YPR137W / RRP9

Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR137W / RRP9

Click on Significant Values for Screen Details ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.38|P-value:9.48E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.77|P-value:4.50E-7 ID:SGTC_456|Compound:gingerol|FD-Score:4.51|P-value:6.08E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.99|P-value:9.64E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:3.80|P-value:6.20E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:7.89|P-value:8.81E-12 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.25|P-value:1.35E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.63|P-value:7.96E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:6.92|P-value:1.85E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:5.76|P-value:4.60E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.83|P-value:5.20E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:12.50|P-value:5.44E-27 ID:SGTC_832|Compound:4083-0019|FD-Score:4.17|P-value:1.92E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.84|P-value:5.36E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.64|P-value:3.93E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-5.80|P-value:3.50E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.52|P-value:5.41E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.85|P-value:1.82E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.32|P-value:1.20E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:-4.37|P-value:9.10E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.25|P-value:3.89E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:-5.77|P-value:3.86E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:-5.83|P-value:2.98E-7 ID:SGTC_1406|Compound:3909-7906|FD-Score:-5.05|P-value:7.53E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:-4.59|P-value:4.16E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.09|P-value:7.39E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.89|P-value:4.72E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.85|P-value:1.84E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.38|P-value:9.53E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.30|P-value:3.18E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:-5.77|P-value:3.92E-7 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.77|P-value:6.71E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:-4.57|P-value:4.58E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:-5.87|P-value:2.50E-7 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-4.08|P-value:2.34E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.67|P-value:8.19E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.99|P-value:3.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-6.87|P-value:2.07E-9 ID:SGTC_1677|Compound:st019204|FD-Score:4.29|P-value:1.29E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.03|P-value:2.99E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-4.01|P-value:2.98E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-7.20|P-value:3.71E-10 ID:SGTC_1829|Compound:berberine|FD-Score:-6.28|P-value:3.77E-8 ID:SGTC_1944|Compound:st076371|FD-Score:3.88|P-value:4.75E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.91|P-value:4.01E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-4.08|P-value:2.39E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.86|P-value:4.71E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.83|P-value:5.65E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.07|P-value:2.47E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-7.22|P-value:3.30E-10 ID:SGTC_2296|Compound:7971656|FD-Score:-3.69|P-value:7.74E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.31|P-value:1.12E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.11|P-value:9.49E-8 ID:SGTC_2483|Compound:5729050|FD-Score:3.89|P-value:4.59E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:7.79|P-value:1.55E-11 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.85|P-value:4.83E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:5.65|P-value:7.30E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.36|P-value:9.53E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.73|P-value:7.43E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.81|P-value:3.34E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.00|P-value:9.12E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:5.68|P-value:6.53E-7 ID:SGTC_2920|Compound:7982904|FD-Score:4.50|P-value:6.46E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.76|P-value:6.39E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.03|P-value:2.74E-4 ID:SGTC_2964|Compound:9083345|FD-Score:6.57|P-value:1.10E-8 ID:SGTC_2965|Compound:9082772|FD-Score:-4.74|P-value:2.46E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-6.47|P-value:1.52E-8 ID:SGTC_2969|Compound:9091408|FD-Score:-3.64|P-value:9.07E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.61|P-value:9.79E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.97|P-value:1.03E-5 ID:SGTC_3006|Compound:9075424|FD-Score:8.19|P-value:1.44E-12 ID:SGTC_3007|Compound:9078383|FD-Score:5.40|P-value:2.12E-6 ID:SGTC_3101|Compound:9120531|FD-Score:-5.30|P-value:2.88E-6 ID:SGTC_3137|Compound:9097352|FD-Score:-3.85|P-value:4.82E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.72|P-value:7.82E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.72|P-value:7.77E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.30|P-value:1.16E-4 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:4.38|P-value:9.48E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.77|P-value:4.50E-7 ID:SGTC_456|Compound:gingerol|FD-Score:4.51|P-value:6.08E-5 ID:SGTC_490|Compound:phenamil|FD-Score:-4.99|P-value:9.64E-6 ID:SGTC_544|Compound:k015-0020|FD-Score:3.80|P-value:6.20E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:7.89|P-value:8.81E-12 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.25|P-value:1.35E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.63|P-value:7.96E-7 ID:SGTC_691|Compound:1548-0686|FD-Score:6.92|P-value:1.85E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:5.76|P-value:4.60E-7 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.83|P-value:5.20E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:12.50|P-value:5.44E-27 ID:SGTC_832|Compound:4083-0019|FD-Score:4.17|P-value:1.92E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.84|P-value:5.36E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:4.64|P-value:3.93E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:-5.80|P-value:3.50E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.52|P-value:5.41E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:4.85|P-value:1.82E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:4.32|P-value:1.20E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:-4.37|P-value:9.10E-5 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.25|P-value:3.89E-6 ID:SGTC_1404|Compound:3909-7820|FD-Score:-5.77|P-value:3.86E-7 ID:SGTC_1405|Compound:3909-7894|FD-Score:-5.83|P-value:2.98E-7 ID:SGTC_1406|Compound:3909-7906|FD-Score:-5.05|P-value:7.53E-6 ID:SGTC_1407|Compound:3909-7909|FD-Score:-4.59|P-value:4.16E-5 ID:SGTC_1449|Compound:4112-4002|FD-Score:5.09|P-value:7.39E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.89|P-value:4.72E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.85|P-value:1.84E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:4.38|P-value:9.53E-5 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.30|P-value:3.18E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:-5.77|P-value:3.92E-7 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.77|P-value:6.71E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:-4.57|P-value:4.58E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:-5.87|P-value:2.50E-7 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:-4.08|P-value:2.34E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.67|P-value:8.19E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.99|P-value:3.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-6.87|P-value:2.07E-9 ID:SGTC_1677|Compound:st019204|FD-Score:4.29|P-value:1.29E-4 ID:SGTC_1781|Compound:st038725|FD-Score:4.03|P-value:2.99E-4 ID:SGTC_1824|Compound:st053723|FD-Score:-4.01|P-value:2.98E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-7.20|P-value:3.71E-10 ID:SGTC_1829|Compound:berberine|FD-Score:-6.28|P-value:3.77E-8 ID:SGTC_1944|Compound:st076371|FD-Score:3.88|P-value:4.75E-4 ID:SGTC_1963|Compound:st076565|FD-Score:-3.91|P-value:4.01E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-4.08|P-value:2.39E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.86|P-value:4.71E-4 ID:SGTC_2146|Compound:5545642|FD-Score:3.83|P-value:5.65E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.07|P-value:2.47E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-7.22|P-value:3.30E-10 ID:SGTC_2296|Compound:7971656|FD-Score:-3.69|P-value:7.74E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.31|P-value:1.12E-4 ID:SGTC_2302|Compound:7771753|FD-Score:6.11|P-value:9.49E-8 ID:SGTC_2483|Compound:5729050|FD-Score:3.89|P-value:4.59E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:7.79|P-value:1.55E-11 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.85|P-value:4.83E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:5.65|P-value:7.30E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.36|P-value:9.53E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.73|P-value:7.43E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.81|P-value:3.34E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-5.00|P-value:9.12E-6 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:5.68|P-value:6.53E-7 ID:SGTC_2920|Compound:7982904|FD-Score:4.50|P-value:6.46E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-3.76|P-value:6.39E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.03|P-value:2.74E-4 ID:SGTC_2964|Compound:9083345|FD-Score:6.57|P-value:1.10E-8 ID:SGTC_2965|Compound:9082772|FD-Score:-4.74|P-value:2.46E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-6.47|P-value:1.52E-8 ID:SGTC_2969|Compound:9091408|FD-Score:-3.64|P-value:9.07E-4 ID:SGTC_2980|Compound:9014342|FD-Score:-3.61|P-value:9.79E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-4.97|P-value:1.03E-5 ID:SGTC_3006|Compound:9075424|FD-Score:8.19|P-value:1.44E-12 ID:SGTC_3007|Compound:9078383|FD-Score:5.40|P-value:2.12E-6 ID:SGTC_3101|Compound:9120531|FD-Score:-5.30|P-value:2.88E-6 ID:SGTC_3137|Compound:9097352|FD-Score:-3.85|P-value:4.82E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.72|P-value:7.82E-4 ID:SGTC_3145|Compound:9085516|FD-Score:4.30|P-value:1.25E-4 ID:SGTC_3180|Compound:9109287|FD-Score:3.72|P-value:7.77E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.30|P-value:1.16E-4

Top fitness defect scores for YPR137W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_800 3448-7362 12.50 155.0 µM 5.44E-27 translation 2 2.38E-36 2.06
2 SGTC_3006 9075424 8.19 71.4 µM 1.44E-12 1 1.29E-16 3.19
3 SGTC_617 3770-0098 7.89 35.0 µM 8.81E-12 exosome 9 1.54E-15 0.05
4 SGTC_2538 3',7'-epoxycaryophyllan-6-one 7.79 100.0 µM 1.55E-11 1 3.31E-15 1.95
5 SGTC_691 1548-0686 6.92 185.0 µM 1.85E-9 2 2.28E-12 1.18
6 SGTC_2964 9083345 6.57 53.4 µM 1.10E-8 2 2.59E-11 0.26
7 SGTC_2302 7771753 6.11 200.0 µM 9.49E-8 1 4.88E-10 1.30
8 SGTC_445 e6 berbamine 5.77 66.0 µM 4.50E-7 NEO1-PIK1 17 4.06E-9 0.65
9 SGTC_708 3448-5400 5.76 146.0 µM 4.60E-7 5 4.18E-9 0.23
10 SGTC_2768 sulfasalazine 5.68 50.2 µM 6.53E-7 3 6.75E-9 0.80
11 SGTC_2606 farnesol 5.65 9.8 µM 7.30E-7 4 7.85E-9 0.17
12 SGTC_625 k213-0058 5.63 121.0 µM 7.96E-7 translation 4 8.83E-9 0.21
13 SGTC_3007 9078383 5.40 71.4 µM 2.12E-6 2 3.34E-8 0.76
14 SGTC_1469 k284-2957 5.30 126.0 µM 3.18E-6 6 5.81E-8 0.23
15 SGTC_1079 idarubicin 5.25 2.4 µM 3.89E-6 DNA damage response 4 7.65E-8 0.70
16 SGTC_1449 4112-4002 5.09 201.0 µM 7.39E-6 RPP1 & pyrimidine depletion 2 1.83E-7 0.26
17 SGTC_997 3996-0078 4.85 137.0 µM 1.82E-5 3 6.20E-7 0.40
18 SGTC_1456 k015-0012 4.85 13.0 µM 1.84E-5 6 6.29E-7 0.71
19 SGTC_889 0919-1524 4.64 82.7 µM 3.93E-5 1 1.77E-6 0.57
20 SGTC_456 gingerol 4.51 170.0 µM 6.08E-5 3 3.19E-6 0.29

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.334 5.21E-88 YHL015W RPS20 het Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10
0.304 1.44E-72 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.288 3.71E-65 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.263 4.30E-54 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.239 6.43E-45 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.237 4.38E-44 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.220 7.39E-38 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.218 1.68E-37 YHR069C RRP4 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.202 4.65E-32 YDR449C UTP6 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.201 9.01E-32 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.197 1.19E-30 YJL069C UTP18 het Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
0.188 4.40E-28 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.183 8.84E-27 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.180 1.00E-25 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.167 3.18E-22 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp