YPR139C / LOA1

Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR139C / LOA1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.94|P-value:3.11E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.96|P-value:2.35E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.45|P-value:5.55E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.19|P-value:3.53E-8 ID:SGTC_232|Compound:clozapine|FD-Score:4.79|P-value:1.59E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:7.22|P-value:1.60E-10 ID:SGTC_364|Compound:0083-0097|FD-Score:4.00|P-value:2.60E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.65|P-value:7.67E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.66|P-value:7.41E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.17|P-value:1.44E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.56|P-value:3.71E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.34|P-value:8.01E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:4.07|P-value:2.03E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.92|P-value:3.28E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:5.10|P-value:4.62E-6 ID:SGTC_918|Compound:glabranin|FD-Score:3.82|P-value:4.54E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.73|P-value:6.12E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.84|P-value:4.23E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.05|P-value:2.18E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.92|P-value:3.31E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:6.29|P-value:2.11E-8 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.76|P-value:5.50E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.69|P-value:6.90E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.80|P-value:4.93E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:6.32|P-value:1.84E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.02|P-value:1.98E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.95|P-value:1.13E-7 ID:SGTC_1781|Compound:st038725|FD-Score:5.19|P-value:3.16E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.12|P-value:4.18E-6 ID:SGTC_1963|Compound:st076565|FD-Score:5.95|P-value:1.11E-7 ID:SGTC_2055|Compound:5235184|FD-Score:4.29|P-value:9.53E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.82|P-value:4.58E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.85|P-value:4.19E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.00|P-value:2.09E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.86|P-value:3.99E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.90|P-value:3.58E-4 ID:SGTC_2873|Compound:9040596|FD-Score:7.35|P-value:7.65E-11 ID:SGTC_2886|Compound:9058944|FD-Score:-3.52|P-value:9.47E-4 ID:SGTC_2887|Compound:9044784|FD-Score:8.98|P-value:2.42E-15 ID:SGTC_2899|Compound:9053889|FD-Score:-4.45|P-value:4.41E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.28|P-value:7.93E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.05|P-value:2.15E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.08|P-value:1.99E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.87|P-value:3.90E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.19|P-value:1.39E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.94|P-value:3.11E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.96|P-value:2.35E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.45|P-value:5.55E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:6.19|P-value:3.53E-8 ID:SGTC_232|Compound:clozapine|FD-Score:4.79|P-value:1.59E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:7.22|P-value:1.60E-10 ID:SGTC_364|Compound:0083-0097|FD-Score:4.00|P-value:2.60E-4 ID:SGTC_389|Compound:tpck|FD-Score:3.65|P-value:7.67E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.66|P-value:7.41E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:4.17|P-value:1.44E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:4.56|P-value:3.71E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:4.34|P-value:8.01E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:4.07|P-value:2.03E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.92|P-value:3.28E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:5.10|P-value:4.62E-6 ID:SGTC_918|Compound:glabranin|FD-Score:3.82|P-value:4.54E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.73|P-value:6.12E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.84|P-value:4.23E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.05|P-value:2.18E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:3.92|P-value:3.31E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:6.29|P-value:2.11E-8 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.76|P-value:5.50E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.69|P-value:6.90E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.80|P-value:4.93E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:6.32|P-value:1.84E-8 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.02|P-value:1.98E-4 ID:SGTC_1724|Compound:st037281|FD-Score:5.95|P-value:1.13E-7 ID:SGTC_1781|Compound:st038725|FD-Score:5.19|P-value:3.16E-6 ID:SGTC_1959|Compound:st077091|FD-Score:5.12|P-value:4.18E-6 ID:SGTC_1963|Compound:st076565|FD-Score:5.95|P-value:1.11E-7 ID:SGTC_2055|Compound:5235184|FD-Score:4.29|P-value:9.53E-5 ID:SGTC_2322|Compound:7413319|FD-Score:3.82|P-value:4.58E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.85|P-value:4.19E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.00|P-value:2.09E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:3.86|P-value:3.99E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.90|P-value:3.58E-4 ID:SGTC_2873|Compound:9040596|FD-Score:7.35|P-value:7.65E-11 ID:SGTC_2886|Compound:9058944|FD-Score:-3.52|P-value:9.47E-4 ID:SGTC_2887|Compound:9044784|FD-Score:8.98|P-value:2.42E-15 ID:SGTC_2899|Compound:9053889|FD-Score:-4.45|P-value:4.41E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-4.28|P-value:7.93E-5 ID:SGTC_3137|Compound:9097352|FD-Score:4.05|P-value:2.15E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.08|P-value:1.99E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.87|P-value:3.90E-4 ID:SGTC_3320|Compound:9137005|FD-Score:4.19|P-value:1.39E-4

Top fitness defect scores for YPR139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2887 9044784 8.98 58.4 µM 2.42E-15 fatty acid desaturase (OLE1) 5 1.37E-19
2 SGTC_2873 9040596 7.35 71.4 µM 7.65E-11 8 1.02E-13
3 SGTC_301 4119-0100 7.22 24.5 µM 1.60E-10 NEO1 28 2.66E-13
4 SGTC_1680 diphenhydramine 6.32 100.0 µM 1.84E-8 NEO1 4 1.30E-10
5 SGTC_1394 3474-0001 6.29 65.7 µM 2.11E-8 endomembrane recycling 12 1.55E-10
6 SGTC_221 trifluoperazine 6.19 10.3 µM 3.53E-8 NEO1-PIK1 118 3.03E-10
7 SGTC_1963 st076565 5.95 50.3 µM 1.11E-7 1 1.34E-9
8 SGTC_1724 st037281 5.95 8.3 µM 1.13E-7 10 1.37E-9
9 SGTC_1781 st038725 5.19 66.3 µM 3.16E-6 NEO1 68 1.05E-7
10 SGTC_1959 st077091 5.12 55.8 µM 4.18E-6 RPP1 & pyrimidine depletion 18 1.51E-7
11 SGTC_876 0720-0963 5.10 56.8 µM 4.62E-6 6 1.72E-7
12 SGTC_232 clozapine 4.79 119.0 µM 1.59E-5 NEO1 51 8.55E-7
13 SGTC_686 1319-0111 4.56 510.0 µM 3.71E-5 60S ribosome export 17 2.57E-6
14 SGTC_70 0141-0289 4.45 43.3 µM 5.55E-5 mitochondrial stress 142 4.35E-6
15 SGTC_733 4069-0007 4.34 56.1 µM 8.01E-5 ERAD & cell cycle 74 7.00E-6
16 SGTC_2055 5235184 4.29 200.0 µM 9.53E-5 ERG2 21 8.77E-6
17 SGTC_3320 9137005 4.19 35.1 µM 1.39E-4 endomembrane recycling 11 1.42E-5
18 SGTC_562 3772-2733 4.17 112.0 µM 1.44E-4 ERG2 72 1.49E-5
19 SGTC_3157 9099274 4.08 49.5 µM 1.99E-4 18 2.27E-5
20 SGTC_749 1000-0129 4.07 128.0 µM 2.03E-4 amide catabolism 19 2.33E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 9.39E-44 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.234 9.16E-43 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.228 9.21E-41 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.223 6.03E-39 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.214 3.26E-36 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.214 6.27E-36 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.198 5.50E-31 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.197 1.23E-30 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.190 1.04E-28 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.184 4.46E-27 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.179 1.71E-25 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.178 2.65E-25 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.174 3.02E-24 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.172 7.99E-24 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.171 2.10E-23 YGL072C_d YGL072C_d hom Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2