|P-value:3.70E-9 ID:SGTC_736|Compound:0958-0254|FD-Score:3.95|P-value:6.41E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.25|P-value:8.03E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.38|P-value:5.11E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.69|P-value:4.16E-11 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:5.64E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.32|P-value:6.31E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-3.65|P-value:1.95E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-4.15|P-value:2.83E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.58|P-value:2.59E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.64|P-value:2.07E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.33|P-value:6.04E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.22|P-value:8.81E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.33|P-value:6.12E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.07|P-value:3.98E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-3.91|P-value:7.30E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.48|P-value:3.61E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.87|P-value:8.75E-5 ID:SGTC_1619|Compound:st003326|FD-Score:-4.67|P-value:2.90E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.58|P-value:2.54E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.69|P-value:1.72E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:7.03|P-value:4.40E-12 ID:SGTC_1931|Compound:st074438|FD-Score:4.84|P-value:1.30E-6 ID:SGTC_2040|Compound:5100729|FD-Score:3.32|P-value:6.48E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.51|P-value:5.98E-6 ID:SGTC_2126|Compound:5251174|FD-Score:4.23|P-value:2.04E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.40|P-value:4.90E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.92|P-value:9.21E-7 ID:SGTC_2168|Compound:5727979|FD-Score:-3.27|P-value:7.40E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.33|P-value:1.29E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-5.66|P-value:1.95E-8 ID:SGTC_2181|Compound:6316240|FD-Score:4.87|P-value:1.14E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.46|P-value:3.89E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.95|P-value:7.75E-7 ID:SGTC_2338|Compound:7999974|FD-Score:-4.10|P-value:3.40E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.22|P-value:8.99E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-4.27|P-value:1.72E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.63|P-value:2.15E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.19|P-value:9.87E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.58|P-value:2.53E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.38|P-value:5.23E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-5.13|P-value:3.24E-7 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.35|P-value:5.81E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.58|P-value:2.61E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.26|P-value:1.69E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.70|P-value:1.63E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.74|P-value:1.43E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.21|P-value:2.13E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:4.47|P-value:7.32E-6 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.07|P-value:4.02E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.77|P-value:1.28E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.78|P-value:1.24E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.56|P-value:3.35E-8 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.42|P-value:9.01E-6 ID:SGTC_2787|Compound:5284540|FD-Score:3.29|P-value:7.07E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.32|P-value:1.24E-7 ID:SGTC_2972|Compound:9093619|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.32|P-value:6.33E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.12|P-value:3.32E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-3.71|P-value:1.57E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.72|P-value:1.51E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.03|P-value:4.58E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-4.04|P-value:4.40E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.68|P-value:2.75E-6 ID:SGTC_3305|Compound:9127027|FD-Score:3.21|P-value:9.30E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.01|P-value:4.87E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.20|P-value:9.48E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:-3.89|P-value:7.89E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.71|P-value:1.62E-4 ID:SGTC_223|Compound:busulfan|FD-Score:3.23|P-value:8.78E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.49|P-value:3.48E-4 ID:SGTC_321|Compound:4534-3890|FD-Score:6.15|P-value:1.18E-9 ID:SGTC_391|Compound:gliotoxin|FD-Score:3.38|P-value:5.17E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:6.68|P-value:4.65E-11 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.32|P-value:1.37E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.60|P-value:2.41E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.58|P-value:2.59E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.54|P-value:2.99E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:5.96|P-value:3.70E-9 ID:SGTC_736|Compound:0958-0254|FD-Score:3.95|P-value:6.41E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.25|P-value:8.03E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.38|P-value:5.11E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:6.69|P-value:4.16E-11 ID:SGTC_832|Compound:4083-0019|FD-Score:3.36|P-value:5.64E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:3.32|P-value:6.31E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:-3.65|P-value:1.95E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:-4.15|P-value:2.83E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:-3.58|P-value:2.59E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.65|P-value:1.99E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-3.64|P-value:2.07E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.33|P-value:6.04E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:-3.22|P-value:8.81E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.33|P-value:6.12E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.07|P-value:3.98E-5 ID:SGTC_1522|Compound:st012842|FD-Score:-3.91|P-value:7.30E-5 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-3.48|P-value:3.61E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-3.87|P-value:8.75E-5 ID:SGTC_1619|Compound:st003326|FD-Score:-4.67|P-value:2.90E-6 ID:SGTC_1758|Compound:st042942|FD-Score:3.58|P-value:2.54E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.69|P-value:1.72E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:7.03|P-value:4.40E-12 ID:SGTC_1931|Compound:st074438|FD-Score:4.84|P-value:1.30E-6 ID:SGTC_2040|Compound:5100729|FD-Score:3.32|P-value:6.48E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.51|P-value:5.98E-6 ID:SGTC_2126|Compound:5251174|FD-Score:4.23|P-value:2.04E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.40|P-value:4.90E-4 ID:SGTC_2164|Compound:5685496|FD-Score:4.92|P-value:9.21E-7 ID:SGTC_2168|Compound:5727979|FD-Score:-3.27|P-value:7.40E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.33|P-value:1.29E-5 ID:SGTC_2179|Compound:6298986|FD-Score:-5.66|P-value:1.95E-8 ID:SGTC_2181|Compound:6316240|FD-Score:4.87|P-value:1.14E-6 ID:SGTC_2290|Compound:7904846|FD-Score:3.46|P-value:3.89E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-4.95|P-value:7.75E-7 ID:SGTC_2338|Compound:7999974|FD-Score:-4.10|P-value:3.40E-5 ID:SGTC_2350|Compound:9023895|FD-Score:-3.22|P-value:8.99E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-4.27|P-value:1.72E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:3.63|P-value:2.15E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:3.19|P-value:9.87E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.58|P-value:2.53E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.38|P-value:5.23E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-5.13|P-value:3.24E-7 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.35|P-value:5.81E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:3.58|P-value:2.61E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:5.26|P-value:1.69E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.70|P-value:1.63E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.74|P-value:1.43E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.21|P-value:2.13E-7 ID:SGTC_2652|Compound:actinonin|FD-Score:4.47|P-value:7.32E-6 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:4.07|P-value:4.02E-5 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.77|P-value:1.28E-4 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.78|P-value:1.24E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.56|P-value:3.35E-8 ID:SGTC_2766|Compound:oltipraz|FD-Score:-4.42|P-value:9.01E-6 ID:SGTC_2787|Compound:5284540|FD-Score:3.29|P-value:7.07E-4 ID:SGTC_2920|Compound:7982904|FD-Score:5.32|P-value:1.24E-7 ID:SGTC_2972|Compound:9093619|FD-Score:4.00|P-value:5.19E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_3148|Compound:9097893|FD-Score:3.32|P-value:6.33E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.12|P-value:3.32E-7 ID:SGTC_3222|Compound:9128301|FD-Score:-3.71|P-value:1.57E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-3.72|P-value:1.51E-4 ID:SGTC_3286|Compound:9117135|FD-Score:4.03|P-value:4.58E-5 ID:SGTC_3287|Compound:9117173|FD-Score:-4.04|P-value:4.40E-5 ID:SGTC_3296|Compound:9122258|FD-Score:-4.68|P-value:2.75E-6 ID:SGTC_3305|Compound:9127027|FD-Score:3.21|P-value:9.30E-4

Top fitness defect scores for YPR136C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1879 gemcitabine 7.03 100.0 µM 4.40E-12 1 9.97E-13 2.64
2 SGTC_800 3448-7362 6.69 155.0 µM 4.16E-11 translation 18 1.08E-11 0.31
3 SGTC_617 3770-0098 6.68 35.0 µM 4.65E-11 exosome 13 1.22E-11 0.06
4 SGTC_321 4534-3890 6.15 65.3 µM 1.18E-9 RPP1 & pyrimidine depletion 1 3.76E-10 1.07
5 SGTC_708 3448-5400 5.96 146.0 µM 3.70E-9 4 1.26E-9 0.20
6 SGTC_2920 7982904 5.32 15.8 µM 1.24E-7 5 5.24E-8 0.31
7 SGTC_2603 homopterocarpin 5.26 100.0 µM 1.69E-7 1 7.30E-8 0.43
8 SGTC_2164 5685496 4.92 200.0 µM 9.21E-7 5 4.39E-7 0.46
9 SGTC_2181 6316240 4.87 54.3 µM 1.14E-6 1 5.49E-7 0.83
10 SGTC_1931 st074438 4.84 57.1 µM 1.30E-6 2 6.33E-7 0.22
11 SGTC_2652 actinonin 4.47 100.0 µM 7.32E-6 1 3.95E-6 0.35
12 SGTC_2126 5251174 4.23 33.9 µM 2.04E-5 6 1.17E-5 0.17
13 SGTC_1520 flindersine 4.07 88.0 µM 3.98E-5 10 2.38E-5 0.17
14 SGTC_2654 protoveratrine a 4.07 100.0 µM 4.02E-5 3 2.40E-5 0.21
15 SGTC_3286 9117135 4.03 37.2 µM 4.58E-5 11 2.76E-5 0.15
16 SGTC_2972 9093619 4.00 59.9 µM 5.19E-5 6 3.15E-5 0.40
17 SGTC_736 0958-0254 3.95 92.6 µM 6.41E-5 Golgi 5 3.94E-5 0.01
18 SGTC_2626 ethyl orsellinate 3.74 100.0 µM 1.43E-4 11 9.23E-5 0.16
19 SGTC_220 paclitaxel 3.71 373.4 µM 1.62E-4 3 1.05E-4 0.47
20 SGTC_2611 pyromycin 3.70 23.9 µM 1.63E-4 9 1.06E-4 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 1.44E-72 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.282 3.41E-62 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.252 9.37E-50 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.252 1.38E-49 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.226 3.64E-40 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.225 1.02E-39 YDR324C UTP4 het Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript
0.208 3.85E-34 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.204 5.79E-33 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.191 7.08E-29 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.189 2.92E-28 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.178 3.06E-25 YOR146W_d YOR146W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
0.178 3.13E-25 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.172 8.64E-24 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.171 1.87E-23 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.169 8.11E-23 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp